Review
Clinical Neurology
Min Cheol Chang, Yoo Jin Choo, Gun Woo Lee
Summary: Comparing traditional pedicle screws with cortical bone trajectory-pedicle screws in posterior lumbar fusion surgery, it was found that the cortical screw group had less blood loss and shorter operative time, with a lower total complication rate. However, these findings were based on limited, bias-prone retrospective studies.
Article
Clinical Neurology
Xiaofei Cheng, Kai Zhang, Xiaojiang Sun, Haijun Tian, Changqing Zhao, Jie Zhao
Summary: This study compared the clinical and radiographic outcomes of TLIF with UPSF and BPSF in the treatment of LFS. The results showed that UPSF achieved similar treatment effects to BPSF, with slightly shorter operative time and less blood loss.
Article
Multidisciplinary Sciences
Xi-nuo Zhang, Qing-jun Su, Bao-qing Pei, Ai-xing Pan, Hong-hao Yang, Hong-tao Ding, Yong Hai, Yu-zeng Liu
Summary: The accuracy of cortical bone trajectory (CBT) screw placement guided by a spinous process clamp (SPC) guide was assessed in this study. Compared to the fluoroscopy-assisted free-hand (FH) technique, SPC-guided screw placement showed higher rates of clinically acceptable screw placement and lower rates of misplacement screws and proximal facet joint violation. It also had comparable radiation dose and time, but longer operative time. The clinical outcomes were similar between the two techniques.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Wenhao Zhao, Chuanli Zhou, Hao Zhang, Jianwei Guo, Jialuo Han, Antao Lin, Yan Wang, Xuexiao Ma
Summary: This study compared the outcomes and characteristics of oblique lumbar interbody fusion stand-alone (OLIF-SA) and OLIF with posterior pedicle screw fixation (OLIF-PPS) in the treatment of degenerative lumbar spondylolisthesis. The results showed that the clinical and radiographic outcomes were similar in both groups, but the OLIF-PPS group had better improvement in spinal deformity, restoration of disc height, and fusion speed.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Clinical Neurology
Keitaro Matsukawa, Tsunehiko Konomi, Kohei Matsubayashi, Junichi Yamane, Yoshiyuki Yato
Summary: This retrospective case series aimed to investigate the influence of screw size on bone fusion in posterior lumbar interbody fusion (PLIF). The study found that screw fitness in the pedicle and screw insertion depth in the vertebra were significant factors affecting bone fusion. The results suggest that screw size should be determined based on individual vertebral anatomy, considering the screw fitness in the pedicle and screw insertion depth in the vertebra for L4-L5 PLIF.
GLOBAL SPINE JOURNAL
(2022)
Article
Orthopedics
Xiao-bing Zhao, Hai-jun Ma, Bin Geng, Hong-gang Zhou, Ya-yi Xia
Summary: Comparing the clinical efficacy of Endo-TLIF with PPSs and MIS-TLIF for the treatment of degenerative LSS, it was found that the former group had lower blood loss and shorter hospital stay, with significant improvement in postoperative pain. There were no significant differences in intervertebral fusion rates and clinical satisfaction between the Endo-TLIF and MIS-TLIF groups.
ORTHOPAEDIC SURGERY
(2021)
Article
Health Care Sciences & Services
Bin Zhang, Yuan Hu, Qingquan Kong, Pin Feng, Junlin Liu, Junsong Ma
Summary: For patients with adjacent segment disease (ASD) requiring decompression after lumbar fusion, oblique lumbar interbody fusion combined with posterior decompression (OLIF-PD) may be an alternative revision strategy. Compared with traditional posterior lumbar interbody fusion (PLIF) revision surgery, OLIF-PD has similar clinical outcomes but with reduced operation time, blood loss, hospital stay, and complications. These findings suggest that OLIF-PD is a feasible option for ASD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Bungo Otsuki, Shunsuke Fujibayashi, Shimei Tanida, Takayoshi Shimizu, Koichi Murata, Shuichi Matsuda
Summary: The study found that a larger filling index and older age were risk factors for pseudoarthrosis after lumbar fusion surgery. Patients with pseudoarthrosis had significantly worse Japanese Orthopaedic Association scores and recovery rates compared to those with fusion.
WORLD NEUROSURGERY
(2021)
Article
Orthopedics
Rui Zhang, Alafate Kahaer, Hanqian Niu, Jingwen Wang, Ayididaer Jumahan, Yanning Qiu, Hailong Guo, Paerhati Rexiti
Summary: The study found through 3-dimensional finite element analysis that the hybrid use of bilateral pedicle screw - bilateral cortical screw and hybrid bilateral cortical screw - bilateral pedicle screw has positive effects on adjacent segment disk degeneration. Among them, the hybrid use of bilateral pedicle screw - bilateral cortical screw has the best results in reducing disc stress and protecting paravertebral tissues.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Surgery
Meng-Ting Wu, Tzu-Tsao Chung, Shao-Ching Chen, Tzu-Jen Kao, Wen-Shin Song
Summary: This study analyzed the clinical and radiographic efficacy of one-stage OLIF and two-stage OLIF for lumbar diseases. Two-stage OLIF was associated with longer operation times, longer hospital stays, and a greater likelihood of complications. Improvements in radiographic parameters were comparable between one-stage and two-stage OLIF. Long-term follow-up is necessary for confirming treatment outcomes.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Hirooki Endo, Hideki Murakami, Daisuke Yamabe, Yusuke Chiba, Ryosuke Oikawa, Hirotaka Yan, Minoru Doita
Summary: This study compared radiological and clinical outcomes between multilevel lateral lumbar interbody fusion (LLIF) + hybrid posterior fixation (PF) and multilevel LLIF + conventional open PF in patients with adult spinal deformity (ASD). The results showed that the hybrid PF group had significantly less blood loss and lower CRP levels after 7 days of surgery compared to the open PF group. There were no significant differences between the two groups in other demographic variables and radiographic parameters, but the open PF group had a higher percentage of major complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Quan-You Gao, Fei-Long Wei, Tian Li, Kai-Long Zhu, Ming-Rui Du, Wei Heng, Fan Yang, Hao-Ran Gao, Ji-Xian Qian, Cheng-Pei Zhou
Summary: This study compared the outcomes and complications of patients with lumbar spinal stenosis (LSS) undergoing oblique lateral interbody fusion (OLIF) or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). The results showed that OLIF and MIS-TLIF had similar postoperative improvements, but OLIF was more successful at restoring disc height, foraminal height, and lumbar lordotic angle. The complication rates were comparable between the two procedures.
FRONTIERS IN MEDICINE
(2022)
Article
Orthopedics
Alafate Kahaer, Rui Zhang, Yixi Wang, Haopeng Luan, Abulikemu Maimaiti, Dongshan Liu, Wenjie Shi, Tao Zhang, Hailong Guo, Paerhati Rexiti
Summary: This study investigated the biomechanical properties of the hybrid fixation technique with bilateral pedicle screw (BPS) and bilateral modified cortical bone trajectory screw (BMCS) in L4-L5 transforaminal lumbar interbody fusion (TLIF). Three finite element (FE) models of the lumbar spine were established and the range of motion (ROM) and stress distribution were analyzed. The results showed that the BPS-BMCS technique had the lowest ROM in extension and rotation, while the BMCS-BMCS technique had the lowest ROM in flexion and lateral bending. The BPS-BMCS technique had a lower risk of screw breakage, and the BMCS-BPS technique had a lower risk of rod breakage.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, General & Internal
Ying Tan, Masato Tanaka, Sumeet Sonawane, Koji Uotani, Yoshiaki Oda, Yoshihiro Fujiwara, Shinya Arataki, Taro Yamauchi, Tomoyuki Takigawa, Yasuo Ito
Summary: Simultaneous single-position O-arm-navigated OLIF can reduce surgical time, blood loss, and time to ambulation after surgery. It also achieves good indirect decompression with comparable fusion rates and lower complication rates compared to MI-PLIF/TLIF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Ming-Chin Lin, Heng-Wei Liu, Yu-Kai Su, Wei-Lun Lo, Chien-Min Lin
Summary: This study compared the outcomes of robot-guided and freehand fluoroscopy-guided MIS-TLIF surgery. The results showed that patients who underwent robot-guided surgery had a lower incidence of pedicle breach and less operative blood loss. They also had a shorter operative duration in higher-level spinal surgery. The postoperative outcomes were similar for both robot-guided and freehand fluoroscopy-guided procedures.
NEUROSURGICAL FOCUS
(2022)
Article
Orthopedics
Gun Woo Lee, Jong-Uk Mun, Myun-Whan Ahn
JOURNAL OF ORTHOPAEDIC SURGERY
(2020)
Review
Biochemistry & Molecular Biology
Gi Beom Kim, Min-Soo Seo, Wook Tae Park, Gun Woo Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Gang-Un Kim, Gun Woo Lee
WORLD NEUROSURGERY
(2020)
Article
Chemistry, Multidisciplinary
Gi Beom Kim, Jae-Do Kim, Young Choi, Chang Hyun Choi, Gun Woo Lee
APPLIED SCIENCES-BASEL
(2020)
Article
Clinical Neurology
Gang-Un Kim, Myun-Whan Ahn, Gun Woo Lee
Summary: This study compared two surgical modalities for treating patients with athetoid-type cerebral palsy and cervical myelopathy, and found that combined anterior-posterior fusion resulted in superior clinical and radiological outcomes compared to posterior fusion alone.
GLOBAL SPINE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Si-Joon Lee, KilSoo Kim, Ju-Hyeon Lim, Seung Yun Yang, Seul-Ki Kim, Min-Soo Seo, Gun Woo Lee
Summary: Extracellular vesicles (EVs) are membrane-bound particles secreted by cells, and stem cell-derived EVs have been shown to have therapeutic effects similar to stem cells. This study isolated EVs from human epidural fat-derived mesenchymal stem cells and human fibroblasts, and found that EVs from the MSCs exhibited stronger anti-inflammatory effects compared to those from fibroblasts. The results suggest that EVs from human epidural fat MSCs may be valuable for treating inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Gi Beom Kim, Oog-Jin Shon, Min-Soo Seo, Young Choi, Wook Tae Park, Gun Woo Lee
Summary: Although conventional MSC-based therapies have limitations, MSC-derived exosomes offer advantages such as small dimensions, low immunogenicity, and potent therapeutic effects for osteoarthritis treatment. Exosomes are nano-sized vesicles containing nucleic acids, functional proteins, and bioactive lipids, secreted by various cell types. They play a role in tissue repair, immune regulation, and inflammation reduction, demonstrating potential for a new therapeutic approach in osteoarthritis. Further research is needed to confirm their clinical effectiveness and feasibility.
Article
Biochemistry & Molecular Biology
Minkyoung Sung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun Woo Lee, Hyo-Deog Rim, Byung-Soo Kim, Seunghee Won, Kyungmin Kim, Seoyoung Jang, Min-Soo Seo, Jungmin Woo
Summary: This study analyzed miRNAs in serum-derived neuronal exosomes to investigate potential biomarkers of acute stress, revealing specific miRNAs in nEVs from an acute severe-stress animal model. These miRNAs show differential expression over time, with the most prominent brain damage observed 7 days after foot shock treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Min Cheol Chang, Gang-Un Kim, Yoo Jin Choo, Gun Woo Lee
Summary: This systematic review compared oblique lumbar interbody fusion (OLIF) with transforaminal interbody fusion (TLIF) for degenerative spondylolisthesis patients undergoing lumbar fusion surgery. The study found no significant difference in clinical and radiological outcomes between OLIF and TLIF, but OLIF had shorter hospital stays and less blood loss. The results were based on low-quality evidence from a small number of retrospective studies.
Article
Medicine, General & Internal
Gun Woo Lee, Gi Beom Kim, In Jun Lee
Summary: During the COVID-19 pandemic, the cancellation rate of orthopedic elective surgeries was significantly higher than in the same period of the previous year. Orthopedic healthcare workers showed no significant psychological distress, and after preventive surgeries all medical staff involved tested negative.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2021)
Review
Clinical Neurology
Min Cheol Chang, Gang-Un Kim, Yoo Jin Choo, Gun Woo Lee
Summary: The study found that the cervical group had better fusion rates, less blood loss, and shorter operation times compared to the thoracic group. However, the cervical group had higher rates of adjacent segment disease and related complications. Therefore, for patients with higher risk factors for adjacent-segment degeneration, crossing the CTJ may be warranted.
Article
Biochemistry & Molecular Biology
Minkyoung Sung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun Woo Lee, Hyo-Deog Rim, Seunghee Won, Byung-Soo Kim, Kyungmin Kim, Seoyoung Jang, Sang Gyu Kwak, Jungmin Woo, Min-Soo Seo
Summary: Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by symptoms like eczema and itching. Psychological stress can trigger neuroinflammation in the brain in AD patients, leading to changes in microRNAs (miRNAs) in neuronal exosomes (nEVs). This study found that certain miRNAs in nEVs may serve as stress-related biomarkers associated with AD and stress-induced depression.
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Sang-Gu Yim, Ju-Hyeon Lim, Hyun-Gyu Seok, Seung-Yun Yang, Gun-Woo Lee
Summary: This study demonstrated that exosomes isolated from human epidural adipose tissue-derived MSCs can help restore locomotor function in rats with SCI by reducing inflammatory response.
Letter
Clinical Neurology
Min Cheol, Wook-Tae Park, Gun Woo Lee
Article
Orthopedics
Wook Tae Park, In Ha Woo, Sung Jin Park, Gun Woo Lee
Summary: This study aimed to identify predictors of endplate fracture (EF) after oblique lumbar interbody fusion (OLIF). The study found that sex, inferior endplate concave depth, disc wedge angle, lumbar lordosis, pelvic incidence, sagittal vertical axis, sacral slope, L3-4 level, and L4-5 level were significantly related to EF.
CLINICS IN ORTHOPEDIC SURGERY
(2023)