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Multidisciplinary Sciences
Hai-Qing Tu, Sen Li, Yu-Ling Xu, Yu-Cheng Zhang, Pei-Yao Li, Li-Yun Liang, Guang-Ping Song, Xiao-Xiao Jian, Min Wu, Zeng-Qing Song, Ting -Ting Li, Huai -Bin Hu, Jin-Feng Yuan, Xiao-Lin Shen, Jia-Ning Li, Qiu-Ying Han, Kai Wang, Tao Zhang, Tao Zhou, Ai -Ling Li, Xue-Min Zhang, Hui-Yan Li
Summary: The primary cilia in neuromedin S-producing (NMS) neurons are crucial for intercellular coupling and maintaining the robustness of the internal clock in the suprachiasmatic nucleus (SCN) of mice. Genetic ablation of ciliogenesis in NMS neurons leads to rapid phase shifts of the internal clock under jet-lag conditions and loss of coherence in the circadian rhythms of individual neurons. The cilia-Shh signaling pathway plays a role in intercellular coupling by driving oscillations of Sonic Hedgehog (Shh) signaling and clock gene expression.
Article
Multidisciplinary Sciences
Yannuo Li, Ioannis P. Androulakis
Summary: The SCN functions as the central pacemaker aligning physiological and behavioral oscillations, with the VL core entraining the DM shell via VIP to regulate the circadian secretion of AVP and glucocorticoids. The study discusses a mathematical model that explores how synchronized systems lead to robust circadian oscillations, predicting personalized synchronization strategies for adapting to light schedule changes and identifying potential approaches to address shift work and jet lag related disorders.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Summary: The study describes a mouse mutant with the central pacemaker SCN genetically ablated, leading to arrhythmicity in circadian rhythms and metabolic parameters, although the mutants could still anticipate food availability. Despite disruptions to SCN cell identity and circuitry, the mutants' activity levels were altered and other zeitgebers could not restore rhythmicity.
Article
Cell Biology
Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen
Summary: This study reveals that visual itch information is transmitted from the retina to GRP neurons through ipRGCs and GRPR neurons in the SCN mediate contagious itch behavior. The PVT is involved in relaying itch information. These findings suggest the existence of a previously unknown visual pathway that encodes salient environmental cues and enables animals to imitate behaviors of conspecifics to cope with adverse conditions.
Article
Neurosciences
Michael C. Tackenberg, Jacob J. Hughey, Douglas G. McMahon
Summary: The research shows that selective activation of VIPergic SCN neurons induces photoperiodic network plasticity in the SCN, underlying photoperiodic entrainment of behavior.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anouk W. van Beurden, Robin A. Schoonderwoerd, Mayke M. H. Tersteeg, Pablo de Torres Gutierrez, Stephan Michel, Ruben Blommers, Jos H. T. Rohling, Johanna H. Meijer
Summary: Our study investigated the effect of a 6-hour delay in the light-dark cycle on PERIOD2::LUCIFERASE expression at the single-cell level in mouse SCN organotypic explants. We found a bimodal distribution of phase shift response in the anterior and central SCN, with ventrolateral SCN neurons showing rapid phase shifts while dorsal SCN neurons did not respond. Additionally, there were similarities between the distribution of neurons with rapid shifting response and neurons excited by electrical stimulation. This suggests that light-excited neurons in the anterior and central SCN play a crucial role in adapting to changes in the external light-dark cycle.
Article
Endocrinology & Metabolism
Jason D. Meadows, Joseph A. Breuer, Shanna N. Lavalle, Michael R. Hirschenberger, Meera M. Patel, Duong Nguyen, Alyssa Kim, Jessica Cassin, Michael R. Gorman, David K. Welsh, Pamela L. Mellon, Hanne M. Hoffmann
Summary: This study investigates the role of the Six3 gene in mature neurons and its impact on metabolic function. The deletion of Six3 in mature neurons causes dwarfism, disrupted circadian wheel-running activity, and improved metabolic function. It affects growth hormone release, glucose metabolism, muscle function, and bone health. Interestingly, the mice lacking Six3 gene exhibit improved glucose tolerance and increased metabolic rates in adulthood, but also reduced bone mineralization and density.
MOLECULAR METABOLISM
(2022)
Article
Physiology
Tracey O. Hermanstyne, Nien-Du Yang, Daniel Granados-Fuentes, Xiaofan Li, Rebecca L. Mellor, Timothy Jegla, Erik D. Herzog, Jeanne M. Nerbonne
Summary: Considerable evidence suggests that subthreshold potassium (K+) channels play a regulatory role in the day-night rhythms of neurons in the suprachiasmatic nucleus (SCN). This study identifies Kv12.1 and Kv12.2-encoded K+ channels as important regulators of the daily oscillations in the firing rates of SCN neurons.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Natthapong Sueviriyapan, Daniel Granados-Fuentes, Tatiana Simon, Erik D. Herzog, Michael A. Henson
Summary: In the SCN, different types of GABA(A) receptors have been found to regulate circadian rhythms, with blocking GABA signaling modestly increasing synchrony and increasing the relative density of gamma over delta subunits significantly increasing synchrony.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Multidisciplinary Sciences
Sarah L. Chellappa, Jingyi Qian, Nina Vujovic, Christopher J. Morris, Arlet Nedeltcheva, Hoa Nguyen, Nishath Rahman, Su Wei Heng, Lauren Kelly, Kayla Kerlin-Monteiro, Suhina Srivastav, Wei Wang, Daniel Aeschbach, Charles A. Czeisler, Steven A. Shea, Gail K. Adler, Marta Garaulet, Frank A. J. L. Scheer
Summary: Working night shifts increases the risk of diabetes, as the misalignment between central circadian clock and daily behaviors impairs glucose tolerance. Research shows that restricting nighttime eating can prevent the misalignment between central and peripheral circadian rhythms and impaired glucose tolerance.
Article
Multidisciplinary Sciences
Melissa E. S. Richardson, Cherie-Akilah Browne, Citlali I. Huerta Mazariegos
Summary: This study discovered an environmental method that can reduce or eliminate the 24-hour circadian locomotor behavior in mice, and the behavior can be restored through exposure to constant darkness or constant light.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Martin R. Ralph, Shu-qun Shi, Carl H. Johnson, Pavel Houdek, Tenjin C. Shrestha, Priya Crosby, John S. O'Neill, Martin Sladek, Adam R. Stinchcombe, Alena Sumova
Summary: Modification of the Per2 clock gene in mPer2(Luc) reporter mice leads to significant alterations in circadian function, such as lengthened behavioral period, increased bimodality, enhanced phase resetting, and altered entrainment to scheduled feeding. Mechanistic mathematical modelling and experimental evidence support the role of enhanced protein interactions and differential clock regulation in driving these effects.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Avinaash Subramaniam, Bumjoon Park, Domenick Raphael, Michelle Landstrom, K. C. Hayes
Summary: High glycemic load (GLoad) coupled with high caloric consumption was found to be most problematic in diabetes induction in Nile rats. The study suggested that rapid growth and caloric intake may have an epigenetic impact on diabetes resistance.
Article
Multidisciplinary Sciences
Viera Jerigova, Michal Zeman, Monika Okuliarova
Summary: This study investigated the impact of artificial light at night (ALAN) on the time dependency of the acute inflammatory response in a rat model. The results showed that dim ALAN attenuated the anorectic response and reduced the daily variability in inflammatory changes in blood leukocyte numbers. Furthermore, ALAN disrupted the molecular clock and inflammatory responsiveness, indicating a causal mechanism between light pollution and negative health effects.
SCIENTIFIC REPORTS
(2023)
Article
Mathematics, Applied
Yitong Huang, Yuanzhao Zhang, Rosemary Braun
Summary: The mammalian circadian system consists of a central clock and peripheral clocks that are tightly coordinated to regulate physiological and behavioral functions. Aging can disrupt these rhythms, with major factors including attenuated input from the sympathetic pathway, reduced responsiveness to light, and a decline in neurotransmitter expression. Understanding these age-related effects can provide insights into interventions for circadian re-entrainment.
Article
Biology
Adam C. Stowie, J. David Glass
JOURNAL OF BIOLOGICAL RHYTHMS
(2015)
Article
Neurosciences
A. C. Stowie, M. J. Amicarelli, R. A. Prosser, J. D. Glass
Article
Neurosciences
C. A. Martin-Fairey, C. Ramanathan, A. Stowie, E. Walaszczyk, L. Smale, A. A. Nunez
Article
Multidisciplinary Sciences
Dong Liu, Adam Stowie, Nuria de Zavalia, Tanya Leise, Salil Saurav Pathak, Lester R. Drewes, Alec J. Davidson, Shimon Amir, Nahum Sonenberg, Ruifeng Cao
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Physiology
J. David Glass, Allison J. Brager, Adam C. Stowie, Rebecca A. Prosser
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2012)
Article
Behavioral Sciences
Allison J. Brager, Adam C. Stowie, Rebecca A. Prosser, J. David Glass
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Biology
Adam C. Stowie, Mario J. Amicarelli, Caitlin J. Crosier, Ryan Mymko, J. David Glass
CHRONOBIOLOGY INTERNATIONAL
(2015)
Article
Neurosciences
Chidambaram Ramanathan, Adam Stowie, Laura Smale, Antonio Nunez
NEUROSCIENCE LETTERS
(2010)
Article
Multidisciplinary Sciences
Adam Stowie, Ivory Ellis, Kandis Adams, Oscar Castanon-Cervantes, Alec J. Davidson
Article
Biology
Anne M. Ramsey, Adam Stowie, Oscar Castanon-Cervantes, Alec J. Davidson
JOURNAL OF BIOLOGICAL RHYTHMS
(2020)
Article
Physiology
Atlantis M. Hill, G. Ryan Crislip, Adam Stowie, Ivory Ellis, Anne Ramsey, Oscar Castanon-Cervantes, Michelle L. Gumz, Alec J. Davidson
Summary: Nontraditional work schedules, such as shift work, can disrupt the circadian rhythms in the kidney, leading to accelerated kidney injury and potentially contributing to the development of hypertension and adverse health outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.