期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 36, 期 1, 页码 254-270出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2011.06.003
关键词
Arousal; Circadian rhythms; Entrainment; Food anticipatory activity (FAA); Food entrainable oscillator (FEO); Light/dark cycle (LD); Light entrainable oscillator (LEO); Suprachiasmatic nucleus (SCN); Circadian pacemaker
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Fonds de la recherche en sante du Quebec (FRSQ)
Food anticipation and its behavioural manifestation, food anticipatory activity (FAA), require entrainment of a suprachiasmatic nucleus (SCN) independent circadian mechanism, a food entrainable oscillator (FEO), with an unknown neural substrate. While the FEO entrains to fasting/feeding related cues and drives FAA independently of the pacemaker in the SCN, it must disengage the suppressing signals of the SCN for the behavioural and physiological manifestations of meal anticipation to occur outside of the typical period of arousal. This review provides a brief overview of mammalian circadian biology before summarizing experimental data demonstrating several mechanisms by which this may occur, including: reducing activation of SCN cells receiving retinal input, transient disorganization of SCN outputs, and reduced sensitivity to SCN signals in hypothalamic sites responsible for integrating homeostatic and circadian information. Further investigation of these mechanisms will be key to elucidating pharmacological or behavioural interventions that suppress the negative psychological and health effects of light-driven circadian rhythms in humans, specifically those with work schedules that do not conform to the solar day. (C) 2011 Elsevier Ltd. All rights reserved.
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