Article
Neurosciences
Annalise N. Binette, Jianfeng Liu, Hugo Bayer, Kennedi L. Crayton, Laila Melissari, Samantha O. Sweck, Stephen Maren
Summary: Stress has a significant impact on fear extinction and affects the activity of PV interneurons in the mPFC. PV interneurons regulate extinction learning under stress in a sex-dependent manner, and this effect is mediated by amygdaloprefrontal projections.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Christine Stubbendorff, Carl W. Stevenson
Summary: Research has shown that dopamine plays a crucial role in regulating various contextual fear processes, although the related neurochemical mechanisms are still not fully understood. Understanding how dopamine regulates contextual fear can provide novel insights into the neurochemical modulation of neural circuit function underlying memory processing.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Rebecca A. Mount, Sudiksha Sridhar, Kyle R. Hansen, Ali Mohammed, Moona Abdulkerim, Robb Kessel, Bobak Nazer, Howard J. Gritton, Xue Han
Summary: The study found that different populations of hippocampal CA1 neurons play different roles in trace conditioning and extinction learning, with unique connectivity patterns. Additionally, differences in CA1 network connectivity were observed between conditioning and extinction, despite overall connectivity density remaining constant.
Article
Neurosciences
Han-Qing Pan, Xiao-Xuan Liu, Ye He, Jin Zhou, Cai-Zhi Liao, Wen-Jie You, Si-Ying Jiang, Xia Qin, Wen-Bing Chen, Er-Kang Fei, Wen-Hua Zhang, Bing-Xing Pan
Summary: This study reveals the unconventional and permissive role of extrasynaptic GABA(A) receptors in fear extinction through a route relying on nonsynaptic plasticity. The expression and function of GABA(A)(δ)R in the medial prefrontal cortex (mPFC) are positively correlated with fear extinction, and knockdown of GABA(A)(δ)R in the mPFC impairs fear extinction. Mechanistically, GABA(A)(δ)R enables the extinction-evoked plastic regulation of neuronal excitability in mPFC projection neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Ning Xu, Lian Geng, Xianxia Yan, Aijun Niu, Hui Yu, Bo Su
Summary: The Wnt signaling pathway is involved in adult extinction, and manipulating this pathway can facilitate or impair the extinction process. Inhibition of the pathway using Dkk1 accelerates extinction, while enhancement of the pathway impairs extinction. These findings provide insights into the role of the Wnt signaling pathway in memory extinction and suggest its potential therapeutic implications for psychiatric disorders.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Weronika Szadzinska, Konrad Danielewski, Kacper Kondrakiewicz, Karolina Andraka, Evgeni Nikolaev, Marta Mikosz, Ewelina Knapska
Summary: Fear extinction training gradually changes the vHIP-PL connectivity, allowing for fear suppression. In the absence of fear suppression from the vHIP, signals from the BL play a dominant role, resulting in heightened fear levels.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jessica A. Babb, Agnieszka Zuberer, Stephen Heinrichs, Kendra K. Rumbika, Lauren Alfiler, Gabrielle A. Lakis, Kimberly A. Leite-Morris, Gary B. Kaplan
Summary: Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) frequently co-occur in both military and civilian populations. In a mouse model of mTBI, fear learning and neural systems involved in fear extinction were examined. LFP 1.7 mice demonstrated within-session aberrant fear extinction and alterations in brain morphology and dendritic plasticity.
BRAIN RESEARCH BULLETIN
(2023)
Article
Multidisciplinary Sciences
J. Courtin, Y. Bitterman, S. Muller, J. Hinz, K. M. Hagihara, C. Muller, A. Luthi
Summary: This study investigates the neuronal mechanisms in the basolateral amygdala that control behavior motivation. The findings suggest that distinct neuronal activity patterns play a role in encoding and maintaining specific motivational states necessary for adaptive behavior towards prospective rewards.
Article
Behavioral Sciences
Wiktor Bilecki, Joachim Latusz, Kinga Gawlinska, Magdalena Chmelova, Marzena Mackowiak
Summary: The study showed that short-term adolescent social isolation did not significantly affect fear memory and anxiety in adult rats, but altered protein levels related to synapse maturation and energy transfer. Additionally, the impact of adolescent social isolation on normally developing brains was different than those with a history of MAM administration.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Oncology
Yihua Chen, Nengyuan Hu, Jianming Yang, Tianming Gao
Summary: Pathological anxiety, a difficult neuropsychiatric disease to treat, has been linked to structural changes in the prefrontal cortex (PFC) and functional changes in PFC communication with other brain structures. Therapies that affect PFC activity can reverse anxiety-related circuit abnormalities. Rodent models and advanced techniques have provided insights into the neural circuits underlying anxiety and fear, aiding the development of therapies for pathological anxiety.
FRONTIERS OF MEDICINE
(2022)
Review
Clinical Neurology
Yan Yan, Ailikemu Aierken, Chunjian Wang, Wei Jin, Zhenzhen Quan, Zhe Wang, Hong Qing, Junjun Ni, Juan Zhao
Summary: This review discusses the use of optogenetics and in vivo imaging techniques to study the neural circuits underlying the extinction and discrimination of fear memory. It also highlights the challenge of translating these findings into effective therapeutic treatments for PTSD.
Article
Cell Biology
Rongzhen Yan, Tianyu Wang, Xiaoyan Ma, Xinyang Zhang, Rui Zheng, Qiang Zhou
Summary: The probabilistic association between cause and effect plays a crucial role in memory formation, especially in psychiatric diseases. Research shows that 50% association between conditioned and unconditioned stimuli can reduce fear responses and neural spiking activity in the dorsomedial prefrontal cortex. The formation of probabilistic memory involves enhanced inhibition from PV-neurons, increased synaptic inputs, and activation of the ventral hippocampus to detect mismatch during conditioning. Stress can impair the formation of probabilistic memory by affecting PV-neuronal plasticity, while prior stress to memory retrieval can revert enhanced PV-neuron activity.
Article
Clinical Neurology
Andries Van Schuerbeek, Marie-Anne Vanderhasselt, Chris Baeken, Anouk Pierre, Ilse Smolders, Vincent Van Waes, Dimitri De Bundel
Summary: This study explored the effects of repeated anodal tDCS over the prefrontal cortex on fear extinction in mice, finding that tDCS significantly lowered freezing during extinction acquisition with high fear conditioning intensity. Combining tDCS with a strong extinction protocol also improved early extinction recall, and tDCS reduced generalized fear induced by contextual cues with high conditioning intensity and limited extinction training.
Review
Medicine, Research & Experimental
Yongmin Sung, Bong-Kiun Kaang
Summary: Fear memory recruits multiple brain regions and causes subcellular events throughout the brain. Different regions within the medial prefrontal cortex play distinct roles in different fear memory states. Recent studies have shown that memory trace cells in these regions may contribute preferentially to processing specific fear memory. Understanding the molecular, synaptic, and cellular events in the medial prefrontal cortex during different memory stages is important for comprehending fear memory.
EXPERIMENTAL NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Limeng Huang, Yiwen Chen, Sen Jin, Li Lin, Shumin Duan, Ke Si, Wei Gong, J. Julius Zhu
Summary: The study reveals that the output neurons of the amygdala receive diverse inputs with different weights and contextual representations. Additionally, the four major output neuronal groups receive inputs from virtually identical origins with similar input weights, indicating an organized input-output neuronal circuit in the amygdala.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jonathan P. Fadok, Sabine Krabbe, Milica Markovic, Julien Courtin, Chun Xu, Lema Massi, Paolo Botta, Kristine Bylund, Christian Mueller, Aleksandar Kovacevic, Philip Tovote, Andreas Luthi
Article
Neurosciences
Robert R. Rozeske, Cyril Herry
CURRENT OPINION IN NEUROBIOLOGY
(2018)
Article
Medicine, Research & Experimental
Marc Scherlinger, Thomas C. M. Bienvenu, Max Piffoux, Perrine Seguin
M S-MEDECINE SCIENCES
(2018)
Article
Neurosciences
Robert R. Rozeske, Daniel Jercog, Nikolaos Karalis, Fabrice Chaudun, Suzana Khoder, Delphine Girard, Nanci Winke, Cyril Herry
Article
Neurosciences
Sabine Krabbe, Enrica Paradiso, Simon D'Aquin, Yael Bitterman, Julien Courtin, Chun Xu, Keisuke Yonehara, Milica Markovic, Christian Mueller, Tobias Eichlisberger, Jan Grundemann, Francesco Ferraguti, Andreas Luthi
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Sophie Bagur, Julie M. Lefort, Marie M. Lacroix, Gaetan de Lavilleon, Cyril Herry, Mathilde Chouvaeff, Clara Billand, Helene Geoffroy, Karim Benchenane
Summary: Brain-body interactions play an important role in emotions, with the olfactory bulb transmitting 4 Hz breathing rhythm to the prefrontal cortex to regulate freezing maintenance during fear-related behavior in mice.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Daniel Jercog, Nanci Winke, Kibong Sung, Mario Martin Fernandez, Claire Francioni, Domitille Rajot, Julien Courtin, Fabrice Chaudun, Pablo E. Jercog, Stephane Valerio, Cyril Herry
Summary: The study found that threat representations and avoidance behavior initiation are dynamically encoded in the overall population activity of dmPFC neurons in mice. While dmPFC population activity at stimulus onset encodes sustained threat representations driven by the amygdala, it does not predict action outcome. Transient dmPFC population activity before the initiation of action reliably predicts avoided from non-avoided trials, revealing the dynamic process of information linking threats with defensive actions within prefrontal networks.
Review
Neurosciences
Thomas C. M. Bienvenu, Cyril Dejean, Daniel Jercog, Bruno Aouizerate, Mael Lemoine, Cyril Herry
Summary: The translational research on PTSD has seen limited improvements in clinical practice, primarily due to the ill-defined variety of fear conditioning-based models. This article takes a historical and conceptual approach to address these issues and suggests future research directions involving transdisciplinary collaboration.
Article
Multidisciplinary Sciences
Nigel Whittle, Jonathan Fadok, Kathryn P. MacPherson, Robin Nguyen, Paolo Botta, Steffen B. E. Wolff, Christian Mueller, Cyril Herry, Philip Tovote, Andrew Holmes, Nicolas Singewald, Andreas Luethi, Stephane Ciocchi
Summary: Fear extinction involves the reduction of defensive responses following repeated exposure to fear-related stimuli without harm, with recent studies indicating the involvement of central amygdala inhibitory microcircuits in this process. These microcircuits produce reversible, stimulus- and context-specific changes in neuronal responses, absent in cases of deficient extinction, and impair fear extinction when PKC delta neurons are selectively silenced.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
J. Courtin, Y. Bitterman, S. Muller, J. Hinz, K. M. Hagihara, C. Muller, A. Luthi
Summary: This study investigates the neuronal mechanisms in the basolateral amygdala that control behavior motivation. The findings suggest that distinct neuronal activity patterns play a role in encoding and maintaining specific motivational states necessary for adaptive behavior towards prospective rewards.
Review
Psychiatry
Gay Florian, Allison Singier, Bruno Aouizerate, Francesco Salvo, Thomas C. M. Bienvenu
Summary: The study suggests that neuromodulation therapies such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) may be effective in reducing anxiety symptoms. However, most studies have a high risk of bias.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Lema Massi, Kenta M. Hagihara, Julien Courtin, Julian Hinz, Christian Mueller, Maria Sol Fustinana, Chun Xu, Nikolaos Karalis, Andreas Luthi
Summary: Memory encoding and retrieval rely on specific interactions across multiple brain areas, but the anatomical and functional specificity of neuronal circuit organization underlying information transfer across these areas is still unclear.
Article
Neurosciences
Mario Martin-Fernandez, Ana Paula Menegolla, Guillem Lopez-Fernandez, Nanci Winke, Daniel Jercog, Ha-Rang Kim, Delphine Girard, Cyril Dejean, Cyril Herry
Summary: Behavioral adaptation requires encoding both the global representation of danger and the specific threatening encounters. The prefrontal cortex plays a crucial role in controlling threat-related behaviors.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Juliette Vivien, Anass El Azraoui, Cloe Lheraux, Frederic Lanore, Bruno Aouizerate, Cyril Herry, Yann Humeau, Thomas C. M. Bienvenu
Summary: The imbalance between excitation and inhibition in the cerebral cortex is a key theory in the pathophysiology of neuropsychiatric disorders. Varieties of highly specialized GABAergic interneuron types, especially axo-axonic cells, play a crucial role in regulating cortical inhibition and organizing neural network activities. While alterations of axo-axonic cells have been implicated in epilepsy, schizophrenia, and autism spectrum disorder, the evidence for their involvement in disease remains limited to narrative reviews. This systematic review highlights the need for additional research to better understand the role of axo-axonic cells in neuropsychiatric disorders and their impact on cortical dysregulation and pathological states.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biology
Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stephane Valerio, Marie Oule, Laura Pantaleon, Valerie Lamothe, Mylene Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Aline Marighetto
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.