Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Sergey L. Malkin, Maria Zakharova, Ilya Smolensky, Olga E. Zubareva, Aleksey Zaitsev
Summary: Disruption of glutamate clearance in the synaptic cleft can lead to synaptic dysfunction and neurological diseases, potentially causing excitotoxicity. Increased glutamate clearance has been shown to reduce long-term synaptic potentiation (LTP). Treatment with the enhancer of glutamate transporter 1 expression, ceftriaxone, weakened LTP in the hippocampus of young rats, likely due to reduced spillover of glutamate leading to decreased activation of synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Cell Biology
Tatyana Y. Postnikova, Dmitry V. Amakhin, Alina M. Trofimova, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Daria S. Kalinina, Anna A. Kovalenko, Anastasiia D. Shcherbitskaia, Dmitry S. Vasilev, Aleksey V. Zaitsev
Summary: Maternal hyperhomocysteinemia during pregnancy leads to memory impairments in rats, associated with reduced long-term potentiation (LTP) and altered NMDA receptor desensitization in the hippocampus. Expression of glutamate receptor subunits is unaffected except for GluN1. Additionally, delayed hippocampal maturation and decreased synaptopodin-positive spines were observed in offspring.
Review
Behavioral Sciences
Martin Stacho, Denise Manahan-Vaughan
Summary: Long-term potentiation (LTP) and long-term depression (LTD) are cellular mechanisms related to learning and memory. LTD has a specific role in hippocampus-dependent associative learning and information encoding, reducing excitatory synapses and restricting the effects of LTP. It acts in conjunction with LTP to contribute to learning.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Immunology
David C. Consoli, Brittany D. Spitznagel, Benjamin M. Owen, Hakmook Kang, Shawniqua Williams Roberson, Pratik Pandharipande, E. Wesley Ely, William P. Nobis, Julie A. Bastarache, Fiona E. Harrison
Summary: This study utilized a mouse model to characterize inattention and persistent cognitive deficits following polymicrobial sepsis through concurrent measures of telemetric EEG recordings and neurobehavioral tasks. The results showed that during the 24-hour critical illness period, mice exhibited slow-wave EEG dominance, sleep disruption, and hypersensitivity to auditory stimuli, resembling clinical observations in delirious patients. Furthermore, mice that showed poor nest building ability at 7 days after sepsis induction also exhibited molecular changes in hippocampal long-term potentiation, offering a robust mouse model for investigating the molecular pathways underlying brain and behavioral changes during and after acute illness such as sepsis.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Fouad Lemtiri-Chlieh, Eric S. Levine
Summary: It is widely accepted that exogenous cannabinoids can impair short-term memory and cognition. Conversely, the activation of endogenous cannabinoids may enhance synaptic plasticity. This study found that the simultaneous activation of CB1 receptors by 2-AG and anandamide enhances LTP by suppressing inhibition at GABAergic synapses.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Toxicology
Wei Sun, Yang Yang, Yazi Mei, Yuanhua Wu, Xiao Chen, Lei An
Summary: The study revealed that prenatal exposure to cyanuric acid (CA) impairs learning and memory function in a dose-dependent manner. It affects synaptic function in the hippocampal circuitry, with a decrease in NMDA-GluN2A levels. These findings support the hypothesis that CA treatment can negatively impact spatial cognition in fetuses.
TOXICOLOGY LETTERS
(2022)
Review
Neurosciences
Alex Sonneborn, Robert W. Greene
Summary: The locus coeruleus (LC) has been established as the major source of dopamine release to the dorsal hippocampus, and its activity is highly correlated with attentional processes and memory. Blocking the norepinephrine transporter (NET) may be a plausible mechanism for LC-mediated dopamine release.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Hanna Dumanska, Nikolai Veselovsky
Summary: The study found that hypoxia leads to long-term potentiation of NMDA neurotransmission, and the protein kinase C (PKC) signaling pathway plays an important role in this process. It was discovered that adding a PKC inhibitor can block the induction of long-term potentiation, but cannot reverse the shortening of current kinetics. These findings provide insights into the prevention and treatment of hypoxic injuries and the underlying mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Madeleine Kyrke-Smith, Barbara Logan, Wickliffe C. Abraham, Joanna M. Williams
Summary: By examining the activity of HDAC1 and HDAC2 following LTP induction, it was found that HDACs may negatively regulate gene transcription in the early stages of LTP, without affecting its long-term maintenance.
Article
Biochemistry & Molecular Biology
Caroline Lahogue, Jean-Marie Billard, Thomas Freret, Valentine Bouet
Summary: The 5-HT6 receptors antagonist SB-271046 increases excitatory synaptic transmission and NMDAR activation at the CA3/CA1 hippocampal connections in mice. In male mice, this improvement is related to GABAAR antagonism, while in female mice it is not. Furthermore, the 5-HT6 receptors blockade has no significant effect on synaptic plasticity.
Article
Neurosciences
Gabriel Henrique Schirmbeck, Marina Seady, Fernanda Telles Froes, Jessica Taday, Carollina Da Re, Jessica Maria Souza, Carlos Alberto Goncalves, Marina Concli Leite
Summary: This study investigated the impact of low-grade repeated inflammation stimuli induced by LPS on hippocampal function and spatial memory in rats. The findings suggest that long-term repeated systemic inflammation can lead to memory impairment and disturbance in astrocyte function.
Article
Biochemistry & Molecular Biology
Yu-Ran Lee, Eun Young Bae, Hong Ryang Kil, Byeong-Hwa Jeon, Geena Kim
Summary: This study investigated the association between APE1/Ref-1 and Kawasaki disease (KD). The results showed that APE1/Ref-1 levels were significantly higher in KD patients, especially in refractory KD. APE1/Ref-1 could be a beneficial biomarker for the diagnosis and prognosis of KD.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Chemistry, Medicinal
Yoo Jin Kim, You Kyoung Shin, Eunhye Seo, Geun Hee Seol
Summary: This study investigated the interactions between inflammation and loss of cholinergic transmission in neurons, astrocytes, and microglia. The findings suggest that linalyl acetate (LA) can protect neurons and microglia by reducing store-operated calcium entry (SOCE) induced by inflammatory responses and inhibiting muscarinic receptors via Na+-K+ ATPase and the forward mode of NCX. Additionally, astrocytes may protect microglia by reducing increased SOCE under the conditions of inflammation and a muscarinic receptor blockade.
Article
Behavioral Sciences
Dong-Hee Kim, Bo-Ryoung Choi, In-Beom Jin, Jin-Ah Jeon, Sang-Pil Park, Jung-Soo Han
Summary: A previous study found that lateral habenula (LHb) lesions slowed down appetitive extinction. Therefore, we investigated whether LHb activation could accelerate appetitive extinction. In this study, rats underwent appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation expedited the decrease in conditioned food-cup responses during extinction. The present findings, along with previous LHb lesion studies, suggest that LHb mediates appetitive extinction.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
In-Beom Jin, Yong-Jae Jeon, Jeiwon Cho, Jung-Soo Han
Summary: Recent studies have shown that the LHb plays a critical role in mediating the association between CS and the absence of US. The LHb is involved in the conditioned inhibitory properties of CS acquired through explicit unpaired training, but preexposure to the same number of lights does not significantly retard the acquisition of subsequent excitatory associations.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Jae-Yeon Kim, You Kyoung Shin, Geun Hee Seol
Summary: This retrospective observational study aimed to identify the incidence and risk factors for pressure injury in non-small cell lung cancer (NSCLC) patients. Among 645 hospitalized NSCLC patients, 27.9% developed pressure injury. Patients with pressure injury had higher levels of serum C-reactive protein (CRP), neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio. Increased serum CRP levels at admission were a major risk factor for the development of pressure injury.
JOURNAL OF TISSUE VIABILITY
(2023)
Review
Neurosciences
Hee-Ju Kang, Ju-Wan Kim, Sung-Wan Kim, Jung-Soo Han, In Kyoon Lyoo, Jae-Min Kim
Summary: Biomarkers, especially peripheral ones, can contribute to the development of preventive and intervention strategies for suicidal behavior. These biomarkers should be easily accessible, cost-effective, and minimally invasive. Several peripheral biomarkers are associated with suicidal behavior, such as decreased levels of peripheral interleukin-2 in suicide attempts and elevated levels of certain substances in cerebrospinal fluid related to suicide risk and suicide death. Combining multiple potential biomarkers may improve screening, diagnosis, and prediction of suicidal behavior.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.
Article
Nutrition & Dietetics
Uihwan Kim, You Kyoung Shin, Jubin Park, Geun Hee Seol
Summary: This study demonstrates the vasorelaxant effects of Codonopsis lanceolata extract under high potassium conditions, particularly in the presence of endothelial dysfunction. The mechanism of action involves voltage-dependent calcium channels (VDCCs) rather than potassium channels.
Article
Chemistry, Medicinal
Jubin Park, You Kyoung Shin, Uihwan Kim, Geun Hee Seol
Summary: Ginsenoside Rb-1 reduces hyper-vasoconstriction and endothelial dysfunction induced by high glucose by inhibiting calcium influx through receptor-operated and voltage-gated calcium channels. This study provides further evidence for the potential therapeutic role of Rb-1 in treating endothelial dysfunction in diabetes.
Article
Pharmacology & Pharmacy
Eu-Gene Kim, Wonseok Chang, SangYep Shin, Anjana Silwal Adhikari, Geun Hee Seol, Dae-Yong Song, Sun Seek Min
Summary: It has been reported that early life stressful events can influence adult behavior and are associated with various psychiatric disorders. Maternal separation (MS) in animals is a well-known model for studying childhood stress and depression. This study investigated the effects of MS on anxiety and aggression-like behavior as well as the number of GABAergic neurons in the hippocampus. The results showed that MS led to increased anxiety and aggression in behavior tests and an increase in GAD67 and PV positive neurons in different regions of the hippocampus. These changes were accompanied by an increase in corticosterone, suggesting involvement of the HPA axis. Overall, MS alters anxiety and aggression levels, possibly through changes in hippocampal cytoarchitecture and HPA axis function.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
A. Young Han, Su Min Ha, You Kyoung Shin, Geun Hee Seol
Summary: In this study, the researchers found that Rg-1 inhibits high glucose-induced calcium influx, thus protecting vascular endothelial and smooth muscle cells from calcium increases caused by high blood sugar.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
