Article
Multidisciplinary Sciences
Naqash Alam, Sadiq Ali, Nazia Akbar, Muhammad Ilyas, Habib Ahmed, Arooj Mustafa, Shehzada Khurram, Zeeshan Sajid, Najeeb Ullah, Shumaila Qayyum, Tariq Rahim, Mian Syed Usman, Nawad Ali, Imad Khan, Khola Pervez, BiBi Sumaira, Nasir Ali, Nighat Sultana, Adeel Yunus Tanoli, Madiha Islam
Summary: This study aimed to investigate the association between single nucleotide polymorphisms in 6 candidate genes linked to the neurobiology of major depressive disorder in the North-Western population of Pakistan, but no statistically significant correlation was observed. The research did not support the major role of these polymorphisms in contributing to MDD susceptibility.
Article
Biochemistry & Molecular Biology
Alexander Mordhorst, Priyavathi Dhandapani, Susann Matthes, Valentina Mosienko, Michael Rothe, Mihail Todiras, Julie Self, Wolf-Hagen Schunck, Anja Schutz, Michael Bader, Natalia Alenina
Summary: Serotonin synthesis involves the hydroxylation of tryptophan, with most vertebrates having two known enzymes for this step. However, even in animals lacking these two enzymes, there is still some serotonin production, suggesting the presence of a third enzyme. The study found evidence that phenylalanine hydroxylase (PAH) may act as a third tryptophan hydroxylase in mammals, contributing to serotonin levels in the blood and potentially serving as a local source of serotonin in organs where other TPHs are not expressed.
Article
Biochemistry & Molecular Biology
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Summary: Peripheral serotonin levels have an influence on brain functions under basal and dynamic situations. The lack of peripheral serotonin can reduce anxiety-like behavior, as well as neuronal activation and the expression of brain plasticity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Alma Delia Genis-Mendoza, Yazmin Hernandez-Diaz, Thelma Beatriz Gonzalez-Castro, Carlos Alfonso Tovilla-Zarate, Rosa Giannina Castillo-Avila, Maria Lilia Lopez-Narvaez, Miguel angel Ramos-Mendez, Humberto Nicolini
Summary: This study conducted a systematic review and meta-analysis to explore the association between TPH1 gene polymorphisms and the risk of suicide behavior. The results revealed a potential link between the A218C polymorphism of TPH1 gene and increased risk of suicide behavior, particularly in the European population. However, no evidence of an association with suicide behavior was found for the A779C and A6526G polymorphisms.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Fan Zhang, Andrew D. Ellington
Summary: Escherichia coli have evolved to utilize 4- and 5-fluoroindole and replace tryptophan with fluorinated derivatives throughout their proteomes, showing potential applications in research and industry.
ACS CENTRAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xinjie Shi, Guiyun Zhao, Hu Li, Zhijie Zhao, Wei Li, Miaolian Wu, Yi-Ling Du
Summary: The authors have identified a new class of tryptophan hydroxylases in bacteria, which are mechanistically distinct from their eukaryotic counterparts and can be used for the synthesis of melatonin.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Atae Akhrif, Marcel Romanos, Katharina Peters, Ann-Kathrin Furtmann, Julian Caspers, Klaus-Peter Lesch, Eva M. Meisenzahl-Lechner, Susanne Neufang
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood. In this study, the interaction of genetic and environmental factors in causing ADHD symptoms, such as impulsivity, was investigated. The TPH2 gene and DNA methylation in the 5' untranslated region of TPH2 were found to be associated with brain activity and behavioral performance in ADHD patients. This study provides insights into how genetic and epigenetic factors contribute to ADHD and impulsivity.
Article
Multidisciplinary Sciences
Emmeline R. I. S. Howarth, Isabelle J. Szott, Claire Witham, Craig Wilding, Emily Bethell
Summary: Behavior has a heritable component, and this study investigated the relationship between genes and survival behaviors in adult rhesus macaques. The analysis revealed that certain genes and gene variants were significantly associated with cognitive and observational measures of wellbeing and survival. Understanding these genetic underpinnings can have implications for managing primate populations and understanding emotions in humans.
Editorial Material
Multidisciplinary Sciences
Anthony Burke
Summary: As the crisis at the Zaporizhzhia plant worsens, it is necessary to extend international agreements to ensure nuclear safety during war.
Article
Biochemistry & Molecular Biology
Vanessa Bottino-Rojas, Igor Ferreira-Almeida, Rodrigo D. Nunes, Xuechun Feng, Thai Binh Pham, Adam Kelsey, Rebeca Carballar-Lejarazu, Valentino Gantz, Pedro L. Oliveira, Anthony A. James
Summary: Mutations in the ommochrome biosynthesis pathway have varying effects on the survival and reproduction of mosquitoes, as well as compromising the permeability barrier function of the midgut in some species. Surprisingly, these mutations lead to an increase in microbiota without a general induction of immune genes. Antibiotic treatment can rescue some deleterious traits, and supplementation of xanthurenic acid can limit microbiota proliferation. These findings are important for the development of genetic strategies targeting vector mosquitoes.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jadwiga Snarska, Ewa Fiedorowicz, Dominika Rozmus, Konrad Wronski, Maria Latacz, Natalia Kordulewska, Janusz Plominski, Roman Grzybowski, Huub F. J. Savelkoul, Elzbieta Kostyra, Anna Cieslinska
Summary: This study revealed an association between a specific genetic factor (rs211105 T/G polymorphism in TPH1 gene) and the concentration of tryptophan hydroxylase 1 in blood serum in acute pancreatitis patients. The study also found different correlations between TPH concentration and serotonin levels in different genotypes of TPH1 gene, suggesting potential implications for serotonin metabolic pathway in acute pancreatitis.
BMC GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Polyna D. Komleva, Ghofran Alhalabi, Arseniy E. Izyurov, Nikita V. Khotskin, Alexander V. Kulikov
Summary: This study investigates the effects of the TPH2 and Raly-Agouti gene mutations on body mass, behavior, and the 5-HT and melanocortin systems in the brain of mice. The mutations increase TPH2 enzyme activity and Agouti gene expression, but have no effect on 5-HT and 5-HIAA levels or the expression of other genes. The mutations have different effects on weight gain and depressive-like behavior, and when combined, cause hind limb dystonia in mice.
Review
Biochemistry & Molecular Biology
Jens F. Rehfeld
Summary: CCK, the most abundant peptidergic transmitter system in the brain, is associated with panic disorder. CCK-4 can induce panic attacks similar to those in panic disorder patients, suggesting a potential role of CCK in the pathogenesis of anxiety and panic disorders. Therapeutic attempts with CCK2-receptor antagonists have been discussed as well.
Article
Endocrinology & Metabolism
Shelley R. Winn, Sandra Dudley, Tanja Scherer, Nicole Rimann, Beat Thoeny, Sydney Boutros, Destine Krenik, Jacob Raber, Cary O. Harding
Summary: The study found that lifelong weekly pegvaliase treatment can prevent cognitive deficits associated with hyperphenylalaninemia in mice, particularly with significant improvements in overall growth of the mice with early treatment. However, cognitive deficits may reappear after discontinuation of treatment, especially when treatment is stopped in adulthood.
MOLECULAR GENETICS AND METABOLISM
(2022)
Review
Biotechnology & Applied Microbiology
Xin-Xin Liu, Bin Zhang, Lian-Zhong Ai
Summary: 5-hydroxytryptophan (5-HTP) plays a crucial role in regulating various physiological functions and is used in treating depression, insomnia, and other diseases. Due to inadequate natural extraction methods, increasing production efficiency through enzyme directed evolution and substrate supply pathways has become necessary to meet market demands.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Neurosciences
Indrek Heinla, Este Leidmaa, Karina Kongi, Airi Pennert, Juergen Innos, Kaarel Nurk, Triin Tekko, Katyayani Singh, Taavi Vanaveski, Riin Reimets, Merle Mandel, Aavo Lang, Kersti Lillevaeli, Allen Kaasik, Eero Vasar, Mari-Anne Philips
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Psychiatry
R. Balotsev, K. Koido, V. Vasar, S. Janno, K. Kriisa, R. Mahlapuu, U. Ljubajev, M. Parksepp, P. Veiksaar, V. Volke, A. Lang, L. Haring, M. Zilmer, E. Vasar
EUROPEAN PSYCHIATRY
(2017)
Article
Environmental Sciences
Hans Orru, Jane Idavain, Mihkel Pindus, Kati Orru, Kaisa Kesanurm, Aavo Lang, Jelena Tomasova
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Genetics & Heredity
Anne Must, Gunnar Tasa, Aavo Lang, Eero Vasar, Sulev Koks, Eduard Maron, Marika Vali
BMC MEDICAL GENETICS
(2008)
Article
Medicine, Legal
M. Sadam, G. Tasa, A. Tiidla, A. Lang, E. Podovsovnik Axelsson, I. Zupanic Pajnic
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2015)
Article
Neurosciences
Anne Must, Sulev Koks, Eero Vasar, Gunnar Tasa, Aavo Lang, Eduard Maron, Marika Vali
NEUROMOLECULAR MEDICINE
(2009)
Article
Neurosciences
Anne Must, Gunnar Tasa, Aavo Lang, Eero Vasar, Sulev Koks, Eduard Maron, Marika Vaeli
NEUROSCIENCE LETTERS
(2009)
Article
Environmental Sciences
J. Idavain, K. Julge, T. Rebane, A. Lang, H. Orru
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
Jane Idavain, Katrin Lang, Jelena Tomasova, Aavo Lang, Hans Orru
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Psychiatry
Roman Balotsev, Liina Haring, Kati Koido, Vambola Leping, Kart Kriisa, Mihkel Zilmer, Veiko Vasar, Anneli Piir, Aavo Lang, Eero Vasar
EARLY INTERVENTION IN PSYCHIATRY
(2019)
Meeting Abstract
Physiology
Kertu Ruenkorg, Aavo Lang, Ain Reimets, Jana Kivastik
Meeting Abstract
Clinical Neurology
P. Pokk, K. Okva, A. Lang, T. Nevalainen
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2007)
Article
Neurosciences
Eduard Maron, Innar Toru, Anne Must, Gunnar Tasa, Egle Toover, Veiko Vasar, Aavo Lang, Jakov Shlik
NEUROSCIENCE LETTERS
(2007)
Article
Veterinary Sciences
Kai Okva, Aavo Lang, Timo Nevalainen, Kari Mauranen, Marika Vali, Paavo Pokk
SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE
(2008)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)