Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Review
Medicine, General & Internal
Cristina M. Pedrero-Prieto, Javier Frontinan-Rubio, Francisco J. Alcain, Mario Duran-Prado, Juan R. Peinado, Yoana Rabanal-Ruiz
Summary: CSF is considered the best target for biomarker discovery in neurodegenerative diseases due to its deep irrigation of the brain and ease of sample extraction. Discoveries of new proteins in CSF have identified important biomarkers related to AD, and deeper analysis of data from multiple proteomic studies may reveal disrupted components or metabolic pathways in AD.
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Geriatrics & Gerontology
Mana Shams, Sara Shams, Juha Martola, Lena Cavallin, Tobias Granberg, Magnus Kaijser, Max Wintermark, Eric Westman, Peter Aspelin, Maria Kristoffersen Wiberg, Lars-Olof Wahlund
Summary: The study found that APOE epsilon 4 is associated with MRI markers of SVD related to amyloid pathology, specifically CMBs and A beta 42 plaque formation in the brain, as reflected by decreased CSF A beta 42 levels. On the other hand, APOE epsilon 3 and epsilon 2 are associated with markers of hypertensive arteriopathy, such as the association with CMBs in deep and infratentorial brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleo, Jose Luis Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms
Summary: The levels of total tau (t-tau) in cerebrospinal fluid (CSF) in AD are associated with changes in proteins related to neuronal plasticity and dysfunction of the blood-brain and blood-CSF barriers. These protein changes are disease traits and may affect treatment response. Therefore, future research may need to stratify based on CSF t-tau levels.
MOLECULAR NEURODEGENERATION
(2022)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Jiacheng Zhong, Xiaohu Ren, Wei Liu, Shuqi Wang, Yuan Lv, Lulin Nie, Rongying Lin, Xiaoping Tian, Xifei Yang, Feiqi Zhu, Jianjun Liu
Summary: The study identified 360 neuron-derived exosomal proteins using a quantitative proteomic approach, revealing intersections between immune response pathway proteins and Alzheimer's disease progression, where C7 and ZYX might serve as potential markers for evaluating cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi, Pengcheng Fan
Summary: This study analyzed the clinical and proteomic data of patients with Japanese encephalitis (JE) and identified two subtypes of JE with significantly different prognoses. The JE2 subtype was associated with a higher risk of cognitive impairment. The findings also provided potential target proteins for the treatment of cognitive impairments caused by JE.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Una Smailovic, Ingemar Kareholt, Thomas Koenig, Nicholas J. Ashton, Bengt Winblad, Kina Hoglund, Per Nilsson, Henrik Zetterberg, Kaj Blennow, Vesna Jelic
Summary: The study found that CSF neurogranin and qEEG measures are associated with clinical deterioration in MCI patients and can serve as independent predictors of progression to AD dementia. Multimodal diagnostic and prognostic approaches incorporating molecular and neurophysiological synaptic markers may have additive value in dementia management.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Oncology
Ratna Priya, Vaishali Jain, Javed Akhtar, Neeraj Saklani, Puja Sakhuja, Anil Kumar Agarwal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar, Poonam Gautam
Summary: This study analyzed the protein content of extracellular vesicles derived from gallbladder cancer cell lines, identifying potential biomarkers for the detection of gallbladder cancer. Haptoglobin (HP) levels were found to be increased in gallbladder cancer, suggesting its potential as a biomarker.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Virginie Imbault, Chiara Dionisi, Gilles Naeije, David Communi, Massimo Pandolfo
Summary: This study aimed to identify potential biomarkers in FRDA patients by analyzing changes in cerebrospinal fluid (CSF) proteins. The researchers found 172 differentially expressed proteins between FRDA patients and controls, indicating possible involvement of various signaling pathways and pathogenic mechanisms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Li, Yinhua Zhou, Zhaofan Luo, Rixin Tang, Yuxuan Sun, Qiangsheng He, Bin Xia, Kuiqing Lu, Qinghua Hou, Jinqiu Yuan
Summary: This study aims to construct a lipid score system to predict the risk of progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The results showed that the lipid score system based on serum lipidomics can accurately predict the progression risk from MCI to AD.
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Madhurima Chatterjee, Selcuk Oezdemir, Marcel Kunadt, Marleen Koel-Simmelink, Walter Boiten, Lars Piepkorn, Thang V. Pham, Davide Chiasserini, Sander R. Piersma, Jaco C. Knol, Wiebke Moebius, Brit Mollenhauer, Wiesje M. van der Flier, Connie R. Jimenez, Charlotte E. Teunissen, Olaf Jahn, Anja Schneider
Summary: This study aims to comprehensively characterize the proteome of cerebrospinal fluid (CSF) extracellular vesicles (EVs) to identify proteins and pathways altered in Alzheimer's disease (AD). By screening and detecting protein expression, more than 30 differentially expressed proteins involved in immune-regulation were found in AD EVs. The results suggest that EVs may serve as potential biomarkers for AD and play an unprecedented role in immune regulation.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Nicolas Delcourt, Alix-Marie Pouget, Alicia Grivaud, Leonor Nogueira, Frederic Larvor, Philippe Marchand, Eric Schmidt, Bruno Le Bizec
Summary: This study found that PFAS compounds, widely used in various products, are present in human cerebrospinal fluid and are associated with clinical and biological markers of Alzheimer's disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)