Article
Neurosciences
Benjamin R. Troutwine, Taylor A. Strope, Edziu Franczak, Colton R. Lysaker, Laylan Hamid, Clayton Mansel, Julia A. Stopperan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins
Summary: The study found that Alzheimer's disease (AD) patients have mitochondrial dysfunction, specifically reduced brain cytochrome oxidase (COX) function and complex II Vmax. APOE epsilon 4 carriers also have deficits in COX, complex II, and III. These results suggest a dysregulated relationship between brain mitochondrial function and A beta pathology in AD.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Agriculture, Multidisciplinary
Jialong Chen, Mingque Li, Xueqiong Zhou, Ailun Xie, Ziwei Cai, Chunlai Fu, Yongming Peng, He Zhang, Linhua Liu
Summary: The study revealed a novel feedback mechanism of p38-Parkin-ROS regulating rotenone-induced Parkinson's disease. Both p38 activation and Parkin inactivation contribute to the disruption of Parkin-mediated mitophagy, leading to increased reactive oxygen species (ROS) production. Inhibiting p38 and enhancing Parkin activity can reduce ROS levels and restore cell death and mitochondrial function in rotenone-induced PD models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Dmitry Troshev, Dmitry Voronkov, Anastasia Pavlova, Denis Abaimov, Alexander Latanov, Tatiana Fedorova, Daniil Berezhnoy
Summary: This study describes the timecourse of motor and non-motor symptoms in a low-dose rotenone mouse model of Parkinson's disease. The study found that the pathology in this model is linked with metabolic changes, rather than with oxidative stress or tonic neurotransmitter release levels.
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Immunology
Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang
Summary: This study investigated the role of microglia in cognitive deficits in a rotenone-induced mouse PD model. The findings suggest that microglial activation contributes to cognitive impairments via neuroinflammation, oxidative stress, and apoptosis, providing novel insight into the immunopathogenesis of cognitive deficits in PD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Plant Sciences
Yu Zhang, Sheng Li, Liyan Hou, Mingyang Wu, Jianing Liu, Ruonan Wang, Qingshan Wang, Jie Zhao
Summary: Research found that SVHRSP, a single component extracted from scorpion venom, has neuroprotective effects in Parkinson's disease. The study further discovered that SVHRSP achieves neuroprotection by inhibiting microglia-mediated neuroinflammatory pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Luke E. Formosa, Shadi Maghool, Alice J. Sharpe, Boris Reljic, Linden Muellner-Wong, David A. Stroud, Michael T. Ryan, Megan J. Maher
Summary: COA7 is a crucial assembly factor for the biogenesis of mitochondrial complex IV. It interacts with SCO1 and SCO2 to catalyze copper relay and reduction of disulfide bonds, which are important for complex IV assembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Leilei Chen, Yujv Huang, Xing Yu, Jiahong Lu, Wenting Jia, Juxian Song, Liangfeng Liu, Youcui Wang, Yingyu Huang, Junxia Xie, Min Li
Summary: Cory from Uncaria rhynchophylla has been shown to exhibit neuroprotective effects in rotenone-induced PD animal models by reducing neuroinflammation and diminishing alpha-synuclein aggregates through various pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Rui Han, Yanting Liu, Shihua Li, Xiao-Jiang Li, Weili Yang
Summary: Mitophagy is an important intracellular process that removes damaged mitochondria to prevent neuronal degeneration. The role of PINK1 in mitophagy has been extensively studied, but discrepancies exist due to different experimental models.
Article
Biochemistry & Molecular Biology
Md Yousuf Ali, Claudia R. Oliva, Susanne Flor, Prabhat C. Goswami, Corinne E. Griguer
Summary: This study identified the molecular mechanism of radioresistance in glioblastoma (GBM) as changes in the cellular labile iron pool (LIP) and the activity of cytochrome c oxidase (CcO). By manipulating CcO and LIP, the sensitivity of radioresistant GBM cells to radiation may be restored.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Michele Brischigliaro, Alfredo Cabrera-Orefice, Mattia Sturlese, Dei M. Elurbe, Elena Frigo, Erika Fernandez-Vizarra, Stefano Moro, Martijn A. Huynen, Susanne Arnold, Carlo Viscomi, Massimo Zeviani
Summary: The composition of cytochrome c oxidase (COX) is functionally conserved between vertebrate and invertebrate species, despite potential differences in individual structures.
Article
Cell Biology
Tiejian Nie, Kai Tao, Lin Zhu, Lu Huang, Sijun Hu, Ruixin Yang, Pingyi Xu, Zixu Mao, Qian Yang
Summary: This study demonstrates the critical role of chaperone-mediated autophagy (CMA) in maintaining proper mitochondria dynamics. Loss of this regulatory control may occur in Parkinson's disease (PD), leading to impaired mitochondria function. Increasing CMA activity promotes MARCHF5 turnover, reduces mitochondria fragmentation, and alleviates mitochondrial dysfunction under oxidative stress.
Article
Biochemistry & Molecular Biology
Chih-Chang Chao, Chuen-Lin Huang, Jing-Jy Cheng, Chun-Tang Chiou, I-Jung Lee, Ying-Chen Yang, Ting-Huang Hsu, Chia-En Yei, Pei-Ying Lin, Jih-Jung Chen, Nai-Kuei Huang
Summary: This study investigated the protective mechanism and therapeutic potential of SRT1720 in alleviating the toxicity of PQ-induced cellular and animal models of PD. Results showed that SRT1720 alleviates PQ-induced toxicity in cell and animal models by targeting SIRT1 and activating downstream PGC-1 alpha and NRF2 signalings.
Review
Neurosciences
Nicola Simola, Sylvie Granon
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murta, Maria Antonietta De Luca, Nicola Simola, Liana Fattore
Meeting Abstract
Neurosciences
Xinlong Wang, Hashini Wanniarachchi, Francisco Gonzalez-Lima, Hanli Liu
BIOLOGICAL PSYCHIATRY
(2019)
Meeting Abstract
Neurosciences
Francisco Gonzalez-Lima, Douglas Barrett, Celeste Saucedo, Courtney Alexander, Hanli Liu, Andreana Haley
BIOLOGICAL PSYCHIATRY
(2019)
Article
Neurosciences
Emma Holmes, Douglas W. Barrett, Celeste L. Saucedo, Patrick O'Connor, Hanli Liu, F. Gonzalez-Lima
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Psychology, Biological
Araceli Vazquez, Andres Hernandez-Oliveras, Juan Santiago-Garcia, Mario Caba, Francisco Gonzalez-Lima, Diana Olivo, Aleph A. Corona-Morales
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Neurosciences
Allison M. Auchter, Douglas W. Barrett, Marie H. Monfils, F. Gonzalez-Lima
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Aurora Musa, Nicola Simola, Gessica Piras, Francesca Caria, Emmanuel Shan Onaivi, Maria Antonietta De Luca
Article
Geriatrics & Gerontology
Courtney M. O'Donnell, Douglas W. Barrett, Latham H. Fink, Erica C. Garcia-Pittman, Francisco Gonzalez-Lima
Summary: This study is the first to investigate the effects of TILS on cognition in older euthymic bipolar patients, showing potential improvements in cognitive flexibility and impulsivity with TILS treatment.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Article
Neurosciences
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
Summary: The study suggests that prenatal exposure to glucocorticoids may increase the susceptibility to central toxicity of amphetamine-related drugs used later in life in an age-dependent manner. Prenatal exposure to high levels of glucocorticoids induced dopaminergic damage and glia activation when the offspring were later treated with the psychoactive drug MDMA.
Article
Pharmacology & Pharmacy
Nicholas Pintori, Maria Paola Castelli, Cristina Miliano, Nicola Simola, Paola Fadda, Liana Fattore, Maria Scherma, Maria Grazia Ennas, Rafaela Mostallino, Giovanna Flore, Marta De Felice, Claudia Sagheddu, Marco Pistis, Gaetano Di Chiara, Maria Antonietta De Luca
Summary: Repeated exposure to JWH-018 induced anxious and aversive behaviors, decreased dopamine neurons in the VTA, and altered dopaminergic transmission. The drug also affected dopamine sensitivity in the NAc shell and core, while causing neuroinflammatory responses in specific brain areas. This study suggests that recurring use of Spice/K2 drugs may have detrimental effects on behavior and dopamine regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Marcello Serra, Jacopo Marongiu, Nicola Simola
Summary: The study evaluated the emission of ultrasonic vocalizations in C57BL/6J mice after repeated treatment with amphetamine and dopamine receptor agonist. The results showed that mice emitted USVs during social contacts, but did not significantly vocalize after drug administration or drug-paired environmental cues.
NEUROSCIENCE LETTERS
(2021)
Review
Cell Biology
Fabrizio dos Santos Cardoso, F. Gonzalez-Lima, Sergio Gomes da Silva
Summary: Longevity is a great triumph of humanity, but it also brings challenges such as age-related cognitive decline and neurological diseases. Photobiomodulation (PBM) has shown promising effects in improving brain functions in aging populations, with studies demonstrating neuroprotective and neuromodulatory capacities in both animals and humans. More controlled studies are needed to further understand the mechanisms and benefits of PBM in older populations.
AGEING RESEARCH REVIEWS
(2021)
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicola Simola
Summary: The study found that rats emitted different frequencies of USVs during tickling, novel object recognition test (NOR), and single trial continuous spontaneous alternation behavior (SAB) test, but this calling behavior was not linked with behavioral readouts indicative of memory function. However, rats that predominantly emitted 22-kHz USVs during tickling displayed impaired performance in the NOR test.
Article
Cell Biology
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta
Summary: The study demonstrates that intracerebral infusion of pre-formed human alpha synuclein oligomers (H-alpha SynOs) provides a valid model for studying cognitive symptoms in Parkinson's disease, accompanied by neuroinflammation, shedding light on the mechanisms underlying cognitive impairment.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.