Article
Clinical Neurology
Anna M. De Kort, H. Bea Kuiperij, Iris Kersten, Alexandra A. M. Versleijen, Floris H. B. M. Schreuder, William E. Van Nostrand, Steven M. Greenberg, Catharina J. M. Klijn, Jurgen A. H. R. Claassen, Marcel M. Verbeek
Summary: The study found that CSF PDGFR beta levels are associated with Alzheimer's disease, but are not suitable as a biomarker for cerebral amyloid angiopathy or the clinical syndrome of amnestic mild cognitive impairment/Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Haoshen Shi, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Ousman Jallow, Krishna Mandalia, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Andrei A. Kramerov, Alexander V. Ljubimov, Debra Hawes, Carol A. Miller, Keith L. Black, Roxana O. Carare, Maya Koronyo-Hamaoui
Summary: This study found that vascular amyloid beta (Aβ) protein deposits were detected in retinas of mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients, and these deposits were linked to disease status. The study also revealed that the components of retinal vascular tight junctions (TJs) and Aβ expression were correlated with neuropathology. The severe decreases in retinal vascular zonula occludens-1 (ZO-1) and claudin-5 were identified in MCI and AD patients, which correlated with arteriolar Aβ(40) deposition and cerebral pathology and cognitive deficits.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Hai-ling Wang, Chun-lin Zhang, Yan-mei Qiu, An-qi Chen, Ya-nan Li, Bo Hu
Summary: Cerebral microbleeds (CMBs) are small lesions in the brain's microvessels that are linked to various neurological conditions. The exact pathogenesis and treatment options for CMBs require further investigation and research.
Article
Biochemistry & Molecular Biology
Yasuteru Inoue, Masayoshi Tasaki, Teruaki Masuda, Yohei Misumi, Toshiya Nomura, Yukio Ando, Mitsuharu Ueda
Summary: In this study, the researchers found that α-enolase (ENO1) can interact with amyloid beta (Aβ) and inhibit its fibril formation. They also demonstrated that ENO1 can disrupt Aβ fibrils and weaken their cytotoxic effects by degrading Aβ peptides. Additionally, infusion of ENO1 into mouse brains reduced cerebrovascular Aβ deposits and improved cognitive impairment. These findings suggest that ENO1 may be a therapeutic target in cerebral amyloid angiopathy (CAA).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo
Summary: Neurovascular dysfunction plays an important role in the development and progression of chronic neurodegenerative processes in Alzheimer's disease. The blood-brain barrier (BBB) pathway is crucial for the clearance of amyloid-beta (A beta) in the brain, and endothelial cells are key players in A beta transport. Dysregulation of A beta clearance is considered the main reason for its accumulation in the brain. Understanding the interactions between A beta and brain capillary endothelial cells, including their receptors and transporters, may provide new therapeutic strategies for A beta clearance in Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Review
Cell Biology
Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo
Summary: Neurovascular dysfunction plays an important role in the onset and progression of Alzheimer's disease, and the blood-brain barrier pathway is a key pathway for amyloid-beta (Aβ) clearance in the brain. Brain capillary endothelial cells are crucial for Aβ clearance mediated by the blood-brain barrier. Dysregulation of Aβ clearance leads to its accumulation in the brain parenchyma. Understanding the interactions between Aβ and brain capillary endothelial cells and developing new therapeutic strategies could improve Aβ clearance in Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Niya Wang, Xiang Yang, Zhong Zhao, Da Liu, Xiaoyan Wang, Hao Tang, Chuyu Zhong, Xinzhang Chen, Wenli Chen, Qiang Meng
Summary: The amyloid-β (Aβ) hypothesis, once believed to be the pathogenic process of Alzheimer's disease (AD), has been challenged due to the failure of clinical drug development and increasing understanding of the disease. Recent investigations have shown that the vascular system plays a significant role in the course of AD, with vascular damage occurring prior to Aβ deposition and neurofibrillary tangles (NFTs). This review outlines the various vascular dysfunctions associated with AD and highlights the importance of understanding the Aβ-neurovascular unit (NVU) interaction in disease pathophysiology.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Xiaofang Xu, Huikang Xu, Zhaocai Zhang
Summary: Cerebral amyloid angiopathy (CAA) is a disease characterized by the deposition of amyloid beta (A beta) and other amyloid proteins in the brain's blood vessels, leading to cerebrovascular and brain damage. CAA is often associated with cardiac injury, involving A beta, tau, and transthyroxine amyloid (ATTR). A beta acts as the main damaging factor, causing coronary artery atherosclerosis, aortic valve calcification, and cardiomyocyte degeneration. The progression of CAA can further impact the heart through amyloidosis, inflammation, and cerebral hemorrhage. The interaction between CAA and cardiac injury creates a vicious cycle that accelerates the progression of both conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vaibhav Gurunathan, John Hamre, Dmitri K. Klimov, Mohsin Saleet Jafri
Summary: Alzheimer's disease, the most common form of dementia, currently has no cure. This study utilized machine learning techniques and molecular dynamics simulation data to explore the relationship between A beta torsion angles and disease measures. The research has the potential to help determine which specific residues of A beta should be targeted for drug development.
Article
Clinical Neurology
Anuska V. Andjelkovic, Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Jianming Xiang, Richard F. Keep
Summary: Cerebral endothelial cells and their tight junctions form the blood-brain barrier (BBB), which is a unique, dynamic, and multi-functional interface. This review focuses on the changes in BBB and the neurovascular unit in normal aging and neurodegenerative disorders, particularly Alzheimer's disease, cerebral amyloid angiopathy, and vascular dementia. Evidence suggests that BBB dysfunction contributes to neurodegeneration. The mechanisms underlying BBB dysfunction and its potential as a therapeutic target, including enhancing drug delivery, clearance of neurotoxic compounds, and preventing BBB dysfunction, are discussed. The need for novel biomarkers of BBB dysfunction is also addressed.
Article
Endocrinology & Metabolism
Susanne J. van Veluw, Matthew P. Frosch, Ashley A. Scherlek, Daniel Lee, Steven M. Greenberg, Brian J. Bacskai
Summary: This study used in vivo two-photon microscopy to observe aged APP/PS1 mice with mild-to-moderate CAA, finding extravascular fibrin-positive clots at individual rupture sites. Compared to wild-type controls, transgenic mice were more likely to experience spontaneous extravascular leakage, suggesting that CAA does not directly predispose vessels to leak but is influenced by complex flow dynamics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Clinical Neurology
Carolin Kurz, Lauren Walker, Boris-Stephan Rauchmann, Robert Perneczky
Summary: The pathological processes leading to synapse loss, neuronal loss, brain atrophy and gliosis in Alzheimer's disease (AD) are not fully understood. This review focuses on the clinical correlations and pathophysiological concepts of blood-brain barrier (BBB) damage in AD. Specific changes in intercellular structures, reduced expression of transendothelial carriers, and activation of astroglia and monocytes/macrophages characterize BBB damage in AD. Magnetic resonance imaging shows early BBB dysfunction in AD-specific brain regions. Novel therapeutic approaches aim to open the BBB and improve drainage of amyloid-beta (A beta) from the brain.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Qing-Qing Tao, Rong-Rong Lin, Yi-He Chen, Zhi-Ying Wu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the accumulation of Aβ and tau in the brain. The dysfunction of the blood brain barrier (BBB) is increasingly recognized as a causative factor of cognitive impairment, but its role in the pathogenesis of AD is still not fully understood. Additional research is needed to determine the underlying mechanisms between BBB dysfunction and AD, as well as explore new therapies for BBB regulation to treat AD in the future.
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Bruna Bellaver, Albert Puig-Pijoan, Joao Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cecile Tissot, Guilherme Povala, Joseph Therriault, Andrea L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suarez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal
Summary: The permeability of the blood-brain barrier (BBB) may affect the levels of brain-derived proteins in the blood, which in turn can impact the relationship between brain and blood biomarkers. The study found that BBB permeability influenced the relationship between plasma A beta(42/40) and CSF A beta(42/40) as well as A beta-PET positivity, but did not significantly impact the relationship between brain and plasma p-tau levels.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Medical Laboratory Technology
Clara Wai Shan Lo, Kirsten Hoad, Tze Ping Loh, Sjoerd van den Berg, Brian R. Cooke, Ronda F. Greaves, Michaela F. Hartmann, Stefan A. Wudy, Chung Shun Ho
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Clinical Neurology
Mara S. S. Tihaya, Karlien Mul, Judit Balog, Jessica C. C. de Greef, Stephen J. J. Tapscott, Rabi Tawil, Jeffrey M. M. Statland, Silvere M. van der Maarel
Summary: Advances in the molecular understanding of FSHD have revealed the epigenetic de-repression of the DUX4 gene in skeletal muscle as the cause of the disease. This has led to the identification of potential targeted therapies and improved understanding of the disease mechanism. The development of disease modifying treatments, ongoing clinical trials, and specific outcome measures and assessment tools for FSHD are discussed in this review.
NATURE REVIEWS NEUROLOGY
(2023)
Review
Endocrinology & Metabolism
Susanne Kuckuck, Eline S. van Der Valk, Anton J. W. Scheurink, Bibian van Der Voorn, Anand M. Iyer, Jenny A. Visser, Patric J. D. Delhanty, Sjoerd A. A. van den Berg, Elisabeth F. C. van Rossum
Summary: Disrupted hormonal appetite signaling plays a crucial role in obesity, and glucocorticoid excess may impair appetite signaling and eating control. Counteracting glucocorticoid excess is a crucial target for obesity prevention and treatment, as it can improve appetite signaling and potentially have positive effects on cardio-metabolic outcomes and mood.
Article
Endocrinology & Metabolism
Jenneke E. van Atteveld, Demi T. C. de Winter, Vincent G. Pluimakers, Marta Fiocco, Rutger A. J. Nievelstein, Monique G. G. Hobbelink, Andrica C. H. de Vries, Jacqueline J. Loonen, Eline van Dulmen-den Broeder, Helena J. van der Pal, Saskia M. F. Pluijm, Leontien C. M. Kremer, Cecile M. Ronckers, Margriet van der Heiden-van der Loo, A. Birgitta Versluijs, Marloes Louwerens, Dorine Bresters, Hanneke M. van Santen, Daniel S. Olsson, Imo Hoefer, Sjoerd A. A. van den Berg, Jaap den Hartogh, Wim J. E. Tissing, Sebastian J. C. M. M. Neggers, Marry M. van den Heuvel-Eibrink, Dutch LATER Study Grp
Summary: This study examined the risk factors for low bone mineral density (BMD), fractures, and vertebral fractures in adult childhood cancer survivors in the Netherlands. The results showed that childhood cancer survivors have an increased risk of fractures, and factors associated with low BMD and fractures include gender, underweight, radiotherapy dose, hormone disorders, lack of physical activity, and vitamin D deficiency. The findings highlight the importance of monitoring bone health and providing interventions for endocrine disorders and vitamin deficiencies in childhood cancer survivors.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
R. H. M. Dykgraaf, S. Schalekamp-Timmermans, M. C. Adank, S. A. A. van den Berg, B. M. N. van de Lang-born, T. I. M. Korevaar, A. Kumar, B. Kalra, G. Savjani, E. A. P. Steegers, Y. Louwers, J. S. E. Laven
Summary: The primary objective of this study was to establish maternal reference values of anti-Mullerian hormone (AMH) in a fertile multi-ethnic urban pregnant population and to evaluate the effect of gestational age. The study found that AMH levels in early pregnancy decrease with advancing gestational age. Higher AMH levels were associated with a higher level of placental biomarkers, suggesting a better placental development and lower vascular resistance in mothers with higher AMH levels. AMH might be useful in predicting adverse pregnancy outcomes due to impaired placental development.
ENDOCRINE CONNECTIONS
(2023)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Sabine E. Hannema, Katja P. Wolffenbuttel, Yolande van Bever, Hennie T. Bruggenwirth, Sjoerd A. A. van den Berg, Remko Hersmus, J. Wolter Oosterhuis, Leendert H. J. Looijenga
Summary: Individuals with 45,X/46,XY or 46,XY gonadal dysgenesis have an increased risk of germ cell malignancies. This study aimed to determine if undetectable preoperative serum anti-Mullerian hormone (AMH) and inhibin B can predict the absence of germ cells or (pre)malignant conditions. The results suggest that undetectable AMH and inhibin B cannot reliably predict the absence of germ cells in individuals with gonadal dysgenesis. Rating: 8/10.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Physiology
Susanne Kuckuck, Eline S. S. van der Valk, Anton J. W. Scheurink, Robin Lengton, Mostafa Mohseni, Jenny A. A. Visser, Anand M. M. Iyer, Sjoerd A. A. van den Berg, Elisabeth F. C. van Rossum
Summary: This study investigated the changes in appetite-regulating hormone levels during a combined lifestyle intervention (CLI) in obese patients. The results showed that CLI-induced weight loss was associated with changes in long-term adiposity-related hormone levels, but not with most short-term appetite signals. The clinical impact of alterations in appetite-regulating hormones during modest weight loss remains questionable and further studies are needed.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Carlinde W. Broeks, Nina Molenaar, Marlies Brouwer, Erica L. T. van den Akker, Elisabeth F. C. van Rossum, Rien Van, Sjoerd A. A. van den Berg, Manon Hillegers, Witte J. G. Hoogendijk, Huibert Burger, Claudi Bockting, Astrid M. Kamperman, Mijke P. Lambregtse-Van den Berg
Summary: This study explored the effects of maternal childhood trauma, current mental symptoms, and recent life events on long-term cortisol levels in mothers with depressive and anxiety disorders and their infants. The results showed a positive curvilinear relationship between maternal childhood trauma and maternal cortisol levels, as well as a negative linear relationship between maternal childhood trauma and infant cortisol levels. Maternal depression, anxiety symptoms, and recent life events were not associated with cortisol levels.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
Mina Mirzaian, Sofie K. M. van Zundert, Wim F. Schilleman, Mostafa Mohseni, Susanne Kuckuck, Elisabeth F. C. van Rossum, Ron H. N. van Schaik, Sjoerd A. A. van den Berg
Summary: This study developed an LC-MS/MS method for accurate quantification of cortisone and cortisol in human scalp hair. It also provided a novel approach for data analysis and interpretation. Improved sample preparation and chromatographic separation techniques minimized matrix interference.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Endocrinology & Metabolism
Denise H. van Abswoude, Karlijn Pellikaan, Naomi Nguyen, Anna G. W. Rosenberg, Kirsten Davidse, Franciska M. E. Hoekstra, Ilse M. Rood, Christine Poitou, Graziano Grugni, Charlotte Hoybye, Tania P. Markovic, Assumpta Caixas, Antonino Crino, Sjoerd A. van den Berg, Aart J. van der Lely, Laura C. G. de Graaff
Summary: Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by various physical and developmental issues, including obesity, hypertension, and type 2 diabetes mellitus (DM2), which are known risk factors for cardiovascular disease (CVD) and chronic kidney disease (CKD). In this study, the researchers screened a group of adults with PWS and found that approximately 20% of them had early signs of microvascular disease in the kidneys, as indicated by elevated urinary albumin or (micro)albuminuria. These individuals did not have a formal diagnosis of CVD and had normal estimated glomerular filtration rate (eGFR), suggesting that conventional diagnostic methods may not be reliable in this patient group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Silvia Ciancia, Sjoerd A. A. van den Berg, Erica L. T. van den Akker
Summary: The ACTH stimulation test is the most reliable method for diagnosing adrenal insufficiency, while salivary cortisol is not as reliable as serum cortisol.
Article
Critical Care Medicine
Letao Li, Sebastiaan Sassen, Nicole Hunfeld, Tim Smeets, Tim Ewoldt, Sjoerd A. A. van den Berg, Birgit C. P. Koch, Henrik Endeman
Summary: The purpose of this study was to design a population pharmacokinetic study to understand the pharmacokinetics of dexamethasone in critically ill COVID-19 patients and identify relevant covariates for personalized dosing regimens. Blood samples were collected from critically ill patients receiving fixed-dose intravenous dexamethasone for COVID-19 treatment. The data were analyzed using Nonlinear Mixed Effects Modeling, and the covariate analysis showed a significant negative correlation between dexamethasone clearance and CRP. The findings suggest that fixed-dose dexamethasone may not be appropriate for ICU COVID patients.
JOURNAL OF CRITICAL CARE
(2023)
Article
Geriatrics & Gerontology
Jenneke E. van Atteveld, Demi T. C. de Winter, Vincent G. Pluimakers, Marta Fiocco, Rutger A. J. Nievelstein, Monique G. G. Hobbelink, Leontien C. M. Kremer, Martha A. Grootenhuis, Heleen Maurice-Stam, Wim J. E. Tissing, Andrica C. H. de Vries, Jacqueline J. Loonen, Eline van Dulmen-den Broeder, HelenaJ H. van der Pal, Saskia M. F. Pluijm, Margriet van der Heiden-van der Loo, A. Birgitta Versluijs, Marloes Louwerens, Dorine Bresters, Hanneke M. van Santen, Imo Hoefer, Sjoerd A. A. van denBerg, Jaap den Hartogh, Jan H. J. Hoeijmakers, Sebastian J. C. M. M. Neggers, Marry M. van den Heuvel-Eibrink
Summary: This study investigated the prevalence and high-risk groups for frailty and sarcopenia in Dutch childhood cancer survivors, and found that these aging phenotypes already occur at the age of 33 in this population. Early recognition and interventions for endocrine disorders and dietary deficiencies may be important in minimizing the risk of frailty and sarcopenia in this group.
LANCET HEALTHY LONGEVITY
(2023)
Article
Endocrinology & Metabolism
Mostafa Mohseni, Susanne Kuckuck, Renate E. H. Meeusen, Geranne Jiskoot, Robin Lengton, Mesut Savas, Kirsten A. C. Berk, Eline S. Van der Valk, Bibian Van der Voorn, Sjoerd A. A. Van den Berg, Anand M. Iyer, Johannes B. J. Bussmann, Pieter J. M. Leenen, Wim A. Dik, Cornelis J. de Groot, Erica L. T. Van den Akker, Elisabeth F. C. Van Rossum
Summary: Obesity is a complex disease with various negative impacts on health. Lifestyle interventions are important for its treatment, but the definition of treatment success based solely on weight loss may be limited. This study showed the comprehensive effects of a multidisciplinary lifestyle intervention on physiological, psychological, and behavioral health in individuals with obesity, and found that changes in health outcomes were not solely dependent on weight loss.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
