Review
Behavioral Sciences
Brandon C. Yarns, Justina T. Cassidy, Amy M. Jimenez
Summary: Experts have recently introduced research-driven subtypes of chronic pain based on proposed underlying mechanisms, with nociplastic pain potentially involving factors such as brain plasticity and emotion regulation. Data suggest a correlation between anger, anger regulation, and the presence/severity of nociplastic pain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Andrea Tinnirello, Silvia Mazzoleni, Carola Santi
Summary: Research on pain in the elderly shows conflicting results, with some studies suggesting a modest decrease in pain sensitivity and others finding a reduced pain threshold. Elderly individuals are more prone to hyperalgesia, with pathologic changes in the central nervous system affecting pain processing.
Review
Medicine, General & Internal
Nicholas J. Pondelis, Eric A. Moulton
Summary: Understanding the mechanisms of eye pain is crucial for the treatment of neuropathic eye conditions.
FRONTIERS IN MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
M. Lim, T. D. Nascimento, D. J. Kim, V. L. Ellingrod, A. F. DaSilva
Summary: The study found aberrant BOLDSV in specific frequency bands in chronic myofascial TMD patients, which correlated with pain frequency and severity. The COMT Val(158)Met polymorphism may affect clinical symptoms.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biology
Alexandra Tinnermann, Christian Sprenger, Christian Buechel
Summary: This study investigated the effects of the opioid remifentanil on healthy male participants using combined corticospinal functional MRI. The results showed that opioids altered activity in regions involved in pain processing and pain modulation and coupling strength could differentiate between opioid analgesia and unspecific reductions in pain.
Article
Medicine, General & Internal
Irina T. Duff, Kristen N. Krolick, Hana Mohamed Mahmoud, Vidya Chidambaran
Summary: Currently, there are gaps in the research on mechanisms and biomarkers of chronic pain transition in children, as well as the lack of objective biomarkers for diagnosis, risk stratification, and prognosis. This article provides a summary of the current evidence on the mechanisms and biomarkers of acute to chronic pain transitions in infants and children from a developmental perspective, aiming to identify research gaps and outline future directions for a developmentally informed theory of pain chronification in the pediatric population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Scott F. Farrell, Adrian Campos, Pik-Fang Kho, Rutger M. J. de Zoete, Michele Sterling, Miguel E. Renteria, Trung Thanh Ngo, Gabriel Cuellar-Partida
Summary: Genetic factors were found to be associated with decreased regional grey matter in specific brain regions in individuals with chronic pain, suggesting a shared genetic basis for reduced grey matter morphology and chronic pain. These novel findings warrant further investigation into the neurogenetic pathways underlying chronic pain conditions.
Article
Clinical Neurology
Kenta Wakaizumi, Andrew D. Vigotsky, Rami Jabakhanji, Maryam Abdallah, Joana Barroso, Thomas J. Schnitzer, Apkar Vania Apkarian, Marwan N. Baliki
Summary: This study examined the psychological, functional, and brain morphology effects of long-term opioid use in patients with chronic pain. The results showed that patients on opioids displayed more negative emotion, poorer physical function, and increased pain interference, as well as decreased gray matter volumes in specific brain regions.
Article
Substance Abuse
Fares Qeadan, Erin Fanning Madden
Summary: The study found that receiving a naloxone prescription was associated with an increased risk of subsequent opioid overdose among patients with acute and chronic pain, suggesting that prescribers often identify patients most in need of naloxone.
Article
Medicine, General & Internal
Marium M. Raza, Ruth Zaslansky, Debra B. Gordon, Jeanne M. Wildisen, Marcus Komann, Ulrike M. Stamer, Dale J. Langford
Summary: The presence of preexisting chronic breast pain is associated with more severe acute postoperative pain and higher opioid consumption in women undergoing surgery for breast cancer, suggesting it may be an important risk factor for poor pain-related postoperative outcomes. Targeted intervention for this subgroup may improve recovery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Anatomy & Morphology
Thijs Vande Vyvere, Amber De Groote, An De Groef, Vincent Haenen, Wiebren Tjalma, Pieter Van Dyck, Mira Meeus
Summary: The purpose of this study was to review the literature on brain changes in chronic cancer-related pain patients using neuroimaging techniques. The results showed that there are morphological and functional changes in the brains of patients with chronic cancer-related pain compared to pain-free cancer patients or healthy volunteers. However, there were inconsistencies in findings and variations in methodology and sample size, leading to inconclusive results.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Pediatrics
Gerbrich E. van den Bosch, Dick Tibboel, Jurgen C. de Graaff, Hanan El Marroun, Aad van der Lugt, Tonya White, Monique van Dijk
Summary: Children and adolescents exposed to high levels of opioids in early life showed worse neuropsychological functioning 8-19 years later, but overall, no major long-term effects of neonatal exposure to pain, opioids, or anesthetics were observed in this study.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Barry J. Sessle
Summary: Diagnosing and treating chronic orofacial pain conditions can be challenging due to their complexity. Variability between individuals in risk factors and pain expression suggests a role for genetic and environmental factors. Understanding underlying mechanisms and individual differences is crucial for effective management of chronic orofacial pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Kannan Aravagiri, Adam Ali, Hank C. Wang, Kenneth D. Candido, Nebojsa Nick Knezevic
Summary: This article explores the mechanisms and current research related to the transition from acute to chronic pain, highlighting potential treatment strategies for chronic pain prevention.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Anesthesiology
Ria E. Hopkins, Gabrielle Campbell, Louisa Degenhardt, Suzanne Nielsen, Fiona Blyth, Milton Cohen, Natasa Gisev
Summary: Although multimodal management is recommended for chronic noncancer pain (CNCP), little is known about the long-term treatment utilization patterns among individuals using opioids. This study conducted in Australia found that many Australians using opioids for CNCP also used nonopioid pharmacological and nonpharmacological treatments. However, some treatment use was inconsistent with guidelines and the use of nonpharmacological treatments was associated with having private health insurance.
Review
Anesthesiology
Todd B. Monroe, Roger B. Fillingim, Stephen P. Bruehl, Baxter P. Rogers, Mary S. Dietrich, John C. Gore, Sebastian W. Atalla, Ronald L. Cowan
Article
Anesthesiology
Teresa A. Lillis, John Burns, Frances Aranda, Yanina A. Purim-Shem-Tov, Stephen Bruehl, Jean C. Beckham, Stevan E. Hobfoll
CLINICAL JOURNAL OF PAIN
(2018)
Article
Urology & Nephrology
W. Stuart Reynolds, Casey Kowalik, Joshua Cohn, Melissa Kaufman, Alan Wein, Roger Dmochowski, Stephen Bruehl
JOURNAL OF UROLOGY
(2018)
Article
Anesthesiology
James I. Gerhart, John W. Burns, Stephen Bruehl, David A. Smith, Kristina M. Post, Laura S. Porter, Erik Schuster, Asokumar Buvanendran, Anne Marie Fras, Francis J. Keefe
Article
Clinical Neurology
Roy Freeman, Robert Edwards, Ralf Baron, Stephen Bruehl, Giorgio Cruccu, Robert H. Dworkin, Simon Haroutounian
Article
Clinical Neurology
Michael L. Kent, Patrick J. Tighe, Stephen Bruehl, Dennis C. Turk, Robert H. Dworkin
Article
Public, Environmental & Occupational Health
Deva Sharma, Melissa E. Day, Sarah-Jo Stimpson, Mark Rodeghier, Djamila Ghafuri, Michael Callaghan, Ahmar Urooj Zaidi, Bryan Hannan, Adetola Kassim, William Zempsky, Melissa Wellons, Andra James, Stephen Bruehl, Michael R. DeBaun
JOURNAL OF WOMENS HEALTH
(2019)
Article
Anesthesiology
Stephen Bruehl, John W. Burns, Amanda Morgan, Kelli Koltyn, Rajnish Gupta, Asokumar Buvanendran, David Edwards, Melissa Chont, Philip J. Kingsley, Larry Marnett, Amanda Stone, Sachin Patel
Article
Anesthesiology
Stephen Bruehl, Amanda L. Stone, Cassandra Palmer, David A. Edwards, Asokumar Buvanendran, Rajnish Gupta, Melissa Chont, Mary Kennedy, John W. Burns
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2019)
Article
Anesthesiology
Lindsey C. McKernan, Benjamin N. Johnson, Leslie J. Crofford, Mark A. Lumley, Stephen Bruehl, Jennifer S. Cheavens
CLINICAL JOURNAL OF PAIN
(2019)
Article
Anesthesiology
Helen J. Burgess, John W. Burns, Asokumar Buvanendran, Rajnish Gupta, Melissa Chont, Mary Kennedy, Stephen Bruehl
CLINICAL JOURNAL OF PAIN
(2019)
Article
Anesthesiology
Stephen Bruehl, Eric R. Gamazon, Thomas Van de Ven, Thomas Buchheit, Colin G. Walsh, Puneet Mishra, Krishnan Ramanujan, Andrew Shaw
Article
Psychology, Clinical
Ryan W. Carpenter, Sean P. Lane, Stephen Bruehl, Timothy J. Trull
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2019)
Article
Neurosciences
Allison E. Gaffey, Frances Aranda, John W. Burns, Yanina A. Purim-Shem-Tov, Helen J. Burgess, Jean C. Beckham, Stephen Bruehl, Stevan E. Hobfoll
ANXIETY STRESS AND COPING
(2019)
Article
Psychology, Multidisciplinary
Pablo de la Coba, Stephen Bruehl, Judy Garber, Craig A. Smith, Lynn S. Walker
ANNALS OF BEHAVIORAL MEDICINE
(2018)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)