Article
Neurosciences
Elga Esposito, Ester Licastro, Ornella Cuomo, Eng H. Lo, Kazuhide Hayakawa, Giuseppe Pignataro
Summary: Experimental studies show that ischemic postconditioning can interfere with cell death mechanisms and reduce infarction during the acute phase after focal cerebral ischemia. However, there are many limitations to its clinical translation. This study aims to explore the mechanisms of improved long-term recovery after ischemic postconditioning, and the results suggest that it may involve the promotion of neurogenesis and angiogenic remodeling via BDNF released by astrocytes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Plant Sciences
Ning Jiang, Haixia Wang, Chenchen Li, Guirong Zeng, Jingwei Lv, Qiong Wang, Yin Chen, Xinmin Liu
Summary: The traditional Chinese medicine formula SY exhibits antidepressant effects on rats with CUMS-induced depressive behaviors, potentially by promoting hippocampal neurogenesis and activating the BDNF signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Robert R. Kraemer, Bradley R. Kraemer
Summary: In the past decade, research has shown that exercise has beneficial effects on hippocampal neurogenesis and cognitive function. Studies with animals and humans have provided new understanding of how endocrine signaling stimulates neurogenesis and the impact of exercise on circulating hormones. Given the decline of specific endocrine factors with aging, insights in this area of research are particularly important.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Gui Cao, Ting Gong, Yue Du, Yicun Wang, Tongtong Ge, Jingyu Liu
Summary: Metformin, a first-line drug for the treatment of type 2 diabetes mellitus (T2DM), has been widely studied. It has been found to have potential neuroprotective and regulatory effects on the central nervous system (CNS), in addition to its known benefits for diabetes management.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Cristian Bis-Humbert, Ruben Garcia-Cabrerizo, M. Julia Garcia-Fuster
Summary: This study compared the effects of nortriptyline on adolescent and adult rats, finding that low doses had antidepressant effects in adolescents while higher doses had negative outcomes. In adult rats, nortriptyline did not significantly impact behavioral and neurochemical responses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Liu
Summary: The Shen Yuan prescription, comprising Panax ginseng and Polygala tenuifolia, has shown superior antidepressant activity compared with individual components. It successfully reversed depressive-like behaviors induced by chronic social defeat stress (CSDS) in mice, by promoting hippocampal neurogenesis and activating the BDNF signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Julia Leschik, Antonietta Gentile, Cigdem Cicek, Sophie Peron, Margaryta Tevosian, Annika Beer, Konstantin Radyushkin, Anna Bludau, Karl Ebner, Inga Neumann, Nicolas Singewald, Benedikt Berninger, Volkmar Lessmann, Beat Lutz
Summary: The neurotrophin brain-derived neurotrophic factor (BDNF) affects adult neurogenesis, structural plasticity and function of serotonergic neurons. Both BDNF/TrkB signaling and serotonergic system regulate behavioral responses to stress. Overexpression of BDNF in serotonergic neurons enhances hippocampus-dependent contextual learning and reduces the impact of chronic social defeat stress (CSDS). Increased neurogenesis is correlated with improved stress resilience.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Britt J. Heidinger, Samuel P. Slowinski, Aubrey E. Sirman, Jeffrey Kittilson, Nicole M. Gerlach, Ellen D. Ketterson
Summary: Elevated testosterone in male dark-eyed juncos leads to increased telomere shortening with age, potentially affecting longevity. This suggests that the impact of testosterone on telomeres may be a long-term cost of reproduction in male vertebrates.
Article
Pharmacology & Pharmacy
Ning Jiang, Hong Huang, Yiwen Zhang, Jingwei Lv, Qiong Wang, Qinghu He, Xinmin Liu
Summary: The study demonstrated that Ginsenoside Rb1 can significantly reverse depressive-like behaviors induced by chronic social defeat stress through enhancing the BDNF signaling cascade and promoting hippocampal neurogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liang Yu, Jiajia Wang, Ying Xia, Wugang Hou, Xi Yao, Yaru Guo, Jin Wang, Haidong Wei, Shiquan Wang
Summary: Adiponectin enhances neurogenesis and functional recovery after ischemic stroke via the STAT3/BDNF pathway in astrocytes.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Wan Yan, Huafu Chen, Zili You
Summary: IL4-driven microglia expressing Arg1 in the hippocampus play a crucial role in maintaining neurogenesis and enhancing stress resilience. Modulating the expression of these microglia through IL4 signaling can restore neurogenesis and resilience. Additionally, BDNF is necessary for the proneurogenesis effects of these microglia.
Article
Chemistry, Multidisciplinary
Yuan Xiong, Ze Lin, Pengzhen Bu, Tao Yu, Yori Endo, Wu Zhou, Yun Sun, Faqi Cao, Guandong Dai, Yiqiang Hu, Li Lu, Lang Chen, Peng Cheng, Kangkang Zha, Mohammad-Ali Shahbazi, Qian Feng, Bobin Mi, Guohui Liu
Summary: Diabetic wound therapy is a significant challenge in medicine. A whole-course-repair system using a hydrogel has been introduced to achieve concurrent neurogenesis and angiogenesis for accelerated wound healing. The hydrogel can be injected into wounds to provide a physical barrier and release magnesium ions and engineered small extracellular vesicles for synergistic effects. This system recruits mesenchymal stem cells and stimulates neurogenic differentiation, while also promoting angiogenesis at the wound site. It offers a novel platform for combined diabetic wound therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiangyu Liu, Mei Yang, Fang Lei, Yaru Wang, Mingying Yang, Chuanbin Mao
Summary: Filamentous phages engineered to display RGD peptide on silk protein microparticles can promote adhesion, proliferation, and differentiation of neural stem cells, stimulate angiogenesis and neurogenesis, and lead to brain-tissue regeneration and functional recovery in stroke therapy.
ADVANCED MATERIALS
(2022)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Article
Geriatrics & Gerontology
Nina E. Baumgartner, Katelyn L. Black, Shannon M. McQuillen, Jill M. Daniel
Summary: Both previous and continuous midlife estradiol treatment can increase levels of nuclear ER alpha in the hippocampus, impacting gene expression and protein levels related to estrogen effects on memory, indicating a long-lasting regulatory role of hippocampal ER alpha in memory.
NEUROBIOLOGY OF AGING
(2021)
Review
Cell & Tissue Engineering
M. Joana Osorio, David H. Rowitch, Paul Tesar, Marius Wernig, Martha S. Windrem, Steven A. Goldman
Editorial Material
Medicine, Research & Experimental
Steven A. Goldman
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Editorial Material
Biochemistry & Molecular Biology
Steven A. Goldman
Review
Cell & Tissue Engineering
Roger A. Barker, Melissa K. Carpenter, Stuart Forbes, Steven A. Goldman, Catriona Jamieson, Charles E. Murry, Jun Takahashi, Gordon Weir
Article
Cell & Tissue Engineering
Mikhail Osipovitch, Andrea Asenjo Martinez, John N. Mariani, Adam Cornwell, Simrat Dhaliwal, Lisa Zou, Devin Chandler-Militello, Su Wang, Xiaojie Li, Sarah-Jehanne Benraiss, Robert Agate, Andrea Lampp, Abdellatif Benraiss, Martha S. Windrem, Steven A. Goldman
Article
Cell Biology
Zhengshan Liu, Mikhail Osipovitch, Abdellatif Benraiss, Nguyen P. T. Huynh, Rossana Foti, Janna Bates, Devin Chandler-Militello, Robert L. Findling, Paul J. Tesar, Maiken Nedergaard, Martha S. Windrem, Steven A. Goldman
Review
Multidisciplinary Sciences
Steven A. Goldman
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Review
Multidisciplinary Sciences
Maiken Nedergaard, Steven A. Goldman
Article
Computer Science, Artificial Intelligence
Hans J. T. Stephensen, Anne Marie Svane, Carlos B. Villanueva, Steven A. Goldman, Jon Sporring
Summary: The paper introduces a theory on geometrical interaction between biological objects, describing the relation between a reference and an observed object, and defining measures on their intersections. These measures reveal further details about the shape of individual objects and their pairwise geometrical relation.
JOURNAL OF MATHEMATICAL IMAGING AND VISION
(2021)
Article
Neurosciences
Maria Joana Osorio, John N. Mariani, Lisa Zou, Steven J. Schanz, Kate Heffernan, Adam Cornwell, Steven A. Goldman
Summary: Genomic analyses reveal heterogeneity among glial progenitor cells (GPCs) in human grey and white brain matter, with distinct architecture and associated gene expression. White matter GPCs show lower expression of genes associated with astrocytic fate and have simpler morphology compared to grey matter GPCs. Human grey matter GPCs exhibit more complex morphology compared to white matter GPCs and their mouse counterparts.
Review
Multidisciplinary Sciences
Baljit S. Khakh, Steven A. Goldman
Summary: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a mutation in the huntingtin gene. Astrocytes in the striatum, a brain region affected in HD, play a role in the pathology of the disease. Dysfunctions in astrocytes contribute to cellular and metabolic abnormalities in HD, suggesting the potential for therapeutic targeting of these cells to restore normal function.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Multidisciplinary Sciences
Jeffrey A. Stogsdill, Corey C. Harwell, Steven A. Goldman
Summary: Astrocytes are crucial for the development, plasticity, and maintenance of neural circuits in the central nervous system. They have diverse functions and play integral roles in regulating neural activity. Dysfunction of astrocytes has been implicated in various neurodegenerative and neuropsychiatric disorders. This review focuses on the contributions of astrocytes to synaptic development and maturation, as well as their role in supporting myelin integrity and potential therapeutic strategies targeting these cells.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Multidisciplinary Sciences
Carlos Benitez Villanueva, Hans J. T. Stephensen, Rajmund Mokso, Abdellatif Benraiss, Jon Sporring, Steven A. Goldman
Summary: This study investigates the relationship between astroglial cells and medium spiny neurons (MSN) synapses in Huntington's disease (HD). The results show that HD astrocytes have impaired connection and function with synaptic sites compared to normal astrocytes, leading to striatal hyperexcitability and the development of HD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell & Tissue Engineering
Martha S. Windrem, Mikhail Osipovitch, Zhengshan Liu, Janna Bates, Devin Chandler-Militello, Lisa Zou, Jared Munir, Steven Schanz, Katherine Mccoy, Robert H. Miller, Su Wang, Maiken Nedergaard, Robert L. Findling, Paul J. Tesar, Steven A. Goldman
Article
Genetics & Heredity
Zachary S. Nevin, Daniel C. Factor, Robert T. Karl, Panagiotis Douvaras, Jeremy Laukka, Martha S. Windrem, Steven A. Goldman, Valentina Fossati, Grace M. Hobson, Paul J. Tesar
AMERICAN JOURNAL OF HUMAN GENETICS
(2017)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.