Article
Neurosciences
Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyama
Summary: Our study demonstrated that neuronal BDNF prevents microglia from engulfing mossy fiber synapses in the hippocampus, while microglial BDNF affects the structural and functional properties of neurons.
Article
Pharmacology & Pharmacy
Cristian Bis-Humbert, Ruben Garcia-Cabrerizo, M. Julia Garcia-Fuster
Summary: This study compared the effects of nortriptyline on adolescent and adult rats, finding that low doses had antidepressant effects in adolescents while higher doses had negative outcomes. In adult rats, nortriptyline did not significantly impact behavioral and neurochemical responses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Yu
Summary: This study investigates the antidepressant property of PEA and its potential therapeutic effects on depressive mood disorders. The results suggest that PEA can target hippocampal neuroplasticity, including increasing adult neurogenesis and synaptic plasticity, as well as reducing neuronal apoptosis, to remodel hippocampal circuitries. The PPAR & alpha; pathway may be involved in this process.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Review
Neurosciences
Lise Jennen, Victor Mazereel, Aleksandra Lecei, Celine Samaey, Davy Vancampfort, Ruud van Winkel
Summary: Exercise has a positive effect on pattern separation in the hippocampus, improving episodic memory. It achieves this through pathways involving neuroplasticity, anti-inflammatory effects, and hormonal effects, leading to functional and structural changes in the hippocampus with ultimately impacts on pattern separation.
REVIEWS IN THE NEUROSCIENCES
(2022)
Article
Biology
John Darby Cole, Jacobo Sarabia Del Castillo, Gabriele Gut, Daniel Gonzalez-Bohorquez, Lucas Pelkmans, Sebastian Jessberger
Summary: Advancing age leads to decreased hippocampal neurogenesis, which is associated with age-related cognitive decline. The reorganization of the dentate gyrus (DG) niche and changes in the cell-type contributions to the blood-brain barrier and microenvironments surrounding neural stem cells (NSCs) play a pivotal role in maintaining neurogenic permissiveness.
Article
Chemistry, Multidisciplinary
Chen Hong, Zhi Wang, Si-li Zheng, Wen-jun Hu, Shu-na Wang, Yan Zhao, Chao-yu Miao
Summary: Aging is a main risk factor for cognitive dysfunction, and Metrnl, a neurotrophic factor, has been found to regulate cognitive functions and hippocampal BDNF levels during the aging process. Metrnl may become a new candidate for the treatment or alleviation of aging-related cognitive dysfunction.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Food Science & Technology
Ji Yeon Hong, Jae-Jun Ban, Qing-Ling Quan, Ji-Eun Eom, Hee Soon Shin, Jin Ho Chung
Summary: Tomato and lemon extracts can reduce cellular oxidative stress and increase neurogenesis, while the mixture of the two shows synergistic effects in anti-oxidation and hippocampal neurogenesis.
Article
Geriatrics & Gerontology
Andra Ionescu-Tucker, Christopher W. Butler, Nicole C. Berchtold, Dina P. Matheos, Marcelo A. Wood, Carl W. Cotman
Summary: Exercise and the drug ETP69 can regulate neuronal plasticity genes by reducing the binding of H3K9me3 at their promoter regions, improving synaptic density, BDNF, and cognitive performance in aged mice. Age impacts the repression of H3K9me3 at BDNF and GABA receptor promoters, with exercise and SUV39H1 inhibition showing differential effects on gene expression based on age.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Review
Nutrition & Dietetics
Rut Fado, Anna Molins, Rocio Rojas, Nuria Casals
Summary: In recent years, traditional eating habits have been replaced by a more globalized diet rich in saturated fatty acids and simple sugars. Extensive evidence shows that this diet contributes to cognitive health impairment and increases the incidence of metabolic diseases such as obesity and diabetes. However, the mechanisms through which these nutrients modulate synaptic function and neuroplasticity are not well understood. This review focuses on the effects of Western, ketogenic, and paleolithic diets on cognition and their correlations with synaptic changes, primarily in animal models, to understand the molecular alterations that may contribute to impaired human cognition.
Article
Neurosciences
Oladiran I. Olateju, Lorenzo More, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Neurogenesis in the adult hippocampus can be stimulated by exposure to an enriched environment, leading to increased production of neurons and benefits for health and cognition. MSK1 plays a negative regulatory role post-enrichment by influencing the number of cells destined to become neurons, thereby potentially serving as a homeostatic control on the integration of new neurons into the dentate gyrus.
Article
Biochemistry & Molecular Biology
Mitsuki Umino, Mayumi Okuda, Takeshi Ohkubo, Tsutomu Fujii, Kiminori Matsubara
Summary: In this study, we evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The results showed that GPC intake suppressed microglial activation, protected BBB integrity, and sustained neurogenesis in the hippocampus of aged mice.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gerardo Bernabe Ramirez-Rodriguez, Sandra Olvera-Hernandez, Nelly Maritza Vega-Rivera, Leonardo Ortiz-Lopez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Gerardo Bernabe Ramirez-Rodriguez, Diana Montserrat Palacios-Cabriales, Leonardo Ortiz-Lopez, Erika Montserrat Estrada-Camarena, Nelly Maritza Vega-Rivera
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Nelly Maritza Vega-Rivera, Leonardo Ortiz-Lopez, Andrea Granados-Juarez, Erika Monserrat Estrada-Camarena, Gerardo Bernabe Ramirez-Rodriguez
Article
Biochemistry & Molecular Biology
E. M. Estrada-Camarena, C. Lopez-Rubalcava, G. B. Ramirez-Rodriguez, D. Pulido, N. Cervantes-Anaya, G. Azpilcueta-Morales, A. Granados-Juarez, N. M. Vega-Rivera, D. Islas-Preciado, S. Trevino, P. de Gortari, M. E. Gonzalez-Trujano, C. Garcia-Viguera
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Cell & Tissue Engineering
Muhammad Ichwan, Tara L. Walker, Zeina Nicola, Jutta Ludwig-Mueller, Christoph Boettcher, Rupert W. Overall, Vijay S. Adusumilli, Merve Bulut, Alex M. Sykes, Norbert Huebner, Gerardo Ramirez-Rodriguez, Leonardo Ortiz-Lopez, Enrique A. Lugo-Hernandez, Gerd Kempermann
Summary: This study found that bioactive factors in apples, such as quercetin and 3,5-dihydroxybenzoic acid, can promote hippocampal neurogenesis in adult mice. Quercetin was shown to be pro-neurogenic at low concentrations, while 3,5-dihydroxybenzoic acid increased neural precursor cell proliferation and neurogenesis. These compounds not only activate precursor cell proliferation but also promote cell cycle exit, cellular survival, and neuronal differentiation.
Article
Biochemistry & Molecular Biology
Gerardo Bernabe Ramirez-Rodriguez, Nelly Maritza Vega-Rivera, David Meneses-San Juan, Leonardo Ortiz-Lopez, Erika Montserrat Estrada-Camarena, Monica Flores-Ramos
Summary: The study found that fluoxetine, environmental enrichment, and their combination had significant effects on depressive-associated behavior, with fluoxetine reversing anhedonia and the environmental enrichment improving the coat deterioration and anhedonia. Additionally, the combination of fluoxetine and environmental enrichment showed more significant effects than fluoxetine alone on certain events of the neurogenic process, indicating that environmental enrichment enhances the benefits of pharmacological treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Edith Araceli Cabrera-Munoz, Sandra Olvera-Hernandez, Nelly Maritza Vega-Rivera, David Meneses-San Juan, Daniel Reyes-Haro, Leonardo Ortiz-Lopez, Gerardo Bernabe Ramirez Rodriguez
Summary: This study found that environmental enrichment has different effects on neuroplasticity and social/agonistic behavior in FVB/N mice. Females showed increased neurogenesis and social interaction in enriched environments, while males exhibited increased neurogenesis and agonistic behavior. Neural circuit analysis revealed lower activation in the amygdala of enriched males and higher activation in enriched females. Enriched females also showed higher activation in the frontal cortex.
NEUROCHEMICAL RESEARCH
(2022)
Article
Psychiatry
Monica Flores-Ramos, Maria Yoldi-Negrete, Rodrigo Guiza-Zayas, Gerardo-Bernabe Ramirez-Rodriguez, Adolfo Montes-Castrejon, Ana Fresan
Summary: This study aimed to create and test an EE indicator based on the FCAS, SILLS, and IPAQ. The results showed that the EE indicator clearly differentiated between participants with major depression and control subjects.
Article
Neurosciences
Gerardo Bernabe Ramirez-Rodriguez, David Meneses-San Juan, Jorge Julio Gonzalez-Olvera
Summary: This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on cognition, neurogenic-associated modifications, and neuronal activation in the hippocampus of female Swiss Webster mice. The results showed that rTMS twice a day for 14 days improved cognition and increased cell proliferation, doublecortin cells, dendrite morphology, c-Fos expression, and FosB/Delta-FosB immunoreactivity in the mice. The volume of the granular cell layer, mossy fibers, and CA3 also increased. These findings suggest that rTMS can enhance cognitive behavior, cell proliferation, and neuronal activation in healthy mice.
BRAIN RESEARCH BULLETIN
(2022)
Article
Psychology, Biological
Gerardo Bernabe Ramirez-Rodriguez, Beatriz Gutierrez-Vera, Leonardo Ortiz-Lopez, Nelly Maritza Vega-Rivera, David Meneses-San Juan, Andrea Granados-Juarez, Dana Vianey Castro-de Aquino, Mario Castro-Garcia, Monica Flores Ramos
Summary: This study investigated the effects of environmental enrichment on hippocampal neurogenesis and anxiety, and found that any change in environmental complexity reduced anxiety. Furthermore, voluntary physical activity promoted cell maturation in the granular cell layer of the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Gerardo Bernabe Ramirez-Rodriguez, Maria del Angel Ocana-Fernandez, Leonardo Ortiz-Lopez
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
