PHOSPHORYLATION OF ΔFosB MEDIATES ITS STABILITY IN VIVO

The transcription factor, Delta FosB, accumulates in a region-specific manner in brain in response to many types of chronic stimulation due to the unusual stability of the protein. The phosphorylation of Ser27 in Delta FosB has been shown to promote this stability in vitro. We show here that this phosphorylation reaction is also important for Delta FosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.