Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Gao
Summary: Itch is a complex sensation regulated by neural circuits involving the nucleus accumbens (NAc) and excitatory afferents from the medial prefrontal cortex (mPFC), amygdala, and hippocampus. This study reveals that acute itch decreases the intrinsic membrane excitability in dopamine receptor D1-expressing medium spiny neurons (Drd1-MSNs) in the NAc core, and that chemogenetic activation of Drd1-MSNs alleviates itch-induced scratching behaviors. Furthermore, it was found that excitatory synaptic afferents from the mPFC play a crucial role in itch modulation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yusuf S. Althobaiti, Farooq M. Almutairi, Fahad S. Alshehri, Ebtehal Altowairqi, Aliyah M. Marghalani, Amal A. Alghorabi, Walaa F. Alsanie, Ahmed Gaber, Hashem O. Alsaab, Atiah H. Almalki, Alqassem Y. Hakami, Turki Alkhalifa, Ahmad D. Almalki, Ana M. G. Hardy, Zahoor A. Shah
Summary: This study found that pregabalin-induced reward behavior is mediated through dopamine-1 receptors. Blocking dopamine-1 receptors can completely prevent pregabalin-induced place preference.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
David Quispe Escudero
Summary: D1-like receptors are metabotropic and activated by phasic dopamine. A proposed model suggests that the amount of contact between D1-like receptors and dopamine determines long term potentiation in the prefrontal cortex. This model also explains the detrimental cognitive effects of stimulants on regular substance consumers.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Summary: Age-related declines in cognition, especially in working memory and executive function, are mediated by the prefrontal cortex and the dopamine system within it. Administering the DA D1 R agonist PF-6294 to aged female rhesus monkeys improved memory span on the Delayed Recognition Span Task, particularly on repeated trials.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Summary: This study explored the impact of dopamine D1 and D2 receptors in the prefrontal cortex on attention and neuronal activity in various brain regions. Both receptor antagonists induced attentional impairment in a mouse attention test, indicating their association with attention. Neuronal activity analysis revealed selective activation of different brain regions based on receptor types, suggesting distinct roles of dopamine D1 and D2 receptors in attention regulation.
Article
Geriatrics & Gerontology
Michael F. Salvatore, Ella A. Kasanga, D. Parker Kelley, Katy E. Venable, Tamara R. McInnis, Mark A. Cantu, Jennifer Terrebonne, Kathryn Lanza, Samantha M. Meadows, Ashley Centner, Christopher Bishop, Donald K. Ingram
Summary: This study investigates the contributions of nigral and striatal dopamine mechanisms to aging-related parkinsonian signs. Calorie restriction can alleviate parkinsonian signs, and this effect can be maintained in advanced age. Moreover, changes in nigral dopamine signaling may modulate certain parameters of locomotor activity autonomously from striatal dopamine signaling.
Article
Biochemistry & Molecular Biology
Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya
Summary: Schizophrenia may be attributed to perinatal neurodevelopmental deficits and influenced by environmental factors. Hypofrontality and dysfunction in glutamatergic and dopaminergic neurons are known factors, while early enriched environment and low-intensity exercise training during adolescence may help prevent and ameliorate the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Brittney Yegla, Asha Rani, Ashok Kumar
Summary: Age-associated decrease in NMDAR-mediated synaptic function contributes to cognitive impairments. Enhancing NMDAR function via increased SR expression in middle age rats improves learning and synaptic transmission. Prefrontal SR upregulation can improve visual discrimination and increase NMDAR activity.
Article
Plant Sciences
Yunjeong Song, Sowoon Seo, Santosh Lamichhane, Jungwon Seo, Jin Tae Hong, Hye Jin Cha, Jaesuk Yun
Summary: Limonene exhibits anxiolytic effects by regulating dopamine and GABA neurotransmission to inhibit anxiety-related behavior. Moreover, the action of limonene is mediated by adenosine A2A receptor.
Article
Multidisciplinary Sciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Chenjie Shen, Keith M. Skaggs, Yuanyuan Hou, Morgan Fleishman, Olivia Mosto, Alyssa Weninger, Guoping Feng
Summary: A specific region of the anterior thalamic nuclei plays a key role in spatial working memory tasks in aged mice, and targeting this region may be more beneficial for cognitive functions with fewer unintended effects compared to direct manipulation of the prefrontal cortex. Activation of neurons or circuits in this region can improve working memory, while direct activation of prefrontal cortex neurons may lead to increased anxiety levels in aged mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Min Liu, Shouhong Mu, Weikai Han, Xu Tan, E. Liu, Zhaofang Hang, Shaowei Zhu, Qingwei Yue, Jinhao Sun
Summary: The study demonstrated that methamphetamine (MA) increases c-Fos expression and synaptic plasticity in the orbitofrontal cortex (OFC) and dorsal striatum (DS). MA activates projection neurons from the OFC to the DS and affects conditioned place preference (CPP) scores. The study also showed that DA release in the OFC is increased in the MA group, and D1R neurons in the OFC-DS pathway play a role in MA addiction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Mark G. Baxter, Mary T. Roberts, Jeffrey A. Roberts, Peter R. Rapp
Summary: Aged rhesus monkeys, like aged humans, show declines in cognitive function. Cognitive test data from a large sample of male and female rhesus monkeys demonstrate that aged monkeys perform worse than young monkeys on multiple cognitive tasks and that cognitive aging is independent in task domains dependent on different brain regions. Sex and chronological age are not reliable predictors of individual differences in cognitive outcome among the aged monkeys.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.