Article
Clinical Neurology
Olivia Wagemann, Yan Li, Jason Hassenstab, Andrew J. Aschenbrenner, Nicole S. McKay, Brian A. Gordon, Tammie L. S. Benzinger, Chengjie Xiong, Carlos Cruchaga, Alan E. Renton, Richard J. Perrin, Sarah B. Berman, Jasmeer P. Chhatwal, Martin R. Farlow, Gregory S. Day, Takeshi Ikeuchi, Mathias Jucker, Francisco Lopera, Hiroshi Mori, James M. Noble, Raquel Sanchez-Valle, Peter R. Schofield, John C. Morris, Alisha Daniels, Johannes Levin, Randall J. Bateman, Eric Mcdade, Jorge J. Llibre-Guerra
Summary: Studies found that female carriers of DIAD initially show better cognitive reserve but experience a pronounced increase in neurodegeneration and worse performance on delayed recall at later stages of the disease. The study also revealed that there were no sex differences in PiB PET and established CSF AD markers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Lindsey Isla Sinclair, Harriet Ann Ball, Blanca Miriam Bolea-Alamanac
Summary: This study investigates the link between depression, inflammation, and dementia. The results show that depression in individuals aged over 50 is not associated with increased cognitive decline.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Lindsey Sinclair, Harriet A. Ball, Sarah Bauermeister, John E. J. Gallacher, Blanca M. Bolea-Alamanac
Summary: Later-life depression appears to have different underlying pathology compared to depression in younger adults. This study aimed to investigate the link between depression, inflammation, and dementia. The results showed that individuals with recurrent depression performed better in some cognitive tasks but worse in others. However, this effect was not mediated by chronic inflammatory disease.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
E. Lydia Wu-Chung, Stephanie L. Leal, Bryan T. Denny, Samantha L. Cheng, Christopher P. Fagundes
Summary: Accumulating research suggests that stressful life events, especially those that threaten close intimate bonds, are associated with an increased risk of dementia. Grieving the loss of a spouse, whether in the form of caregiving or after the death, ranks among 'life's most significant stressors', evoking intense psychological and physiological distress. This systematic review summarizes findings across 64 empirical studies and proposes a biopsychosocial model of cognitive decline that explains how caregiving and bereavement may lead to cognitive impairment or Alzheimer's disease. More longitudinal studies are needed to further understand the link between partner loss and abnormal cognitive decline.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Clara Vila-Castelar, Pierre N. Tariot, Kaycee M. Sink, David Clayton, Jessica B. Langbaum, Ronald G. Thomas, Yinghua Chen, Yi Su, Kewei Chen, Nan Hu, Margarita Giraldo-Chica, Carlos Tobon, Natalia Acosta-Baena, Ernesto Luna, Marisol Londono, Paula Ospina, Victoria Tirado, Claudia Munoz, Eliana Henao, Yamile Bocanegra, Sergio Alvarez, Silvia Rios-Romenets, Valentina Ghisays, Dhruman Goradia, Wendy Lee, Ji Luo, Michael H. Malek-Ahmadi, Hillary D. Protas, Francisco Lopera, Eric M. Reiman, Yakeel T. Quiroz
Summary: This study examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired individuals with and without the Presenilin-1 (PSEN1) E280A mutation. The results suggest that females may have greater cognitive resilience to AD pathology and neurodegeneration than males.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Shih-Jen Tsai
Summary: Low grade neuroinflammation, particularly involving interleukin-8 (IL-8), has been suggested as an underlying mechanism for various psychiatric diseases and cognitive disorders. Elevated peripheral levels of IL-8 have been reported in conditions such as schizophrenia, bipolar disorder, obstructive sleep apnea, and autism spectrum disorder. However, the exact role of IL-8 in major depression remains inconsistent in the literature.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Masa Cater, Sabine M. Hoelter
Summary: Diabetes is strongly linked to neurodegenerative disorders, especially Alzheimer's disease, and insulin resistance has been proven to be connected to cognitive decline and dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vivek Kumar Sharma, Thakur Gurjeet Singh, Nikhil Garg, Sonia Dhiman, Saurabh Gupta, Md. Habibur Rahman, Agnieszka Najda, Magdalena Walasek-Janusz, Mohamed Kamel, Ghadeer M. Albadrani, Muhammad Furqan Akhtar, Ammara Saleem, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: Alzheimer's disease is an incurable neuropsychiatric condition characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Changes in gut microbiota composition are linked to neuronal pathologies, and chronic stress plays a role in the pathological progression of AD. The dysbiosis-stress axis may offer insights for AD treatment.
Article
Clinical Neurology
Clara Vila-Castelar, Yinghua Chen, Stephanie Langella, Francisco Lopera, Henrik Zetterberg, Oskar Hansson, Jeffrey L. Dage, Shorena Janelidzde, Yi Su, Kewei Chen, Celina Pluim McDowell, Jairo E. Martinez, Liliana Ramirez-Gomez, Gloria Garcia, David Aguillon, Ana Baena, Margarita Giraldo-Chica, Hillary D. Protas, Valentina Ghisays, Silvia Rios-Romenets, Pierre N. Tariot, Kaj Blennow, Eric M. Reiman, Yakeel T. Quiroz
Summary: This study found that female carriers of Presenilin-1 E280A mutation had higher levels of plasma phosphorylated tau at threonine 217 (P-tau217) than male carriers when their cognitive abilities were intact, but as the disease progressed, female carriers showed a greater increase in plasma neurofilament light (NfL) levels than male carriers. However, among non-carriers, there were no significant differences in sex and plasma biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: Chronic glucocorticoid exposure can accelerate neuronal damage and beta-amyloid production by activating oxidative stress and NLRP1 inflammasome, leading to the deterioration of Alzheimer's disease. Inhibition of NLRP1 inflammasome may be an important strategy in improving chronic glucocorticoid-induced neuronal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Microbiology
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Chaiyavat Chaiyasut
Summary: Alzheimer's (AD) and Parkinson's diseases (PD) are common in older people, while autism spectrum disorders (ASD), anxiety, depression, stress, and cognitive impairment are prevalent among people of all ages. The incidence of neurological disorders has been increasing in recent decades, and the communication between the gut microbiota and the brain is crucial for maintaining the gut, brain, and immune functions. The bidirectional link among the gut, gut microbiota, and the brain, known as the microbiota-gut-brain axis, plays a role in regulating the host's immune system and the functions of tissue barriers. Dysfunctions in the gut microbiota disrupt the gut-brain interplay and may contribute to various gut disorders and neurocognitive and psychiatric disorders. Probiotics can protect intestinal integrity, enhance gut functions, promote the synthesis of brain-derived neurotrophic factors, and support neuronal survival and differentiation.
Article
Psychiatry
Sid E. O'Bryant, Melissa Petersen, James Hall, Leigh A. Johnson
Summary: This study reveals differences in risk factors and biomarkers of Alzheimer's disease (AD) between Mexican Americans and non-Hispanic whites. Depressive symptoms have a greater impact on cognition and AD-relevant biomarkers among Mexican Americans, particularly among APOE ε4 non-carriers.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Gabriela Juszczyk, Joanna Mikulska, Kamila Kasperek, Diana Pietrzak, Weronika Mrozek, Mariola Herbet
Summary: Chronic stress leads to oxidative stress in the brain, contributing to depression and AD. Antioxidants play a significant role in treating these diseases, with compounds like curcumin, Vitamin E, and selenium showing promising results for AD treatment, and curcumin, zinc, and selenium demonstrating potential in depression treatment.
Article
Chemistry, Medicinal
Ramon Cacabelos, Juan C. Carril, Lola Corzo, Lucia Fernandez-Novoa, Rocio Pego, Natalia Cacabelos, Pablo Cacabelos, Margarita Alcaraz, Ivan Tellado, Vinogran Naidoo
Summary: Mood disorders are a risk factor for dementia and genetic variants can influence treatment outcomes. The study found that female patients are more likely to experience anxiety and depression, while APOE-3 carriers show better response to treatment.
Article
Clinical Neurology
Jose Contador, Agnes Perez-Millan, Nuria Guillen, Jordi Sarto, Adria Tort-Merino, Mircea Balasa, Neus Falgas, Magdalena Castellvi, Sergi Borrego-Ecija, Jordi Junca-Parella, Beatriz Bosch, Guadalupe Fernandez-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargallo, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Llado
Summary: Sex differences exist in cognitive impairment, atrophy burden, and CSF tau levels in early-onset Alzheimer's disease, with female patients showing worse symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cell Biology
Tiago Silveira-Rosa, Antonio Mateus-Pinheiro, Joana Sofia Correia, Joana Margarida Silva, Joana Martins-Macedo, Bruna Araujo, Ana Rita Machado-Santos, Nuno Dinis Alves, Mariana Silva, Eduardo Loureiro-Campos, Ioannis Sotiropoulos, Joao Miguel Bessa, Ana Joao Rodrigues, Nuno Sousa, Patricia Patricio, Luisa Pinto
Summary: Our study demonstrates that regulation of the HPA axis response by hABN is sex-differentiated. Male GFAP-Tk rats show heightened acute stress response, while female GFAP-Tk rats exhibit increased corticosterone secretion at nadir and a heightened yet delayed response to an acute stress stimulus.
CELL PROLIFERATION
(2022)
Article
Immunology
Joao Canto-Gomes, Carolina S. Silva, Rita Rb-Silva, Daniela Boleixa, Ana Martins da Silva, Remi Cheynier, Patricio Costa, Ines Gonzalez-Suarez, Margarida Correia-Neves, Joao J. Cerqueira, Claudia Nobrega
Summary: The aim of this study is to assess the peripheral immune system of newly diagnosed patients with relapsing remitting multiple sclerosis (RRMS) and identify immune features associated with clinical onset.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sofia P. das Neves, Claudia Serre-Miranda, Joao C. Sousa, Patricio S. Costa, Nuna Sousa, Joao J. Cerqueira, Fernanda Marques
Summary: The contribution of lipocalin-2 (LCN2) to multiple sclerosis (MS) remains controversial. In this study, we induced experimental autoimmune encephalomyelitis (EAE) in LCN2-null and wild-type mice, and found that LCN2-null EAE mice had decreased expression of interferon gamma and less demyelination in the cerebellum. Both genotypes showed similar alterations in thymocyte and splenocyte populations. In MS patients, higher levels of LCN2 in cerebrospinal fluid (CSF) at diagnosis may be associated with faster disease progression, but further studies are needed to confirm this, as the association disappeared after controlling for other factors.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Immunology
Gisela Bevilacqua Rolfsen Ferreira da Silva, Sofia Pereira das Neves, Susana Cristina Roque Oliveira, Fernanda Marques, Anselmo Gomes de Oliveira, Fabio de Lima Leite, Joao Jose Cerqueira
Summary: By incorporating DMF into solid lipid nanoparticles (SLNs), it was found that the progression of experimental autoimmune encephalomyelitis (EAE) in mice could be effectively reduced, with a decrease in adverse effects such as lymphopenia.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Chemistry, Analytical
Cristiana Pinheiro, Joana Figueiredo, Joao Cerqueira, Cristina P. Santos
Summary: This review provides recommendations for future research on robotic biofeedback in post-stroke gait rehabilitation. Most studies found that visual biofeedback was effective in improving outcomes, and future research could focus on personalized biofeedback using multiple sensors and actuators, as well as exploring the complementarities between BSs and different assistive devices and physiotherapist-oriented cues.
Article
Medicine, General & Internal
Maria Jose Sa, Carlos Basilio, Carlos Capela, Joao Jose Cerqueira, Irene Mendes, Armando Morganho, Joao Correia De Sa, Vasco Salgado, Ana Martins Silva, Jose Vale, Livia Sousa
Summary: This study aimed to monitor patients with multiple sclerosis (MS) and identify key variables for early identification of disease progression through the Delphi method. The results showed consensus in functional, cognitive, imaging, biomarkers, and additional evaluations, as well as determination of monitoring time, evaluation scales, and clinical variables.
ACTA MEDICA PORTUGUESA
(2023)
Article
Cell Biology
Joao Canto-Gomes, Sara Da Silva-Ferreira, Carolina S. Silva, Daniela Boleixa, Ana Martins da Silva, Ines Gonzalez-Suarez, Joao J. Cerqueira, Margarida Correia-Neves, Claudia Nobrega
Summary: This study investigates the alterations in immune cells in primary progressive multiple sclerosis (PPMS) patients without disease-modifying drugs (DMD). The findings reveal decreased numbers of central memory CD4(+) and CD8(+) T cells, as well as activated HLA-DR+ regulatory T cells (Tregs) in pwPPMS. Moreover, changes in NK cell populations are found to be strongly correlated with disease severity.
Article
Cell Biology
Joana Martins-Macedo, Antonio Mateus-Pinheiro, Catia Alves, Fernando Veloso, Eduardo D. Gomes, Ines Ribeiro, Joana S. Correia, Tiago Silveira-Rosa, Nuno D. Alves, Ana J. Rodrigues, Joao M. Bessa, Nuno Sousa, Joao F. Oliveira, Patricia Patricio, Luisa Pinto
Summary: This study developed an automated system for exposing rodents to a standard unpredictable chronic mild stress (uCMS) protocol. Comparing manual (uCMS) and automated (auCMS) stress-exposure protocols, the data showed similar impacts on behavioral and physiological measurements. This automated method represents a step forward in preclinical research with advantages in time and standardization.
Article
Economics
Paulo Martins, Bjorn Vandewalle, Jorge Felix, Carlos M. Capela, Joao J. Cerqueira, Antonio Salgado, Diana G. Ferreira, Isabel Monteiro
Summary: This study evaluated the clinical and economic impact of Ocrelizumab in the treatment of multiple sclerosis and compared it with other disease-modifying therapies.
PHARMACOECONOMICS-OPEN
(2023)
Article
Cell Biology
Patricia A. Gomes, Cristian Bodo, Carlos Nogueras-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana M. Silva, Barbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Summary: Background: Extracellular vesicles (EVs) have great potential in the diagnosis and treatment of brain disorders, and are a valuable tool for precision medicine. However, the collection and characterization of physiologically relevant EVs are of utmost importance.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, General & Internal
Torcato Meira, Ana Coelho, Seyda Onat, Luis Ruano, Joao Jose Cerqueira
Summary: This study revealed that 1-year regional brain volume changes may serve as potential predictors of cognitive deficits in multiple sclerosis. This suggests a possible role of these regions in such deficits and could help identify cognitively deteriorating patients, whose detection remains unsatisfactory in clinical practice.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Cell Biology
Sofia Pereira das Neves, Joao Carlos Sousa, Ricardo Magalhaes, Fuying Gao, Giovanni Coppola, Sebatien Meriaux, Fawzi Boumezbeur, Nuno Sousa, Joao Jose Cerqueira, Fernanda Marques
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Recent research has shown that reactive astrocytes in MS lesions undergo metabolic alterations and exhibit increased reactivity, potentially contributing to the progression of the disease.
Review
Clinical Neurology
Francisca Monteiro, Oscar Carvalho, Nuno Sousa, Filipe S. Silva, Ioannis Sotiropoulos
Summary: Light-based therapeutic modalities such as photobiomodulation (PBM) and visual stimulation (VS) show promise in attenuating Alzheimer's disease neuropathology and improving cognitive performance in both animal models and human studies. Further clinical investigation is needed to clarify their beneficial impact on AD patients.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Patricia Gomes, Cristian Bodo, Carlos Noguera-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana Silva, Barbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
JOURNAL OF NEUROCHEMISTRY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Joana Margarida Silva, Patricia Amorim Gomes, Nuno Sousa, Benjamin Wolozin, Ioannis Sotiropoulos
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
