期刊
NEUROSCIENCE
卷 166, 期 2, 页码 416-421出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2009.12.071
关键词
spinal trigeminal nucleus; reactive oxygen species; mastication overload
资金
- PhD school in Neuroscience
- Second University of Naples
The aim of the present study was to evaluate the production of superoxide anion (O-2(-)) in the trigeminal complex nuclei after a functional mechanical overload of the teeth due to the preference for masticating on one side in rats. The preference for masticating on one side was induced by the discomfort due to a small abrasion of one molar; such lateralisation in mastication was confirmed by electromyography. The production of O-2(-) was evaluated in the trigeminal nuclei by fluorescence microscopy after an injection of dihydroethidium. The results showed that there was an increased production of O-2(-) in the subnucleus oralis of the spinal trigeminal nucleus in the same side where the mastication was preferred. This result demonstrates that an increased activity of non-painful sensory neurons can enhance the production of reactive oxygen species within the central second order sensory nuclei. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
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