期刊
NEUROSCIENCE LETTERS
卷 448, 期 3, 页码 260-262出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.067
关键词
Intrathecal; Morphine; Mu-opioid receptor; Naloxone; Respiratory depression; Voltage-sensitive calcium channel
资金
- Indian Council of Medical Research, New Delhi
- NIDA [DA02110]
Opioids like morphine produce antinociception after intrathecal administration. Being hydrophilic in nature, morphine also spreads rostrally which leads to respiratory depression. Loperamide has been reported to produce antinociception after both intracisternal and intrathecal administration. It is also hydrophobic, which could restrict its diffusion in the spinal canal. However, the mechanism of its anti nociceptive action after intrathecal administration is not definitely known. In the present study, the antinociceptive effect of loperamide was evaluated by the formalin test. It significantly inhibited Phase II flinching behavior. This antinociceptive effect was reversed by pre-administration of naloxone indicating that it was predominantly due to activation of opioid receptors. (C) 2008 Published by Elsevier Ireland Ltd.
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