Article
Pharmacology & Pharmacy
Rafael Gonzalez-Cano, Angeles Montilla-Garcia, Gloria Perazzoli, Jesus M. Torres, Francisco J. Canizares, Eduardo Fernandez-Segura, Michael Costigan, Jose M. Baeyens, Enrique J. Cobos
Summary: Both TRPA1 and purinergic P2X receptors are proposed as potential targets for the treatment of visceral pain. While a low dose of mustard oil induces visceral pain dependent on TRPA1, a higher dose results in pain mostly independent of TRPA1 but enhanced by ATP released from damaged tissues. Thus, TRPA1 inhibition may not be sufficient to decrease visceral pain significantly during tissue injury, and purinergic antagonism appears to be a more effective strategy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mircea Iftinca, Manon Defaye, Christophe Altier
Summary: TRPV1 is a significant channel in pain perception and its agonists are being studied for chronic pain management. While TRPV1 antagonists have limited clinical use due to side effects, capsaicin offers a potential avenue for long-lasting pain relief by defunctionalising nociceptors. The development of TRPV1-targeted drugs could provide a new generation of analgesics for various pain conditions.
Article
Chemistry, Medicinal
Isabella Romeo, Antonella Brizzi, Federica Pessina, Francesca Alessandra Ambrosio, Francesca Aiello, Carmela Belardo, Gabriele Carullo, Giosue Costa, Luciano De Petrocellis, Maria Frosini, Livio Luongo, Samuele Maramai, Marco Paolino, Aniello Schiano Moriello, Claudia Mugnaini, Francesco Scorzelli, Sabatino Maione, Federico Corelli, Vincenzo Di Marzo, Stefano Alcaro, Anna Artese
Summary: We developed a rational drug design strategy and synthesized ligands to improve the binding properties and potency of a previously identified TRPV1 agonist. Molecular modeling and simulations guided the design towards introducing a lipophilic iodine and a flat pyridine/benzene at a specific position in the ligand. Most synthesized compounds showed high TRPV1 efficacy, selectivity, and protective properties against oxidative stress-induced ROS formation. The compounds also exhibited neuroprotective and antinociceptive effects in biological evaluations.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Arpad Szallasi
Summary: Resiniferatoxin (RTX) is a potent analgesic with a wide range of pharmacological actions. Targeted RTX therapy shows promise in cancer pain management and treatment of knee pain in patients with osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Arpad Szallasi
Summary: Today's sedentary lifestyle and poor dietary habits contribute to the increasing prevalence of hypertension, a major risk factor for stroke. Recent research suggests that the activation of TRPV1 receptor by capsaicin, a compound found in chili peppers, can lower blood pressure and potentially be a therapeutic target for hypertensive patients. However, the mechanism of action of capsaicin on blood pressure regulation is more complex than previously understood. Further studies are needed to explore the potential benefits of TRPV1-targeting drugs in treating hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Jin Mi Kang, Sun Ok Kwon, Jihyae Ann, Sunho Lee, Changhoon Kim, Nayeon Do, Jin Ju Jeong, Peter M. Blumberg, Heejin Ha, Thi Ngoc Lan Vu, Sanghee Yoon, Sun Choi, Robert Frank-Foltyn, Bernhard Lesch, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph, Jeewoo Lee
Summary: The series of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists, with halogenated phenyl A-region analogs showing a broad functional profile. Antagonists 28 and 92 exhibited potent antagonism against capsaicin for hTRPV1, with antagonist 92 displaying promising analgesic activity in vivo. Molecular modeling of compound 92 suggested that the two fluoro groups in the A-region interacted hydrophobically with the receptor.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Tatsuya Kida, Nobuaki Takahashi, Masayuki X. Mori, Jiacheng H. Sun, Hideto Oota, Kosuke Nishino, Takashi Okauchi, Yuta Ochi, Daisuke Kano, Ukihide Tateishi, Yasuyoshi Watanabe, Yilong Cui, Yasuo Mori, Hisashi Doi
Summary: TRPV1-targeted compounds were synthesized by modifying the structure of SB366791, and higher antagonistic activities were achieved by avoiding amide-iminol tautomerization. Additionally, explorative PET imaging trials were conducted using labeled derivatives, providing a basis for further applications.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Yong-fu Zhu, Peng-cheng Zhang, Jie Zhou, Li Wang, You-mou Chen, Ye-han Sun, Jia Ma, Gao-xiang Wang, Ming-ran Xie, Mei-qi Zhou
Summary: This study suggests that electroacupuncture (EA) can physiologically alleviate the symptoms of chronic cough and dyspnea, and improve the quality of life (QOL) in patients. The mechanism might be related to the decreased expression of TRPV1 and neurogenic factors after electroacupuncture treatment.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: It was discovered that acetaminophen was able to prevent adverse movement symptoms induced by antipsychotic drugs, and this effect was achieved by activating TRPV1 channels to increase the activity of indirect pathway neurons.
Article
Environmental Sciences
Emmanuel Rapp, Zhenyu Lu, Lili Sun, Samantha N. Serna, Marysol Almestica-Roberts, Katherine L. Burrell, Nam D. Nguyen, Cassandra E. Deering-Rice, Christopher A. Reilly
Summary: This study investigated the impact of TRPA1 and TRPV1 gene polymorphisms on airway epithelial cells and asthma symptom control. The results suggest that increased expression of TRPA1 may contribute to worse asthma symptom control among children with the TRPV1 I585I/V genotype, by sensitizing epithelial cells to particulate materials and other TRPA1 agonists. Additionally, this study provides insights into the regulatory mechanisms of TRPA1 and TRPV1 genes.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Medicine, Research & Experimental
Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke
Summary: This study provides direct evidence in humans for pain-related functional changes linked to TRPV1, a potential target in the development of pain relievers. Two individuals carrying a homozygous missense mutation in TRPV1 demonstrated insensitivity to heat stimulation, elevated pain thresholds, and abnormal responses to a TRPA1 channel activator. These findings highlight the importance of TRPV1 in pain modulation and may contribute to the development of novel pain therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Tina Blazevic, Cosmin I. Ciotu, Markus Gold-Binder, Elke H. Heiss, Michael J. M. Fischer, Verena M. Dirsch
Summary: Capsaicin, an active compound of chili peppers, can inhibit platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle cells (VSMCs), possibly through a role of TRPV1. However, commercially available antibodies were ineffective in detecting TRPV1 expression. Moreover, TRPV1 agonists did not increase intracellular calcium levels in VSMCs. RT-qPCR results showed low TRPV1 expression in VSMCs, suggesting the absence of canonical TRPV1 channel activity.
Article
Pharmacology & Pharmacy
Ankush M. Korishettar, Yoshinori Nishijima, Zhihao Wang, Yangjing Xie, Juan Fang, David A. Wilcox, David X. Zhang
Summary: TRPV1 channels are expressed in the human vasculature and affect vascular tone of human arterioles when activated. Their vasomotor function is modulated by endothelin-1, partly mediated by protein kinase C.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jenny Wilzopolski, Manfred Kietzmann, Santosh K. Mishra, Holger Stark, Wolfgang Baeumer, Kristine Rossbach
Summary: The study found that both TRPV1 and TRPA1 channels play important roles in the transmission of histamine-induced itch, with TRPV1 inhibition reducing itch induced by both H1R and H4R, while TRPA1 inhibition only reduced H4R-induced itch. In vitro experiments showed that inhibition of TRPV1 and TRPA1 led to reduced Ca2+ influx into sensory neurons.
Article
Biochemistry & Molecular Biology
Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian
Summary: In this study, three series of new piperazine urea TRPV1 antagonists were designed, synthesized, and evaluated, among which compound 5ac showed excellent TRPV1 antagonistic activity, good bioavailability, and no hyperthermia side effects. The molecular docking study revealed that compound 5ac interacted well with the amino acid residues on rTRPV1 through hydrophobic interaction, making it an efficient TRPV1 antagonist and a potential candidate for analgesic drug development.
BIOORGANIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Eva Borbely, Maria Simon, Eberhard Fuchs, Ove Wiborg, Boldizsar Czeh, Zsuzsanna Helyes
Summary: This article reviews the treatment of major depressive disorder, focusing on overcoming treatment-resistant depression. Current clinical trials are investigating novel drug targets and candidates, including modulation of neurotransmission, opioidergic system, and hallucinogenic tryptamine derivatives. The only registered drug for treatment-resistant depression is the NMDA receptor antagonist, but combination therapies with other agents have also shown efficacy. Additionally, there is significant research being done on large-scale omics and neuroimaging studies, which may provide new insights into molecular mechanisms and potential therapeutic strategies.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tamas Csipo, Agnes Czikora, Gabor A. Fulop, Hajnalka Gulyas, Ibolya Rutkai, Eniko Pasztorne Toth, Robert Porszasz, Andrea Szalai, Kata Bolcskei, Zsuzsanna Helyes, Erika Pinter, Zoltan Papp, Zoltan Ungvari, Attila Toth
Summary: TRPM4 plays a significant role in peripheral arteries by amplifying intracellular Ca2+ signals, contributing to myogenic tone and agonist responses. It may have important implications for circulation and hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fruzsina Kiss, Viktoria Kormos, Eva Szoke, Angela Kecskes, Norbert Toth, Anita Steib, Arpad Szallasi, Balint Scheich, Balazs Gaszner, Jozsef Kun, Gabor Fulop, Krisztina Pohoczky, Zsuzsanna Helyes
Summary: The expression of TRPA1 and TRPV1 is upregulated in oral squamous cell carcinoma (OSCC) and their activation may regulate cancer cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lilla Toth, Mark F. Juhasz, Laszlo Szabo, Alan Abada, Fruzsina Kiss, Peter Hegyi, Nelli Farkas, Gyoergy Nagy, Zsuzsanna Helyes
Summary: JAK inhibitors have been shown to be effective in treating rheumatoid arthritis (RA) by reducing joint inflammation and providing direct analgesic effect. This meta-analysis provides comprehensive evidence of the superiority of JAK inhibitors in improving patient-reported outcomes and disease activity indices in RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Krisztina Takacs-Lovasz, Jozsef Kun, Timea Aczel, Peter Urban, Attila Gyenesei, Kata Boelcskei, Eva Szoke, Zsuzsanna Helyes
Summary: In this study, the signaling pathways induced by PACAP-38 and PACAP(6-38) were compared using transcriptomic analysis. The results showed that both peptides had 200 common differentially expressed genes, with downregulation of NADH: ubiquinone oxidoreductase subunit B6 and upregulation of transient receptor potential cation channel, subfamily M, member 8. This suggests that PACAP may activate trigeminal primary sensory neurons through a mechanism independent of the known receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Kata P. Szilveszter, Simon Vikar, Adam Horvath, Zsuzsanna Helyes, Miklos Sardy, Attila Mocsai
Summary: Phospholipase C gamma 2 (PLC gamma 2) plays a critical role in the pathogenesis of inflammatory epidermolysis bullosa acquisita by regulating the tissue infiltration of immune cells and the release of proinflammatory mediators.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lina Hudhud, David R. Chisholm, Andrew Whiting, Anita Steib, Krisztina Pohoczky, Angela Kecskes, Eva Szoke, Zsuzsanna Helyes
Summary: We investigated the effects of stable diphenylacetylene-based analogues of all-trans-retinoic acid (ATRA) on cell viability and genotoxicity. These analogues demonstrated variation in cytotoxic activity, with some showing stronger genotoxicity at higher concentrations. Although these compounds exhibited retinoid receptor-independent genotoxicity, further research is needed to understand their molecular mechanisms and complex biological functions.
Review
Immunology
Andreas Goebel, David Andersson, Zsuzsanna Helyes, J. David Clark, Debra Dulake, Camilla Svensson
Summary: Chronic pain is a major cause of disability worldwide, but its etiology and treatment methods are still uncertain. Research has found that autoimmune factors may be related to certain chronic pain conditions, caused by antibody-mediated autoimmune mechanisms. These findings suggest that antibody-mediated autoimmune mechanisms may play an important role in multiple conditions and further research is needed to elucidate the molecular and cellular details.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Aslam, Hafiza Idrees, Peter Ferdinandy, Zsuzsanna Helyes, Christian Hamm, Rainer Schulz
Summary: Somatostatin primes HUVECs for thrombin-induced hyperpermeability via MEK/ERK signaling and promotes HUVEC proliferation and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dora Szabo, Zsolt Sarszegi, Beata Polgar, Eva Saghy, Dora Reglodi, Tunde Toth, Zsofia Onodi, Przemyslaw Leszek, Zoltan V. Varga, Zsuzsanna Helyes, Agnes Kemeny, Peter Ferdinandy, Andrea Tamas
Summary: This study aimed to investigate the presence of PACAP-38 in heart failure (HF) patients and its correlation with HF predictors. The results showed that plasma PACAP-38 immunoreactivity was higher in acute HF patients, while lower in chronic HF patients. In addition, a positive correlation between plasma PACAP-38 and NT-proBNP levels was observed in acute HF, but a negative correlation in chronic HF. The levels of cytokines IL-1 beta, IL-2, IL-4 were lower in chronic HF, and IL-10 was higher in acute HF. PACAP-38 levels in myocardial tissues were lower in all end-stage HF patients. The study suggests that PACAP-38 may be a potential prognostic biomarker in HF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Viktoria Kormos, Angela Kecskes, Jozsef Farkas, Tamas Gaszner, Valer Csernus, Ammar Alomari, Daniel Hegedus, Eva Renner, Miklos Palkovits, Dora Zelena, Zsuzsanna Helyes, Erika Pinter, Balazs Gaszner
Summary: This study found that the expression of TRPA1 in UCN1 neurons is associated with the regulation of depression-like behavior and stress adaptation response in mice. In addition, decreased TRPA1 expression was observed in the human EWcp of individuals who died by suicide.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Fruzsina Kiss, Krisztina Pohoczky, Aniko Gorbe, Fanni Dembrovszky, Szabolcs Kiss, Peter Hegyi, Lajos Szako, Lilla Toth, Eva Somogyine Ezer, Eszter Szalai, Zsuzsanna Helyes
Summary: This meta-analysis found that the addition of EGFR inhibitors to standard chemotherapy significantly decreased mortality and disease progression in patients with head and neck squamous cell carcinoma (HNSCC), but also increased the risk of skin rashes.
Article
Respiratory System
Kata Cseko, Dora Hargitai, Lilla Draskoczi, Adrienn Keri, Pongsiri Jaikumpun, Beata Keremi, Zsuzsanna Helyes, Akos Zsembery
Summary: This study investigated the safety of hypertonic sodium bicarbonate (NaHCO3) inhalation in chronic cigarette smoke (CS)-exposed guinea pigs, and found that long-term NaHCO3 inhalation did not worsen respiratory parameters and normalized CS-induced transient alterations in respiratory functions.
BMC PULMONARY MEDICINE
(2022)
Editorial Material
Pharmacology & Pharmacy
Imola Wilhelm, Istvan A. Krizbai, Mihaela Gherghiceanu, Eva Szoke, Zsuzsanna Helyes
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Kitti Rusznak, Adam Istvan Horvath, Kinga Pohli-Toth, Anett Futacsi, Agnes Kemeny, Gabriella Kiss, Zsuzsanna Helyes, Boldizsar Czeh
Summary: Acute and chronic arthritis can affect adult hippocampal neurogenesis through a cascade of molecular and cellular changes, resulting in a decrease in the number of doublecortin-positive cells and an increase in the density of CD68-positive macrophages/microglia.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)