期刊
NEUROSCIENCE LETTERS
卷 447, 期 2-3, 页码 167-171出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.09.079
关键词
Heme oxygenase-1; Nrf2; Neuroprotection; NDGA; 3-Nitropropionic acid; Antioxidant response elements
资金
- CONACYT [48812 M, SAF2007-62646, FMMA 2005]
- UNAM
- Spanish Ministry of Science and Innovation
Because the etiopathology of neurodegenerative diseases is tightly connected with oxidative stress, there is an increasing need to find compounds that might elicit an antioxidant and neuroprotective response in neurons. We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H2O2 or 3-nitropropionic acid-induced neurotoxicity. The role of HO-1 in this protective effect was made evident by using an HO inhibitor, tin-mesoporphyrin. Our study identifies NDGA as a new potential therapeutic tool to activate the Nrf2/HO-1 axis for protection against oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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