Article
Neurosciences
Kevin M. Manz, Jennifer C. Becker, Carrie A. Grueter, Brad A. Grueter
Summary: The study reveals that stress-induced histamine signaling in the NAc recruits H-3 heteroreceptor signaling to shift thalamocortical input onto D1(+)-MSNs in the NAc. These findings provide novel insights into an understudied neuromodulatory system within the NAc and implicate histamine in stress-related physiological states.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Kamil Mika, Malgorzata Szafarz, Marek Bednarski, Kamil Kuder, Katarzyna Szczepanska, Krzysztof Pociecha, Bartosz Pomierny, Katarzyna Kiec-Kononwicz, Jacek Sapa, Magdalena Kotanska
Summary: The study supports the use of active histamine H3 receptor ligands as new therapeutic agents for treating obesity. Compounds KSK-61 and KSK-63 are considered as leading structures due to their ability to slow weight gain and compensate for metabolic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil'eva, Andrey Maltsev, Pavel N. Shevtsov, Alexander Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov
Summary: This study found that compounds Tg-2112x and Tg-2113x have protective effects on cells by reducing mitochondrial calcium uptake and preventing cell death and mitochondrial depolarization induced by beta-amyloid. Additionally, Tg-2113x restored fear extinction in aged mice. This research provides a basis for the development of a novel generation of disease-modifying neuroprotective agents.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Yongqian Wang, Xufeng Huang, Hongzhen Fan, Huimei An, Ting Ma, Qi Zhang, Wenxuan Zhao, Yajun Yun, Wenshuang Yang, Xiaolu Zhang, Zhiren Wang, Fude Yang
Summary: This study showed that high-dose betahistine can effectively improve cognitive function but not psychiatric symptoms in Chinese Han patients with schizophrenia. Betahistine (72 mg/d) was considered safe for use in these patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Malgorzata Cyranka, Thomas Monfeuga, Natascia Vedovato, Chelsea M. Larabee, Anandhakumar Chandran, Enrique M. Toledo, Heidi de Wet
Summary: This study demonstrates for the first time that NMDA receptor antagonists increase the release of GLP-1 and highlights the need for comprehensive investigations into their effects on gut hormones, particularly incretin hormones.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Yousef M. Abdulrazzaq, Salim M. A. Bastaki, Ernest Adeghate
Summary: The human histamine H3 receptor plays a regulatory role in histamine synthesis and release in the brain, affecting processes such as cognition, sleep, and homoeostasis. H3 receptor antagonists have the potential to be important in the treatment of disorders related to cognition, sleep, oxidative stress, inflammation, and glucose homoeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
Hu Luo, Xiaofang Li, Runyue Fan, Yuer Ruan, Liyin Qian, Yao Shen, Zizhen Si, Longhui Li, Yu Liu
Summary: This study investigated the effect of H3 receptor blockade on METH-induced cognitive impairment and the underlying mechanism. The results showed that METH exposure led to cognitive impairment and hippocampal apoptosis in mice, as well as increased H3 receptor protein levels in HT22 cells. However, treatment with the H3 receptor antagonist THIO improved METH-induced cognitive impairment and toxicity in both mice and HT22 cells. These findings suggest that THIO has a neuroprotective effect against METH-induced cognitive impairment and cell toxicity via the raf-MEK-ERK signaling pathway.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Review
Chemistry, Organic
Jan Konecny, Eva Mezeiova, Ondrej Soukup, Jan Korabecny
Summary: NMDA receptors are crucial for neuronal plasticity and cognitive functions, but overactivation can lead to excitotoxicity. Dizocilpine, an NMDA receptor antagonist with anticonvulsive properties, is restricted for use in human medicine due to serious side effects, but still used in animal models.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hongling Guo, Tahir Ali, Jianyu Que, Yanmei Zhou, Yang Bai
Summary: This article reviews the role of dendritic spine dynamics in different phases of associative memory processing and highlights the need for suitable tools to measure and control spine dynamics in vivo under behaviorally relevant conditions.
Article
Neurosciences
Dean Shmuel, Sebastian M. Frank, Haggai Sharon, Yuka Sasaki, Takeo Watanabe, Nitzan Censor
Summary: The study demonstrates that noninvasive brain stimulation can modulate well-consolidated visual perceptual memories involving early visual cortical processing. Resting state functional connectivity and the correlation with repeated tasks can predict the magnitude of perceptual threshold modulation.
Article
Clinical Neurology
Luyuan Bai, Weiye Liang, Yongqian Wang, Ning Fan, Qi Zhang, Yun Bian, Fude Yang
Summary: The study investigates the ability of betahistine to inhibit weight gain and abnormal lipid metabolism in patients with chronic schizophrenia. A comparison study was conducted for 4 weeks in 94 patients, where they were randomly divided into two groups receiving either betahistine or placebo therapy. The results show that betahistine may delay metabolic abnormalities in chronic schizophrenia patients, providing new treatment ideas for metabolic syndrome in this population.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: Growing evidence suggests that the histamine system could be a promising target for the management of neuropathic pain. This study investigated the role of H4R in the anti-hyperalgesic action of the H3R antagonist GSK189254 in a mouse model of spared nerve injury (SNI). The results demonstrate the selective contribution of H4R to the attenuation of hypernociceptive behavior induced by the H3R antagonist, which could help identify innovative therapeutic interventions for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Ken Lukowiak
Summary: Animals respond to acute stress by modifying behavior and physiology. The plant flavonoid quercetin enhances memory performance in Lymnaea stagnalis during configural learning, lasting up to 48 hours. Exposure to quercetin upregulates the transcription factor CREB1 in the central nervous system of Lymnaea, positively impacting long-term memory formation.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Satoshi Kida
Summary: Memory retrieval is a dynamic process that involves reconsolidation, where retrieved memories return to a labile state and are re-stored. This discovery challenges the traditional view of memory consolidation and suggests that memory can be modified through reconsolidation. Extinction, on the other hand, weakens a conditioned fear memory through a new inhibitory learning process. In our research, we investigated the relationship between memory reconsolidation and extinction at behavioral, cellular, and molecular levels, finding that they have opposite effects on fear memory and interact with each other in a memory transition process.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.