期刊
NEUROSCIENCE
卷 196, 期 -, 页码 215-227出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2011.08.057
关键词
neurogenesis; depression; ventral dentate gyrus; frontotemporal dementia; tau; neurodegeneration
资金
- Spanish Ministry of Health [SAF 2006-02424]
- Comunidad de Madrid [SAL/0202/2006]
- Fundacion M. Botin
- Fundacion R. Areces
When bearing certain frontotemporal dementia with parkinsonism (FTDP) mutations, overexpression of human tau resulted in a decrease of the dentate gyrus ventral blade, apparently due to a reduction in the proliferation of neuronal precursors and an increase in neuronal cell death. This degenerative process was accompanied by a dramatic increase in behavioral despair, as evident in the Porsolt swim test. Interestingly, we observed an increase in GABAergic innervation in the molecular layer of the dorsal dentate gyrus but not in the ventral domain. We suggest that this increase in GABAergic innervation reflects a compensatory neuroprotective response to the overexpression of toxic tau, which may prevent or delay degeneration in the dorsal blade of the dental gyrus. Finally, we suggest that this transgenic mouse, which overexpresses human FTPD tau, may serve as a useful model to study specific functions of the ventral dentate gyrus. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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