期刊
NEUROSCIENCE LETTERS
卷 431, 期 2, 页码 129-134出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.11.065
关键词
p38 MAPK; microglia; neuropathic pain; rats; chronic constriction injury
Increasing evidences approve the long-term analgesia effects of intrathecal lidocaine in patients with chronic pain and in animal peripheral nerve injury models, but the underlying mechanism remains elusive. Previous evidences suggest that the activation of the p38 MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord involves in nerve injury-induced neuropathic pain. In this study, we demonstrate that attenuating phosphorylation of p38 MAPK in the activated microglia of spinal cord, at least partly, is the mechanism of intrathecal lidocaine reversing established tactile allodynia in chronic constriction injury model of rats. This finding not only provides a new insight into the mechanisms underlying long-term therapeutic effects of lidocaine on neuropathic pain, but also reveals one more specific drug target for analgesia. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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