Article
Biochemistry & Molecular Biology
Jingjing Zhang, Lina Rong, Jinping Shao, Yidan Zhang, Yaping Liu, Sen Zhao, Lei Li, Wenli Yu, Mengya Zhang, Xiuhua Ren, Qingzan Zhao, Changlian Zhu, Huan Luo, Weidong Zang, Jing Cao
Summary: The study demonstrates that miR-137-mediated Kv1.2 impairment plays a crucial role in the pathogenesis of nerve injury-induced neuropathic pain, suggesting it as a novel potential therapeutic target for neuropathic pain management.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Wenliang Su, Huan Cui, Danning Wu, Jiawen Yu, Lulu Ma, Xiuhua Zhang, Yuguang Huang, Chao Ma
Summary: The study revealed the involvement of neuronal TLR4 signaling pathway in endometriosis-related hyperpathia, with blockade of TLR4 and MyD88 serving as a potential treatment for pain in endometriosis.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Moez Eid, Stanislav Rodkin, Maria Pitinova, Svetlana Demyanenko
Summary: This study investigated the expression and localization of E2F1 after axonal injury and found that axotomy increased the expression of E2F1 in neurons. The study also suggested that E2F1 and downstream targets could be potential molecular targets for the development of neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Stanislav Rodkin, Valentina Dzreyan, Mikhail Bibov, Alexey Ermakov, Tatyana Derezina, Evgeniya Kirichenko
Summary: Peripheral-nerve injury can cause disability, and there is currently a lack of clinically effective neuroprotectors. This study investigated the role of NO-dependent expression of p53 in the death of neurons and glial cells following axotomy. The results showed that axotomy led to redistribution of p53 in neurons, and the application of a NO donor increased p53 levels in nuclei and cytoplasm of neurons, as well as karyoplasm of glial cells. In contrast, inhibition of iNOS had a neuroprotective effect. These findings suggest that the NO-dependent expression of p53 may play a signaling mechanism in neural and glial cell death after axotomy.
Article
Biochemistry & Molecular Biology
Yuan Wang, Rong Huang, Zuying Chai, Changhe Wang, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu, Zhuan Zhou
Summary: The newly discovered Ca2+-independent but voltage-dependent secretion mechanism plays an important role in central synaptic transmission and can trigger neurotransmitter release through action potentials, with faster vesicle recycling and less short-term depression.
Article
Neurosciences
Zhenhua Cai, Lini Quan, Xiaotao Chang, Zhijie Qiu, Huacheng Zhou
Summary: This study investigated the mechanism of high-voltage, long-duration pulsed radiofrequency (HL-PRF) in treating neuropathic pain. The results suggest that HL-PRF may alleviate pain symptoms by reducing the expression of Cav2.2 channels.
Article
Biochemistry & Molecular Biology
Svetlana Demyanenko, Maria A. Pitinova, Yulia N. Kalyuzhnaya, Andrey M. Khaitin, Svetlana A. Batalshchikova, Natalya M. Dobaeva, Yulia A. Shevtsova, Kirill Goryunov, Egor Y. Plotnikov, Svetlana G. Pashkevich, Gennady T. Sukhikh, Denis N. Silachev
Summary: Peripheral nerve injury is a significant medical problem without effective treatment currently. However, the use of multipotent mesenchymal cells (MSCs)-derived extracellular vesicles (EVs) shows promise in promoting the regeneration of peripheral nerves after injury. In a rat model of sciatic nerve injury, the application of MSCs-EVs gel significantly reduced muscle atrophy and improved functional recovery. The results suggest that this therapeutic approach may be efficient for the treatment of acute peripheral nervous system injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jahanzaib Irfan, Muhammad Rizki Febrianto, Anju Sharma, Thomas Rose, Yasamin Mahmudzade, Simone Di Giovanni, Istvan Nagy, Jose Vicente Torres-Perez
Summary: This article summarizes and evaluates the effects of DNA methylation and non-coding RNA expression, two epigenetic mechanisms, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. The potential of controlling these mechanisms as novel analgesic approaches and/or biomarkers of persistent pain is assessed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kjeld Morten Mohr, Lone Tjener Pallesen, Mette Richner, Christian Bjerggaard Vaegter
Summary: Satellite glial cells (SGCs) surrounding neuronal somas are sensitive to neuronal stressors and exhibit induced gliosis, however, GFAP may not be a universally suitable marker for SGC reactivity across species and experimental models.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Pharmacology & Pharmacy
Onur Avci, Ercan Ozdemir, Ahmet Sevki Taskiran, Zeynep Deniz Sahin Inan, Sinan Gursoy
Summary: The study found that metformin can alleviate the tolerance to morphine in diabetic rats and exhibit anti-apoptotic activity in DRG neurons.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Rongzhen Li, Mingxi Ou, Shaomin Yang, Jiabin Huang, Jiamin Chen, Donglin Xiong, Lizu Xiao, Songbin Wu
Summary: Pain is the most common neurological complication of herpes zoster, including postherpetic neuralgia (PHN), and the occurrence and development of PHN are still elusive. However, research has found that VZV may participate in zoster-associated pain by upregulating the expression of Cav3.2 in DRG and SDH, providing a new promising drug target for relieving PHN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Tom Medici, Peter J. Shortland
Article
Neurosciences
Vincent Cibert-Goton, Justin P. Phillips, Peter J. Shortland
SOMATOSENSORY AND MOTOR RESEARCH
(2015)
Article
Multidisciplinary Sciences
Jan Hoeber, Carl Trolle, Niclas Konig, Zhongwei Du, Alessandro Gallo, Emmanuel Hermans, Hakan Aldskogius, Peter Shortland, Su-Chun Zhang, Ronald Deumens, Elena N. Kozlova
SCIENTIFIC REPORTS
(2015)
Editorial Material
Cell Biology
Peter J. Shortland, David A. Mahns
NEURAL REGENERATION RESEARCH
(2016)
Article
Neurosciences
Sumaiya Shaikh, Peter Shortland, Antonio Lauto, Matthew Barton, John W. Morley, David A. Mahns
SOMATOSENSORY AND MOTOR RESEARCH
(2016)
Article
Clinical Neurology
Mohamad Samir Samour, Saad Saulat Nagi, Peter John Shortland, David Anthony Mahns
Article
Neurosciences
Mohamad S. Samour, Sumaiya M. Shaikh, David A. Mahns, Peter J. Shortland
NEUROSCIENCE LETTERS
(2017)
Review
Oncology
Endale Gebreegziabher Gebremedhn, Peter John Shortland, David Anthony Mahns
Article
Cell & Tissue Engineering
Niclas Konig, Carl Trolle, Katarina Kapuralin, Igor Adameyko, Dinko Mitrecic, Hakan Aldskogius, Peter J. Shortland, Elena N. Kozlova
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Oncology
Endale G. Gebremedhn, Peter J. Shortland, David A. Mahns
JOURNAL OF ONCOLOGY
(2019)
Article
Cell Biology
Monokesh K. Sen, Mohammed S. M. Almuslehi, Erika Gyengesi, Simon J. Myers, Peter J. Shortland, David A. Mahns, Jens R. Coorssen
Review
Behavioral Sciences
Monokesh K. Sen, David A. Mahns, Jens R. Coorssen, Peter J. Shortland
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Review
Biochemistry & Molecular Biology
Monokesh K. Sen, Mohammed S. M. Almuslehi, Peter J. Shortland, David A. Mahns, Jens R. Coorssen
Summary: This review examines proteomic studies of multiple sclerosis (MS) patients and animal models to assess their effectiveness in mimicking MS and identifying potential biomarkers. The importance of evaluating proteoforms and challenges in identifying rational biomarkers are discussed, highlighting the need for preclinical biomarkers for early diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Monokesh K. Sen, David A. Mahns, Jens R. Coorssen, Peter J. Shortland
Summary: Microglia and astrocytes play important roles in the clearance of myelin debris and remyelination in human demyelinating diseases. Recent studies have shown that up-regulation of signaling proteins in microglia facilitates effective phagocytosis of myelin debris and the release of protective mediators accelerates remyelination. However, inadequate activation or recruitment of microglia, as well as the production of toxic mediators, impairs remyelination and leads to progressive demyelination.
Article
Biochemistry & Molecular Biology
Mohammed S. M. Almuslehi, Monokesh K. Sen, Peter J. Shortland, David A. Mahns, Jens R. Coorssen
Summary: A study using histology and proteomics found that a change in visual perception is an early symptom of multiple sclerosis (MS). Although histological investigation did not detect clear pathological changes, proteomic analysis revealed significant alterations in protein forms in the optic nerve, suggesting that these proteoforms could serve as potential early markers for degenerative demyelinating conditions.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)