期刊
NEUROSCIENCE LETTERS
卷 449, 期 2, 页码 137-141出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.105
关键词
Electrical stimulation; Nucleus basalis magnocellularis; Basal forebrain; Immediate-early gene expression; Learning and memory; Rat
资金
- Universitat Autonoma de Barcelona [UNI/20781202]
- Generalitat de Catalunya [SGR2005-00551]
- Ministerio de Educacion y Ciencia [SEJ2005-02518]
The present study examined the expression of the immediate-early gene c-fos in different brain regions following a single 20-min session of unilateral electrical stimulation of the nucleus basalis magnocellularis (NBM). Current findings confirm that NBM stimulation provides specific activation of several cortical and subcortical regions closely related to the NBM and involved in learning and memory processes, such as the cingulate, parietal, piriform and perirhinal cortices, dorsal subiculum, and the parafascicular, central lateral and central medial nuclei of the thalamus. In contrast, NBM stimulation did not increase c-Fos expression in some expected areas that receive direct NBM projections such as the entorhinal cortex or amygdala nuclei. Results are discussed in terms of the possibility that NBM electrical stimulation facilitates learning by inducing neural changes related to transcription factors such as c-Fos. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据