Review
Physiology
Francesca Copperi, Jung Dae Kim, Sabrina Diano
Summary: The melanocortin system plays a crucial role not only in regulating energy homeostasis, food intake, and glucose levels, but also in modulating cardiovascular functions such as blood pressure and heart rate. Its effects are exerted through central and peripheral mechanisms involving receptors MC3R and MC4R, influencing sympathetic nervous activity and potentially improving cardiovascular outcomes in diseases like myocardial and cerebral ischemia. This review discusses the central regulation of the melanocortin system in essential cardiovascular functions and its protective role in ischemic events.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Vera Flasbeck, Christoph Bamberg, Martin Brune
Summary: This study investigated the effects of fasting and consumption of standardized carbohydrate and protein shakes on interoception. Results showed that fasting and intake of shakes can influence cardiac measures of autonomic nervous system functioning and neural correlates of cardiac interoception. These findings may have relevance for diets and psychosomatic disorders, including eating disorders.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Igor S. A. Felippe, Tymoteusz Zera, Melina P. da Silva, Davi J. A. Moraes, Fiona McBryde, Julian F. R. Paton
Summary: This study investigated the role of sympathetic innervation in the hyperexcitability of carotid bodies (CBs) in spontaneously hypertensive (SH) rats. The results showed that the sympathetic innervation enhanced the CB-evoked sympathoexcitation in SH rats but not in Wistar rats. This enhanced sympathoexcitation appears to be mediated by α1-adrenoceptors located on blood vessels and/or glomus cells. These findings are important for understanding and controlling the pathophysiology of hypertension.
CARDIOVASCULAR RESEARCH
(2023)
Review
Clinical Neurology
Effrosyni Koutsouraki, Koukoulidis Theodoros, Georgiadou Eleni, Kalampouka Marianna, Nikolaidou Areti, Koukoulidou Ariadni, Michmizos Dimitrios
Summary: Multiple sclerosis (MS) is a chronic progressive disease affecting both the central nervous system (CNS) and autonomic nervous system (ANS), leading to a range of urological, sexual, gastrointestinal, cardiovascular, and thermoregulatory disorders as well as increased fatigue. The manifestations of ANS dysfunction in MS are often underestimated due to the non-specificity of symptoms and limited evaluation in clinical practice. The underlying mechanisms causing these disorders have yet to be fully investigated, hindering targeted etiological treatment. Early diagnosis and individualized treatment regimens, incorporating multiple approaches, have shown the best results in managing ANS dysfunction in MS patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zongzhen Liao, Dihang Lin, Jirong Jia, Ran Cai, Yang Yu, Wensheng Li
Summary: The study found that fasting and refeeding in zebrafish can lead to compensatory growth and have an impact on their innate immune system. Zebrafish showed increased susceptibility to certain pathogens after starvation, kidney oxidative stress, increased antioxidant enzyme activity, and affected innate immune parameters. In addition, fasting led to altered mRNA expression of immune-related genes in response to lipopolysaccharides challenge.
Article
Endocrinology & Metabolism
Rajesh Gupta, Manqi Wang, Yunbing Ma, Stefan Offermanns, Matthew D. Whim
Summary: During fasting, activation of the GPR109A pathway leads to increased sympathetic adrenal activity and plasticity in the adrenal medulla. The release of epinephrine and the production of β-hydroxybutyrate during fasting are coupled with changes in adrenal physiology, indicating the existence of an autonomic-adipose-hepatic feedback circuit.
Review
Biochemistry & Molecular Biology
Benedetta Russo, Marika Menduni, Patrizia Borboni, Fabiana Picconi, Simona Frontoni
Summary: This review discusses the role of the autonomic nervous system in obesity and insulin-resistance, highlighting the bi-directional effects of related mechanisms, and exploring the neural, hormonal, and nutritional mechanisms involved. Leptin is emphasized for its crucial role in appetite regulation, glucose homeostasis, and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xuan Li, Shicheng Fan, Chenghui Cai, Yue Gao, Xinhui Wang, Yifei Zhang, Hangfei Liang, Huilin Li, Jie Yang, Min Huang, Huichang Bi
Summary: Liver size undergoes dynamic changes during the transition from fasting to refeeding, with fasting reducing liver size and inhibiting hepatocyte proliferation, while refeeding promotes hepatocyte enlargement and proliferation. YAP, a key regulator of organ size, is involved in these changes and regulates the expression of CCND1, a protein related to proliferation. This study provides new evidence for the role of YAP in regulating liver size under energy stress.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Jae Ho Kim, Moon-Moo Kim
Summary: This study aimed to investigate the relationship between melanin production and lipofuscin formation, and found that TYR gene knockout cells exhibited decreased melanin production and increased lipofuscin formation.
Article
Medicine, General & Internal
Francesca Massimello, Lucia Billeci, Alessio Canu, Maria Magdalena Montt-Guevara, Gaia Impastato, Maurizio Varanini, Andrea Giannini, Tommaso Simoncini, Paolo Mannella
Summary: This study examined the effect of music stimulation on fetal heart rate and autonomic nervous system activity. The results showed that music stimulation can enhance fetal heart rate variability without changing the mean value of fetal heart rate. This effect is mainly attributed to the activation of the parasympathetic nervous system, indicating that music can induce a state of relaxation in the fetus.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Francisca de Castro Mendes, Ines Paciencia, Joao Cavaleiro Rufo, Mariana Farraia, Diana Silva, Patricia Padrao, Luis Delgado, Vanessa Garcia-Larsen, Andre Moreira, Pedro Moreira
Summary: The study found a positive association between vegetable diversity consumption and the ANS response in school-aged children, indicating a potential early link between diet and health.
Article
Agriculture, Dairy & Animal Science
Yi-Oh Kim, Sung-Yong Oh, Taewon Kim
Summary: This study investigated the effects of different feeding regimes on the compensatory growth of leopard mandarin fish. The results showed that after four weeks of treatment, all fasting groups achieved full compensatory growth and reached the weight of the control group.
Article
Endocrinology & Metabolism
Yotam Kolben, Sarah Weksler-Zangen, Yaron Ilan
Summary: Adropin, a peptide hormone, plays a significant role in energy homeostasis and metabolic regulation, influenced by circadian rhythms. The autonomic nervous system and circadian clocks are crucial in regulating metabolic pathways and energy balance, with chronotherapy showing beneficial effects in various systems. There is potential for adropin to act as a mediator in the metabolic system-autonomic nervous system axis, with personalized adropin and circadian rhythm-based platforms for chronotherapy being discussed for enhancing treatment efficacy.
Article
Multidisciplinary Sciences
Yurika Nishida, Sumie Yamada, Yoshiro Nakagawa, Tomoki Aoyama
Summary: This study aimed to explore the relationship between task interest and physiological changes in the autonomic nervous system among healthy individuals, as well as its correlation with psychological characteristics. The findings showed a negative correlation between task interest and cardiac sympathetic index during the uninteresting task. Task interest may contribute to reducing mental and physiological loads and suppressing sympathetic dominance.
Article
Biochemistry & Molecular Biology
Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Sobarathne Senel Sanjaya, Kyoung Tae Lee, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sung-Pyo Hur, Gi-Young Kim
Summary: In this study, it was found that pinostrobin effectively inhibits melanogenesis in vitro and in vivo by regulating the cAMP-CREB-MITF axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Giannini, Matteo Pagnesi, Gianluca Campo, Michael Donahue, Luca A. Ferri, Carlo Briguori, Giulio G. Stefanini, Raffaele Scardala, Gennaro Sardella, Salvatore De Rosa, Filippo Figini, Alberto Monello, Luigi E. Pastormerlo, Luca Testa, Annamaria Nicolino, Alfonso Ielasi, Alessandro Durante, Angelo Leone, Giorgios Tzanis, Antonio Mangieri, Giovanni Ciccarelli, Martina Briani, Bernhard Reimers, Andrea Ceccacci, Ciro Indolfi, Imad Sheiban, Cataldo Palmieri, Francesco Bedogni, Maurizio Tespili, Azeem Latib, Antonio Colombo, Francesco Gallo
Summary: The study demonstrated a progressive decrease in the use of bare metal stents over the past 5 years, with main reasons for implantation being ST-elevation myocardial infarction, advanced age, and perceived high-bleeding risk by physicians. High rates of mortality and MACE were observed in this high-risk population.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Neurosciences
Natali N. Guerrero-Vargas, Carmen Zarate-Mozo, Mara A. Guzman-Ruiz, Alfredo Cardenas-Rivera, Carolina Escobar
Summary: Research shows that shift-work can have detrimental effects on health, leading to mood disorders and neuroinflammation, but time-restricted feeding can prevent these effects.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Cell Biology
Walter A. Boiten, Inger van Steenoven, MeiFang Xiao, Paul F. Worley, Barbara Noli, Cristina Cocco, Gian-Luca Ferri, Afina W. Lemstra, Charlotte E. Teunissen
Summary: The study revealed that NPTX2 cerebrospinal fluid levels were reduced in patients with Dementia with Lewy bodies (DLB) and were closely correlated with decreased VGF and alpha-synuclein cerebrospinal fluid levels. The combination of these protein markers had high differentiating power between DLB and cognitively healthy subjects, while NPTX2 levels were related to decreased functioning in the visual spatial domain.
Article
Anatomy & Morphology
Giulia Corda, Barbara Noli, Barbara Manconi, Carla Brancia, Manuela Pellegrini, Fabio Naro, Alessandra Olianas, Gian-Luca Ferri, Cristina Cocco
Summary: The study showed that TLQP-21 peptide may be released from islets under hyperglycemic conditions to enhance insulin secretion. C3a-R1 was localized in approximately 50% of TLQP-labeled islet cells, while gC1q-R was detected in around 25% of the cells.
Article
Anatomy & Morphology
Raffaele De Caro, Rafael Boscolo-Berto, Marco Artico, Eugenio Bertelli, Mario Cannas, Francesco Cappello, Guido Carpino, Sergio Castorina, Amelia Cataldi, Guido Angelo Cavaletti, Saverio Cinti, Lucio Ildebrando Cocco, Ottavio Cremona, Enrico Crivellato, Antonio De Luca, Mirella Falconi, Giuseppe Familiari, Gian Luca Ferri, Francesco Fornai, Marco Gesi, Stefano Geuna, Daniele Maria Gibelli, Antonio Giordano, Pietro Gobbi, Germano Guerra, Massimo Gulisano, Veronica Macchi, Guido Macchiarelli, Lucia Manzoli, Fabrizio Michetti, Sebastiano Miscia, Stefania Montagnani, Andrea Costantino Mario Montella, Sergio Morini, Paolo Onori, Carla Palumbo, Michele Papa, Andrea Porzionato, Daniela Elena Quacci, Mario Raspanti, Mario Rende, Rita Rezzani, Domenico Ribatti, Maurizio Ripani, Luigi Fabrizio Rodella, Pellegrino Rossi, Andrea Sbarbati, Paola Secchiero, Chiarella Sforza, Carla Stecco, Roberto Toni, Alessandro Vercelli, Marco Vitale, Carlo Zancanaro, Giorgio Zauli, Sandra Zecchi, Giuseppe Pio Anastasi, Eugenio Gaudio
Summary: The study discusses specific issues in recent Italian legislation concerning the donation and use of postmortem bodies and tissues, providing suggestions for optimizing the regulatory framework. Critical issues include the role of learners, type of training activities, position of academic institutes, and the limited efficiency of the current donation system.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Correction
Cell Biology
Walter A. Boiten, Inger van Steenoven, Mei-Fang Xiao, Paul F. Worley, Barbara Noli, Cristina Cocco, Gian-Luca Ferri, Afina W. Lemstra, Charlotte E. Teunissen
Article
Public Administration
Francesca Manes-Rossi, Luca Ferri, Annamaria Zampella, Adele Caldarelli
Summary: This paper examines the factors influencing the disclosure of anticorruption plans by local governments and highlights the significance of governance, economic, and socio-political features on anticorruption disclosure. The findings emphasize the need for enhanced surveillance of anticorruption regulations and the implementation of key mechanisms for more effective anticorruption action.
INTERNATIONAL JOURNAL OF PUBLIC ADMINISTRATION
(2023)
Article
Biology
Alexandra J. Trott, Ben J. Greenwell, Tejas R. Karhadkar, Natali N. Guerrero-Vargas, Carolina Escobar, Ruud M. Buijs, Jerome S. Menet
Summary: Shift work has been shown to have impacts on the heart transcriptome in rats, independent of food consumption. Restricting food intake during shift work affects the expression of hundreds of genes related to extracellular matrix components and inflammatory markers in the heart. While maintaining food access during shift work has less effects on gene expression, it still leads to cardiac fibrosis without inflammation.
Article
Cardiac & Cardiovascular Systems
Gianmarco Iannopollo, Vittorio Romano, Antonio Esposito, Giulia Guazzoni, Marco Ancona, Luca Ferri, Filippo Russo, Barbara Bellini, Nicola Buzzatti, Jonathan Curio, Bernard Prendergast, Matteo Montorfano
Summary: This study confirmed the feasibility of the LIRA method in a larger cohort of patients, evaluated the 30-day outcomes, and analyzed the interaction of prosthetic valves with the surrounding anatomy. The LIRA method showed high success in patients with RAphe-type BAV disease, with good clinical outcomes at 30 days.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ciro Vella, Vittorio Romano, Marco B. Ancona, Giulia Botti, Luca Ferri, Filippo Russo, Barbara Bellini, Giulia Ghizzoni, Alessandro Beneduce, Matteo Montorfano
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Business, Finance
Rosanna Spano, Maurizio Massaro, Luca Ferri, John Dumay, Jana Schmitz
Summary: This article reviews the various implications of blockchain in accounting research and reveals the negative environmental and social implications of the technology. It also emphasizes the need for accounting research to extensively investigate contemporary issues.
ACCOUNTING AUDITING & ACCOUNTABILITY JOURNAL
(2022)
Article
Materials Science, Biomaterials
Mariana Gutierrez-Perez, Shellye Gonzalez-Gonzalez, Karla P. Estrada-Rodriguez, Estefania Espitia-Bautista, Mara A. Guzman-Ruiz, Rene Escalona, Carolina Escobar, Natali N. Guerrero-Vargas
Summary: Inhabitants of urban areas are exposed to light at night, which disrupts their circadian rhythms. The study focused on female rats and found that exposure to dim light at night (DLAN) resulted in the loss of activity and body temperature fluctuations. DLAN also decreased nocturnal food intake and disrupted reproductive function and behavior, possibly due to decreased melatonin levels. This study emphasizes the importance of avoiding light at night to maintain physiological circadian organization, particularly in females.
Article
Neurosciences
Veronica E. Lopez-Alonso, Samantha Hernandez-Correa, Carolina Escobar, Rodrigo E. Escartin-Perez, Juan M. Mancilla-Diaz, Daniel Diaz-Urbina
Summary: Sugar solutions increase the risk of obesity and binge-type behavior by promoting hedonic feeding. Dopamine release is enhanced in the brain's reward regions when rodents ingest sugar solutions, indicating changes in hedonic intake and reward processes. The dopamine receptors D2R/D3R contribute to the enjoyment of palatable solutions, but it is unknown if the D4R also regulates the hedonic intake of sugar solutions.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Business, Finance
Luca Ferri, Alessandra Allini, Marco Maffei, Rosanna Spano
Summary: This study investigates the readability of financial risk disclosure by listed banks in five European countries and finds a positive relationship between readability and completeness of risk disclosure, and a negative relationship between readability and banks' discretionary accruals.
MEDITARI ACCOUNTANCY RESEARCH
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
