期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 34, 期 6, 页码 821-834出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2009.09.002
关键词
Stress hyporesponsive period; Maternal separation; Maternal deprivation; Stress; Behaviour; HPA axis
资金
- Fundacao de Pesquisa do Estado de Sao Paulo (FAPESP) [2006/06415-4]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [479671/2004-4]
- Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
- CAPES
- CNPq
The hypothalamic-pituitary-adrenal (HPA) axis is the main neuroendocrine system of response to stress, and an imbalance of this system's activity is believed to be at the core of numerous psychiatric pathologies. During the neonatal period, the glucocorticoid response to stress is maintained at low levels by specific maternal behaviours, which is essential for proper brain development. Effective evaluation of the impact of increased secretion of corticosterone during an essentially anabolic developmental period on adulthood behaviour involved separation of the neonate from its mother for periods ranging from 3 to 24 h. It has been shown that disinhibition of the stress response is achieved by such procedures. The pioneering studies by Seymour Levine set the stage for a prolific and promising field of study that may help neuroscientists unveil the neurobiological underpinnings of stress-related disorders. Based on a series of studies, we propose that maternal separation and maternal deprivation change stress-related behaviours, but that corticosterone seem to be only partially involved in these changes in adulthood. It appears that extra-hypothalamic corticotrophin-releasing factor and neurotransmitter systems may be the primary mediators of these behavioural outcomes. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据