Review
Neurosciences
Ana Carolina P. Campos, Rosana L. Pagano, Nir Lipsman, Clement Hamani
Summary: Treatment-resistant depression (TRD) affects millions of individuals worldwide and deep brain stimulation (DBS) has been proposed as an adjuvant therapy for TRD. The antidepressant efficacy of DBS is still controversial, and its mechanisms of action remain poorly understood. Astrocytes, which play a major role in brain homeostasis, neuroinflammation, and neuroplasticity, may be pivotal in understanding the effects of DBS on TRD.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Engineering, Biomedical
Wenhao Wu, Jun Zhou, Panling Huang, Chunyang Pan, Zhixiang Huang, Changfeng Xu
Summary: This paper investigates the influence of longitudinal vibration on friction force during needle insertion, and experiments show that vibration can change friction force by affecting the equivalent friction coefficient and the positive pressure of tissue against the needle.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Medicine, Research & Experimental
Oskar Puk, Magdalena Jablonska, Pawel Sokal
Summary: This systematic review consolidates findings on the immunological and endocrine effects of Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS), revealing that both these neurostimulation techniques have anti-inflammatory effects by modulating local immune responses. These findings provide a foundation for future research in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Linda J. Dalic, Aaron E. L. Warren, Kristian J. Bulluss, Wesley Thevathasan, Annie Roten, Leonid Churilov, John S. Archer
Summary: In this study, deep brain stimulation to the centromedian thalamic nucleus (CM-DBS) was found to reduce electrographic seizures in patients with Lennox-Gastaut syndrome (LGS), with 50% of participants experiencing a >= 50% reduction in diary-recorded seizures after 3 months of stimulation.
ANNALS OF NEUROLOGY
(2022)
Article
Neurosciences
Salla M. Kangas, Jaakko Teppo, Maija J. Lahtinen, Anu Suoranta, Bishwa Ghimire, Pirkko Mattila, Johanna Uusimaa, Markku Varjosalo, Jani Katisko, Reetta Hinttala
Summary: This study presents an improved method for collecting fresh brain tissue samples from surgical instruments used in deep brain stimulation (DBS) procedures. The collected tissues were used for transcriptomic and proteomic analyses. The results indicate that the surgical instruments retain sufficient brain material for protein and gene expression studies, and the approach is robust and reproducible.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Psychiatry
Lora Kahn, Brianne Sutton, Helena R. Winston, Aviva Abosch, John A. Thompson, Rachel A. Davis
Summary: This study demonstrated the effectiveness of deep brain stimulation (DBS) in treating obsessive-compulsive disorder (OCD) even in patients with comorbidities. Patients with various comorbid diseases showed significant improvement in OCD symptoms through DBS therapy, emphasizing the importance of accurate electrode placement and programming strategies.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Kanwaljeet Garg, Manmohan Singh, Raghu Samala, Roopa Rajan, Sheffali Gulati, Vinay Goyal
Summary: Bilateral pallidotomy may lead to clinically significant improvement in children with acquired/heredo-degenerative generalized dystonia, although the benefits should be carefully assessed against the risk of permanent bulbar dysfunction. It is a viable option for children in resource-limited settings.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
AnneMarie Brinda, Julia P. Slopsema, Rebecca D. Butler, Salman Ikramuddin, Thomas Beall, William Guo, Cong Chu, Remi Patriat, Henry Braun, Mojgan Goftari, Tara Palnitkar, Joshua Aman, Lauren Schrock, Scott E. Cooper, Joseph Matsumoto, Jerrold L. Vitek, Noam Harel, Matthew D. Johnson
Summary: By using ultra-high field MRI, researchers developed subject-specific pathway activation models for directional DBS leads. The study found that the efficacy and side effects of DBS therapy for Essential Tremor were associated with the activation of different pathways in the brain, and the degree of activation was significantly correlated with the suppression of tremor and the severity of side effects. Therefore, a model-based programming approach can achieve more selective activation of specific regions in the brain.
Article
Computer Science, Information Systems
Tiago Matheus Nordi, Rodrigo Henrique Gounella, Maximiliam Luppe, Joao Navarro Soares Junior, Erich Talamoni Fonoff, Eduardo Colombari, Murilo Araujo Romero, Joao Paulo Pereira do Carmo
Summary: This paper presents a low-noise amplifier for deep-brain stimulation, which has high gain, wide bandwidth, and low power consumption. The amplifier is suitable for implantable devices and occupies a small microdevice area.
Article
Neurosciences
Rachel K. Spooner, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
Summary: Research shows that optimal contact orientations in subthalamic deep brain stimulation can lead to larger cortical responses and smoother hand movements in patients with Parkinson's disease. These findings have clinical implications for optimizing DBS parameter settings to alleviate motor symptoms.
NPJ PARKINSONS DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Jennifer Whitestone, Anmar Salih, Tarun Goswami
Summary: This study evaluated a posthumously extracted deep brain stimulator (DBS) device and found damage to the leads that could potentially affect the clinical treatment. The duration of the leads in vivo was estimated based on mechanical property testing and changes in the leads were observed. The goal was to validate the use of mechanical properties to predict the lifespan of DBS leads through multiple regression analysis.
BIOENGINEERING-BASEL
(2023)
Article
Neurosciences
Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan, Tricia N. Cunningham, Sameer A. Sheth, Nader Pouratian, Katherine W. Scangos, Helen S. Mayberg, Andreas Horn, Kara A. Johnson, Christopher R. Butson, Ro'ee Gilron, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A. Kuhn, Luming Li, Matthew Johnson, Kevin J. Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J. Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Joshua K. Wong, Stephanie Cernera, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D. Foote, Michael S. Okun
Summary: An estimated 208,000 deep brain stimulation (DBS) devices have been implanted worldwide to treat neurological and neuropsychiatric disorders. The DBS Think Tank provides a space for clinicians, engineers, and researchers to discuss current and emerging DBS technologies and ethical issues, with a focus on advancing the field through cutting-edge research and collaboration. The Eighth Annual DBS Think Tank, held virtually in 2020, showcased advancements in optogenetics, emerging DBS technologies, ethical issues, neuromodulatory approaches, novel hardware/software/imaging methodologies, adaptive neurostimulation, and advanced technologies for improved clinical outcomes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Anika Frank, Jonas Bendig, Inaki Schniewind, Witold H. Polanski, Stephan B. Sobottka, Heinz Reichmann, Katja Akgun, Tjalf Ziemssen, Lisa Klingelhoefer, Bjorn H. Falkenburger
Summary: This study found that deep brain stimulation surgery may be associated with neuronal damage, but stimulation itself does not have an impact.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Christos Ganos, Bassam Al-Fatly, Jan-Frederik Fischer, Juan-Carlos Baldermann, Christina Hennen, Veerle Visser-Vandewalle, Clemens Neudorfer, Davide Martino, Jing Li, Tim Bouwens, Linda Ackermanns, Albert F. G. Leentjens, Nadya Pyatigorskaya, Yulia Worbe, Michael D. Fox, Andrea A. Kuehn, Andreas Horn
Summary: Brain lesions can cause tic disorders and provide insights into tic pathophysiology. A study found that tic-inducing lesions were associated with a common network in the human brain, including the insular cortices, cingulate gyrus, striatum, globus pallidus internus, thalami, and cerebellum. Connecting deep brain stimulation electrodes to this network map predicted tic improvement. These findings suggest that this common brain network could be a promising therapeutic target for neuromodulation.
Article
Engineering, Biomedical
Sumedh S. Nagrale, Ali Yousefi, Theoden Netoff, Alik S. Widge
Summary: This study presents an approach to measure and optimize deep brain stimulation in the brain circuitry, aiming to find the electrode contacts that maximize cognitive control. The results show that the optimization can be done in a clinically feasible timespan and does not require specialized recording or imaging hardware.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Psychology, Clinical
Unyoung Chavez-Baldini, Dorien H. Nieman, Amos Keestra, Anja Lok, Roel J. T. Mocking, Pelle de Koning, Valeria V. Krzhizhanovskaya, Claudi L. H. Bockting, Geeske van Rooijen, Dirk J. A. Smit, Arjen L. Sutterland, Karin J. H. Verweij, Guido van Wingen, Johanna T. W. Wigman, Nienke C. Vulink, Damiaan Denys
Summary: Cognitive deficits and psychopathology have independent but related dimensions, and interact in a transdiagnostic manner. Depressive and anxiety symptoms, verbal memory, and visual attention are especially relevant in this network. Future research should take a transdiagnostic approach, focusing on symptom-specific interactions with cognitive domains.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Sophie M. Hardy, Ole Jensen, Linda Wheeldon, Ali Mazaheri, Katrien Segaert
Summary: This study used magnetoencephalography to investigate the neural mechanisms involved in sentence comprehension, specifically the binding of words at the syntax level. The findings revealed that syntax binding was associated with alpha band activity in left-lateralized language regions. Overall, the study highlights the crucial role of alpha band activity in controlling the allocation and coordination of brain resources during syntax composition.
Article
Neurosciences
Helena Voetterl, Guido van Wingen, Giorgia Michelini, Kristi R. Griffiths, Evian Gordon, Roger DeBeus, Mayuresh S. Korgaonkar, Sandra K. Loo, Donna Palmer, Rien Breteler, Damiaan Denys, L. Eugene Arnold, Paul du Jour, Rosalinde van Ruth, Jeanine Jansen, Hanneke van Dijk, Martijn Arns
Summary: This study develops a clinically interpretable and actionable biomarker based on resting-state electroencephalography, which can stratify patients with attention-deficit/hyperactivity disorder to their individual best treatment, thereby increasing remission rates.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Eric Hollander, Siegfried Kasper, Hans-Juergen Moeller, Elias Eriksson, Naomi A. Fineberg, Josef Haettenschwiler, Hisanobu Kaiya, Tatiana Karavaeva, Martin A. Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: According to the guideline by the World Federation of Societies of Biological Psychiatry, OCD and PTSD can be effectively treated with medications and CBT. SSRIs and CBT are first-line treatments for OCD, while SSRIs and venlafaxine are first-line treatments for PTSD.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Roksana Markiewicz, Ali Mazaheri, Andrea Krott
Summary: Bilingualism influences the balance of cognitive control processes during conflict tasks, as shown by behavioral differences and evoked potentials between bilinguals and monolinguals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Clinical Neurology
Amanda M. Legemaat, Marcella A. S. Haagedoorn, Huibert Burger, Damiaan Denys, Claudi L. Bockting, Gert J. Geurtsen
Summary: This study aimed to assess the proportion of Major Depressive Disorder (MDD) patients with demonstrated valid performance and determine their cognitive functioning. The analysis showed that around 94% of MDD patients had valid neuropsychological test performance in studies using Performance Validity Tests (PVT's). However, there is limited information regarding the cognitive functioning of these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
S. E. Cohen, J. B. Zantvoord, B. N. Wezenberg, J. G. Daams, C. L. H. Bockting, D. Denys, G. A. van Wingen
Summary: This study assessed the accuracy of electroencephalography (EEG) in predicting treatment response in major depressive disorder. The results showed that EEG can accurately predict the response to antidepressant treatment, but further validation studies are needed to develop a clinical tool for guiding interventions in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Neurosciences
Vera Korenblik, Marlies E. Brouwer, Aniko Korosi, Damiaan Denys, Claudi L. H. Bockting, Stanley Brul, Anja Lok
Summary: The microbiota-gut-brain axis (MGBA) is the bidirectional communication between the brain and the gut microbiota, and recent research has linked it to health and disease. This study focuses on understanding the impact of neuromodulation on the gut microbiota, investigating the MGBA from the brain to microbiota. The findings suggest that neuromodulation interventions are associated with moderate changes in the gut microbiome.
Article
Psychiatry
Bram W. C. Storosum, Taina Mattila, Tamar D. Wohlfarth, Christine C. Gispen-de Wied, Kit C. B. Roes, Wim van den Brink, Lieuwe de Haan, Damiaan A. J. P. Denys, Jasper B. Zantvoord
Summary: This study aimed to investigate whether gender and menopausal status have an impact on the response to antipsychotic medication in patients with schizophrenia. The results showed that women had a greater reduction in symptoms compared to men, indicating a higher response to treatment in females.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Dirk J. A. Smit, Melissa Bakker, Abdel Abdellaoui, Alexander E. Hoetink, Nienke Vulink, Damiaan Denys
Summary: In this study, the genetic etiology of misophonia was investigated, revealing significant correlations between this symptom and tinnitus, major depression disorder, post-traumatic stress disorder, and generalized anxiety disorder, as well as personality traits consistent with anxiety and PTSD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Felix Carter, Vincent DeLuca, Katrien Segaert, Ali Mazaheri, Andrea Krott
Summary: The study explores how different factors of bilingual experience lead to different neural adaptations and impact cognitive control performance. The findings suggest that language switching behavior and the intensity/diversity of bilingual language use are associated with better interference control, while the duration of bilingual engagement is detrimental to interference control.
Article
Psychiatry
Bram W. C. Storosum, Cedrine Steinz, Sem E. E. Cohen, Taina Mattila, Wim van den Brink, Kit Roes, Lieuwe de Haan, Damiaan A. J. P. Denys, Jasper B. B. Zantvoord
Summary: This study analyzed the data of 3880 patients with schizophrenia and found that ethnicity does not moderate the response to antipsychotic medication.
Article
Psychology
Roksana Markiewicz, Foyzul Rahman, Ian Apperly, Ali Mazaheri, Katrien Segaert
Summary: This research investigated the link between Theory of Mind (ToM) and communicative cooperation. The study found that communicative cooperation is influenced by the ToM ability of both oneself and their cooperative partner. The findings suggest that higher ToM scores are associated with more successful cooperative outcomes.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION
(2023)
Article
Psychiatry
Monique Kammeraat, Geeske van Rooijen, Lisette Kuijper, Julian D. Kiverstein, Damiaan A. J. P. Denys
Summary: Based on the study, the social demographic and psychiatric profiles of patients who requested and received euthanasia and assisted suicide (EAS) were found to be similar. Most of the patients requesting EAS were single females, living independently with a comorbid diagnosis of depression and a history of psychiatric treatment. Among the small group of patients who received EAS, the majority were also single women with depressive disorder. A subgroup of patients with somatic disorders, anxiety disorders, obsessive-compulsive disorders, and neurocognitive disorders were over-represented in the group of patients receiving EAS. Many patients who withdrew their requests for EAS benefited from discussions with end of life experts at EE. Health professionals can make a difference to this vulnerable patient group if they receive training on discussing end of life.
Article
Philosophy
Maarten van Westen, Erik Rietveld, Annemarie van Hout, Damiaan Denys
Summary: Despite technological innovations, clinical expertise remains the cornerstone of psychiatry. Ethnography is a method that can capture the subjective and situation-specific nature of clinical expertise. The study aims to explore the role of clinical expertise in deep brain stimulation optimization for obsessive-compulsive disorder (OCD), and the findings highlight the mutually constitutive relationship between patterns of clinical practice and particular situations.
PHENOMENOLOGY AND THE COGNITIVE SCIENCES
(2023)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
