Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Juan Zhao, Jin Xue, Tengfei Zhu, Hua He, Huaixing Kang, Xuan Jiang, Wen Huang, Ranhui Duan
Summary: Fragile X syndrome (FXS) is a genetic disorder caused by the lack of functional fragile X mental retardation protein (FMRP), which leads to intellectual disability. Recent research identified collapsing response mediator protein (CRMP) as a target of FMRP, and targeting CRMP ameliorated circadian defects in FXS fruit flies.
NEUROSCIENCE BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Clemencia de Rueda, Pablo Diez-Villanueva, Clara Bonanad, Fernando Alfonso
Summary: Ischemic heart disease is the leading cause of death in Western countries. The occurrence and mortality rate of acute cardiac events increase with age. Circadian rhythms play a crucial role in cardiovascular physiology, but exaggerated responses may be harmful for individuals susceptible to acute cardiovascular events. Elderly patients seem to have an increased risk of acute coronary events, especially in the morning, although other distribution patterns have also been observed.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Geriatrics & Gerontology
Shuyuan Yang, Ying Wan, Na Wu, Lu Song, Zhihua Liu, Jiahao Zhao, Ying Liu, Zhenguo Liu, Jing Gan
Summary: The study shows that L-dopa can restore circadian rhythm disturbances in PD rats by regulating the D1R-ERK1/2-mTOR pathway, improving irregular fluctuations in blood pressure and temperature.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Nai-Wei Hsu, Kai-Chen Chou, Yu-Ting Tina Wang, Chung-Lieh Hung, Chien-Feng Kuo, Shin-Yi Tsai
Summary: This study investigates the association between circadian genes and metabolic syndromes in a Taiwanese population and develops a simple model for predicting metabolic syndrome.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Aissatou Bailo Diallo, Soraya Mezouar, Asma Boumaza, Oksana Fiammingo, Benjamin Coiffard, Pierre Pontarotti, Benoit Desnues, Jean-Louis Mege
Summary: A study has found the expression of circadian rhythm molecular clock genes in Escherichia coli, which could potentially lead to new perspectives in antibacterial treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Viktoria Nemeth, Szabina Horvath, Agnes Kinyo, Rolland Gyulai, Zsuzsanna Lengyel
Summary: In this study, perturbations in clock gene transcripts were observed in both uninvolved and lesional psoriatic areas, suggesting their potential as therapeutic targets and the development of chronotherapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Weiying Dai, Swanand A. Wagh, Steffi Chettiar, Grace D. Zhou, Runia Roy, Xingye Qiao, Paul S. Visich, Eric P. Hoffman
Summary: This study found that circadian cortisol levels in children are associated with cardiovascular health outcomes, with lower morning cortisol levels being linked to increased blood pressure, body fat, and poor lipid profiles. Adjusting for potential confounding variables revealed that lower morning cortisol levels in 4th grade were associated with increased blood pressure a year later.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiang-Jun Wang, Yao Guo, Chun-Yan Yao, Ke-Hao Zhang, Qin Li, Chun-Hua Shan, Peng Liu, Mei-Zhi Wang, Feng Zhu, Lei An, Jian-Hui Tian, Zhong-Hong Wu
Summary: This study revealed that mistimed feeding disrupts the behavioral rhythms of growing pigs, reprograms gut microbiota composition, reduces the serum levels of hormones associated with fighting depression and anxiety, and increases the risk of lipid metabolic dysregulation.
Review
Endocrinology & Metabolism
Amirali Hariri, Mina Mirian, Ali Zarrabi, Mohammad Kohandel, Maryam Amini-Pozveh, Amir Reza Aref, Aliye Tabatabaee, Pranav Kumar Prabhakar, Ponnurengam Malliappan Sivakumar
Summary: The occurrence of chronic diseases like type 2 diabetes mellitus is related to the circadian rhythm, and interventions can be made by adjusting lifestyle and molecular pathways.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adam T. Evans, Heidi Vanden Brink, Jessica S. Lim, Brittany Y. Jarrett, Annie W. Lin, Marla E. Lujan, Kathleen Hoeger
Summary: Circulating melatonin is elevated in women with polycystic ovary syndrome (PCOS), and altered patterns of melatonin excretion may be associated with reduced sleep quality in these women. This study found that women with PCOS had lower weekend sleep efficiency compared to controls, and the number of follicles per ovary was positively associated with overnight melatonin levels. These findings suggest that PCOS diagnostic features are related to melatonin production and sleep disturbances.
Review
Endocrinology & Metabolism
Wei-hong Chen, Qiao-yi Huang, Zhi-yi Wang, Xuan-xuan Zhuang, Shu Lin, Qi-yang Shi
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive dysfunction associated with endocrine disorders. The role of circadian rhythm changes in PCOS pathogenesis has gained attention. The changes in circadian rhythm may alter circulating exosomes, leading to related changes in physiological functions and contributing to PCOS development.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Guillermo Garcia-Eguren, Mar Gonzalez-Ramirez, Pedro Vizan, Oriol Giro, Arturo Vega-Beyhart, Laura Boswell, Mireia Mora, Irene Halperin, Francisco Carmona, Meritxell Gracia, Gregori Casals, Mattia Squarcia, Joaquim Ensenat, Oscar Vidal, Luciano Di Croce, Felicia A. Hanzu
Summary: This study identified for the first time the persistent transcriptional and epigenetic signatures induced by hypercortisolism in visceral adipose tissue (VAT), providing a novel integrated view of molecular components driving the long-term VAT impairment associated with Cushing's syndrome (CS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)