Letter
Neurosciences
Ali Nouraeinejad
Summary: Amblyopia severely affects saccadic eye movements and distorts the spatiotemporal coordination between the visual and motor systems. Validated clinical tests related to saccadic eye movements are not currently performed in routine clinical eye examinations.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Camille Metais, Judith Nicolas, Moussa Diarra, Alexis Cheviet, Eric Koun, Denis Pelisson
Summary: Previous studies have shown that the neural substrate for adaptation of saccadic eye movements involves the cerebellum and several cortical areas. This study aimed to understand the differences between forward and backward adaptation of saccades and their error processing and oculomotor changes. The results showed activation in specific cortical and subcortical areas related to adaptation and error signal processing, and revealed the involvement of the occipital cortex and MT/MST in the direction of adaptation. Overall, this study provides further evidence of the role of the cerebral cortex in saccadic adaptation and contributes to our understanding of oculomotor plasticity and its relationship with spatial cognition.
Editorial Material
Clinical Neurology
Ivan Milenkovic, Gregor Kasprian, Gerald Wiest
Summary: The main cerebellar structures involved in ocular motor control include the flocculus, paraflocculus, nodulus, uvula, OMV, and FOR. While the flocculus and paraflocculus play a critical role in smooth pursuit and gaze holding, the vestibulocerebellar centers, OMV, and FOR are exclusively responsible for the control of smooth pursuit and saccades.
Article
Clinical Neurology
Domenica Zaino, Valeria Serchi, Fabio Giannini, Barbara Pucci, Giacomo Veneri, Elena Pretegiani, Francesca Rosini, Lucia Monti, Alessandra Rufa
Summary: This study compared eye movements and visual search behaviors between spinal ALS and bulbar ALS patients, revealing distinct features. The findings suggest early involvement of the parieto-collicular-cerebellar network in spinal ALS and the fronto-brainstem circuit in bulbar ALS.
Article
Computer Science, Artificial Intelligence
Matheus Belizario Brito, Gisele Chiozi Gotardi, Sergio Tosi Rodrigues, Daniela Godoi Jacomassi, Cedrick T. Bonnet, Paula Favaro Polastri
Summary: The study investigated the maintenance of postural control adaptation in challenging situations among young adults. Results showed that adding a working memory task did not affect postural stabilization and adaptive visual reweighting. Young adults are flexible in optimizing their postural control to succeed in multiple tasks even under perturbation.
Article
Biology
Saad Idrees, Matthias-Philipp Baumann, Maria M. Korympidou, Timm Schubert, Alexandra Kling, Katrin Franke, Ziad M. Hafed, Felix Franke, Thomas A. Muench
Summary: Visual perception remains stable across saccades because of the reduction in visual sensitivity known as saccadic suppression. This suppression is achieved through three independent mechanisms in the retina.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shawn M. Willett, J. Patrick Mayo
Summary: Reliable and noninvasive biomarkers are important for neurological diagnoses. Microsaccades, small eye movements, have been proposed as a biomarker for attention, but their direction may not accurately reflect covert spatial attention in complex viewing conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Marcin Leszczynski, Stephan Bickel, Maximilian Nentwich, Brian E. Russ, Lucas Parra, Peter Lakatos, Ashesh Mehta, Charles E. Schroeder
Summary: In natural active vision, humans and other primates use eye movements to sample information from visual scenes. This study shows that saccades also modulate excitability in numerous auditory cortical areas, suggesting a cross-modal effect. The findings suggest that the brain can improve information processing in complex natural settings by linking excitability states between auditory and visual areas using saccadic signals.
Article
Physics, Multidisciplinary
F. S. Mousavinejad, M. Fatehi Nia
Summary: This study models the saccadic eye movements using mathematical dynamical models and introduces alternative functions to represent the response of bursters to error signals more effectively. The modified saccadic model's dynamical behavior is also investigated, and the stability, instability, and existence or lack of bifurcation are evaluated. Simulation results show that the main factors of the model, such as the burst neurons and motor error, exhibit different changes in the phase portrait and time series.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Engineering, Multidisciplinary
Hari Teja Kalidindi, Lorenzo Vannucci, Cecilia Laschi, Egidio Falotico
Summary: This study presents a cerebellum-inspired adaptive filter model that can simultaneously improve accuracy and movement-time, implemented and validated on a humanoid robot. The research found separate plasticity mechanisms in the model cerebellum that control accuracy and movement-time, ensuring optimal saccades are produced by receiving end reaching error direction as an evaluative signal. The model also emulates movement kinematics encoding observed in biological experiments.
BIOINSPIRATION & BIOMIMETICS
(2021)
Article
Neurosciences
Jianqing Lan, Yingan Li, Shasha Pang, Guanrong Zhang, Dianpeng Wu, Cheng Yang, Juan Li, Junyu Lin, Xiyang Yang, Zheng Li, Hang Chu, Li Yan, Jin Zeng
Summary: In this study, using eye-tracking technology, the deviation of visual targets during fixational and saccadic tasks was quantified to reflect the control ability and characteristics of fixational displacement among healthy adults. The results showed that the displacement of visual targets in the horizontal and vertical directions was related to task type and age. This study provides an objective, quantitative, and convenient reference index for the evaluation of fixation stability in visual impairment diseases and the aging phenomenon of visual function.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Ophthalmology
Frauke Heins, Markus Lappe
Summary: This study explores the plasticity of saccadic eye movements and their impact on perceived location. The findings suggest that changes in perceived location may still occur even when saccade amplitude remains unchanged.
Article
Multidisciplinary Sciences
Frauke Heins, Jana Masselink, Joshua-Nikodemus Scherer, Markus Lappe
Summary: The study investigates whether oculomotor behavior can be adapted based on post-saccadic target information alone. The results suggest that, based on post-saccadic information, eye movements and target localization can be adjusted to reduce errors, possibly indicating a continuous updating of the estimated pre-saccadic target location driven by postdictive motor error.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Joris A. Elshout, Tanja C. W. Nijboer, Stefan Van der Stigchel
Summary: In this study, the researchers investigated the pre-saccadic shift of attention in neglect patients and found an imbalance in discrimination performance between the two hemifields, suggesting that attention and eye movements are both unique impairments of neglect patients. The impaired pre-saccadic shift of attention may be a key issue in neglect and could underlie other spatial and non-spatial deficits commonly reported in neglect patients.
Article
Neurosciences
Mayu Takahashi, Yuriko Sugiuchi, Jie Na, Yoshikazu Shinoda
Summary: The study identified different neural inputs from the rostral and caudal superior colliculi to the nucleus raphe interpositus, showing that inhibitory burst neurons suppress activity of omnipause neurons immediately before and during saccades. This suggests a role for IBNs in triggering and controlling eye movements.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
E. Chabanat, S. Jacquin-Courtois, L. Have, C. Kihoulou, C. Tilikete, F. Mauguiere, S. Rheims, Y. Rossetti
Article
Clinical Neurology
Elodie Nerrant, Lucie Abouaf, Frederic Pollet-Villard, Anne-Laure Vie, Sandra Vukusic, Julien Berthiller, Bettina Colombet, Alain Vighetto, Caroline Tilikete
JOURNAL OF NEURO-OPHTHALMOLOGY
(2020)
Article
Behavioral Sciences
Leslie Tricoche, Johan Ferrand-Verdejo, Denis Pelisson, Martine Meunier
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Letter
Clinical Neurology
M. Cescutti, C. Davenas, C. Tilikete, F. Durand-Dubief, R. Marignier, S. Vukusic
REVUE NEUROLOGIQUE
(2020)
Article
Neurosciences
Aasef G. Shaikh, Adolfo Bronstein, Sergio Carmona, Yoon-Hee Cha, Catherine Cho, Fatema F. Ghasia, Daniel Gold, Kemar E. Green, Christoph Helmchen, Richard T. Ibitoye, Jorge Kattah, Ji-Soo Kim, Sudhir Kothari, Mario Manto, Barry M. Seemungal, Dominik Straumann, Michael Strupp, David Szmulewicz, Alexander Tarnutzer, Ali Tehrani, Caroline Tilikete, Miriam Welgampola, Guillermo Zalazar, Amir Kheradmand
Summary: Virtual healthcare practices have seen significant growth in the modern era, especially accelerated by the challenges posed by the COVID-19 pandemic. Guidelines on remote examination methods in neurotology have become crucial, aiming to diagnose inner-ear, brainstem, and cerebellum diseases effectively. The focus has been on determining urgent medical care needs for patients with vestibular disorders versus those who can be managed on an expedited outpatient basis.
Review
Critical Care Medicine
Pascal Seve, Yvan Jamilloux, Caroline Tilikete, Mathieu Gerfaud-Valentin, Laurent Kodjikian, Thomas El Jammal
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Judith Nicolas, Aurelie Bidet-Caulet, Denis Pelisson
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Elvio Blini, Caroline Tilikete, Leonardo Chelazzi, Alessandro Farne, Fadila Hadj-Bouziane
Article
Clinical Neurology
Celine Louapre, Elisabeth Maillart, Caroline Papeix, Sinead Zeidan, Damien Biotti, Zoe Lepine, Abir Wahab, Mickael Zedet, Pierre Labauge, Caroline Tilikete, Julie Pique, Ayman Tourbah, Guillaume Mathey, Dalia Dimitri Boulos, Pierre Branger, Laurent Daniel Kremer, Romain Marignier, Nicolas Collongues, Jerome De Seze
Summary: The outcomes of COVID-19 in patients with NMOSD or MOGAD treated with immunosuppressive therapies were generally favorable in this cohort study. Hospitalized patients tended to be older with shorter disease duration, while outpatients were younger with longer disease duration. Larger international studies are needed to identify risk factors for severe COVID-19 in this immunocompromised population.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
Alexis Cheviet, Laure Pisella, Denis Pelisson
Summary: This study investigated the contribution of the posterior parietal cortex (PPC) to saccadic remapping mechanisms in visual constancy. A patient with a PPC lesion and optic ataxia in the left hemifield was studied in transsaccadic visual localization tasks, showing specific patterns of perceptual deficits. The findings support the crucial role of the PPC in saccadic remapping processes for perceptual visual constancy.
Article
Biology
Leslie Tricoche, Elisabetta Monfardini, Amelie J. Reynaud, Justine Epinat-Duclos, Denis Pelisson, Jerome Prado, Martine Meunier
Summary: The presence of peers can help children perform more like adults, with better response strategies and faster response times. Peer presence influences educational skills and lays the groundwork for understanding how brain mechanisms mediating this social influence evolve during development.
Article
Endocrinology & Metabolism
Claire Marx, Muriel Rabilloud, Francoise Borson Chazot, Caroline Tilikete, Emmanuel Jouanneau, Gerald Raverot
Summary: The study compared the outcomes of patients with pituitary apoplexy managed by conservative or surgical approaches, finding no significant differences at 1 year in terms of visual field defects and visual acuity impairment. The Pituitary Apoplexy Score (PAS) may be a reliable parameter for guiding therapeutic strategy, with surgery recommended for patients with a PAS score >= 4.
Meeting Abstract
Clinical Neurology
C. Louapre, E. Maillart, C. Papeix, S. Zeidan, D. Biotti, Z. Lepine, A. Wahab, M. Zedet, P. Labauge, C. Tilikete, J. Pique, A. Tourbah, G. Mathey, D. Dimitri Boulos, P. Branger, L. Kremer, R. Marignier, N. Collongues, J. De Seze
MULTIPLE SCLEROSIS JOURNAL
(2020)
Editorial Material
Clinical Neurology
Aude Metzger, Laure Pisella, Alain Vighetto, Bastien Joubert, Jerome Honnorat, Caroline Tilikete, Virginie Desestret
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2019)
Article
Medicine, General & Internal
Svenja Specovius, Hanna G. Zimmermann, Frederike Cosima Oertel, Claudia Chien, Charlotte Bereuter, Lawrence J. Cook, Marco Aurelio Lana Peixoto, Mariana Andrade Fontenelle, Ho Jin Kim, Jae-Won Hyun, Su-Kyung Jung, Jacqueline Palace, Adriana Roca-Fernandez, Alejandro Rubio Diaz, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshte Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen Pourazizi, Lekha Pandit, Anitha Dcunha, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Eugene May, Caryl Tongco, Letizia Leocani, Marco Pisa, Marta Radaelli, Elena H. Martinez-Lapiscina, Hadas Stiebel-Kalish, Mark Hellmann, Itay Lotan, Sasitorn Siritho, Jerome de Seze, Thomas Senger, Joachim Havla, Romain Marignier, Caroline Tilikete, Alvaro Cobo Calvo, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Nasrin Asgari, Kerstin Soelberg, Ayse Altintas, Rengin Yildirim, Uygur Tanriverdi, Anu Jacob, Saif Huda, Zoe Rimler, Allyson Reid, Yang Mao-Draayer, Ibis Soto de Castillo, Michael R. Yeaman, Terry J. Smith, Alexander U. Brandt, Friedemann Paul
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)