Review
Cell Biology
Ye Xie, Bo Chen
Summary: This article discusses the regenerative potential of Muller glia (MG) in the mouse retina, focusing on the progress made in the de novo regeneration of retinal neurons through the reprogramming of MG.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Annelies Van Dyck, Ilse Bollaerts, An Beckers, Sophie Vanhunsel, Nynke Glorian, Jessie van Houcke, Tjakko J. van Ham, Lies De Groef, Lien Andries, Lieve Moons
Summary: The study demonstrates that inducing intraocular inflammation can promote axonal regrowth after optic nerve injury in zebrafish. Additionally, acute depletion of microglia and macrophages in the retina compromises optic nerve regeneration, highlighting the importance of altered glial cell interactions in the regenerative process.
Article
Pathology
Tailoi Chan-Ling, Ping Hu, Sergio Li Calzi, Jeff Warner, Nasir Uddin, Mariana DuPont, Martha Neuringer, Paul Kievit, Lauren Renner, Jonathan Stoddard, Renee Ryals, Michael E. Boulton, Trevor McGill, Maria B. Grant
Summary: This study investigated retinal changes in a nonhuman primate model of type 2 diabetes induced by a Western diet. The results showed that the high-fat diet led to retinal venous engorgement, aneurysms, exudates, and hemorrhages, and affected blood vessel density and immune responses. This study is the first to report a primate model of diabetic retinopathy solely induced by a Western diet, successfully replicating key features of human diabetic retinopathy.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Patrick Boyd, Leah J. Campbell, David R. Hyde
Summary: Zebrafish have the ability to regenerate lost neurons in the retina, which is mediated by Muller glia that divide and produce neuronal precursor cells. The early signals that induce this response are not well understood. Alternative ligands of the Ciliary neurotrophic factor receptor (CNTFR), such as Cardiotrophin-like cytokine factor 1 (Clcf1) and Cytokine receptor-like factor 1a (Crlf1a), are expressed in Muller glia of the light-damaged retina. These ligands are required for Muller glia proliferation in the damaged retina and have a neuroprotective effect. CLCF1/CRLF1 injection protects against rod photoreceptor cell death and induces rod precursor cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose-Andres C. Portillo, Jin-Sang Yu, Samuel Hansen, Timothy S. Kern, M. Cecilia Subauste, Carlos S. Subauste
Summary: Inhibition of the CD40-TRAF2,3 pathway is a novel and potent approach to reduce CD40-induced inflammation, while likely diminishing the risk of opportunistic infections.
Article
Neurosciences
Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schloetzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M. Hauck, Antje Grosche
Summary: This study revealed the expression profiles of cone- and rod-associated Muller cells in the human macula and identified pathways related to extracellular matrix and cell adhesion. EPPK1 was highly expressed in macular Muller cells and played a role in intermediate filament organization. Knockout of EPPK1 in a human Muller cell-derived cell line resulted in changes in cell size, shape, and filopodia characteristics. Therefore, EPPK1 is a central molecular player in the region-specific architecture of the human retina, enabling specific functions under mechanical loads in vivo.
Article
Engineering, Biomedical
Sung Suk Jung, Jeonghyun Son, Soo Jin Yi, Kyungha Kim, Han Sang Park, Hyun-Wook Kang, Hong Kyun Kim
Summary: This study developed a three-dimensional biomimetic model using Muller cells to simulate their in vivo functions. The results showed that the model exhibited similar responses to a diabetic model in vivo and had the potential to generate characteristic morphological features in Muller cells.
BIOMEDICAL MATERIALS
(2023)
Article
Neurosciences
Leah J. Campbell, Joshua S. Hobgood, Meng Jia, Patrick Boyd, Rebecca I. Hipp, David R. Hyde
Summary: The negative regulation of Muller glia proliferation in zebrafish retinal regeneration is mediated by Notch3 and DeltaB.
Article
Biochemistry & Molecular Biology
Xiaosong Liu, Yingxin Xie, Xiangdong Wan, Jianliang Wu, Zhenzeng Fan, Lijun Yang
Summary: The study demonstrates that AQP4 deficiency can alleviate brain edema and neurological deficits in TBI patients, improve cognitive outcomes, and enhance longer-term neurological results.
NEUROCHEMICAL RESEARCH
(2021)
Article
Ophthalmology
Satoshi Ueki, Yuji Suzuki, Hironaka Igarashi
Summary: This study investigated the role of AQP4 in the water dynamics of the posterior eye using in vivo JJVCPE MRI in AQP4 KO mice and control mice. The results showed that AQP4 may play a potential role in regulating water inflow into the vitreous body, and its absence in KO mice could lead to decreased water outflow.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Neurosciences
Vanina Netti, Juan Fernandez, Luciana Melamud, Pablo Garcia-Miranda, Gisela Di Giusto, Paula Ford, Miriam Echevarria, Claudia Capurro
Summary: The study reveals that binding of AQP4-IgG to AQP4 in Muller cells leads to partial internalization of AQP4, reducing membrane water permeability and swelling-induced increase in intracellular calcium levels, thereby affecting cell volume regulation and proliferation functions of Muller cells.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Ophthalmology
Liangliang Niu, Yuan Fang, Xiaoqian Yao, Yi Zhang, Jihong Wu, Dong Feng Chen, Xinghuai Sun
Summary: The study suggests that TNF alpha may drive the proliferation and inflammatory response of mouse Muller cells, rather than their neural regenerative potential.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Cell Biology
Seoyoung Kang, Daniel Larbi, Monica Andrade, Sara Reardon, Thomas A. Reh, Stefanie G. Wohl
Summary: The study analyzed miRNAs and mRNAs in reactive MG after injury, finding that the majority of MG miRNAs declined 7 days after light damage, with only a few miRNAs increasing; the top 10 upregulated genes in reactive MG post-light damage included Gfap, Serpina3n, Ednrb, and Cxcl10; the data indicates a key role for MG miRNAs in both Dicer-depleted and light-damaged reactive MG.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Patrick Boyd, David R. Hyde
Summary: This study demonstrates the importance of iron in cell death and Muller glia regeneration in light-damaged retina. The researchers found that Muller glia undergo transcriptional changes following injury to regulate iron levels in the retina. The alterations in iron uptake and export are critical for inducing Muller glia proliferation and regeneration.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Cell Biology
Gregory J. Konar, Claire Ferguson, Zachary Flickinger, Matthew R. Kent, James G. Patton
Summary: The study has identified the genetic pathways and components required for retina regeneration, as well as the key regulatory events controlling the process. Muller glia are reprogrammed as adult retinal stem cells, while miRNAs are recognized as key gene regulatory molecules in controlling retina regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Christian Schori, Christian Trachsel, Jonas Grossmann, Maya Barben, Katrin Klee, Federica Storti, Marijana Samardzija, Christian Grimm
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Genetics & Heredity
Katrin Klee, Federica Storti, Jordi Maggi, Vyara Todorova, Duygu Karademir, Wolfgang Berger, Marijana Samardzija, Christian Grimm
Article
Ophthalmology
Shivani Dixit, Federica Polato, Marijana Samardzija, Mones Abu-Asab, Christian Grimm, Susan E. Crawford, S. Patricia Becerra
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Cell Biology
Valerie Panneels, Ana Diaz, Cornelia Imsand, Manuel Guizar-Sicairos, Elisabeth Mueller, Anne Greet Bittermann, Takashi Ishikawa, Andreas Menzel, Andres Kaech, Mirko Holler, Christian Grimm, Gebhard Schertler
Summary: Ptychographic hard X-ray computed tomography (PXCT) is a recent method that allows imaging with quantitative electron-density contrast, providing isotropic 3D information of cellular and subcellular structures. The potential of PXCT for analyzing disease processes, such as neurodegeneration, at sub-200 nm resolution is illustrated through comparison with tomograms of degenerative retina. PXCT is non-destructive, suitable for correlative imaging, and powerful for tissue volumes analysis.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
L. J. A. Ebner, M. Samardzija, F. Storti, V. Todorova, D. Karademir, J. Behr, F. Simpson, M. Thiersch, C. Grimm
Summary: This study investigates the impact of chronic oxygen deficiency on the retina, revealing that retinal cells have the ability to adapt to long-term hypoxia and that the consequences of hypobaric hypoxia differ from those of normobaric hypoxia. The findings provide insights into the molecular changes in response to various hypoxic conditions and can serve as references for validating and comparing retinal disease models associated with hypoxia.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Jingjing Zang, Matthias Gesemann, Jennifer Keim, Marijana Samardzija, Christian Grimm, Stephan C. F. Neuhauss
Summary: The study found that the circadian rhythm influences the expression and function of visual transduction cascade regulators in diurnal zebrafish and nocturnal mice, impacting their visual abilities and photoresponse kinetics. Additionally, the rhythmicity of these regulators persists in continuous darkness and is disrupted by an inverted light cycle and constant light exposure.
Article
Biochemistry & Molecular Biology
Eva Kiessling, Sarah Noetzli, Vyara Todorova, Merima Forny, Matthias R. Baumgartner, Marijana Samardzija, Jakub Krijt, Viktor Kozich, Christian Grimm, D. Sean Froese
Summary: Combined methylmalonic aciduria with homocystinuria (cblC type) is a rare disease caused by mutations in the MMACHC gene, leading to severe multisystem pathology often presenting in neonatal or early childhood period, including ophthalmological phenotypes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biology
Duygu Karademir, Vyara Todorova, Lynn J. A. Ebner, Marijana Samardzija, Christian Grimm
Summary: This study utilizes droplet-based single-cell RNA sequencing to investigate the degeneration process in rod and cone photoreceptor cells in an RP mouse model. The results identify early changes in rods and potential early responses in cones, suggesting mechanisms involved in secondary cone degeneration. Furthermore, the study implicates EGR1 as a potential key regulator of early degenerative events in both types of photoreceptor cells.
Article
Biochemistry & Molecular Biology
Florian Peters, Lynn J. A. Ebner, David Atac, Jordi Maggi, Wolfgang Berger, Anneke den Hollander, Christian Grimm
Summary: This study focuses on analyzing the dysregulation of ATP-binding cassette transporter A1 (ABCA1) in induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) cells. The results show that genetic variations associated with age-related macular degeneration (AMD) result in increased ABCA1 gene expression, reduced cholesterol efflux, and increased lipid accumulation. Additionally, hypoxia decreases ABCA1 expression and increases intracellular lipid accumulation. Stimulating ABCA1 expression could improve RPE cell survival and reduce the risk of developing AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Annie L. Miller, Paula Fuller-Carter, Klaudija Masarini, Marijana Samardzija, Kim W. Carter, Rabab Rashwan, Xin Ru Lim, Alicia A. Brunet, Abha Chopra, Ramesh Ram, Christian Grimm, Marius Ueffing, Livia S. Carvalho, Dragana Trifunovic
Summary: Inherited retinal diseases (IRDs) are a group of blinding disorders that affect the cone and rod photoreceptors. This study explores the potential therapeutic benefits of a histone demethylase inhibitor, GSK-J4, on cone cell survival in a mouse model of achromatopsia. The results suggest that epigenetic modulation of histones may be a promising approach in slowing down cone degeneration in IRDs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Divya Ail, Marijana Samardzija, Andy C. M. Chang, Jadwiga Keck, Roger R. Reddel, Christian Grimm
Summary: This study investigated the expression of stanniocalcins in the retina and found that Stc2 was induced in acute and chronic hypoxia models, regulated by HIF1, while Stc1 remained stable. Furthermore, Stc2 was expressed in the inner retina, rather than in photoreceptors.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Eva Kiessling, Florian Peters, Lynn J. A. Ebner, Luca Merolla, Marijana Samardzija, Matthias R. Baumgartner, Christian Grimm, Sean Froese
Summary: The MMACHC gene encodes an enzyme involved in vitamin B12 metabolism. Oxidative stress may impair vitamin B12 metabolism by suppressing MMACHC expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Multidisciplinary Sciences
Vyara Todorova, Luca Merolla, Duygu Karademir, Gabriele M. Wogenstein, Julian Behr, Lynn J. A. Ebner, Marijana Samardzija, Christian Grimm
Summary: Understanding the physiology of the retina, particularly the highly polarized photoreceptors, is crucial for advancing our knowledge of normal vision processes and developing effective therapies for retinal degenerative diseases. However, studying the molecular mechanisms of photoreceptors is challenging due to the heterogeneity of retinal tissue and the lack of reliable cell separation methods. In this study, the researchers present a simple technique called ReLayS that successfully separates different parts of photoreceptors, enabling protein and RNA analysis. The method was validated using known proteins and genes and also revealed light-driven translocation of transducin.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Vyara Todorova, Mia Fee Stauffacher, Luca Ravotto, Sarah Notzli, Duygu Karademir, Lynn J. A. Ebner, Cornelia Imsand, Luca Merolla, Stefanie. M. M. Hauck, Marijana Samardzija, Aiman. S. S. Saab, L. Felipe Barros, Bruno Weber, Christian Grimm
Summary: This study investigates the pathological mechanisms of photoreceptor (PR) degeneration during chronic activation of hypoxia-inducible factors (HIFs). The results show that PR cells have an exceptionally high glycolytic flux and the activation of HIFs slows down the cellular anabolism, leading to the shortening of rod outer segments before cell degeneration.
MOLECULAR NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Marijana Samardzija, Andrea Corna, Raquel Gomez-Sintes, Mohamed Ali Jarboui, Angela Armento, Jerome E. Roger, Eleni Petridou, Wadood Haq, Francois Paquet-Durand, Eberhart Zrenner, Pedro de la Villa, Guenther Zeck, Christian Grimm, Patricia Boya, Marius Ueffing, Dragana Trifunovic
Summary: Inhibition of HDAC activity can delay secondary cone cell death in RP patients and support long-term survival, improving visual function.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
