Article
Multidisciplinary Sciences
Amy K. Sutton, Paulette B. Goforth, Ian E. Gonzalez, James Dell'Orco, Hongjuan Pei, Martin G. Myers, David P. Olson
Summary: The study reveals that VMH neurons expressing melanocortin 3 receptor (Mc3R) can sense glucose changes and promote glucose utilization by regulating blood glucose levels. Activation of these neurons can attenuate glucose fluctuations, while silencing them enhances blood glucose excursions following a glucose load.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Caroline S. Johnson, Weizhe Hong, Paul E. Micevych
Summary: Research findings suggest that GABA neurons in the MeApd facilitate lordosis in female mice, while glutamate neurons may direct behavior away from social interactions. Photoinhibition of VGAT neurons decreased lordosis quotient (LQ), while photoexcitation of VGluT2 neurons increased time spent self-grooming, indicating different roles of GABA and glutamate in social and reproductive behaviors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Xu Wang, Haohong Li
Summary: This study found that synaptic remodeling, lipid droplet accumulation, and synaptic dysfunction occur in feeding-related brain regions of obese mice induced by high-fat diet. These impairments are associated with energy homeostasis and reward regulation, which may contribute to overeating in obesity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Teodora Georgescu, Zin Khant Aung, David R. Grattan, Rosemary S. E. Brown
Summary: Aggressive behavior is observed in lactating female mice and is controlled by prolactin receptor in the ventromedial nucleus (VMN), which affects other brain regions involved in maternal behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Amrita R. Nair, Steve W. C. Chang
Summary: This study further explores the role of oxytocin in maintaining social relationships and its interaction with the endocannabinoid system.
Review
Neurosciences
Dongyu Wei, Vaishali Talwar, Dayu Lin
Summary: Social behaviors, such as mating, fighting, and parenting, are fundamental for survival of any vertebrate species. These behaviors are expressed in a stereotypical and species-specific way due to developmentally hardwired neural circuits, but are also flexible and influenced by various factors. The neural mechanisms supporting innate social behaviors also contribute to behavioral plasticity.
Article
Neurosciences
Linjuan Feng, Hsuan Lo, Hanlin You, Wei Wu, Xiaojuan Cheng, Jiawei Xin, Zucheng Ye, Xiaochun Chen, Xiaodong Pan
Summary: This study reveals the important role of CB2 receptors in modulating synaptic pruning in the nucleus accumbens (NAc) during alpha-Synucleinopathy. CB2 receptor knockout leads to changes in microglial morphology and phenotype and affects the activation of related signaling pathways. The findings provide important insights into the mechanisms underlying the development of Alpha-Synucleinopathy.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Marcos Garcia-Juarez, Ailyn Luna-Hernandez, Sandra Tapia-Hernandez, Omar Montes-Narvaez, Raymundo Dominguez-Ordonez, Miriam B. Tecamachaltzi-Silvaran, James G. Pfaus, Oscar Gonzalez-Flores
Summary: This study investigated the effect of apelin-13 on different brain areas at varying doses, and found that it can induce lordosis behavior, with a more pronounced effect in the VMH of EB-primed rats, and only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min.
NEUROSCIENCE LETTERS
(2022)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Endocrinology & Metabolism
Berengere Coupe, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Penicaud, Tamas L. Horvath, Sebastien G. Bouret
Summary: The study investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the ventromedial nucleus of the hypothalamus (VMH) under normal and fasting conditions. It was found that autophagy is nutritionally regulated in VMH neurons and participates in controlling energy homeostasis during fasting.
MOLECULAR METABOLISM
(2021)
Article
Neurosciences
Jun Jiang, Guangyuan Zou, Jiayi Liu, Shuqin Zhou, Jing Xu, Hongqiang Sun, Qihong Zou, Jia-Hong Gao
Summary: Animal experiments demonstrate the crucial role of the hypothalamus in regulating sleep-wake cycles, while neuroimaging studies suggest the presence of wake-promoting and sleep-promoting regions within the human hypothalamus. Functional network organization of the hypothalamus shifts between wakefulness and sleep, with different brain regions showing varying connectivity patterns.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Giulia Miracca, Berta Anuncibay-Soto, Kyoko Tossell, Raquel Yustos, Alexei L. Vyssotski, Nicholas P. Franks, William Wisden
Summary: The lateral preoptic hypothalamus plays a crucial role in NREM and REM sleep induction and NREM sleep homeostasis. Surprisingly, calcium signals in the lateral preoptic hypothalamus were found to be highest during REM sleep. NMDA receptors in the lateral preoptic hypothalamus were identified as the main drivers of excitation. Deleting these NMDA receptors led to insomnia and fragmented sleep patterns. The sleep fragmentation was specifically attributed to NMDA receptors on GABA neurons in the lateral preoptic hypothalamus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Polina A. Anfimova, Lydia G. Pankrasheva, Konstantin Yu Moiseev, Elizaveta S. Shirina, Valentina V. Porseva, Petr M. Masliukov
Summary: The hypothalamus plays a crucial role in regulating homeostasis, biological rhythms, adaptation, and aging. This study found the presence of Lin28-immunoreactive neurons in the ventromedial nucleus of the hypothalamus and their absence in other studied nuclei. The percentage of Lin28-positive neurons increases with age, peaks at 6 months and 1 year, and then declines. These neurons also colocalize components of insulin signaling, indicating their involvement in metabolic regulation. The findings suggest that Lin28 expression in the hypothalamus changes with development and signaling components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ege Kingir, Cem Sevinc, Gunes Unal
Summary: Chronic oral ketamine prevents the reduction of daily activity and loss of desire caused by chronic unpredictable mild stress. This preventive effect is achieved by altering neuronal activation in the lateral habenula and nucleus accumbens shell.
Article
Behavioral Sciences
Alberto Hernandez-Leon, Yarim Elideth De la Luz-Cuellar, Vinicio Granados-Soto, Maria Eva Gonzalez-Trujano, Alonso Fernandez-Guasti
HORMONES AND BEHAVIOR
(2018)
Article
Biochemistry & Molecular Biology
Sonia Nava-Salazar, Saul Gomez-Manzo, Jaime Marcial-Quino, Alfonso Marhx-Bracho, Bryan V. Phillips-Farfan, Carlos Diaz-Avalos, America Vanoye-Carlo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Psychology, Biological
Daniela Rebolledo-Solleiro, Alonso Fernandez-Guasti
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Behavioral Sciences
Sandra Olvera-Hernandez, Alejandra Hernandez, Rebeca Reyes, Alonso Fernandez-Guasti
HORMONES AND BEHAVIOR
(2019)
Article
Immunology
L. Martinez-Alcantar, D. K. Talavera-Carrillo, J. U. Pineda-Salazar, M. Avalos-Viveros, G. Gutierrez-Ospina, B. Phillips-Farfan, A. L. Fuentes-Farias, E. Melendez-Herrera
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Review
Urology & Nephrology
Abigail K. Hernandez-Munive, Daniela Rebolledo-Solleiro, Alonso Fernandez-Guasti
JOURNAL OF SEXUAL MEDICINE
(2019)
Article
Behavioral Sciences
Adriana Alvarez Silva, Alonso Fernandez-Guasti
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2019)
Article
Neurosciences
Itzel Jatziri Contreras-Garcia, Gisela Gomez-Lira, Bryan Victor Phillips-Farfan, Luz Adriana Pichardo-Macias, Mercedes Edna Garcia-Cruz, Juan Luis Chavez-Pacheco, Julieta G. Mendoza-Torreblanca
Summary: Research suggests that the effectiveness of levetiracetam in treating epilepsy is related to the expression levels of SV2A in glutamatergic terminals, where high SV2A-VGLUT co-expression may contribute to a positive response to the treatment.
Review
Biochemistry & Molecular Biology
Bryan Phillips-Farfan, Fernando Gomez-Chavez, Edgar Alejandro Medina-Torres, Jose Antonio Vargas-Villavicencio, Karla Carvajal-Aguilera, Luz Camacho
Summary: The microbiota plays a crucial role in immune development and host immune regulation, through the production of various microbial products that affect the production of short-chain fatty acids, polysaccharides, and polyamines, as well as by binding to specific receptors to modulate immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Luz Camacho-Castillo, Bryan Phillips-Farfan, Gabriela Rosas-Mendoza, Aidee Baires-Lopez, Danira Toral-Rios, Victoria Campos-Pena, Karla Carvajal
Summary: Metabolic disturbances, specifically linked to oxidative stress, play a role in the progression of neurodegenerative diseases like Alzheimer's disease. Early metabolic syndrome induced by sucrose intake in rats resulted in oxidative damage and altered expression of key proteins involved in amyloidogenesis and energy signaling pathways. AMPK activation could be considered a potential preventive therapy for early MetS and associated neurodegenerative diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liliana Areli Robledo-Avila, Bryan Victor Phillips-Farfan, Martha Harfush Melendez, Leonel Lopez Toledo, David Tafolla Venegas, Ma Antonia Herrera Vargas, Diana Vanessa Ruiz Cortes, Esperanza Melendez-Herrera
Summary: Ex-situ conservation in hatcheries can have negative impacts on immune traits of sea turtles, but can increase hatching and emergence success. Body size and spleen development are not influenced by sex, but are associated with ex-situ conservation efforts.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Ecology
Nancy M. Unda-Diaz, Bryan V. Phillips-Farfan, Hector Nava, Leonel Lopez-Toledo, Chiharu Murata, Naima Lajud, Ma. Antonia Herrera-Vargas, Claudia A. Arreola Camacho, Luz Torner, Alma L. Fuentes-Farias, Esperanza Melendez-Herrera
Summary: Ex situ incubation of sea turtle eggs has a negative impact on neurogenesis, ovariogenesis, body size, and self-righting ability in hatchlings. Future studies should evaluate the long-term effects on cognitive and reproductive performance and understand the differential contributions of egg movement, reburial, nesting environment, and parental origin to development.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Pharmacology & Pharmacy
Erick J. Rodriguez-Palma, Isabel Velazquez-Lagunas, Ana Belen Salinas-Abarca, Guadalupe C. Vidal-Cantu, Maria J. Escoto-Rosales, Gabriela Castaneda-Corral, Alonso Fernandez-Guasti, Vinicio Granados-Soto
Summary: Chronic stress can trigger behavioral disorders such as nociceptive hypersensitivity and anxiety, but the mechanisms behind these disorders are not fully understood. This study investigated the role of HMGB1 and TLR4 in chronic stress-induced nociceptive hypersensitivity. The results showed that chronic stress induced tactile allodynia, anxiety-like behaviors, and activation of spinal microglia. HMGB1 and TLR4 expression was increased in the dorsal root ganglion. Blocking HMGB1 and TLR4 reduced nociceptive hypersensitivity and anxiety-like behaviors induced by chronic stress. TLR4 deletion diminished chronic stress-induced tactile allodynia in both male and female mice. The findings suggest that TLR4 could be a potential target for treating nociceptive hypersensitivity associated with chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Psychology, Biological
Bryan V. Phillips-Farfan, Blanca Gomez Quintanar, Rebeca Reyes, Alonso Fernandez-Guasti
Summary: In this study, male rats treated with an aromatase inhibitor that preferred sexually experienced males showed higher expression of estrogen receptors alpha (ER α) and beta (ER β) in specific brain areas. This suggests that the unique brain characteristics of males with same-sex preference may be influenced by the expression of these hormone receptors, contributing to the biological underpinnings of sexual preference.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Psychology, Multidisciplinary
Claudia Amezcua-Gutierrez, Hernandez-Gonzalez Marisela, Alonso Fernandez Guasti, Manuel Alejandro Cruz Aguilar, Miguel Angel Guevara
JOURNAL OF HOMOSEXUALITY
(2020)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)