Review
Endocrinology & Metabolism
Lucie Malbeteau, Ha Thuy Pham, Louisane Eve, Michael R. Stallcup, Coralie Poulard, Muriel Le Romancer
Summary: Steroid receptors (SRs) are important members of the nuclear hormonal receptor family, regulating various physiological functions essential for human health. Dysregulation of SRs may contribute to a wide range of pathologies, highlighting the significance of understanding their regulatory mechanisms.
Article
Endocrinology & Metabolism
Tessa M. Cacciottolo, Elana Henning, Julia M. Keogh, Pierre Bel Lassen, Katherine Lawler, Rebecca Bounds, Rachel Ahmed, Aliki Perdikari, Edson Mendes de Oliveira, Miriam Smith, Edmund M. Godfrey, Elspeth Johnson, Leanne Hodson, Karine Clement, Agatha A. van der Klaauw, I. Sadaf Farooqi
Summary: SRC-1 variant carriers exhibit hyperphagia in childhood, severe obesity, and clinical features of partial hormone resistance. The presence of adipose tissue fibrosis and hepatic fibrosis in young patients suggests that close monitoring for the early development of obesity-associated metabolic complications is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, Research & Experimental
Saad Bakrim, Nasreddine El Omari, Eman Jamil Khan, Asaad Khalid, Ashraf N. Abdalla, Jack Bee Chook, Khang Wen Goh, Long Chiau Ming, Sara Aboulaghras, Abdelhakim Bouyahya
Summary: The purpose of this review is to better understand the mechanistic pathways and explore epidemiological investigations to establish that phytosterols may contribute to the activation of NRs as cancer drivers in hormone-dependent cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Agnieszka Karolina Grzegorzewska, Ewa Grot, Andrzej Sechman
Summary: The in vitro treatment of sodium fluoride (NaF) on 14-day-old chicken embryos' gonads showed differential effects on the mRNA expression of various receptors, and different mechanisms of action within the female and male gonads.
Article
Biochemistry & Molecular Biology
Ana P. Gomez-Escribano, Carlos Mora-Martinez, Marta Roca, Denise S. Walker, Joaquin Panadero, Maria D. Sequedo, Ratni Saini, Hans-Joachim Knoelker, Jose Blanca, Juan Burguera, Agustin Lahoz, Joaquin Canizares, Jose M. Millan, Nick O. Burton, William R. Schafer, Rafael P. Vazquez-Manrique
Summary: Alzheimer's, Parkinson's and Huntington's diseases are caused by mutations that enhance protein aggregation. However, our understanding of the molecular mechanisms involved in these pathways is still limited, hindering the development of effective treatments. In this study, we investigated the protective mechanisms against dysregulated homeostasis by screening for mutations that enhance aggregation in Caenorhabditis elegans. We found that the stomatin homologue UNC-1 activates neurohormonal signalling to modulate protein homeostasis.
Article
Chemistry, Medicinal
Namita Dube, Sabab Hasan Khan, Riley Sasse, C. Denise Okafor
Summary: Allosteric pathways in proteins involve networks of amino acid residues that transmit signals between distant sites. This study uses molecular dynamics simulations and suboptimal path analysis to discover new allosteric networks in steroid receptors, focusing on evolutionarily conserved pathways. The researchers identify a conserved network connecting a predicted allosteric site between helices 9 and 10 of the ligand-binding domain to the activation function surface 2 (AF-2). The study suggests the evolutionary importance of this site in steroid receptors and provides an approach to discover previously unknown allosteric sites in proteins.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Namita Dube, Sabab Hasan Khan, Riley Sasse, C. Denise Okafor
Summary: Allosteric pathways in proteins allow for the transmission of signals between distant sites through inter-residue interactions. This study utilizes molecular dynamics simulations and suboptimal path analysis to identify new allosteric networks in steroid receptors, focusing on evolutionarily conserved pathways. The investigation reveals a conserved network connecting a predicted allosteric site located between helices 9 and 10 of the ligand-binding domain to the activation function surface 2 (AF-2). The importance of this site is highlighted by its presence in a region characterized by conserved inter-residue contacts.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Cell Biology
Gisele Giannocco, Marina Malta Letro Kizys, Rui Monteiro Maciel, Janaina Sena de Souza
Summary: Thyroid hormones, T3 and T4, are crucial for regulating gene expression in tissues from fetal to adult stages, with particular importance in the central nervous system. Environmental substances can interfere with the functioning of the thyroid gland, leading to neurological disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Suryendu Saha, Samya Dey, Somsubhra Nath
Summary: This article discusses the role of steroid hormone receptors in cell cycle regulation, with a focus on their interaction with breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthew A. Cooper, Catherine T. Clinard, Brooke N. Dulka, J. Alex Grizzell, Annie L. Loewen, Ashley V. Campbell, Samuel G. Adler
Summary: Through studying Syrian hamsters, it was found that social experiences can alter individual responses to stress, winning aggressive encounters can increase testosterone levels and affect the neural network, and establishing social dominance can lead to changes in neuroendocrine mechanisms.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Iris A. Feria-Romero, Ivan Bribiesca-Cruz, Angelica Coyoy-Salgado, Julia J. Segura-Uribe, Guadalupe Bautista-Poblet, Alondra Granados-Cervantes, Christian Guerra-Araiza
Summary: In ovariectomized rats treated with tibolone, Hprt1 and Ppia genes showed high stability as housekeeping genes for qPCR analysis. Ppia was the most stable gene in the hypothalamus and cerebellum, whereas Hprt1 was the most stable gene in the prefrontal cortex. The combination of Ppia and Hprt1 was the most stable for the prefrontal cortex and the combination of Ppia and Rpl32 for the cerebellum.
Article
Biochemistry & Molecular Biology
Tatiana S. Kalinina, Vladislav V. Kononchuk, Lyudmila F. Gulyaeva
Summary: Endocrine disruptors, such as organochlorine pesticides (OCPs), are a major concern due to their possible association with hormone-dependent carcinogenesis. Experimental results show that these pesticides can affect the expression of hormone receptors and target genes in breast cancer cells, with the effects varying based on the receptor status of the cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Immunology
Tao Zheng, Zhuo Song, Jun Qiang, Yifan Tao, Haojun Zhu, Junlei Ma, Pao Xu
Summary: This study investigated the skin responses to transport stress in hybrid yellow catfish through transcriptome and biochemical analyses. The results showed that the skin activated immune signaling pathways and regulated mucus secretion to cope with transport stress.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Mitsuhiro Yoshimura, Benjamin P. Flynn, Yvonne M. Kershaw, Zidong Zhao, Yoichi Ueta, Stafford L. Lightman, Becky L. Conway-Campbell
Summary: This study demonstrates how the timing of feeding behavior becomes disordered when glucocorticoid rhythms are dissociated from lighting cues. The dysregulated timing of neuropeptide gene expression is associated with this altered feeding pattern.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Sara Fill Malfertheiner, Evelyn Bataiosu-Zimmer, Holger Michel, Sotirios Fouzas, Luca Bernasconi, Christoph Buehrer, Sven Wellmann
Summary: The study aimed to investigate the levels of AVP and OT in response to birth stress in infants and to characterize AVP secretion by comparing with plasma copeptin. The results showed that AVP and copeptin concentrations were significantly higher in infants born vaginally, while OT levels did not differ between vaginal delivery and cesarean section. AVP was found to indicate acute stress events, while copeptin provided information on cumulative stress events over a longer period, showing that AVP signaling mediates birth stress response in infants.
FRONTIERS IN NEUROSCIENCE
(2021)
Letter
Endocrinology & Metabolism
Joost Brinks, Elon H. C. van Dijk, Robbert G. E. Notenboom, Paul H. A. Quax, Camiel J. F. Boon, Onno C. Meijer
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Eva M. G. Viho, Jacobus C. Buurstede, Jari B. Berkhout, Ahmed Mahfouz, Onno C. Meijer
Summary: Glucocorticoid stress hormones can affect mood and cognitive processes in the brain, with the hippocampus being a prominent target expressing GR and MR receptors. Analysis of single-cell RNA sequencing data confirmed cell-type specificity of GR and MR signaling, providing insights into cellular basis of glucocorticoid effects on hippocampal function.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Robin Lengton, Anand M. Iyer, Eline S. van der Valk, Ellen K. Hoogeveen, Onno C. Meijer, Bibian van der Voorn, Elisabeth F. C. van Rossum
Summary: Increasing glucocorticoid exposure is linked to weight gain, with individuals with obesity often showing high cortisol values. Individual differences in glucocorticoid sensitivity, influenced by genetic and acquired factors, play a crucial role in response to glucocorticoids and personalized treatment options targeting the glucocorticoid receptor.
Article
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Philippe C. Habets, Marit Bogaards, Jan Kroon, Hanneke M. van Santen, Judith M. de Bont, Onno C. Meijer
Summary: This study aims to evaluate whether dexamethasone leads to reduced MR activation in the human brain. The results suggest that dexamethasone may induce MR nuclear translocation in the human brain. However, further research is needed to determine the specific effects of dexamethasone on gene expression in the brain.
ENDOCRINE CONNECTIONS
(2022)
Article
Pharmacology & Pharmacy
Susana N. Paul, Katja Wingenfeld, Christian Otte, Onno C. Meijer
Summary: Brain mineralocorticoid receptors play an important role in stress adaptation and salt homeostasis. Pharmacological intervention targeting MR can alleviate symptoms related to stress and endocrine disorders. Further understanding of MR-dependent pathways can improve psychiatric symptoms.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Alies J. Dekkers, Jorge M. Amaya, Merel van der Meulen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira
Summary: The clinical manifestations of metabolism and cardiovascular system in patients with Cushing's syndrome are well-known. However, recent studies have shown that hypercortisolism, both endogenous and exogenous, affects brain functioning at different time scales. This review discusses the effects of hypercortisolism on the brain, the prevalence of cognitive and neuropsychological deficits, and their course after remission. Possible underlying neuronal changes are also proposed based on experimental models and in vitro studies. Recommendations for future studies are provided.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Freddy Jeanneteau, Onno C. Meijer, Marie-Pierre Moisan
Summary: There is a dissociation between the positive and negative effects of cortisol, a stress hormone, which poses a challenge in developing anti-inflammatory glucocorticoids for brain disorders. Recent advances in structural molecular dynamics allow for the engineering of glucocorticoids that can selectively target downstream signaling pathways, reducing the harmful effects of cortisol on the brain and behavior.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva M. G. Viho, Jan Kroon, Richard A. Feelders, Rene Houtman, Elisabeth S. R. van den Dungen, Alberto M. Pereira, Hazel J. Hunt, Leo J. Hofland, Onno C. Meijer
Summary: Glucocorticoid stress hormones are essential for physiology and exert numerous actions via binding to the glucocorticoid receptor (GR). Relacorilant is a selective GR antagonist being evaluated for the treatment of endogenous Cushing's syndrome. This study compared the effects of relacorilant and the non-selective antagonist mifepristone, showing that relacorilant has potent antagonistic effects on GR signaling and prevents anti-inflammatory effects of glucocorticoids.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Onno C. Meijer, Jacobus C. Buurstede, Eva M. G. Viho, Jorge Miguel Amaya, Anne-Sophie C. A. M. Koning, Merel Van Der Meulen, Lisa T. C. M. Van Weert, Susana N. Paul, Jan Kroon, Lisa L. Koorneef
Summary: Glucocorticoids modulate brain function through the regulation of gene transcription. However, linking gene expression to function is challenging due to the extensive and pleiotropic genomic responses. The transcriptional activity of MR and GR is influenced by cellular context and other active signaling pathways.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Philippe C. Habets, Konstantinos Kalafatakis, Oleh Dzyubachyk, Steven J. A. van der Werff, Arlin Keo, Jamini Thakrar, Ahmed Mahfouz, Alberto M. Pereira, Georgina M. Russell, Stafford L. Lightman, Onno C. Meijer
Summary: Recent evidence suggests that the ultradian cortisol pulsatility is crucial for normal emotional response in humans. This study investigates the anatomical and cell type signature of brain regions sensitive to a loss of ultradian rhythmicity in emotional processing. The findings highlight the importance of GABAergic function and specific genes in cortical brain areas for emotional processing response.
NEUROBIOLOGY OF STRESS
(2023)
Article
Health Care Sciences & Services
Fabian Wolters, Henriet van Middendorp, Omer Van den Bergh, Nienke R. Biermasz, Onno C. Meijer, Andrea W. M. Evers
Summary: This study aims to investigate the effects of scent conditioning during sleep on cortisol and the diurnal rhythm by utilizing the cortisol awakening response (CAR) as an unconditioned response. The results of this study can provide new insights into the effects of learning on cortisol and the diurnal rhythm, with potential clinical implications in the treatment of sleep and stress disorders.
JMIR RESEARCH PROTOCOLS
(2023)
Correction
Multidisciplinary Sciences
S. M. Bruijn, O. G. Meijer, P. J. Beek, J. H. van Dieen
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Biochemistry & Molecular Biology
Eva M. G. Viho, A. Mattijs Punt, Ben Distel, Rene Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Merel van der Meulen, Daphne Schaap, Djaina D. Satoer, Christiaan H. Vinkers, Elisabeth F. C. van Rossum, Wouter R. van Furth, Alberto M. Pereira, Onno C. Meijer, Olaf M. Dekkers
Summary: The proportion of neuropsychiatric adverse effects in patients using synthetic glucocorticoids is high, with depression and mania being the most significant associations. Awareness of possible psychiatric side effects is essential when starting glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Ophthalmology
Joost Brinks, Elon H. C. Van Dijk, Roula Tsonaka, Onno C. Meijer, Camiel J. F. Boon
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.