Review
Anatomy & Morphology
Pradeep Lal, Koichi Kawakami
Summary: The mammalian amygdala and its zebrafish homolog play critical roles in various behaviors and can be further studied using transgenic resources and other tools to understand their functional anatomy.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Behavioral Sciences
Sara Jimenez, Nerea Moreno
Summary: The amygdaloid complex plays a crucial role in socio-emotional conduct, learning, survival, and reproductive behaviors. The pallial portion of the amygdala is currently being reanalyzed, and one proposal is to consider the mouse pallial amygdala as an independent radial histogenetic domain.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Neurosciences
Yan Wen, Zihao Su, Ziwu Wang, Lin Yang, Guoping Liu, Zicong Shang, Yangyang Duan, Heng Du, Zhenmeiyu Li, Yan You, Xiaosu Li, Zhengang Yang, Zhuangzhi Zhang
Summary: The transcription factor Vax1 plays a crucial role in the regionalization of the subpallium by repressing Gsx2 expression. Its absence leads to increased cell proliferation but blocked neuronal differentiation in the subpallium. Overexpression of VAX1 in the LGE progenitors strongly inhibits Gsx2 expression, resulting in abnormal expansion of the subpallium region.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Jacob Fies, Brad J. Gemmell, Stephanie M. Fogerson, Jennifer R. Morgan, Eric D. Tytell, Sean P. Colin
Summary: Swimming performance in lampreys recovering from spinal cord transection does not appear to be directly related to percent axon regeneration, but a certain threshold of axon regeneration is necessary for swimming capability; control lampreys swim more efficiently than transected lampreys.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Isabel Rodriguez-Moldes, Idoia Quintana-Urzainqui, Gabriel Nicolas Santos-Duran, Susana Ferreiro-Galve, Santiago Pereira-Guldris, Maria Candas, Sylvie Mazan, Eva Candal
Summary: Through studying the putative amygdalar complex in the catshark, two possible amygdalar territories were identified, with one possibly representing a ventropallial component and the other related to the pallial-subpallial boundary.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Biology
Yu Zeng, David C. Plachetzki, Kristen Nieders, Hannah Campbell, Marissa Cartee, M. Sabrina Pankey, Kennedy Guillen, Douglas Fudge, Claude Desplan
Summary: When attacked, hagfishes quickly produce a fibrous slime as a defense mechanism. The slime is formed by ejecting mucus and threads into seawater. This biomaterial is believed to have evolved from the epidermis and has a high adhesive property. Transcriptome analysis suggests that the epidermal threads are ancestral to the slime threads, indicating an epidermal origin of hagfish slime.
Article
Biology
Yu-Wen Chung-Davidson, Ugo Bussy, Skye D. Fissette, Anne M. Scott, Weiming Li
Summary: Bile salt levels in sea lampreys vary with different life stages and sexes, and can be influenced by primer pheromones.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Shigeru Watanabe
Summary: This study used Japanese eels to investigate the effects of telencephalic lesions on spatial learning. The lesioned eels were unable to maintain their learning and showed difficulties in re-learning, with different lesion locations impairing different aspects of learning.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Agriculture, Dairy & Animal Science
Fernando Rodriguez, Blanca Quintero, Lucas Amores, David Madrid, Carmen Salas-Pena, Cosme Salas
Summary: Neurobiological research has shown that teleost fish have spatial navigation capabilities similar to mammals and birds, possibly due to shared neural substrates. Fish rely on multiple sensory cues and use various spatial strategies for navigation, each based on different brain mechanisms.
Article
Microbiology
Prince P. Mathai, Muruleedhara N. Byappanahalli, Nicholas S. Johnson, Michael J. Sadowsky
Summary: The gut bacterial communities associated with sea lamprey differ significantly among its larval, parasitic juvenile, and adult life stages, with a notable shift in bacterial community structure and reduction in alpha diversity from larval to parasitic juvenile stage. Different phyla are enriched at different life stages, indicating a dynamic change in the gut microbiota composition throughout the lamprey's life cycle.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Ecology
Philip H. Crowley, Cedric Tentelier
Summary: Unrelated males sometimes cooperate by sharing nests and mates, and the evolutionary explanation for this behavior is explored using a game-theoretic model. The model considers aggressors and tolerators as two types of males and their frequencies in the population. The study uses the sea lamprey as a case study to generate plausible behavioral traits and ecological conditions. The results show that either aggressors or tolerators can persist, but exceptions can arise. Female behavior and environmental factors such as nesting densities and fighting costs also play a role in determining the outcome.
AMERICAN NATURALIST
(2022)
Article
Biochemistry & Molecular Biology
M. J. Lawrence, P. Grayson, J. D. Jeffrey, M. F. Docker, C. J. Garroway, J. M. Wilson, R. G. Manzon, M. P. Wilkie, K. M. Jeffries
Summary: This study characterized the transcriptomic responses of sea lamprey to niclosamide and a TFM:niclosamide mixture, and identified their impacts on mRNA transcript abundance of genes associated with the cell cycle, immune function, and mitochondrial dysregulation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Endocrinology & Metabolism
Andre Barany, Ciaran A. Shaughnessy, Stephen D. McCormick
Summary: During metamorphosis, sea lamprey rely on the control of 11-deoxycortisol (S) to regulate NKA activity in the intestine, enhancing osmoregulation and seawater tolerance.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Biodiversity Conservation
C. Michael Wagner, Jason D. D. Bals, Gregory J. J. Byford, Anne M. M. Scott, Mikaela E. E. Feder
Summary: Understanding how invasive animals perceive and respond to predation threats is crucial to comprehend their successful invasion into new environments. In this study, we investigated the behavioral and olfactory responses of migrating sea lamprey to a conspecific alarm cue, and found that they exhibited threat-sensitivity in space-use by avoiding areas with higher concentrations of the alarm cue. The intensity of avoidance was greater in the field than in the laboratory.
BIOLOGICAL INVASIONS
(2023)
Article
Biology
Daniel Sobrido-Camean, Luis Alfonso Yanez-Guerra, Alexandre Deber, Maria Celina Rodicio, Anton Barreiro-Iglesias
Summary: Kisspeptin peptides play important roles in regulating reproduction and puberty onset in mammals. Duplication of the ancestral kisspeptin gene occurred before the separation of jawless and jawed vertebrates, with the expression of kisspeptin 1 in hypothalamic neurons being an ancestral characteristic in vertebrates.
Article
Anatomy & Morphology
Jose Luis Ferran, Luis Puelles
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Anatomy & Morphology
Carmen Diaz, Luis Puelles
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Anatomy & Morphology
Luis Puelles, Petr Tvrdik, Margaret Martinez-de-la-torre
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Review
Neurosciences
Luis Puelles, Antonia Alonso, Elena Garcia-Calero, Margaret Martinez-de-la-Torre
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Luis Puelles, Carmen Diaz, Thorsten Stuhmer, Jose L. Ferran, Margaret Martinez-de la Torre, John L. R. Rubenstein
Summary: This study provides a thorough analysis of mouse prethalamic histogenetic subdivisions and nuclear derivatives, using a transgenic mouse line expressing LacZ under the control of Dlx5/6-LacZ. The research proposes a model for the prethalamic region, including rostrocaudal and dorsoventral subdivisions and radial stratification, with each cell population showing a characteristic molecular profile.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Hannah Bruguier, Rodrigo Suarez, Paul Manger, Anna Hoerder-Suabedissen, Andrew M. Shelton, David K. Oliver, Adam M. Packer, Jose L. Ferran, Fernando Garcia-Moreno, Luis Puelles, Zoltan Molnar
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Anatomy & Morphology
Elena Garcia-Calero, Lara Lopez-Gonzalez, Margaret Martinez-de-la-Torre, Chen-Ming Fan, Luis Puelles
Summary: The study reveals that Sim1-expressing cells may originate from the alar hypothalamus, migrate through the HyA pathway to the amygdala region, and interconnect with the Tbr1-expressing migration stream to form NLOT2. The generation of these cells involves a variety of required gene functions.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Rosana Reyes-Pinto, Jose L. Ferran, Tomas Vega-Zuniga, Cristian Gonzalez-Cabrera, Harald Luksch, Jorge Mpodozis, Luis Puelles, Gonzalo J. Marin
Summary: In this study, we investigated the neurotransmitter identity development of avian Ipc neurons and found that they express different types of mRNAs at different developmental stages, with a gradual decrease in VAChT mRNA expression as development progresses. Additionally, the morphology of Ipc axons undergoes significant changes, and the labeling of ChAT protein is mainly restricted to sparse portions of the terminal branches.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Behavioral Sciences
Jose Luis Ferran, Manuel Irimia, Luis Puelles
Summary: This essay re-examines the unique rostrally elongated notochord described in amphioxus and proposes an alternative interpretation that it represents a variant form of the prechordal plate. The author compares the observed patterns and gene expression patterns with those of other vertebrates and concludes that the hypothesis of a prechordal nature of the elongated amphioxus notochord is consistent with the evidence presented.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Review
Behavioral Sciences
Luis Puelles
Summary: The paper discusses the hypothesis of homology between the claustro-insular complex in vertebrates, particularly birds and reptiles, based on the comparison of molecular markers and structural features. The findings suggest that there are comparable pallial sectors in the avian and reptilian pallium, supporting the notion of a homologous claustro-insular complex. This has important implications for understanding the evolution of the vertebrate pallium.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Review
Anatomy & Morphology
Luis Puelles
Summary: The traditional columnar brain model has hindered the understanding of causal relationships in the visual system and diverted attention from molecular developmental advances. The prosomeric model provides researchers with the opportunity to address these issues.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Anatomy & Morphology
Manuel A. Pombal, Manuel Megias, Daniel Lozano, Jesus M. Lopez
Summary: This study reports the distribution and characteristics of a marker of nitric oxide synthase activity in the central nervous system of the adult river lamprey and compares it with other vertebrates. The results show that the lamprey possesses a nitrergic system similar to other vertebrates, but with some specific differences.
FRONTIERS IN NEUROANATOMY
(2022)
Review
Anatomy & Morphology
Esra Akat, Melodi Yenmis, Manuel A. Pombal, Pilar Molist, Manuel Megias, Sezgi Arman, Milan Vesely, Rodolfo Anderson, Dincer Ayaz
Summary: Skin serves as a barrier and has multiple functions in organisms. It is composed of three main layers and plays vital roles in all classes of vertebrates. Skin structure and physiological properties vary among different species.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Behavioral Sciences
Jose A. Amat, Margaret Martinez-de-la-Torre, Carmen Maria Trujillo, Barbara Fernandez, Luis Puelles
Summary: Neurogenesis in the developing brain manifests heterotopically, with similar steps occurring in different locations at different times, possibly due to early molecular regionalization and a combination of active/repressed genes. There is overall heterochrony between brain regions, with some species-specific differences in neuromeric heterochrony possibly related to morphogenetic properties. The observed AChE differentiation patterns show a close correlation with genetic patterns.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Neurosciences
Carmen Diaz, Margaret Martinez de la Torre, John L. R. Rubenstein, Luis Puelles
Summary: In this study, the researchers analyzed the expression patterns of 59 molecular markers in the lateral hypothalamus (LH) of mice. They identified different molecularly distinct sectors within the LH and found that these sectors correlated with previously postulated hypothalamic progenitor domains. The study provides insights into the connectivity and function of the LH.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.