Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Mario J. Bertogliat, Raghu Vemuganti
Summary: The study demonstrates that TET3 plays a role in ischemic neuroprotection by regulating the levels of 5hmC at gene promoter regions, modulating multiple neuroprotective pathways, and potentially improving outcomes following ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemical Research Methods
Yuzhen Dan, Nevenka Radic, Marina Gay, Adria Fernandez-Torras, Gianluca Arauz, Marta Vilaseca, Patrick Aloy, Begona Canos, Angel R. Nebreda
Summary: p38α is a protein kinase that regulates cellular responses to various stresses. We identified 35 proteins and 82 phosphoproteins that are modulated by p38α and highlighted the involvement of protein kinases MK2 and mTOR in p38α-regulated signaling networks. Our results provide valuable information on p38α-dependent phosphorylation events in cancer cells and reveal a mechanism by which p38α regulates cell adhesion.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Neurosciences
Hongjie Xi, Tao Tao, Ruru Zhang, Xinxin Xue, Yana Zhu, Jiuyang Liu, Xianyi Xin, Xianzhang Zeng
Summary: This study demonstrates that the selective I2-imidazoline receptor ligand 2BFI can alleviate the severity of ischemic stroke in diabetic patients by reducing microglial NOX2 production, inhibiting inflammatory and oxidative stress responses, and decreasing neuron death.
BRAIN RESEARCH BULLETIN
(2021)
Article
Fisheries
Junjie Wan, Xuelin Zhao, Jiqing Liu, Kaiyu Chen, Chenghua Li
Summary: In this study, a novel SFK homologue (AjSrc) was identified in Apostichopus japonicus, which mediated Vibrio splendidus-induced coelomocytes' phagocytosis via interacting with focal adhesion kinase (AjFAK) and co-phosphorylation. This study enriched the mechanism of phagocytosis in echinoderm and provided a new theoretical foundation for disease control of sea cucumber.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Clinical Neurology
Arjun Paudyal, Flavia Semida Ghinea, Mircea Popescu Driga, Wen-Hui Fang, Giulio Alessandri, Laura Combes, Hans Degens, Mark Slevin, Dirk M. Hermann, Aurel Popa-Wagner
Summary: Research shows that adipose-derived mesenchymal stem cells have a significant protective effect on brain infarction in rats and can improve neurological function. Administration of stem cells loaded with therapeutic peptide p5 led to functional recovery improvement in rats, reducing cell death post-stroke, indicating potential therapeutic benefits for stroke patients.
TRANSLATIONAL STROKE RESEARCH
(2021)
Review
Cell Biology
Teresa de los Reyes, Sergio Casas-Tinto
Summary: This article discusses the importance of inducible heat shock proteins in central nervous system physiology, particularly in the maintenance of synapses and as a balanced protective mechanism in central nervous system development, pathological conditions, and aging.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yue Zhou, Ryota Oki, Akihiro Tanaka, Leixin Song, Atsushi Takashima, Naru Hamada, Satoru Yokoyama, Seiji Yano, Hiroaki Sakurai
Summary: Under cellular stress conditions, non-canonical EphA2 activation occurs through the p38-MK2-RSK pathway and promotes glioblastoma cell migration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf, Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger, Kevin M. Haigis
Summary: Inflammatory bowel diseases (IBDs) are genetically complex and exhibit significant inter-patient heterogeneity. Mouse models of IBD show varied responses to MK2 inhibition, with MK2 suppressing inflammation by targeting inflammatory cells. Using a computational approach, researchers identified IBD patient subgroups predicted to respond to MK2 inhibition, which can aid in identifying which patients will benefit from new therapies.
Article
Multidisciplinary Sciences
Fang Zheng, Elena Lian, Gaby Ramirez, Carley McAlister, Shuo Zhou, Wen Zhang, Chunming Liu, Rushika Perera, Chang-Guo Zhan
Summary: In this study, cytotoxicity assays were performed to examine the potential cytoprotective activity of nicotine against SARS-CoV-2 infection. The results demonstrated that nicotine had no significant cytoprotective activity against SARS-CoV-2 infection in these cells.
Article
Multidisciplinary Sciences
Fang Zheng, Elena Lian, Gaby Ramirez, Carley McAlister, Shuo Zhou, Wen Zhang, Chunming Liu, Rushika Perera, Chang-Guo Zhan
Summary: This study conducted cytotoxicity assays in Vero E6 cells to examine the potential cytoprotective activity of nicotine against SARS-CoV-2 infection. The results demonstrated for the first time that nicotine had no significant cytoprotective activity against SARS-CoV-2 infection in these cells.
Article
Multidisciplinary Sciences
Nydia Tejeda-Munoz, Marco Morselli, Yuki Moriyama, Pooja Sheladiya, Matteo Pellegrini, Edward M. De Robertis
Summary: During canonical Wnt signaling, Wnt induces the endocytosis of focal adhesion proteins and depletion of Integrin beta 1 from the cell surface. This endocytosis leads to changes in the cytoskeleton and is accompanied by the sequestration of Integrin beta 1 within membrane-bounded organelles containing glycogen syntase kinase 3 and focal adhesion-associated proteins.
Article
Immunology
Mian Peng, Wanhua Yi, Murong Min, Na Peng, Huasheng Tong, Mengliu Jiang, Di Jin, Suliu Peng, Weifen Liang, Jingwen Quan, Muman Li, Linna Shi, Guizhen Xiao
Summary: This study aimed to investigate the effects of Akkermansia muciniphila (A. muciniphila) on heat stress-induced dysfunction of intestinal permeability and its preventive effects on heatstroke. The results showed that both live and pasteurized A. muciniphila effectively attenuated the decrease in intestinal permeability caused by heat exposure. Additionally, A. muciniphila significantly elevated the expression of tight junction proteins Occludin and ZO-1 by promoting HSP27 phosphorylation, thereby preventing the distortion and redistribution of tight junction proteins and maintaining the integrity of intestinal morphology.
MICROBIAL PATHOGENESIS
(2023)
Article
Neurosciences
Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Koh
Summary: Chlorogenic acid exhibits strong neuroprotective effects in animal models of cerebral ischemia, alleviating neurological deficits, reducing oxidative stress and apoptosis levels, and attenuating brain edema and infarction caused by ischemic injury.
NEUROSCIENCE LETTERS
(2021)
Letter
Clinical Neurology
Marina Buciuc, Gian Marco Conte, Eugene L. Scharf
Summary: Additional digital content is available in the text.
Article
Immunology
Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori, Sachiko Miyake
Summary: This study demonstrates that B cells in patients with NMOSD are abnormally skewed towards antibody-secreting cells at the transcriptome level during the early differentiation phase, and IL-2 might participate in this pathogenic process. CD25(+) naive B cells are identified as a novel candidate precursor of antibody-secreting cells in autoimmune diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Yuichi Riku, Yasushi Iwasaki, Shinsuke Ishigaki, Akio Akagi, Masato Hasegawa, Kenya Nishioka, Yuanzhe Li, Miho Riku, Takeshi Ikeuchi, Yusuke Fujioka, Hiroaki Miyahara, Jun Sone, Nobutaka Hattori, Mari Yoshida, Masahisa Katsuno, Gen Sobue
Summary: Mislocalization and cytoplasmic aggregation of TDP-43 in spinal cord motor neurons have been found in various neurological disorders, suggesting mechanistic links. Additionally, the severity of TDP-43 pathology in the spinal cord correlates with the severity of 4R-tau aggregates. These findings provide insights into the pathology and potential mechanisms underlying TDP-43-related diseases.
Article
Neurosciences
Christina Andica, Akifumi Hagiwara, Kazumasa Yokoyama, Shimpei Kato, Wataru Uchida, Yuma Nishimura, Shohei Fujita, Koji Kamagata, Masaaki Hori, Yuji Tomizawa, Nobutaka Hattori, Shigeki Aoki
Summary: This study combined NODDI and SyMRI to evaluate GM microstructural alterations in RRMS and NMOSD patients, revealing reduced NDI and MVF and increased ODI and ISOVF in RRMS patients, mainly in limbic and paralimbic regions, while NMOSD patients showed reduced NDI in different cortical areas. RRMS and NMOSD exhibited distinct GM pathologies, with cautious interpretation of the results due to study limitations.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Shinichi Ueno, Norihiro Tada, Nobutaka Hattori
Summary: The study investigated the role of FBXO7 gene mutations in Parkinson's disease and found that these mutations lead to a decrease in dopaminergic neurons and the formation of protein aggregates. They also discovered mitochondrial fragmentation in neuronal cells, suggesting that dysfunction in proteolytic and mitochondrial degradation systems plays a crucial role in the development of Parkinson's disease.
Article
Clinical Neurology
Atsushi Takeda, Yoshio Tsuboi, Masahiro Nomoto, Hideki Mochizuki, Nobutaka Hattori
Summary: This study provides expert perspectives on the use of Safinamide for different clinical scenarios in Japan, offering recommendations for its use in clinical practice.
PARKINSONS DISEASE
(2022)
Letter
Clinical Neurology
Noriko Nishikawa, Taku Hatano, Daiki Kamiyama, Haruna Haginiwa-Hasegawa, Genko Oyama, Nobutaka Hattori
JOURNAL OF MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Tatou Iseki, Yuzuru Imai, Nobutaka Hattori
Summary: Leucine rich-repeat kinase 2 (LRRK2) is the most well-known genetic cause of familial Parkinson's disease (PD). Its functions and relationship to the pathogenesis of PD are not fully understood. Recent studies have suggested that LRRK2 plays a role in glial cell dysfunction and neurodegeneration, particularly in lysosomal dynamics and inflammation. This review discusses the proposed functions of LRRK2 in glial cells and its involvement in the pathomechanisms of PD.
Article
Medicine, General & Internal
Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
Summary: This study aimed to investigate the impact of the COVID-19 pandemic on patients with Parkinson's disease and their caregivers in Japan. The results showed that over 40% of patients reduced their frequency of going out, approximately 7-30% experienced worsened symptoms, and caregivers reported increased burden. The findings suggest the importance of providing support to patients and caregivers during infectious disease epidemics to alleviate their burden.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuri Yamashita, Satoshi Nakada, Kyoko Nakamura, Hidetoshi Sakurai, Kinji Ohno, Tomohide Goto, Yo Mabuchi, Chihiro Akazawa, Nobutaka Hattori, Eri Arikawa-Hirasawa
Summary: Schwartz-Jampel syndrome (SJS) is a rare genetic disorder characterized by myotonia. In this study, a cellular model of SJS was created using patient-derived induced pluripotent stem cells, which showed hyper-responsiveness to acetylcholine. These findings confirmed the use of cellular models in studying SJS and evaluating myotonia in clinical cases.
Editorial Material
Clinical Neurology
Nobutaka Hattori
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Clinical Neurology
Christina Andica, Koji Kamagata, Wataru Uchida, Yuya Saito, Kaito Takabayashi, Akifumi Hagiwara, Haruka Takeshige-Amano, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
Summary: This study compared the white matter differences between nonmedicated patients with early-stage GBA-PD and iPD using a novel technique, fixel-based analysis. The results showed that patients with GBA-PD had lower white matter density, while patients with iPD had larger white matter fiber bundles. These findings may be related to neurodegenerative diseases, α-synuclein accumulation, and cognitive and motor impairments.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Amica C. Mueller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorova, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya Bardien
Summary: The biological basis of Parkinson's disease, a neurodegenerative movement disorder, is still unclear despite being discovered over 200 years ago. This article summarizes the viewpoints of PD experts on the different theories regarding its pathobiology.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Wataru Sako, Yuki Kogo, Michinori Koebis, Yoshiaki Kita, Hajime Yamakage, Takayuki Ishida, Nobutaka Hattori
Summary: This study compared the efficacy, tolerability, and safety of different classes of anti-PD drugs in patients with fluctuating PD who were receiving levodopa. The results showed that ropinirole, pramipexole, and safinamide are well-balanced anti-PD drugs that have both good efficacy and tolerability.
NPJ PARKINSONS DISEASE
(2023)
Article
Biology
Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani, Leonardo A. Sechi, Nobutaka Hattori
Summary: The study analyzed the levels of different IgG subclasses in the blood of Japanese and Italian individuals with relapsing remitting multiple sclerosis (MS) in response to MAP-derived peptides. The study also examined the effects of MAP peptides on MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The results suggest a potential link between MAP and the development or exacerbation of MS, particularly in individuals with elevated serum IgG4 levels.
Article
Clinical Neurology
Anri Sakurai, Taiji Tsunemi, Yuta Ishiguro, Ayami Okuzumi, Taku Hatano, Nobutaka Hattori
Summary: The study found that approximately 29.1% of iNPH patients had comorbid PD/PDD, while about 10.1% had comorbid DLB. Comorbid PD/PDD or DLB showed significant differences in facial expansion and upper-limb parkinsonism. DaTscan and RT-QuIC can help differentiate these diseases and affect their clinical features.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
