Article
Cell Biology
Ji Yeon Lee, Haifeng Zheng, Kenton M. Sanders, Sang Don Koh
Summary: In murine antral smooth muscle cells, low-voltage-activated inward currents are generated by K+ influx via KA channels, rather than T-type Ca2+ channels, Ca2+-activated Cl- channels, or nonselective cation channels.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Neurosciences
June Bryan de la Pena, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Kunder, Sarah Loerch, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Dominique N. James, Salim Megat, Jamie K. Moy, Andi Wanghzou, Pradipta R. Ray, Kenneth Hoyt, Oswald Steward, Theodore J. Price, Jason Shepherd, Zachary T. Campbell
Summary: Studies have shown that activity-dependent protein Arc plays an important role in translational regulation in sensory neurons, potentially regulating neurogenic inflammation in the skin through intercellular signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Willy Carrasquel-Ursulaez, Ignacio Segura, Ignacio Diaz-Franulic, Felipe Echeverria, Yenisleidy Lorenzo-Ceballos, Nicolas Espinoza, Maximiliano Rojas, Jose Antonio Garate, Eduardo Perozo, Osvaldo Alvarez, Fernando D. Gonzalez-Nilo, Ramon Latorre
Summary: This study demonstrates that two arginines in the transmembrane segment S4 function as the gating charges of BK channels, and the energy landscape of gating particles is tuned by a network of salt bridges in the voltage sensor domain (VSD). Unlike Kv channels, the charge movement in BK seems limited to a small displacement of the guanidinium moieties of R210 and R213.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physics, Applied
N. Schaefer, D. Guenzing, T. Jiang, N. Karabas, A. Arzumanov, D. Motta-Meira, K. Ollefs, P. Komissinskiy, M. Major, M. Arnold, N. Pietralla, H. Wende, L. Molina-Luna, D. Luetzenkirchen-Hecht, L. Alff
Summary: This work investigates the influence of the kinetic energy of the deposited particles on the defect structure in Nb3Sn thin films synthesized at low temperatures. The results show that higher kinetic energies of the elemental species during deposition lead to improved local order and elemental homogeneity of the Nb3Sn films, as well as suppressed local inhomogeneities at grain boundaries. The suggested materials' synthesis eliminates the magnetic field-induced reduction of critical currents across weak-links formed at grain boundaries.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Miho Hashimoto, Kenji Takahashi, Toshio Ohta
Summary: Linalool, an essential oil component of lavender, has been commonly used in fragrances and is known to have anxiolytic, sedative, and analgesic actions. This study found that linalool suppresses the activity of TRPA1 and voltage-gated calcium channels, which are important for pain signaling.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Article
Pharmacology & Pharmacy
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart
Summary: Ondansetron inhibits hSK2 currents even under altered ionic conditions, potentially showing antiarrhythmic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Anesthesiology
Anthony J. Burand, Cheryl L. Stucky
Summary: Severe neuropathic pain is a prominent feature of Fabry disease, impacting patients' quality of life significantly. Despite existing treatment options, pain persists in many patients, with unclear understanding of the mechanisms underlying the pain.
Article
Developmental Biology
Mark A. Landy, Megan Goyal, Helen C. Lai
Summary: Sensory neurogenesis in the dorsal root ganglion (DRG) occurs in two waves, with different nociceptor subtypes born continuously between E9.5 to E13.5, and peak births from E10.5 to E11.5. The percentages of nociceptor subtypes born at a particular timepoint are the same for any given nociceptor cell type marker, indicating similar influences on cell type diversity across developmental time. Overall, the patterns of birth fit within the classical two wave description, with touch and proprioceptive fibers primarily born at E10.5, but nociceptors have a slightly broader wave of birthdates.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nipon Ketjoy, Pornthip Mensin, Wisut Chamsa-ard
Summary: This study examines the effects of high humid weather conditions on photovoltaic modules, specifically focusing on insulation resistance. The results show that high humidity leads to decreased insulation resistance and increased leakage voltage, which can disrupt the operation of PV plants and pose safety hazards. Therefore, it is important to avoid prolonged exposure of PV plants to high humidity conditions and implement efficient drainage systems to ensure proper operation and minimize energy losses.
Article
Materials Science, Multidisciplinary
Chengyao Zhang, Jinpeng Bao, Weiqi Gao, Haiyan Lu
Summary: By employing a low voltage electrochemical oxidation method to modify rehmannia glutionosa activated carbon, the capacitance and energy density are significantly increased. The capacity retention rate remains high even after 5000 cycles.
Article
Multidisciplinary Sciences
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Summary: Researchers have discovered a compound, BC5, that interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism. BC5 can activate the channel in the absence of Ca2+ binding, but Ca2+ binding inhibits BC5 effects. This study reveals the importance of the CTD-VSD interaction in the Ca2+ activation mechanism and provides insights for allosteric agonists to modulate BK channel activation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ming Li, Bingbing Zhang, Yufeng Yin, Jianan Wen, Jingjing Wang, Yuxin He, Qianming Jiang, Juan J. Loor, Shuang Wang, Wei Yang, Chuang Xu
Summary: The nutritional status of dairy cows and the metabolism of specific nutrients affect the immune cell function. An increase in fatty acid concentrations can negatively impact immune function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dorina Zoephel, Chantal Hof, Annette Lis
Summary: Aging is an unstoppable process that affects every cell of the organism, especially the changes in Ca2+ signaling in immune cells which may profoundly impact the development of age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Lucy Kundura, Renaud Cezar, Manuela Pastore, Christelle Reynes, Jeremy Deverdun, Emmanuelle Le Bars, Albert Sotto, Jacques Reynes, Alain Makinson, Pierre Corbeau
Summary: HIV infection is associated with immune activation markers that correlate with neurocognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Federico Iseppon, Ana P. Luiz, John E. Linley, John N. Wood
Summary: Oxaliplatin can cause cold and mechanical allodynia in patients, and this study found that it unmasks silent Nav1.8-positive nociceptive cold sensors, which is causally linked to cold allodynia. Pregabalin, when intravenously injected, significantly improves cold allodynia by reducing the number of cold sensitive neurons and changing their excitability and temperature thresholds. Deletion of a28 1 subunits abolishes the effects of pregabalin on cold allodynia and the silencing of sensory neurons, indicating a novel peripheral inhibitory effect of pregabalin on silent cold-sensing neurons in oxaliplatin-dependent cold allodynia.
Article
Neurosciences
Charles Campbell, Sarah Lindhartsen, Adam Knyaz, Alev Erisir, Marc Nahmani
Article
Neurosciences
Erin E. Maher, McKenzie E. Prillaman, Elif N. Keskinoz, Heywood M. Petry, Alev Erisir
Summary: This study examined the synaptic inputs in the VPMP of tree shrews, finding similarities to nonchemical sensory thalamic nuclei. It revealed that all primary sensory thalamic nuclei in higher mammals share a structural template for processing sensory information. However, significant morphological and molecular differences in taste nuclei between rodents and tree shrews suggest fundamental divergence in cellular processing mechanisms for taste input between these two species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Nicolo Sella, Tommaso Pettenuzzo, Francesco Zarantonello, Giulio Andreatta, Alessandro De Cassai, Chiara Schiavolin, Caterina Simoni, Laura Pasin, Annalisa Boscolo, Paolo Navalesi
Summary: Setting the proper level of positive end-expiratory pressure (PEEP) using Electrical Impedance Tomography (EIT) can effectively prevent atelectrauma and alveolar overdistension, providing a promising technique for individualizing PEEP in mechanically ventilated patients. However, further exploration is needed to fully understand the advantages and limitations of EIT for optimizing PEEP.
RESPIRATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Tommaso Pettenuzzo, Chiara Giraudo, Giulia Fichera, Michele Della Paolera, Martina Tocco, Michael Weber, Davide Gorgi, Silvia Carlucci, Federico Lionello, Sara Lococo, Annalisa Boscolo, Alessandro De Cassai, Laura Pasin, Marco Rossato, Andrea Vianello, Roberto Vettor, Nicolo Sella, Paolo Navalesi
Summary: This retrospective study aimed to assess whether the CARE score, previously validated in COVID-19 patients, could predict the need for endotracheal intubation and escalation of respiratory support in COVID-19 patients undergoing noninvasive respiratory support (NIRS). The study found that the CARE score at NIRS initiation was not predictive of the need for endotracheal intubation or escalation of treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Annalisa Boscolo, Andrea Dell'Amore, Tommaso Pettenuzzo, Nicolo Sella, Alessandro De Cassai, Elisa Pistollato, Nicola Cacco, Andrea Manzan, Agnese De Carolis, Federico Geraldini, Giulia Lorenzoni, Federica Pezzuto, Giovanni Zambello, Marco Schiavon, Fiorella Calabrese, Dario Gregori, Emanuele Cozzi, Federico Rea, Paolo Navalesi
Summary: This study aimed to investigate the impact of 'prophylactic' veno-arterial extracorporeal membrane oxygenation (VA ECMO) and tacrolimus on lung transplant recipients. The results showed that 'prophylactic' VA ECMO had comparable 72-hour primary graft dysfunction (PGD) values to the 'off-pump' group, while tacrolimus was associated with a lower risk of 30-day acute cellular rejection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Aygul Balcioglu, Rebecca Gillani, Michael Doron, Kendyll Burnell, Taeyun Ku, Alev Erisir, Kwanghun Chung, Idan Segev, Elly Nedivi
Summary: This study investigates the synaptic connections between thalamus and visual cortex neurons in mice, revealing sparse, small, and heterogeneous distribution. The findings suggest that a few neurons can reliably decode visual input from the thalamus. The study provides important insights into the processing of sensory information in the brain.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Fiorella Calabrese, Federica Pezzuto, Francesco Fortarezza, Francesca Lunardi, Eleonora Faccioli, Giulia Lorenzoni, Annalisa Boscolo, Nicolo Sella, Dario Gregori, Marco Schiavon, Paolo Navalesi, Andrea Dell'Amore, Federico Rea
Summary: This study investigated tissue/molecular pathways and tissue injury in lung transplantation recipients supported by intraoperative VA-ECMO. The findings suggest lower lung tissue injury and decreased leukocyte margination in the ECMO group compared to the non-ECMO group.
Letter
Anesthesiology
Francesco Zarantonello, Nicolo Sella, Tommaso Pettenuzzo, Annalisa Boscolo, Paolo Navalesi
Review
Respiratory System
Annalisa Boscolo, Tommaso Pettenuzzo, Nicola Sella, Matteo Zatta, Michele Salvagno, Martina Tassone, Chiara Pretto, Arianna Peralta, Luisa Muraro, Francesco Zarantonello, Andrea Bruni, Federico Geraldini, Alessandro De Cassai, Paolo Navalesi
Summary: This study assessed the effects of noninvasive respiratory support (NRS) on post-extubation respiratory failure and found that NRS reduced re-intubations and ventilator-associated pneumonia (VAP) but increased discomfort. Prophylactic NRS did not prevent extubation failure in low-risk or hypoxaemic patients.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Immunology
Chengsan Sun, Shuqiu Zheng, Justin S. A. Perry, Geoffrey T. Norris, Mei Cheng, Fanzhen Kong, Rolf Skyberg, Jianhua Cang, Alev Erisir, Jonathan Kipnis, David L. Hill
Summary: Microglia play a crucial role in the refinement of central gustatory circuits during normal postnatal development. This process can be disrupted by restricting the mother's dietary sodium intake in the early prenatal period, when microglia progenitors migrate from the yolk sac to the brain. The pruning of gustatory terminal fields in the nucleus of the solitary tract (NST) is driven by NaCl-elicited taste activity and involves the complement system. Offspring of mothers with a low NaCl diet fail to prune the gustatory terminal fields, despite normal peripheral taste activity. However, the ability to prune can be rescued by activating myeloid cells postnatally.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nicol Bernardinello, Elisabetta Cocconcelli, Annalisa Boscolo, Gioele Castelli, Nicolo Sella, Chiara Giraudo, Elisabetta Zanatta, Federico Rea, Marina Saetta, Paolo Navalesi, Paolo Spagnolo, Elisabetta Balestro
Summary: Diaphragm ultrasound can be used to assess diaphragm function in patients with ILD. The prevalence of diaphragmatic dysfunction was 29% in patients with ILD and it was associated with dyspnea. CTD-ILD had lower diaphragm displacement compared to IPF and a higher prevalence of diaphragmatic dysfunction compared to controls.
RESPIRATORY MEDICINE
(2023)
Article
Anesthesiology
Alessandro De Cassai, Martina Tassone, Federico Geraldini, Massimo Sergi, Nicolo Sella, Annalisa Boscolo, Marina Munari
Summary: This study used meta-analyses published in the Korean Journal of Anesthesiology to demonstrate possible TSA scenarios and their significance. Results showed that while most TSAs confirmed the meta-analyses' results, only a few met the required sample size, indicating TSA can strengthen meta-analysis conclusions but require proper pre-registration to ensure validity.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2021)
Letter
Anesthesiology
Alessandro De Cassai, Laura Pasin, Annalisa Boscolo, Michele Salvagno, Paolo Navalesi
KOREAN JOURNAL OF ANESTHESIOLOGY
(2021)
Article
Anesthesiology
Alessandro De Cassai, Giulio Andreatta, Annalisa Boscolo, Marina Munari, Paolo Navalesi
KOREAN JOURNAL OF ANESTHESIOLOGY
(2020)
Article
Anesthesiology
Annalisa Boscolo, Luca Spiezia, Elena Campello, Diana Bertini, Vittorio Lucchetta, Eleonora Piasentini, Alessandro De Cassai, Paolo Simioni
KOREAN JOURNAL OF ANESTHESIOLOGY
(2020)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.