期刊
NEUROSCIENCE LETTERS
卷 440, 期 2, 页码 130-133出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.05.081
关键词
interleukin-1 beta; sciatic nerve; nerve regeneration
Nerve injury brings about axonal disconnection, and thus axonal extension is one of the important steps for nerve regeneration. Expression of the pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) is increased at the early stage of nervous system injury, and previously IL-1 beta has been reported to promote neurite outgrowth by inhibiting RhoA activity in vitro. However, the effect of IL-1 beta on axonal extension in vivo has not been obvious. Now we examine whether IL-1 beta takes advantages on sciatic nerve regeneration. Sciatic nerves of rats are transected and sutured, and IL-1 beta or PBS is locally administered for 2 weeks. Although IL-1 beta does not influence on motor functional recovery, it promotes sensory functional recovery, estimated by toe pinch test, and increases the number and the area of neurofilament-positive axons at 12 weeks compared with PBS. Moreover IL-1 beta, which promotes Schwann cell proliferation and thus may inhibit myelination, does not impair remyelination, estimated by myelin basic protein. These findings suggest that IL-1 beta may contribute to sensory nerve regeneration following sciatic nerve injury by promoting axonal extension. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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