Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Shole Jamali, Shahram Zarrabian, Abbas Haghparast
Summary: The study demonstrated that Orx1Rs in the mPFC regulate the reward-related effects of morphine- and food-induced reward behaviors.
Article
Neurosciences
Cesar Huerta, Raul G. Paredes, Teresa Morales, Mario Daniel Caba-Flores, Enrique Meza, Mario Caba
Summary: This study aims to establish whether rabbits can be conditioned using CPP protocol by conducting experiments with caloric restriction. It demonstrates for the first time that rabbits can be conditioned using CPP paradigm through food-induced place preference, opening up new opportunities to study positive affective states in a species with important behavioral and physiological differences from rodents.
Article
Biochemistry & Molecular Biology
Soichiro Ide, Noriaki Iwase, Kenichi Arai, Masahiro Kojima, Shigeru Ushiyama, Kaori Taniko, Kazutaka Ikeda
Summary: Despite the widespread use of opioids for pain management, opioid addiction and the overdose crisis are becoming increasingly serious. A new nonpeptide ligand, UD-030, has been found to be a selective mu-opioid receptor antagonist and shows promise as a treatment option for opioid use disorder, with different characteristics from traditional medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Gao
Summary: Studies have shown that protein phosphorylation is important in morphine abuse, but the role of protein phosphatase 2A (PP2A) in the morphine-priming process is unclear. In this study, conditional knockout mice were used to investigate the role of hippocampal PP2A in morphine priming. The results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Article
Plant Sciences
Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Shu
Summary: The study found that processed Aconiti tuber (PAT) shortens the extinction of morphine-induced CPP when administered before CPP formation, but extends the extinction when administered after CPP acquisition. PAT has no effect on the reinstatement of CPP. The dynorphin concentration in the nucleus accumbens increases with PAT administration.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Ali Ahmadian Salami, Mohaddeseh Sadat Alavi, Mohammad Saeid Souri, Ali Roohbakhsh
Summary: This study evaluated the pharmacological effects of TRPA1 inhibition on morphine. The results showed that the TRPA1 antagonist HC030031 reduced morphine-induced conditioned place preference and physical dependence.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Neurosciences
Adel Kashefi, Carlos Tomaz, Shole Jamali, Ali Rashidy-Pour, Abbas Ali Vafaei, Abbas Haghparast
Summary: The study showed that CBD administration had a significant impact on extinction and reinstatement of MPH-induced conditioning place preference (CPP) in rats, suggesting its potential as a method to alleviate symptoms of drug addiction.
BRAIN RESEARCH BULLETIN
(2021)
Article
Behavioral Sciences
Mahsa Anooshe, Kiana Nouri, Saeideh Karimi-Haghighi, Zahra Mousavi, Abbas Haghparast
Summary: The study found that Cannabidiol (CBD) has an inhibitory effect on Methamphetamine-induced conditioned place preference, with a more potent impact in the acquisition phase. This suggests that CBD could be a beneficial compound for treating drug abuse, but further research is needed to fully understand its effectiveness.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Wanyu Tu, Tengteng Zhang, Chenchen Li, Wenge Jia, Zhijun Yao, Shanyong Yi, Hongyun Chen, Yuan Liu, Danya Zhou, Chuansheng Wang, Ruiling Zhang, Zhe Shi, Tifei Yuan, Bin Zhao, Lai Wei
Summary: This study investigated the role of alpha 1 adrenoceptor in the ventrolateral orbital cortex of rats with repeated morphine treatment and its underlying molecular mechanisms. The results showed that prazosin enhanced the addictive effects of morphine and affected neurotransmitter NE and peripheral inflammatory factors. These findings suggest that the NE system may be a potential therapeutic target in morphine addiction.
Article
Psychiatry
Arash Khanegheini, Masoumeh Khani, Shahram Zarrabian, Shahrokh Yousefzadeh-Chabok, Behrooz Khakpour Taleghani, Abbas Haghparast
Summary: The study looked at the potential interaction between CBD and METH during the sensitization phase on the rewarding effect of METH, with results indicating that CBD may reduce the motivation for METH seeking. Additionally, the study found that prior exposure to METH and the use of CBD could create sensitization to METH CPP even at sub-threshold doses of METH.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Rezvan Hassanpour, Atieh Chizari, Amir-Hossein Bayat, Ronak Azizbeigi, Maedeh Mahmoudi, Zahra Mousavi, Abbas Haghparast
Summary: Insulin plays a modulatory role in morphine-induced conditioned place preference (CPP), and insulin replacement can reduce the rewarding properties of morphine in diabetes conditions.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Behavioral Sciences
Andleeb Shahzadi, Oruc Yunusoglu, Enes Karabulut, Haktan Sonmez, Zeliha Yazici
Summary: The present study aimed to investigate the effects of ropinirole D2/3 agonist on the rewarding and reinforcing properties of morphine. The results showed that ropinirole attenuated the conditioned place preference (CPP) and reinstatement of morphine, while leading to the extinction of morphine-induced CPP. Ropinirole also alleviated naloxone-precipitated morphine withdrawal symptoms, although increased jumping behavior. Thus, ropinirole influences the dopaminergic system to reduce drug seeking and weaken reinstatement, showing its potential in attenuating dependence.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Public, Environmental & Occupational Health
Alaa M. Hammad, Rania Hamed, Walid Al-Qerem, Ameena Bandar, Frank Scott Hall
Summary: This study examined misconceptions towards the novel coronavirus in the Jordanian population and found that females, those who had not attended a lecture on coronavirus, had lower education levels, were not in the medical field, and lived in rural areas were more likely to have misconceptions. The use of social media also played a significant role in influencing false beliefs.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Behavioral Sciences
F. Scott Hall, Yu Chen, Federico Resendiz-Gutierrez
Summary: Research on the genetic basis of drug dependence has transitioned over history, influenced by new technologies and changing perspectives. Initial research was limited by available technology, shaping the study of genetic causes of addiction. Genome-wide approaches have now emerged to address biases in candidate gene studies, but assumptions of genetic causation and allelic heterogeneity may need revision in future studies.
BRAIN BEHAVIOR AND EVOLUTION
(2021)
Article
Neurosciences
Alaa M. Hammad, Ghadeer M. S. Swiss, F. Scott Hall, Suhair Hikmat, Youssef Sari, T. M. Al-Qirim, H. A. Amawi
Summary: Exposure to waterpipe tobacco smoke was found to increase neuroinflammation and alter glutamate transport expression, leading to increased anxiety-like behavior. Treatment with ceftriaxone attenuated these effects.
Article
Behavioral Sciences
Alaa M. Hammad, Yasmeen A. Ibrahim, Sawsan I. Khdair, F. Scott Hall, Malek Alfaraj, Yazan Jarrar, Abdulqader Fadhil Abed
Summary: The study found that metformin can alleviate the depression-like symptoms induced by oxandrolone by regulating neuroinflammation.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Editorial Material
Behavioral Sciences
F. Scott Hall, Elena Choleris, Farida Sohrabji
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Michael T. Bowen, Olivier George, Dawn E. Muskiewicz, F. Scott Hall
Summary: Understanding the factors that contribute to the escalation of alcohol consumption is crucial for understanding the transition from non/social drinking to AUD and improving treatment. This review discusses how the way ethanol is consumed, as well as individual and environmental factors, contribute to the escalation of ethanol consumption. Additionally, the review examines how these factors are modeled in animals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Alaa M. Hammad, Sara Jamal Meknas, F. Scott Hall, Suhair Hikmat, Youssef Sari, T. M. Al-Qirim, Malek Alfaraj, Haneen Amawi
Summary: This study examined the effects of waterpipe tobacco smoke on cannabinoid receptors in different brain regions of rats. It found that WTS exposure leads to anxiety-like behavior, but this effect can be reduced by treatment with ceftriaxone.
BRAIN RESEARCH BULLETIN
(2022)
Article
Public, Environmental & Occupational Health
Alaa M. Hammad, Walid Al-Qerem, Alaa Abu Zaid, Sawsan Khdair, F. Scott Hall
Summary: This study assesses misconceptions about the COVID-19 vaccine and identifies factors associated with misconception among Jordanians. The findings reveal that females, individuals in the 18-29 age group, those with higher education levels, living in urban areas, and those who have received the vaccine have lower levels of misconception. Targeted campaigns and vaccine safety information can help alleviate concerns about vaccine safety as part of broader health education efforts.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Neurosciences
Yu Chen, Alexander S. Wisner, Isaac T. Schiefer, Frederick E. Williams, F. Scott Hall
Summary: In this study, the acute toxicity and underlying mechanisms of methamphetamine (METH) in zebrafish larvae were investigated. The results showed that METH induced dose-dependent lethality in zebrafish larvae, accompanied by sympathomimetic activation and cardiotoxicity. Additionally, increased levels of ammonia in the excreted water and decreased internal levels were observed, along with evidence of seizures. Co-administration of glutamate AMPA receptor antagonist and dopamine D2 receptor antagonist attenuated METH-induced lethality, suggesting a potential interaction between glutamatergic and dopaminergic systems. Overall, this study provides a baseline for understanding the toxicity of amphetamine compounds in zebrafish larvae and offers a high-throughput approach for investigating new psychoactive substances.
PSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Alaa M. Hammad, Asma'a Naser, Haneen Amawi, F. Scott Hall, Amit K. Tiwari, Bahaa Al-Trad
Summary: Substance abuse is a global problem with significant consequences. Pregabalin, a medication commonly used for neuropathic pain, has raised concerns for its potential abuse and misuse. This study found that pregabalin can produce rewarding effects and alter glutamate homeostasis, indicating its abuse liability. The findings suggest that the abuse potential of pregabalin should be further examined, and the mechanisms underlying its effects are similar to other drugs of abuse.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alaa M. M. Hammad, Lujain F. F. Alzaghari, Malek Alfaraj, Walid Al-Qerem, Wamidh H. H. Talib, Fawaz Alasmari, Haneen Amawi, F. Scott Hall
Summary: Chronic exposure to cigarette smoke leads to neuroinflammation and changes in neurotransmitter systems. This study investigated the effects of cigarette smoke on astroglial glutamate transporters and NF-kappa B expression in the prefrontal cortex (PFC) and nucleus accumbens (NAc). The results showed that cigarette smoke exposure increased anxiety-like behavior, upregulated NF kappa B expression, and downregulated glutamate transporter expression. Acetylsalicylic acid treatment attenuated these effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuki Moriya, Yoshiyuki Kasahara, Masafumi Shimada, Yasufumi Sakakibara, Hideaki Fujii, Hiroshi Nagase, Soichiro Ide, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, Ichiro Sora
Summary: The study investigated the effects of MOP and DOP activation on behavioral despair using mouse models. The results showed that DOP agonists reduced immobility time in both tests, while the absence of MOP had no significant effect. This suggests that DOP activation can independently impact behavioral despair, regardless of MOP.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Junichi Kitanaka, Nobue Kitanaka, Kazuo Tomita, F. Scott Hall, Kento Igarashi, George R. R. Uhl, Tomoaki Sato
Summary: We used a newly modified, infrared beam sensor-based automated apparatus to investigate the effects of glycogen synthase kinase-3 (GSK-3) inhibitors on morphine-induced Straub's tail reaction (STR) in mice. We found that pretreatment with the GSK-3 inhibitors significantly inhibited STR and reduced its duration in a dose-dependent manner. The inhibitory effect of the inhibitors on STR might not depend on the direct blockade of GSK-3 beta function. Additionally, the mechanism of action of the inhibitors seems to be central rather than peripheral.
NEUROCHEMICAL RESEARCH
(2023)
Article
Environmental Sciences
Alaa M. M. Hammad, Baraa Shawaqfeh, Suhair Hikmat, Tariq Al-Qirim, Lama Hamadneh, Sameer Al-Kouz, Mariam M. M. Awad, Frank S. S. Hall
Summary: This study investigated the effect of vitamin E on acute acetaminophen toxicity in pregnant rats. The results showed that a high dose of acetaminophen during late pregnancy can cause oxidative stress and dysregulation in Cyp isoform expression, and that vitamin E treatment can attenuate these effects.
Article
Neurosciences
Yoko Hagino, Frank Scott Hall, George R. Uhl, Ichiro Sora, Kazutaka Ikeda
Summary: The study found that 5-MeO-DIPT mainly affects 5-HT levels in the brain by acting on SERT and 5-HT1A receptors, while also increasing DA levels in the PFC. In the presence of WAY100635, 5-MeO-DIPT significantly increases 5-HT levels.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
