期刊
NEUROSCIENCE LETTERS
卷 444, 期 2, 页码 153-156出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.08.030
关键词
Pituitary adenylate cyclase-activating polypeptide (PACAP); Neuropeptide; Knockout mice; Sympathetic nerve; Corticosterone; c-Fos
资金
- Japan Society for the Promotion of Science
- Uehara Memorial Foundation
- Senri Life Science Foundation
- Public Health Research Foundation
- Taisho Pharmaceutical Co., Ltd.
PACAP is a neurotransmitter involved in the signal transduction of light stimulation in the suprachiasmatic nucleus (SCN). Light stimulation affects autonomic nerve activity via the SCN, and here we tested whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice. Light stimulation (100 lux, 30 min) significantly elevated both renal sympathetic nerve activity (RSNA), which was monitored on a digital oscilloscope, and plasma corticosterone levels in wildtype mice, but both responses were almost abolished in Adcyap1(-/-) mice. Although light-induced c-Fos expression in the SCN was observed in both genotypes, the numbers of c-Fos positive cells were significantly decreased in Adcyap1(-/-) mice. These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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