期刊
NEUROSCIENCE LETTERS
卷 465, 期 3, 页码 290-294出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.09.037
关键词
Vangl2; Fish; Nociception; Telencephalon (forebrain)
资金
- BBSRC
- MRC [G0701003] Funding Source: UKRI
- NERC [NBAF010002] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [S19809] Funding Source: researchfish
- Medical Research Council [G0701003] Funding Source: researchfish
- Natural Environment Research Council [NER/B/S/2002/00285, NBAF010002] Funding Source: researchfish
The Van Gogh-like 2 (vangl2) gene is typically associated with planar cell polarity pathways. which is essential for correct orientation of epithelial cells during development. The encoded protein of this gene is a transmembrane protein and is highly conserved through evolution Van Gogh-like 2 was selected for further study on the basis of consistent regulation after a nociceptive stimulus in adult common carp and rainbow trout in a microarray study. An in situ hybridisation was conducted in the brain of mature common carp (Cyprinus carpio), 1.5 and 3 h after a nociceptive stimulus comprising of an acetic acid injection to the lips of the fish and compared with a saline-injected control The vangl2 gene was expressed in all brain regions, and particularly intensely in neurons of the telencephalon and in ependymal cells. In the cerebellum, a greater number (P = 0.018) of Purkinje cells expressed vangl2 after nociception (n = 7) compared with controls (n = 5). This regulation opens the possibility that vangl2 is involved in nociceptive processing in the adult fish brain and may be a novel target for central nociception in vertebrates. (C) 2009 Elsevier Ireland Ltd All rights reserved.
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