Article
Clinical Neurology
Dou Zhi, Yuna Guo, Liangliang He, Liqiang Yang
Summary: Performing percutaneous balloon compression (PBC) under conscious sedation of local anesthesia is a safe and effective treatment option for trigeminal neuralgia, providing immediate pain relief and improving the quality of life for patients without complications.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anesthesiology
Huidan Lin, Gang Cao, Guanjun Jin, Zhaodong Yang, Changshun Huang, Jinghan Shao, Ming Yao, Bing Huang
Summary: Percutaneous radiofrequency ablation of the trigeminal Gasserian ganglion via the foramen ovale remains a classic treatment for primary trigeminal neuralgia. However, a study conducted in Jiaxing, China showed that performing radiofrequency thermocoagulation through the foramen ovale for isolated mandibular branch trigeminal neuralgia can provide satisfactory results and improve the safety of treatment for trigeminal neuralgia.
Article
Neurosciences
K. C. Elina, Jaisan Islam, Soochong Kim, Hyong Kyu Kim, Young Seok Park
Summary: Inhibiting TG through optogenetics can reduce neuronal activity and pain behavior in TN rats, indicating its potential as a management approach for trigeminal neuralgia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yuying Huang, Hong Chen, Daozhong Jin, Shao-Rui Chen, Hui -Lin Pan
Summary: The spinal dorsal horn contains excitatory neurons expressing vesicular glutamate transporter-2 (VGluT2) and inhibitory neurons expressing vesicular GABA transporter (VGAT), which have different roles in nociceptive transmission. The study shows that presynaptic NMDARs amplify primary afferent input in neuropathic pain, while postsynaptic NMDARs play a dominant role in chronic pain caused by traumatic nerve injury. This reveals the divergent synaptic connectivity and functional significance of presynaptic and postsynaptic NMDARs in regulating cell type-specific nociceptive input in neuropathic pain with different etiologies.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Yasmine Belaidouni, Diabe Diabira, Jinwei Zhang, Jean-Charles Graziano, Francesca Bader, Aurelie Montheil, Clement Menuet, Gary A. Wayman, Jean-Luc Gaiarsa
Summary: The study found that in late symptomatic stages, there was no difference in the relative amount of KCC2 and NKCC1 in the hippocampus of Mecp2-null mice, but there was over-phosphorylation. There were also no differences in the inhibitory strength and reversal potential of GABA(A)-receptor-mediated responses in Mecp2-null CA3 pyramidal neurons compared to wild-type at any stages studied. These data indicate the presence of a functional chloride extrusion mechanism in Mecp2-null CA3 pyramidal neurons at symptomatic stages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Raviteja Bethamcharla, Hussam Abou-Al-Shaar, Stine Maarbjerg, Yue-Fang Chang, Caroline N. Gacka, Raymond F. Sekula Jr
Summary: In patients with specific subtypes of trigeminal neuralgia, percutaneous glycerol rhizolysis of the trigeminal ganglion provides short-term pain relief but has limited long-term effectiveness.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Physiology
Celine Caravagna, Alexis Casciato, Jacques-Olivier Coq, Sylvie Liabeuf, Cecile Brocard, Julie Peyronnet, Laurence Bodineau, Florence Cayetanot
Summary: Prenatal hypoxia disrupts the development of Cl- cotransporters KCC2 and NKCC1, leading to alterations in central respiratory drive. This disruption may have long-term effects on the functioning of GABA(A) and glycinergic systems.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Mengzhen Xu, Jin Liu, Hui Zhang, Ruiting Li, Junni Wei
Summary: This study investigated the clinical outcome of trigeminal ganglion electrical stimulation for the treatment of trigeminal postherpetic neuralgia. The results showed that this treatment effectively relieved pain, improved sleep quality, alleviated anxiety and depression symptoms, and reduced the use of analgesics.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Neurosciences
Cancan Yin, Wenhao Shen, Mingming Zhang, Lequan Wen, Ruoyu Huang, Mengyun Sun, Yun Gao, Wei Xiong
Summary: This study found that palmatine may alleviate mechanical facial pain in TN rats by modulating the expression of P2X7 receptor and affecting the production of proinflammatory cytokines.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Anesthesiology
Andre Marques Mansano, Thiago Nouer Frederico, Sergio Luiz de Mirando, Adonai Peixoto Cheim Junior
Summary: This study describes a treatment method for refractory trigeminal neuralgia by implanting a dorsal root ganglion (DRG) stimulation electrode. The patient experienced effective pain relief without electrode displacement during the follow-up period.
Article
Biochemistry & Molecular Biology
Eligija Damanskiene, Ingrida Balnyte, Angelija Valanciute, Marta Maria Alonso, Aidanas Preiksaitis, Donatas Stakisaitis
Summary: The study found that a 100 mu g dose of TMZ reduced invasion and blood vessels in PBT24 xenografts, with no impact on SF8628 tumors. TMZ had a significant effect on PCNA expression in both PBT24 and SF8628 tumors, but did not alter EZH2 expression. A 50 mu M dose of TMZ significantly increased RNA expression of the NKCC1 gene in both cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yan Tereshko, Mariarosaria Valente, Enrico Belgrado, Chiara Dalla Torre, Simone Dal Bello, Giovanni Merlino, Gian Luigi Gigli, Christian Lettieri
Summary: Botulinum toxin type A effectively reduces pain and paroxysm frequency in both type 1 and type 2 trigeminal neuralgia patients without significant differences. Facial asymmetry is the only adverse event.
Article
Anesthesiology
Chang-Ming Wang, Zhan-Ying Guan, Ping Zhao, Hai-Tao Huang, Jing Zhang, Yan-Feng Li, Yi Ma
Summary: Atropine pretreatment can effectively reduce the sudden decrease in heart rate during percutaneous compression of the trigeminal ganglion for trigeminal neuralgia.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Anesthesiology
Zhangtian Xia, Ying Ma, Zhiqiang Zhang, Ruxiang Wang, Ming Yao
Summary: Both RFT and PBC were effective in relieving primary multibranch TN, but patients in the PBC group had a lower recurrence-free survival rate, fewer complications, and a better safety profile. Further follow-up studies with a larger patient sample at multiple locations should be conducted.
Review
Geriatrics & Gerontology
Pavel A. Kipnis, Shilpa D. Kadam
Summary: Epilepsy is a complex disorder associated with various neurological conditions, causing ongoing seizures for millions of patients worldwide despite optimal treatment. Refractory epilepsy poses a challenge for effective management, especially in cases of early-life seizures like those caused by perinatal hypoxic ischemic encephalopathy.
Article
Neurosciences
Hideki Miwa, Ken Kobayashi, Shinobu Hirai, Mitsuhiko Yamada, Masahiko Watanabe, Haruo Okado, Yuchio Yanagawa
Summary: The study reveals the critical role of GABA in establishing connections between basket cells and Purkinje cells in the cerebellum, and its association with motor coordination in mice.
Article
Cell Biology
Anussara Kamnate, Juthathip Sirisin, Masahiko Watanabe, Hisatake Kondo, Wiphawi Hipkaeo, Surang Chomphoo
Summary: The study found that cannabinoid receptor type 1 (CB1) is localized on mitochondrial membranes in ovarian interstitial gland cells of adult mice, potentially modulating the synthetic process of progesterone through CB1.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Neurosciences
Ken Matsuura, Shizuka Kobayashi, Kohtarou Konno, Miwako Yamasaki, Takahiro Horiuchi, Takao Senda, Tomoatsu Hayashi, Kiyotoshi Satoh, Fumiko Arima-Yoshida, Kei Iwasaki, Lumi Negishi, Naomi Yasui-Shimizu, Kazuyoshi Kohu, Shigenori Kawahara, Yutaka Kirino, Tsutomu Nakamura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe, Tetsu Akiyama
Summary: The study reveals that SIPA1L1 is mainly localized to submembranous regions in neurons, and its deficiency may be associated with neuropsychiatric disorders related to dysregulated GPCR signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Czarina Ramos, Stefano Lutzu, Miwako Yamasaki, Yuchio Yanagawa, Kenji Sakimura, Susumu Tomita, Masahiko Watanabe, Pablo E. Castillo
Summary: This study provides the first direct evidence of functional extrasynaptic kainate receptors (KARs) on mossy cells (MCs) in the hippocampus. These KARs are mainly located extrasynaptically and play a critical role in the activity of MCs. Increases in ambient glutamate can activate the KARs on MCs.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell & Tissue Engineering
Yuka Kasahara, Daiki Masukawa, Kenta Kobayashi, Miwako Yamasaki, Masahiko Watanabe, Yoshio Goshima
Summary: Neurogenesis in the hippocampus is regulated by L-DOPA and its receptor GPR143 independently of dopamine. Low concentrations of L-DOPA promote neurogenesis, and its effect is abolished in GPR143 gene-deficient mice. Decreased neurogenesis and exacerbated depression-like behavior are observed in adult GPR143 gene-deficient mice, but can be attenuated by replenishment of GPR143 in the hippocampus.
Article
Biochemistry & Molecular Biology
Takafumi Kawai, Hirotaka Narita, Kohtarou Konno, Sharmin Akter, Rizki Tsari Andriani, Hirohide Iwasaki, Shoji Nishikawa, Norihiko Yokoi, Yuko Fukata, Masaki Fukata, Pattama Wiriyasermkul, Pornparn Kongpracha, Shushi Nagamori, Keizo Takao, Tsuyoshi Miyakawa, Manabu Abe, Kenji Sakimura, Masahiko Watanabe, Atsushi Nakagawa, Yasushi Okamura
Summary: Voltage-sensing protein TMEM266 has a unique voltage-sensing mechanism and interacts with specific splice variants. The coiled-coil region plays a significant role in forming homodimers, and the cytosolic region at the C-terminal of TMEM266 may bind to various targets. TMEM266 deficiency is associated with behavioral abnormalities.
BIOCHEMICAL JOURNAL
(2022)
Article
Neurosciences
Mayuko Hashimoto, Masaki Fujimoto, Kohtarou Konno, Ming-Liang Lee, Yui Yamada, Koya Yamashita, Chitoku Toda, Michio Tomura, Masahiko Watanabe, Osamu Inanami, Hiroshi Kitamura
Summary: This study reveals that hypothalamic USP2 regulates blood glucose levels through the ROS-AMPK-sympathetic nerve axis. Inhibition of USP2 leads to mitochondrial dysfunction and AMPK phosphorylation, resulting in increased blood glucose and norepinephrine levels.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Eriko Miura, Masahiko Watanabe
Summary: This study investigated the expression of calcineurin (CN) in the mouse brain and found that CNA alpha, CNA, and CNB1 were predominantly expressed. The protein localization experiments revealed that CNB1 and CNA were co-distributed in various cerebellar neurons and glia, while CNA alpha was exclusive to granule cell elements. These findings provide anatomical evidence for the regulatory roles of CN in long-term depression and transmitter release function at synapses.
NEUROSCIENCE RESEARCH
(2022)
Article
Cell Biology
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi
Summary: This study found that the presynaptic cell adhesion molecules NRXNs play a crucial role in the survival of cerebellar granule cells and synapse formation. They not only maintain cell survival, but also promote the formation of presynaptic protein clusters and the secretion of neurotrophic factors.
Article
Biochemistry & Molecular Biology
Miho Watanabe, Takashi Ito, Atsuo Fukuda
Summary: Research shows that taurine plays important roles in anxiety-like behavior, hearing, muscular endurance, and maintenance of body weight in mice.
Article
Biology
Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai, Nils Brose
Summary: The study reveals the involvement of Nrxn genes in the modulation of 5-HT transmission and behavior, suggesting a potential link between Nrxn mutations and ASD.
Article
Biochemistry & Molecular Biology
Yashuang Ping, Kenji Ohata, Kenji Kikushima, Takumi Sakamoto, Ariful Islam, Lili Xu, Hengsen Zhang, Bin Chen, Jing Yan, Fumihiro Eto, Chiho Nakane, Keizo Takao, Tsuyoshi Miyakawa, Katsuya Kabashima, Miho Watanabe, Tomoaki Kahyo, Ikuko Yao, Atsuo Fukuda, Koji Ikegami, Yoshiyuki Konishi, Mitsutoshi Setou
Summary: As an important neurotransmitter, glutamate functions in the majority of excitatory synapses in the human brain. The metabolic pathway of glutamate is complex, and the exact role of glutamate pool in neurons remains unclear. This study utilized Ttll1 and Ttll7 knockout mice to investigate the impact of tubulin polyglutamylation on neuronal behavior. Matrix-assisted laser desorption/ionization (MALDI) Imaging mass spectrometry (IMS) analysis revealed increased levels of glutamate in the brains of knockout mice, suggesting that tubulin polyglutamylation by TTLLs acts as a reservoir of glutamate in neurons and modulates other glutamate-related amino acids.
Article
Biology
Kieran A. Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C. Dickie, Andrew H. Cooper, Andrew M. Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I. Hughes, Gregory A. Weir, John S. Riddell, Andrew J. Todd
Summary: This study investigates the role of interneurons that continue to express neuropeptide Y (NPY-INs) in the adult mouse spinal cord. The findings suggest that activation of NPY-INs reduces acute pain and pruritogen-evoked itch, while silencing them causes exaggerated itch responses. Silencing another population of inhibitory interneurons also increases itch, but to a lesser extent.
Article
Multidisciplinary Sciences
Kohtarou Konno, Miwako Yamasaki, Taisuke Miyazaki, Masahiko Watanabe
Summary: The gold-standard fixative for immunohistochemistry is 4% formaldehyde; however, it limits antibody access to buried target molecules. To solve this problem, we used glyoxal as a fixative, which greatly improved antibody penetration, uncovering signals for buried molecules. Glyoxal also enhanced immunosignals of most other molecules, including the controversial synaptic adhesion molecule Neuroligin 1.
Article
Multidisciplinary Sciences
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Summary: This study examined the role of dopamine D-5 receptors in impulse control and found that they are not necessary for impulse control. The results highlight the importance of time series analysis and detailed analysis of the learning process in understanding the behavioral functions of D-5 receptors.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
