Review
Cell & Tissue Engineering
Sijia Li, Lihua Dong, Zhenyu Pan, Guozi Yang
Summary: Background: Glioblastoma, a common and aggressive adult brain tumor, has a high recurrence rate and low survival rate despite conventional treatment. Accumulating evidence suggests that the subventricular zone, which contains neural stem cells and glioma stem cells, plays a crucial role in recurrence and treatment resistance.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Charles P. Couturier, Javad Nadaf, Zhaorong Li, Salma Baig, Gabriele Riva, Phuong Le, Daan J. Kloosterman, Jean Monlong, Andriniaina Nkili Meyong, Redouane Allache, Theresa Degenhard, Mariam Al-Rashid, Marie-Christine Guiot, Guillaume Bourque, Jiannis Ragoussis, Leila Akkari, Francisco J. Quintana, Kevin Petrecca
Summary: Using single-cell RNA sequencing, researchers found that there are multiple neural lineages in new and recurrent glioblastoma, with an enrichment of cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences. They also discovered that neural stem cells (NSCs) in the subventricular zone (SVZ) of glioblastoma patients harbored glioblastoma chromosomal anomalies and were likely the cells of origin. Additionally, they observed that radiotherapy induced similar gene signatures in mesenchymal cancer cells and TME reactive astrocytes in a myeloid-dependent manner.
Article
Immunology
Fernando Janczur Velloso, Anna Wadhwa, Ekta Kumari, Ioana Carcea, Ozlem Gunal, Steven W. Levison
Summary: Epidemiological studies have shown that infections during pregnancy increase the risk of psychiatric disorders in offspring, and interleukin-6 (IL-6) has been implicated as a causal agent. This study aimed to investigate whether elevating IL-6 during a specific period of neural development would affect neurogenesis and lead to behavioral changes associated with neurodevelopmental disorders. The results demonstrate that transient increase in IL-6 during postnatal days 3-6 reduced neurogenesis and astrogliogenesis, and affected behavioral traits in adult male mice.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Oncology
Jee Ye Kahng, Byung-Hee Kang, Soon-Tae Lee, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Jae-Kyung Won, Sung-Hye Park, Jaeman Son, Joo Ho Lee
Summary: This study investigated the relationship between neural stem cells (NSCs) in the subventricular zone (SVZ) and glioblastoma (GBM), as well as the impact of radiotherapeutic strategies. The results showed that GBM patients without SVZ involvement had longer progression-free survival, while patients with GBM in contact with NSCs showed better prognosis after NSC irradiation. This study is of great significance for understanding the origin and treatment of GBM.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Cell Biology
Annadurai Anandhan, Konner R. Kirwan, Mandi J. Corenblum, Lalitha Madhavan
Summary: Increasing NRF2 expression in NSPCs can improve behavioral function and NSPC activity in aging rats, but this effect is only significant if done before a critical period in middle age (11 months) and not after (20 months).
Review
Cell Biology
Milena Tucic, Vera Stamenkovic, Pavle Andjus
Summary: TnC plays a crucial role in regulating cell proliferation and migration during adult neurogenesis, with implications for regenerative therapies. Understanding ECM signaling in the CNS niche is essential for potential therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Isacco Battistini, Valentina Mastrorilli, Vittoria Nicolis di Robilant, Daniele Saraulli, Sara Marinelli, Stefano Farioli Vecchioli
Summary: Traumatic brain injury (TBI) is a common cause of death and disability worldwide, with no effective treatments available. Recent studies have suggested that adult neurogenesis may be a new approach to counteract post-traumatic neurodegeneration. It has been shown that long-term running can enhance adult neurogenesis and promote neuroregeneration and functional recovery after injury. These findings suggest that running could be a promising method to increase neural stem cells and improve endogenous neuroregenerative responses following brain trauma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Valentina Murtaj, Erica Butti, Gianvito Martino, Paola Panina-Bordignon
Summary: In the past twenty years, neural stem cells (NSCs) have been extensively studied for their therapeutic potential. Most of the research focused on cells derived from pluripotent stem cells of rodents or humans and their potential in regenerative medicine. The emergence of high-throughput omics technologies in the past decade has provided a powerful tool to investigate the molecular mechanisms and heterogeneity of endogenous NSCs. The transition from bulk studies to single cell approaches has revealed complex system phenotypes at various levels. This article discusses the literature enriched in the omics era, exploring the nature, function, and neurogenesis process of endogenous NSCs. Overall, omics studies of endogenous NSCs contribute to a better understanding of their role in neurodevelopment in both healthy and perturbed environments.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Yanlu Wang, Chun Li, Xi Gong, Xiao Chen, Chenming Liu, Hailei Zhang, Siguang Li, Yuping Luo
Summary: Through single-cell transcriptomic analysis of adult mouse brain cells, we discovered that single-cell RNA-Seq can uncover rare splicing isoforms and the coexistence of multiple isoforms from the same gene in a single cell. Additionally, there is significant heterogeneity in splicing variants among different cell types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katja Baur, Yomn Abdullah, Claudia Mandl, Gabriele Hoelzl-Wenig, Yan Shi, Udo Edelkraut, Priti Khatri, Anna M. Hagenston, Martin Irmler, Johannes Beckers, Francesca Ciccolini
Summary: According to the current consensus, murine neural stem cells generate differentiated progenitors either through rare asymmetric divisions or by relocating to the basal side of the ventricular-subventricular zone. However, this study finds that adult-born olfactory bulb interneurons largely derive from a different type of neural stem cells residing in the basal V-SVZ. These basal neural stem cells differ from apical neural stem cells in terms of Nestin expression, primary cilia extension, cell division frequency, and activation of Notch-related genes.
Review
Neurosciences
Arrin C. Brooks, Brandon J. Henderson
Summary: Nicotine may have neuroprotective effects on neural stem cells and neural precursor cells, but nicotine withdrawal could affect cognitive function and hippocampal neurogenesis.
Article
Pharmacology & Pharmacy
Diogo M. Lourenco, Rita Soares, Sonia Sa-Santos, Joana M. Mateus, Rui S. Rodrigues, Joao B. Moreira, Sandra H. Vaz, Ana M. Sebastia, Susana Sola, Sara Xapelli
Summary: This study reveals the role of non-psychoactive cannabinoid CBDV in postnatal neurogenesis in the subventricular zone (SVZ) through TRPV1 modulation. CBDV promotes cell survival, proliferation, and neuronal differentiation via TRPV1, while inhibiting oligodendrocyte differentiation and maturation. These findings provide a new perspective for future neural stem cell studies and repair strategies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Catarina Serra-Almeida, Claudia Saraiva, Marta Esteves, Raquel Ferreira, Tiago Santos, Ana Clara Cristovao, Liliana Bernardino
Summary: CtBPs are expressed in various cell types within the SVZ and play a role in regulating the growth of different types of neural cells. Modulating CtBPs can impact the proliferation and maturation of neurons and glial cells, offering potential applications in brain regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sara Mancinelli, Michela Vitiello, Maria Donnini, Francesca Mantile, Giuseppe Palma, Antonio Luciano, Claudio Arra, Laura Cerchia, Giovanna Lucia Liguori, Monica Fedele
Summary: The proper regulation of neurogenesis is crucial for brain development and function. Patz1 plays a key role in maintaining neural stem cells and progenitor cells (NS/PCs), with its absence leading to a reduction in NS/PC numbers and self-renewal capability. This highlights the importance of Patz1 in brain development and suggests potential implications for neurodegenerative disorders and glial brain tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Luana C. Soares, Osama Al-Dalahmah, James Hillis, Christopher C. Young, Isaiah Asbed, Masanori Sakaguchi, Eric O'Neill, Francis G. Szele
Summary: Galectin-3 is a multifunctional protein that drives inflammation in disease, exacerbating conditions like Alzheimer's. It regulates various pathways, including bone morphogenetic protein signaling and Wnt signaling, and plays a role in both pathology and the regulation of neurogenesis in the healthy brain. It can be targeted pharmacologically and has potential therapeutic implications for diseases involving brain inflammation.
Article
Behavioral Sciences
Tania Campos-Ordonez, Emmanuel Alcala, Nereida Ibarra-Castaneda, Jonathan Buritica, Oscar Gonzalez-Perez
Summary: Recreational abuse of solvents persists despite the availability of safe alternatives like cyclohexane (CHX). Inhalation of CHX affects brain functioning, leading to hyperactivity and reduced ataxia, sedation, and seizures. Withdrawal from CHX results in decreased grooming and rearing behaviors, stereotypic circling behavior, and increased locomotion. Histological analysis shows changes in c-Fos expression in various brain regions, indicating long-lasting effects of CHX on the brain.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Anatomy & Morphology
M. P. Madrigal, B. Ballester-Lurbe, O. Gomez, J. A. Moreno-Bravo, E. Puelles, S. Jurado, J. M. Garcia-Verdugo, I. Perez-Roger, Jose Terrado
Summary: Rnd3 is a protein involved in oligodendrocyte maturation, with potential roles in the development of the central nervous system and demyelinating diseases. Its absence leads to hypomyelination, reduced oligodendrocyte numbers, and thinner myelin sheaths in mice, indicating its crucial role in myelination.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Paula Garcia-Belda, Helena Prima-Garcia, Alicia Aliena-Valero, Maria Castello-Ruiz, Maria Jose Ulloa-Navas, Amadeo Ten-Esteve, Luis Marti-Bonmati, Juan B. Salom, Jose Manuel Garcia-Verdugo, Sara Gil-Perotin
Summary: Mesenchymal stem cell therapy after stroke shows promise, but the viability of cells may be compromised.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Neurosciences
Veronica Lopez-Virgen, Oscar Gonzalez-Morales, Oscar Gonzalez-Perez
Summary: In the postnatal brain, there are three regions with high mitotic activity, known as neurogenic niches, which provide a favorable microenvironment for neural stem cell proliferation and differentiation. These cells have the ability to self-renew and generate intermediate precursors that will differentiate into various types of brain cells. The ventricular-subventricular zone (V-SVZ) of the lateral ventricles, the subgranular zone (SGZ) of the dentate gyrus, and the subcallosal zone (SCZ) are the most well-studied neurogenic niches. They have potential therapeutic applications in neural regeneration and neurodegenerative disorders.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Raquel Baviera-Munoz, Lidon Carretero-Vilarroig, Nuria Muelas, Rafael Sivera, Pablo Sopena-Novales, Begona Martinez-Sanchis, Isabel Sastre-Bataller, Marina Campins-Romeu, Irene Martinez-Torres, Jose Manuel Garcia-Verdugo, Jose M. Millan, Teresa Jaijo, Elena Aller, Luis Bataller
Summary: SCA36 is a common cause of hereditary ataxia in Eastern Spain, with a strong founder effect. Its clinical features include hypoacusis, pyramidal signs, lingual fasciculations/atrophy, dystonia, and parkinsonism. SCA36 analysis should be considered as a priority in the study of hereditary ataxia, especially in patients with late onset.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, Research & Experimental
Laura Martinez-Ruiz, Javier Florido, Cesar Rodriguez-Santana, Alba Lopez-Rodrigueza, Ana Guerra-Librero, Beatriz I. Fernandez-Gild, Patricia Garcia-Tarraga, Jose Manuel Garcia-Verdugo, Felix Oppel, Holger Sudhoff, David Sanchez-Porras, Amadeo Ten-Steve, Jose Fernandez-Martinez, Pilar Gonzalez-Garcia, Iryna Rusanova, Dario Acuna-Castroviejoa, Victor Carriel, Germaine Escames
Summary: The study investigates the mechanisms for increasing melatonin bioavailability in head and neck squamous cell carcinoma (HNSCC) and its potential as an adjuvant to improve cisplatin therapeutic efficacy. The results demonstrate that intratumoral injection of melatonin significantly inhibits tumor progression and enhances the effects of cisplatin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Alba Ortega-Gasco, Antoni Parcerisas, Keiko Hino, Vicente Herranz-Perez, Fausto Ulloa, Alba Elias-Tersa, Miquel Bosch, Jose Manuel Garcia-Verdugo, Sergi Simo, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2 plays a significant role in the regulation of RGPs during adult neurogenesis and corticogenesis.
Article
Neurosciences
Tania Campos-Ordonez, Susana Gonzalez-Granero, Marielena Eudave-Patino, Jonathan Buritica, Vicente Herranz-Perez, Jose M. Garcia-Verdugo, Oscar Gonzalez-Perez
Summary: This study investigates the effects of normal pressure hydrocephalus (NPH) on the morphology and functioning of the corpus callosum (CC). Results showed that NPH led to a reduction in CC width, myelin abnormalities, degenerative changes in white matter (WM), and an increase in hyperdense axons. Additionally, NPH caused a decrease in myelin-related proteins and impaired oligodendrocyte precursor cell (OPC) proliferation. Importantly, these abnormalities persisted even after hydrocephalus treatment, suggesting irreversible changes in the CC white matter.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alejandra Suarez-Carrillo, Monica Alvarez-Cordoba, Ana Romero-Gonzalez, Marta Talaveron-Rey, Suleva Povea-Cabello, Paula Cilleros-Holgado, Rocio Pinero-Perez, Diana Reche-Lopez, David Gomez-Fernandez, Jose Manuel Romero-Dominguez, Manuel Munuera-Cabeza, Antonio Diaz, Susana Gonzalez-Granero, Jose Manuel Garcia-Verdugo, Jose A. Sanchez-Alcazar
Summary: In this study, autophagic defects and secondary pathological consequences were demonstrated in cellular models derived from patients with WDR45 mutations in beta-propeller protein-associated neurodegeneration (BPAN). The study showed that WDR45 mutations impaired autophagy, iron metabolism, and cell bioenergetics. While antioxidants partially improved cellular physiopathology, autophagy and cell bioenergetics remained affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrian-Silla, Susana Gonzalez-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric J. Huang, Ethan A. Winkler, Mercedes F. Paredes, Rothem Kovner, Nenad Sestan, Alex A. Pollen, Pengyuan Liu, Jingjing Li, Xianhua Piao, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Zhandong Liu, Arnold R. Kriegstein
Summary: This study generates a cross-species proteomic map of synapse development in the neocortex of human, macaque and mouse. The results show that human PSDs mature slower than other species and contain higher levels of Rho guanine nucleotide exchange factors in the perinatal period. In addition, PSD proteins can be divided into four modules that exert stage- and cell-type-specific functions. The findings provide insights into the molecular basis and evolutionary changes of synapse maturation.
Article
Cell Biology
Kimberly K. Hoi, Wenlong Xia, Ming Ming Wei, Maria Jose Ulloa Navas, Jose-Manuel Garcia Verdugo, Maxence Nachury, Jeremy F. Reiter, Stephen P. J. Fancy
Summary: Remyelination after white matter injury (WMI) often fails in diseases like multiple sclerosis due to improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions. Primary cilia play a crucial role in the OPC response to WMI through the GPCR/cAMP/CREB signaling axis.
Article
Clinical Neurology
Alma Y. Galvez-Contreras, Jorge Guzman-Muniz, Norma A. Moy-Lopez, Oscar Gonzalez-Perez
Summary: Research in neuroscience and psychology in Latin America has shown sustained growth over the past few years, with the majority of scientific productivity concentrated in Brazil, Mexico, Argentina, Chile, and Colombia.
REVISTA MEXICANA DE NEUROCIENCIA
(2022)
Article
Multidisciplinary Sciences
Vicente Herranz-Perez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel Garcia-Verdugo, Shinya Ohata
Summary: This study found the peak expression of ZFTA in mouse embryos and observed that ZFTA may be regulated by ciliary transcription factors. However, ZFTA is not essential for the development or flow of supratentorial ependymoma.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
