Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Biochemistry & Molecular Biology
Xianan Sun, Yi Zu, Xiang Li, Shulei Zhao, Xiao Sun, Lu Li, Xinjing Zhang, Wei Wang, Yuezhu Liang, Wenyao Wang, Xuankai Liang, Mingqi Gao, Chi Sun, Xue Guan, Man Tang
Summary: The study found that decreased extracellular 5-HT, increased 5-HT reuptake efficiency, and absence of 5-HT response to CORT injections may be signature features in the depressive state. Fluoxetine (FLX) was able to reverse these changes, but in FLX nonresponsive mice, these features persisted and worsened.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Feras Altwal, Fernando E. Padovan-Neto, Alexandra Ritger, Heinz Steiner, Anthony R. West
Summary: Research has shown that vilazodone may reduce dyskinesia in patients with Parkinson's disease without interfering with the prokinetic effects of L-DOPA, possibly through its action on 5-HT receptors.
Article
Pharmacology & Pharmacy
Jiajia Dai, Hyangin Kim, Zerong You, Michael F. F. McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Mao
Summary: The reduced effectiveness of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine in treating depression and pain during maintenance treatment has been observed. In this study, researchers investigated the molecular mechanism behind this phenomenon and found that fluoxetine exposure resulted in upregulation of the 5-HT1A receptor and IDO1 in the brainstem DRN, thereby altering tryptophan metabolism and reducing the effects of fluoxetine. Blocking the 5-HT1A receptor or inhibiting IDO1 activity sustained the effectiveness of fluoxetine, suggesting a potential strategy for improving the therapeutic efficacy of SSRIs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Cynthia Kwan, Imane Frouni, Dominique Bedard, Adjia Hamadjida, Stephen G. Nuara, Jim C. Gourdon, Philippe Huot
Summary: Nelotanserin, a serotonin 2A and 2C inverse agonist, was tested for its anti-dyskinetic potential in MPTP-lesioned marmosets. It was found that nelotanserin significantly reduced peak dose dyskinesia and global dyskinesia severity when combined with L-DOPA without affecting its anti-parkinsonian action.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
R. Depoortere, J. Bergman, P. M. Beardsley, R. I. Desai, C. A. Paronis, D. M. Walentiny, M. A. Varney, A. Newman-Tancredi
Summary: NLX-112 exhibits exceptional selectivity and biased agonism at serotonin 5-HT1A receptors, and displays robust analgesic activity in various pain models. The study suggests that NLX-112 does not possess misuse potential in rat and macaque models, making it an ideal compound for treating Parkinson's disease patients with comorbid chronic pain.
Article
Immunology
Anastasiya Sviridova, Vladimir Rogovskii, Vladimir Kudrin, Mikhail Pashenkov, Alexey Boyko, Mikhail Melnikov
Summary: Fluoxetine inhibits the production of pro-inflammatory cytokines from Th17 and Th1 cells in both multiple sclerosis patients and healthy subjects by activating 5-HT2B receptors, indicating its potential anti-inflammatory role in MS.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Yi, Yaping Xue, Kangzhi Chen, Tao Wang, Jiahui Yu, Zusheng Wang, Chuanfei Jin
Summary: In this study, a series of novel 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole derivatives were designed and synthesized via a hybridization strategy. The optimal compound C14 showed significantly increased affinity for 5-HT6R compared to idalopirdine, along with good pharmacokinetic and in vitro metabolic properties. Furthermore, C14 efficiently reversed scopolamine induced memory deficits in rats, suggesting its potential as a cognition-enhancing agent.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Ji Hae Jun, Ju Eun Oh, Jae-Kwang Shim, Young-Lan Kwak, Jin Sun Cho
Summary: BPA promotes proliferation and migration of colon cancer cells, decreases E-cadherin expression, and increases 5-HT3 receptor expression. In nude mouse xenograft models, tumor volume was significantly higher in the BPA-treated group.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kruti Borderwala, Sachin Rathod, Sarita Yadav, Bhavin Vyas, Pranav Shah
Summary: This study utilized Eudragit S100 surface-engineered 5-FU nanostructured lipid carriers prepared using hot high-pressure homogenization technique and optimized through Quality by Design approach. The optimized drug demonstrated superior spatial and temporal release for colon cancer treatment, showing increased bioavailability and cytotoxicity in cell and rat experiments. The multifaceted strategy combining nanotechnology and surface engineering presented effective chemotherapy with enhanced safety and efficacy.
Article
Multidisciplinary Sciences
Sanaz Hashemian, Caitriona O'Rourke, James B. Phillips, Ingrid Stromberg, Sara af Bjerken
Article
Neurosciences
Jaakko J. Kopra, Anne Panhelainen, Sara af Bjerken, Lauriina L. Porokuokka, Kart Varendi, Soophie Olfat, Heidi Montonen, T. Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Sonia Olmedo-Diaz, Hector Estevez-Silva, Greger Oradd, Sara Af Bjerken, Daniel Marcellino, Ana Virel
Article
Neurosciences
Erin R. Hascup, Sara af Bjerken, Kevin N. Hascup, Francois Pomerleau, Peter Huettl, Ingrid Stromberg, Greg A. Gerhardt
Article
Neurosciences
Sanaz Hashemian, Franziska Marschinke, Sara af Bjerken, Ingrid Stromberg
Article
Developmental Biology
Sara af Bjerken, Franziska Marschinke, Ingrid Stromberg
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2008)
Article
Biochemistry & Molecular Biology
Martin Lundblad, Sara af Bjerken, M. Angela Cenci, Francois Pomerleau, Greg A. Gerhardt, Ingrid Stromberg
JOURNAL OF NEUROCHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Nina Nevalainen, Sara af Bjerken, Martin Lundblad, Greg A. Gerhardt, Ingrid Stromberg
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanna Jakobson Mo, Jan Axelsson, Lars Jonasson, Anne Larsson, Mattias J. Ogren, Margareta Ogren, Andrea Varrone, Linda Eriksson, David Backstrom, Sara af Bjerken, Jan Linder, Katrine Riklund
Article
Neurosciences
Ana Virel, Ilona Dudka, Rutger Laterveer, Sara af Bjerken
MOLECULAR AND CELLULAR NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Sara af Bjerken, Rasmus Stenmark Persson, Anna Barkander, Nina Karalija, Noelia Pelegrina-Hidalgo, Greg A. Gerhardt, Ana Virel, Ingrid Stromberg
NEUROCHEMISTRY INTERNATIONAL
(2019)
Article
Neurosciences
Ana Virel, Jarkko Johansson, Jan Axelsson, Madelene Ericsson, Rutger Laterveer, Mattias Ogren, Greger Oradd, Susanna Jakobson Mo, Sara af Bjerken
Summary: This study investigates the beneficial effects of the antioxidant N-acetylcysteine (NAC) on the degenerated dopamine system using positron emission tomography (PET) imaging. The results show that NAC has a strong influence on the non-lesioned hemisphere, decreasing the levels of dopamine transporter (DAT) in the striatum early after the lesion and suggesting a beneficial compensatory effect induced by NAC.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Elisabet Berglof, Sara Af Bjerken, Ingrid Stromberg
JOURNAL OF COMPARATIVE NEUROLOGY
(2007)
Article
Neurosciences
Sara af Bjerken, Heather A. Boger, Matthew Nelson, Barry J. Hoffer, Ann-Charlotte Granholm, Ingrid Stromberg
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.