Review
Behavioral Sciences
Marta Mendez-Couz, Denise Manahan-Vaughan, Ana Paula Silva, Hector Gonzalez-Pardo, Jorge Luis Arias, Nelida Maria Conejo
Summary: The neuropeptide Y2 receptors play a significant role in hippocampus-dependent spatial memory, with receptor expression dynamically regulated by learning experiences. Antagonism of the receptors in the dorsal intrahippocampal area improves spatial reference memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Vishwa Goudar, Barbara Peysakhovich, David J. Freedman, Elizabeth A. Buffalo, Xiao-Jing Wang
Summary: Learning-to-learn refers to the progressive acceleration of solving a series of problems with shared structure. This study demonstrates that in recurrent neural networks, learning-to-learn emerges through the reuse and refinement of a neural state subspace underlying schema formation. It is a core process of knowledge acquisition, attracting attention in both neuroscience and artificial intelligence. The study trained a recurrent neural network model on arbitrary sensorimotor mappings dependent on the prefrontal cortex, showing an exponential time course of accelerated learning. The emergence and reuse of a schema within a low-dimensional population activity subspace facilitate learning by restricting connection weight changes.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
P. Abad-Perez, F. J. Molina-Paya, L. Martinez-Otero, V. Borrell, R. L. Redondo, J. R. Brotons-Mas
Summary: We investigated the role of NMDAr function in pathological oscillations and behavior in schizophrenia. Our results show that NMDAr blockade disrupted the correlation between oscillations and speed of movement, crucial for internal representations of distance. Moreover, NMDAr function might explain several cognitive symptoms of schizophrenia and be crucial to hippocampal-prefrontal cortex interaction.
Article
Behavioral Sciences
Ekaterina Pershina, Tatyana P. Kulagina, Tatyana A. Savina, Alexander Aripovsky, Sergey G. Levin, Vladimir Arkhipov
Summary: The study found significant changes in fatty acid levels in the prefrontal cortex and hippocampus of rats trained for a task with food reinforcement. These changes returned to control levels 72 hours after training. The reversible increase in fatty acid levels may support and protect cellular processes involved in memory acquisition.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Mareike A. Gann, Bradley R. King, Nina Dolfen, Menno P. Veldman, Kimberly L. Chan, Nicolaas A. J. Puts, Richard A. E. Edden, Marco Davare, Stephan P. Swinnen, Dante Mantini, Edwin M. Robertson, Genevieve Albouy
Summary: This study provides experimental evidence that targeted brain stimulation can alter functional responses in the striatum and hippocampus during motor learning in humans. While the stimulation did not directly affect motor performance or task-related brain activity, it did influence connectivity patterns within networks and the levels of GABA neurotransmitter.
Article
Behavioral Sciences
Xia Shan, Maria Paz Contreras, Anuck Sawangjit, Stoyan Dimitrov, Jan Born, Marion Inostroza
Summary: This study examined the role of rearing in the emergence of spatial representations based on distal cues in developing rats. The results demonstrated that recognition of distal novelty was associated with increased c-Fos expression in the hippocampus and medial prefrontal cortex. Additionally, the findings suggested that rearing plays a critical role in the early development of allocentric representations integrating distal space.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biology
Tarek Amer, Lila Davachi
Summary: Pattern separation is the process by which highly similar stimuli or experiences in memory are represented by non-overlapping neural ensembles. It has been traditionally attributed to the hippocampus, but recent evidence suggests that it involves a network of brain regions. The 'cortico-hippocampal pattern separation' (CHiPS) framework proposes that cognitive control regions play a significant role in pattern separation, either by resolving interference in sensory regions or by directly modulating hippocampal processes.
Article
Neurosciences
Cong Wang, Teri M. Furlong, Peter G. Stratton, Conrad C. Y. Lee, Li Xu, Sam Merlin, Chris Nolan, Ehsan Arabzadeh, Roger Marek, Pankaj Sah
Summary: During recognition memory, coupled theta activity between the hippocampus and medial prefrontal cortex plays a key role in novelty discrimination, with monosynaptic connections identified as crucial for guiding behavior based on recognition memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Conor R. Dickson, Gregory L. Holmes, Jeremy M. Barry
Summary: The coordination of theta frequency within and between mPFC, dHC, and vHC is influenced by connectivity and increases with task learning. Coherence levels are highest between mPFC and dHC, particularly during early training. The coherence patterns between mPFC and both hippocampal poles are similar during spatial avoidance epochs, suggesting frequency-specific roles in task-relevant processing. Theta coherence subbandwidths, particularly an 8-9Hz mPFC theta signal, play a role in the generation and processing of different types of information in the mPFC-HC circuit.
Article
Behavioral Sciences
Kathryn N. Graves, Brynn E. Sherman, David Huberdeau, Eyiyemisi Damisah, Imran H. Quraishi, Nicholas B. Turk-Browne
Summary: The study found that in spatial navigation, the hippocampus may contribute to the initial extraction of regularities before cortical consolidation, while the mPFC gradually represents these regularities during the consolidation process.
Article
Neurosciences
S. F. A. Axelsson, N. K. Horst, Naotaka Horiguchi, A. C. Roberts, T. W. Robbins
Summary: Studies have shown the significant role of ventrolateral prefrontal cortex (vlPFC) in higher order cognitive functions, with inactivation causing disruption in sequencing accuracy. Dopamine and serotonergic blockade had contrasting effects on performance, with dopamine producing error perseveration and serotonin significantly impairing accuracy.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biology
Jennifer C. Robinson, Mark P. Brandon
Summary: The passage discusses the connection between envisioning the future and remembering the past, explaining the roles of the prefrontal cortex and hippocampus in memory and future planning, as well as how brain regions support the temporal organization of information.
Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Article
Behavioral Sciences
Nicholas A. Heroux, Colin J. Horgan, Mark E. Stanton
Summary: The CPFE is a variant of contextual fear conditioning where prefrontal inactivation disrupts retention test freezing in adolescent rats, and the mPFC shows robust learning-related gene expression during immediate-shock training. NMDA receptor plasticity in the prefrontal cortex is important for the acquisition and/or consolidation of incidental context learning, but not required for context retrieval or acquisition of a context-shock association during immediate-shock training in the CPFE.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Derik E. Haggard, Siba R. Das, Robert L. Tanguay
CHEMICAL RESEARCH IN TOXICOLOGY
(2017)
Article
Microbiology
Stephen C. Heinsch, Siba R. Das, Michael J. Smanski
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Marine & Freshwater Biology
Cory V. Gerlach, Siba R. Das, David C. Volz, William H. Bisson, Siva K. Kolluri, Robert L. Tanguay
AQUATIC TOXICOLOGY
(2014)
Article
Behavioral Sciences
Siba R. Das, Kathy R. Magnusson
BEHAVIOURAL BRAIN RESEARCH
(2011)
Article
Behavioral Sciences
Siba R. Das, Ross Jensen, Rian Kelsay, Michelle Shumaker, Rachele Bochart, Brenna Brim, Daniel Zamzow, Kathy R. Magnusson
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Neurosciences
Siba R. Das, Kathy R. Magnusson
Article
Environmental Sciences
Jiangfei Chen, Siba R. Das, Jane La Du, Margaret M. Corvi, Chenglian Bai, Yuanhong Chen, Xiaojuan Liu, Guonian Zhu, Robert L. Tanguay, Qiaoxiang Dong, Changjiang Huang
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2013)
Article
Geriatrics & Gerontology
Kathy Ruth Magnusson, Siba Ranjan Das, Daniel Kronemann, Andrzej Bartke, Peter R. Patrylo
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2011)
Article
Pharmacology & Pharmacy
Katerine S. Saili, Margaret M. Corvi, Daniel N. Weber, Ami U. Patel, Siba R. Das, Jennifer Przybyla, Kim A. Anderson, Robert L. Tanguay
Review
Geriatrics & Gerontology
Kathy R. Magnusson, Brenna L. Brim, Siba R. Das
FRONTIERS IN AGING NEUROSCIENCE
(2010)
Article
Multidisciplinary Sciences
Maciej Maselko, Nathan Feltman, Ambuj Upadhyay, Amanda Hayward, Siba Das, Nathan Myslicki, Aidan J. Peterson, Michael B. O'Connor, Michael J. Smanski
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Siba R. Das, Maciej Maselko, Ambuj Upadhyay, Michael J. Smanski
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.