期刊
NEUROSCIENCE LETTERS
卷 440, 期 1, 页码 59-62出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.05.047
关键词
prefrontal cortex; striatum; mediodorsal thalamic nucleus; immunoperoxidase labeling; clathrinmediated endocytosis; electron microscopy
资金
- NIMH NIH HHS [R01 MH063271, MH38546, MH63271, P50 MH068789, MH068789, MH44866] Funding Source: Medline
Recent observations suggest that calcyon, a novel single transmembrame protein implicated in schizophrenia and attention-deficit/hyperactivity disorder, regulates clathrin-mediated endocytosis in brain. To explore the role of calcyon in neurotransmission, we investigated its distribution in the neuropil of the primate prefrontal cortex (PFC), striatum (STR) and mediodorsal thalamic nucleus (MID), three brain regions implicated in these neuropsychiatric disorders. Calcyonimmunoreactivity revealed by immunoperoxidase technique, was localized in both pre- and postsynaptic structures including axons, spines and dendrites, as well as myelinated fibers and astroglial processes in all the three brain regions. The morphological diversity of immunopositive boutons suggest that in addition to glutamatergic, calcyon could regulate GABAergic as well as monoaminergic neurotransmission. Consistent with the role of calcyon in endocytosis, calcyon-immunoreactivity was rarely found at the synaptic membrane specializations proper, although it was present in distal compartments of neuronal processes establishing synapses. Given the widespread upregulation of calcyon in schizophrenic brain, these findings underscore a potential association with deficits in a range of neurotransmitter systems in the cortico-basal ganglia-thalamic loop. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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