Article
Neurosciences
Meng-Hua Zhou, Shao-Rui Chen, Li Wang, Yuying Huang, Meichun Deng, Jixiang Zhang, Jiyuan Zhang, Hong Chen, Jiusheng Yan, Hui-Lin Pan
Summary: The study identified the roles of PKC and alpha 2 delta-1 in controlling NMDAR activity, showing that co-expression of alpha 2 delta-1 significantly increased NMDAR activity, while PKC activation only increased receptor activity in cells co-expressing alpha 2 delta-1. Furthermore, phosphoproteomics analysis identified the phosphorylation sites responsible for NMDAR potentiation by PKC and alpha 2 delta-1.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Sajad Hassanzadeh, Soraya Bagheri, Seyed Majid Ahmadi, Seyed Ahmadreza Ahmadi, Isaac Moradishibany, Hosein Dolatkhah, Sajjad Reisi
Summary: This study compared the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients, and the results showed that the clonidine + gabapentin group was significantly more effective in reducing neuropathic pain and its severity compared to the gabapentin group.
BMC ENDOCRINE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Anesthesiology
Oystein Dunker, Margreth Grotle, Marie Bu Kvaloy, Martin Uglem, Sissel Loseth, Ina Elen Hjelland, Inge Petter Kleggetveit, Sara Maria Allen, Maria Dehli Vigeland, Rikke Munk Killingmo, Trond Sand, Kristian Bernhard Nilsen
Summary: This study aimed to investigate the diagnostic accuracy of 3 tools commonly used to differentiate between neuropathic and nonneuropathic pain. The results showed that neither DN4, painDETECT, nor S-LANSS can be confidently used to assess neuropathic pain.
Article
Pharmacology & Pharmacy
Abida Shaheen, Syed Mahboob Alam, Fahad Azam, Moosa Khan, Salman Ahmad Saleem, Afrose Liaquat, Sana Mumtaz
Summary: The study revealed that LAT1 rs4240803 genetic polymorphism affects the clinical efficacy and tolerability of gabapentinoids in patients. GA genotype was more common in the non-responder group, while patients with GG genotype showed better response to treatment.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Polymer Science
Ciprian Puscasu, Anca Zanfirescu, Simona Negres
Summary: Neuropathic pain is a complex and debilitating condition affecting millions globally. Gels, particularly those incorporating nanocarriers such as cubosomes and niosomes, have emerged as a promising option for more effective and safer treatment. These gels offer improved drug stability, enhanced drug penetration, sustained release, and biocompatibility. This narrative review aims to comprehensively analyze the current state of the field, identifying future research directions to develop effective and safe gels for neuropathic pain, thus improving patients' quality of life.
Article
Immunology
Mihaly Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd
Summary: This study demonstrates that colon cancer is associated with latent sensory neuron dysfunction and implicates cytokine/chemokine signaling in this process. These findings may have implications for determining risk factors and treatment responsiveness related to neuropathy in colorectal cancer.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Surgery
Kevin M. Klifto, Pooja S. Yesantharao, Scott D. Lifchez, A. Lee Dellon, C. Scott Hultman
Summary: The study developed a mathematical model based on anatomy-specific variables to predict a patient's risk of developing burn-related nerve pain. The model included 8 variables and identified risk factors for burn-related nerve pain at 11 anatomical locations.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Immunology
Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anesthesiology
Daniela Schmidt, Paula Diaz, Daniela Munoz, Fernanda Espinoza, Alexander Nystrom, Ignacia Fuentes, Marcelo Ezquer, David L. Bennett, Margarita Calvo
Summary: In this study, a mouse model of RDEB was used to investigate the characteristics of the somatosensory system. The results showed that in RDEB, there is distal axonal degeneration caused by damage to small fibres in the epidermis, but without sustained neuroinflammation. This highlights the importance of a healthy cutaneous environment for maintaining epidermal innervation in RDEB patients.
Review
Pharmacology & Pharmacy
Priya Kannan, Umar Muhammad Bello, Stanley John Winser
Summary: The effectiveness of different physiotherapy interventions for managing central neuropathic pain (cNeP) was evaluated in this study. Non-invasive neurostimulation was found to significantly reduce pain severity in patients with spinal cord injury (SCI) and phantom limb pain. Acupuncture for stroke, transcutaneous electrical nerve stimulation (TENS) for multiple sclerosis, and mirror therapy for phantom limb pain also showed beneficial effects in reducing pain severity.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Anesthesiology
Chioma U. U. Odozor, Thomas Kannampallil, Arbi Ben Abdallah, Kristen Roles, Carrie Burk, Benjamin C. C. Warner, Harutyun Alaverdyan, David B. B. Clifford, Jay F. F. Piccirillo, Simon Haroutounian
Summary: This study used an observational cohort design to investigate the occurrence and severity of pain and peripheral neuropathy symptoms in patients with SARS-CoV-2 infection. The results showed that SARS-CoV-2 infection was independently associated with an increased risk of pain and peripheral neuropathy symptoms.
Article
Biochemistry & Molecular Biology
Vittoria Rimola, Tabea Osthues, Vanessa Koenigs, Gerd Geisslinger, Marco Sisignano
Summary: Oxaliplatin treatment leads to transient changes in TRPM8 channel activity, causing acute peripheral pain and neuropathic pain, which may be associated with activation of the PLC pathway and depletion of PIP2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Roser Velasco, Sarah Besora, Andreas A. Argyriou, Cristina Santos, Roso Sala, Cristina Izquierdo, Marta Simo, Miguel Gil-Gil, Beatriz Pardo, Laura Jimenez, Victoria Clapes, Mariona Calvo, Ramon Palmero, Jordi Bruna
Summary: Female gender and short-term CIPN were independently associated with a favorable response to duloxetine, while male gender and long-lasting CIPN significantly limited its use. A minority of cancer survivors with CIPN treated with duloxetine had a meaningful improvement in symptoms, with overall low tolerability.
Article
Anesthesiology
Emmanuel Backryd, Andreas Themistocleous, Anders Larsson, Torsten Gordh, Andrew S. C. Rice, Solomon Tesfaye, David L. Bennett, Bjorn Gerdle
Summary: This study aims to explore the pathophysiological mechanisms underlying neuropathic pain in patients with diabetic DSP. It suggests that low-grade systemic inflammation is related to the severity of neuropathy and neuropathic pain, and identifies specific inflammation-related proteins such as hepatocyte growth factor, colony-stimulating factor 1, and CD40 that may play a crucial role in neuropathic pain.
Correction
Neurosciences
Andrew R. Segerdahl, Melvin Mezue, Thomas W. Okell, John T. Farrar, Irene Tracey
NATURE NEUROSCIENCE
(2015)
Article
Neurosciences
Andrew R. Segerdahl, Melvin Mezue, Thomas W. Okell, John T. Farrar, Irene Tracey
NATURE NEUROSCIENCE
(2015)
Article
Neurosciences
Moss Y. Zhao, Melvin Mezue, Andrew R. Segerdahl, Thomas W. Okell, Irene Tracey, Yingyi Xiao, Michael A. Chappell
Article
Clinical Neurology
Andrew R. Segerdahl, Andreas C. Themistocleous, Dean Fido, David L. Bennett, Irene Tracey
Article
Anesthesiology
J. Blackbeard, V. C. J. Wallace, K. P. O'Dea, F. Hasnie, A. Segerdahl, T. Pheby, M. J. Field, M. Takata, A. S. C. Rice
EUROPEAN JOURNAL OF PAIN
(2012)
Article
Endocrinology & Metabolism
Melvin Mezue, Andrew R. Segerdahl, Thomas W. Okell, Michael A. Chappell, Michael E. Kelly, Irene Tracey
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2014)
Article
Neurosciences
Charlotte J. Stagg, Richard L. Lin, Melvin Mezue, Andrew Segerdahl, Yazhuo Kong, Jingyi Xie, Irene Tracey
JOURNAL OF NEUROSCIENCE
(2013)
Article
Anesthesiology
Andrew R. Segerdahl, Jingyi Xie, Kathryn Paterson, Juan D. Ramirez, Irene Tracey, David L. H. Bennett
Article
Biology
R. R. Thompson, P. S. Dickinson, J. D. Rose, K. A. Dakin, G. M. Civiello, A. Segerdahl, R. Bartlett
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2008)
Article
Neurosciences
Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. Bennett
Article
Radiology, Nuclear Medicine & Medical Imaging
Joana Pinto, Michael A. Chappell, Thomas W. Okell, Melvin Mezue, Andrew R. Segerdahl, Irene Tracey, Pedro Vilela, Patricia Figueiredo
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Rheumatology
Anushka Soni, Stephanie Santos-Paulo, Andrew Segerdahl, M. Kassim Javaid, Rafael Pinedo-Villanueva, Irene Tracey
Article
Neurosciences
Samuel J. Harrison, Janine D. Bijsterbosch, Andrew R. Segerdahl, Sean P. Fitzgibbon, Seyedeh-Rezvan Farahibozorg, Eugene P. Duff, Stephen M. Smith, Mark W. Woolrich
Review
Neurosciences
Marco Luciano Loggia, Andrew Reilly Segerdahl, Matthew Alexander Howard, Irene Tracey
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)