Article
Biochemistry & Molecular Biology
Vy Tran Luu, Sang Phan, Zhu-Qiu Jin
Summary: The differentiation of cardiac fibroblasts to myofibroblasts plays a critical role in the development of heart disease. This study found that PMA can induce dedifferentiation of cardiac myofibroblasts. The researchers also discovered that endogenous PGE(2) has no effect on the dedifferentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kohsuke Shirakawa, Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Yoshinori Katsumata, Kazuhisa Sugai, Yoji Hakamata, Motoaki Sano
Summary: This study demonstrates that hydrogen gas (H-2) can inhibit the formation of neutrophil extracellular traps (NETs) and excessive neutrophil activation, suggesting its potential as a therapeutic strategy for conditions related to NETs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jin-Young Park, Hee Jae Lee, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Yong-Soo Kwon, Wanjoo Chun
Summary: The anti-allergic properties of 3,4,5-Trihydroxycinnamic acid (THC) were investigated, and it was found that THC could inhibit degranulation and histamine release in mast cells by suppressing the MAPKs/ NF-kappa B signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Oliya S. Abdullaeva, Ihor Sahalianov, Malin Silvera Ejneby, Marie Jakesova, Igor Zozoulenko, Sara I. Liin, Eric Daniel Glowacki
Summary: A microfabricated ROS modulation device based on controlled faradaic reactions was developed in this research. The device can generate tunable gradients of peroxide and oxygen concentrations, enabling controlled H2O2 delivery. The prototype devices were tested by modulating human H2O2-sensitive channels to demonstrate the potential of PEDOT as an H2O2 delivery system.
Article
Cell Biology
Juan Carlos Martinez-Morales, Karla D. Gonzalez-Ruiz, M. Teresa Romero-Avila, Ruth Rincon-Heredia, Guadalupe Reyes-Cruz, Jesus Adolfo Garcia-Sainz
Summary: LPA1 receptor internalization was studied using FRET to analyze the interaction between LPA1 and Rab proteins under different stimuli. The results showed that LPA-induced internalization was rapid and transient, while PMA-induced internalization was slower but sustained. LPA stimulated the interaction between LPA1 and Rab5 rapidly but transiently, while PMA showed a rapid but sustained interaction. LPA1-Rab9 interaction was only observed at 60 min, and LPA1-Rab7 interaction was observed after 5 min with LPA and after 60 min with PMA. LPA triggered immediate but transient rapid recycling, while PMA showed slower but sustained recycling. Our findings suggest that LPA1 receptor internalization varies depending on the stimuli.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ya-Ying Chang, Cheng-Wei Lu, Wei-Horng Jean, Jiann-Shing Shieh, Tzu-Yu Lin
Summary: The study revealed that the effects of PMA on THP-1 cells' adherence, cell function, and migration ability were closely related to NO concentrations, while calcium signaling may mediate the PMA-induced upregulation of NO.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Immunology
Sonia Giambelluca, Matthias Ochs, Elena Lopez-Rodriguez
Summary: THP-1 monocytes can be differentiated to macrophages by incubation with PMA, and a 24-hour rest period allows the down-regulation of pro-IL-1 beta without affecting the ability to respond to a second stimulus through activation of the inflammasome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tina V. A. Hansen, Heinz Sager, Celine E. Toutain, Elise Courtot, Cedric Neveu, Claude L. Charvet
Summary: This study investigates the pharmacological characteristics of the DEG-3/DES-2 channel in C. elegans. The results show that the channel is more sensitive to betaine than ACh and choline, but less sensitive to monepantel and monepantel sulfone. These findings provide important insights into the function of the DEG-3/DES-2 channel in C. elegans.
Article
Allergy
Fatima de Lourdes Ochoa-Gonzalez, Yadira Bastian, Valeria Rivera-Carrera, Ivan Alejandro Garcia-Tiscareno, Martin Zapata-Zuniga, Jesus Adrian Lopez, J. Alfredo Mendez, Jose Antonio Enciso-Moreno, Julio Enrique Castaneda-Delgado
Summary: This study investigated the role of protease inhibitors in neutrophil extracellular trap (NET) formation, with a focus on the involvement of calpain in DNA release. The findings suggest that actin remodeling plays a crucial role in NET formation, and that calpain modulates actin cytoskeleton reorganization and DNA release in a calcium-dependent manner.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Shan Chen, Kung-Ssu Yang, Wen-Chun Lin, Chien-Liang Fang, Hsin-Fu Chen, Shew-Meei Sheu
Summary: This study demonstrated the significant inhibitory effect of lipid emulsion on NET formation, reducing the formation of neutrophil extracellular traps through different pathways, with a certain antibacterial effect.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Youngki You, Kavya Mathukumali, Joydip Das
Summary: C1 domains are lipid-binding structural units that associate with the plasma membrane and bind to diacylglycerol/phorbol ester during protein activation. This study investigated the ligand/lipid binding of C1 domains through molecular docking and molecular dynamics simulation. The C1 domains were classified into three types based on the orientation of specific residues, and the type 1 C1 domains showed stronger ligand and membrane binding. This research provides insights into the ligand/lipid binding mechanism of C1 domains, which is important for developing selective modulators of C1 domain-containing proteins.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Gaowa Wang, Yu Qing, Qingshan Zhang, Zhiqiang Han
Summary: People's health is negatively affected by diseases caused by abnormal inflammation, thus requiring urgent need for more effective treatments and research into the underlying mechanisms. Geniposidic acid exhibits anti-inflammatory properties and shows promise in treating aberrant inflammatory illnesses; however, its exact anti-inflammatory mechanism is unknown.
Article
Biochemistry & Molecular Biology
Ankush Prasad, Renuka Ramalingam Manoharan, Michaela Sedlarova, Pavel Pospisil
Summary: The study utilizes U-937 and HL-60 cell lines as a model system to investigate the production of reactive oxygen species (ROS) through stimulation with PMA. Various techniques were used to confirm ROS formation and protein oxidation, providing valuable insights for expanding knowledge of differentiation and protein expression dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jin-Young Park, Hee Jae Lee, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Yong-Soo Kwon, Wanjoo Chun
Summary: The study investigated the anti-allergic properties of caffeic acid methyl ester (CAME) and its underlying mechanism. CAME was found to suppress mast cell degranulation and reduce inflammation through the suppression of MAPKs/NF-κB signaling pathway.
Article
Biochemistry & Molecular Biology
Ankush Prasad, Claudio Rossi, Renuka Ramalingam Manoharan, Michaela Sedlarova, Lorenzo Cangeloni, Deepak Rathi, Gabriella Tamasi, Pavel Pospisil, Marco Consumi
Summary: In this study, the effect of four selected bioactive compounds on reducing oxidative stress in differentiating cells was investigated using U-937 cells as a model system. The results showed that these compounds can reduce the formation of MDA adducts, indicating their beneficial effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Meerza Abdul Razak, Pathan Shajahan Begum, Buddolla Viswanath, Senthilkumar Rajagopal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Editorial Material
Cell Biology
Divya P. Kumar, Saisudha Koka, Chao Li, Senthilkumar Rajagopal
MEDIATORS OF INFLAMMATION
(2019)
Correction
Cell Biology
Meerza Abdul Razak, Pathan Shajahan Begum, Buddolla Viswanath, Senthilkumar Rajagopal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Neurosciences
Senthilkumar Rajagopal, Divya P. Kumar, Albert Baskar Arul
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Manisha Sonthalia, Bhramar Sinha Roy, Divya Chandrawanshi, Goutham V. Ganesh, Ravichandran Jayasuriya, Sundhar Mohandas, Senthilkumar Rajagopal, Kunka Mohanram Ramkumar
Summary: Recent evidence suggests that histone deacetylases play a critical role in the development of diabetes, and their inhibitors are considered as a potential therapeutic strategy for regulating molecular pathways associated with diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Genetics & Heredity
Shoumi Haldar, Nounenuo Yhome, Yuvashree Muralidaran, Senthilkumar Rajagopal, Prabhakar Mishra
Summary: Plastic pollution is a global issue with widespread and increasing contamination, particularly with nanoplastics (<100 nm) whose health consequences remain unknown. It is observed that microplastics can release nanoplastics, suggesting that macroplastic exposure can cause direct and indirect diseases through nanoplastics. This review investigates the presence and impact of nanoplastics in various tissues of organisms that consume plastics, demonstrating physiological reactions and inflammation. It is found that nanoplastics accumulate in the liver through respiratory and gastrointestinal tracts, leading to multi-organ dysfunction and disruptions in the gut microflora.
Article
Respiratory System
Gaurav Sharma, Ramesh Venkataraman, Senthilkumar Rajagopal, Nagarajan Ramakrishnan, Babu K. Abraham, Raymond Dominic Savio
Summary: Patients requiring NIV in the ICU have a high prevalence of malnutrition, with 76% of patients being malnourished. Protocol-driven nutrition delivery in this population is feasible and well tolerated, with few patients experiencing intolerance and complications, and a minority requiring intubation and experiencing mortality.
INDIAN JOURNAL OF RESPIRATORY CARE
(2021)
Article
Critical Care Medicine
Ajay Padmanaban, Ramesh Venkataraman, Senthilkumar Rajagopal, Dedeepiya Devaprasad, Nagarajan Ramakrishnan
JOURNAL OF CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
Alexander Kuruvilla, Ramesh Venkataraman, Senthilkumar Rajagopal, Nagarajan Ramakrishnan
CRITICAL CARE MEDICINE
(2020)
Article
Critical Care Medicine
Ramesh Venkataraman, Vijayaprasad Gopichandran, Lakshmi Ranganathan, Senthilkumar Rajagopal, Babu K. Abraham, Nagarajan Ramakrishnan
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
C. Vignesh, Madhan Kumar, Ramesh Venkataraman, Senthilkumar Rajagopal, Nagarajan Ramakrishnan, Babu K. Abraham
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Biophysics
Ganesan L. Kamatchi, Senthilkumar Rajagopal, Brittney K. Burton
BIOPHYSICAL JOURNAL
(2017)
Article
Biochemistry & Molecular Biology
Senthilkumar Rajagopal, Brittney K. Burton, Blanche L. Fields, India O. El, Ganesan L. Kamatchi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2017)
Article
Biochemistry & Molecular Biology
Fany Sardenne, Edouard Kraffe, Aurelien Amiel, Edwin Fouche, Laurent Debrauwer, Frederic Menard, Nathalie Bodin
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2017)
Article
Engineering, Electrical & Electronic
Senthilkumar Rajagopal, Gokulnath Chennakesavan, Deepak Ram Prasath Subburaj, Raju Srinivasan, Abhaikumar Varadhan
AEU-INTERNATIONAL JOURNAL OF ELECTRONICS AND COMMUNICATIONS
(2017)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.