Article
Biochemistry & Molecular Biology
Watchara Phetluan, Samart Wanchana, Wanchana Aesomnuk, Julian Adams, Mutiara K. Pitaloka, Vinitchan Ruanjaichon, Apichart Vanavichit, Theerayut Toojinda, Julie E. Gray, Siwaret Arikit
Summary: Stomatal density in rice varies significantly and is regulated by multiple QTLs and candidate genes, some of which have been previously associated with stomatal traits in Arabidopsis. These findings provide valuable genetic information for future breeding programs aimed at improving photosynthetic capacity, water use efficiency, and drought tolerance in rice.
Article
Multidisciplinary Sciences
Aditya Ambati, Ryan Hillary, Smaranda Leu-Semenescu, Hanna M. Ollila, Ling Lin, Emmanuel H. During, Neal Farber, Thomas J. Rico, Juliette Faraco, Eileen Leary, Andrea N. Goldstein-Piekarski, Yu-Shu Huang, Fang Han, Yakov Sivan, Michel Lecendreux, Pauline Dodet, Makoto Honda, Natan Gadoth, Sona Nevsimalova, Fabio Pizza, Takashi Kanbayashi, Rosa Peraita-Adrados, Guy D. Leschziner, Rosa Hasan, Francesca Canellas, Kazuhiko Kume, Makrina Daniilidou, Patrice Bourgin, David Rye, Jose L. Vicario, Birgit Hogl, Seung Chul Hong, Guiseppe Plazzi, Geert Mayer, Anne Marie Landtblom, Yves Dauvilliers, Isabelle Arnulf, Emmanuel Jean-Marie Mignot
Summary: KLS is a rare disorder characterized by severe episodic hypersomnia, with possible genetic and obstetrical risk factors. A genome-wide study identified a significant association with TRANK1 gene and reported birth difficulties in KLS cases. Genetic liability and pathway analysis suggest links between KLS, circadian regulation, and bipolar disorder.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Dev Paudel, Rocheteau Dareus, Julia Rosenwald, Maria Munoz-Amatriain, Esteban F. Rios
Summary: Cowpea, a major crop used for human consumption and livestock feed, has been studied for its genetic basis of flowering time through genome-wide association studies, revealing seven reliable SNP markers and candidate genes associated with flowering time, which could facilitate breeding efforts and knowledge transfer to other legume species.
FRONTIERS IN GENETICS
(2021)
Review
Genetics & Heredity
Muhammad Kamran, Farhana Bibi, Asim Ur Rehman, Derek W. Morris
Summary: Major depressive disorder (MDD) is a common mental disorder characterized by symptoms associated with mood, pleasure and daily life activities. The pathogenesis of MDD is complex and not fully understood. Utilizing genetic data to understand the molecular mechanism of MDD, large genome-wide association studies have identified hundreds of loci, providing important information on the risk genes for MDD.
Article
Agronomy
San Mar Lar, Jeonghwan Seo, Seong-Gyu Jang, Hongjia Zhang, Ah-Rim Lee, Fang-Yuan Cao, Ja-Hong Lee, Na-Eun Kim, Yoonjung Lee, Yong-Jin Park, Joohyun Lee, Soon-Wook Kwon
Summary: This study identified three significant loci associated with salt tolerance at the seedling stage in Korean rice through genome-wide association study (GWAS), and selected five candidate genes for further investigation based on their known functions and gene expression profiles.
Article
Plant Sciences
Qibao Liu, Libei Li, Zhen Feng, Shuxun Yu
Summary: This study revealed the genetic basis of cotton senescence through genome-wide association studies and identified multiple genomic regions and candidate genes associated with cotton senescence.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Psychiatry
Tim B. Bigdeli, Ayman H. Fanous, Yuli Li, Nallakkandi Rajeevan, Frederick Sayward, Giulio Genovese, Rishab Gupta, Krishnan Radhakrishnan, Anil K. Malhotra, Ning Sun, Qiongshi Lu, Yiming Hu, Boyang Li, Quan Chen, Shrikant Mane, Perry Miller, Kei-Hoi Cheung, Raquel E. Gur, Tiffany A. Greenwood, David L. Braff, Eric D. Achtyes, Peter F. Buckley, Michael A. Escamilla, Douglas Lehrer, Dolores P. Malaspina, Steven A. McCarroll, Mark H. Rapaport, Marquis P. Vawter, Michele T. Pato, Carlos N. Pato, Hongyu Zhao, Thomas R. Kosten, Mary Brophy, Saiju Pyarajan, Yunling Shi, Timothy J. O'Leary, Theresa Gleason, Ronald Przygodzki, Sumitra Muralidhar, J. Michael Gaziano, Grant D. Huang, John Concato, Larry J. Siever, Mihaela Aslan, Philip D. Harvey
Summary: Schizophrenia and bipolar disorder are debilitating neuropsychiatric disorders that collectively affect 2% of the world's population. A recent study on US Veterans revealed new susceptibility loci and associations for these disorders, demonstrating the robust generalizability of published findings and providing insights for future research.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Veterinary Sciences
Shenping Zhou, Rongrong Ding, Zhanwei Zhuang, Haiyu Zeng, Shuxian Wen, Donglin Ruan, Jie Wu, Yibin Qiu, Enqin Zheng, Gengyuan Cai, Jie Yang, Zhenfang Wu, Ming Yang
Summary: In this study, single-trait and multi-trait genome-wide association studies were performed to investigate the genetics of chest circumference, abdominal circumference, and waist circumference in Duroc pigs. A novel quantitative trait locus on Sus scrofa chromosome one was identified, and 21 significant SNPs associated with the three conformation traits were identified through multi-trait GWAS. Furthermore, three candidate genes related to sphingolipid metabolism and lysosome pathways were discovered.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Plant Sciences
Reena Rani, Ghulam Raza, Hamza Ashfaq, Muhammad Rizwan, Muhammad Khuram Razzaq, Muhammad Qandeel Waheed, Hussein Shimelis, Allah Ditta Babar, Muhammad Arif
Summary: Soybean is a significant crop globally, and this study used genome-wide association studies to identify genes and functional markers associated with soybean agronomic traits, providing valuable data for future breeding programs.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Fisheries
Longping Wu, Shihai Gong, Huanhuan Li, Caihuan Ke, Bo Shi
Summary: In this study, 1,452,168 single-nucleotide polymorphisms (SNPs) in Fujian oysters were used for genome-wide association analysis. The results revealed 141 SNPs significantly associated with Cd accumulation traits, with 131 of them concentrated in the 1.28-9.76 Mb range of Chr.3. The genes ZIP1, ZIP3, Slc46a1, and Slc46a3 within this range were found to be involved in regulating Cd accumulation in Fujian oysters. Furthermore, six SNPs in the coding regions of ZIP1 and ZIP3 were significantly correlated with Cd accumulation, with five SNP sites having missense mutations.
Article
Agronomy
Yingxue Yang, Chao Zhang, De Zhu, Huiying He, Zhaoran Wei, Qiaoling Yuan, Xiaoxia Li, Xu Gao, Bin Zhang, Hongsheng Gao, Bo Wang, Shuaimin Cao, Tianyi Wang, Yuhua Li, Xiaoman Yu, Longbiao Guo, Guanjing Hu, Qian Qian, Lianguang Shang
Summary: This study aims to identify candidate genes and characterize their response patterns during rice adaptation to high temperatures at the seedling stage. Comparison of transcript abundances revealed differentially expressed genes between heat-sensitive and heat-tolerant rice pools under heat stress. Alternative splicing events and gene expression patterns associated with heat stress were also identified. These findings provide valuable insights into the regulatory mechanisms of rice response to heat stress and offer potential targets for breeding heat-tolerant rice varieties.
Article
Agronomy
Yuxuan Duan, Hongliang Zheng, Haoran Wen, Di Qu, Jingnan Cui, Chong Li, Jingguo Wang, Hualong Liu, Luomiao Yang, Yan Jia, Wei Xin, Shuangshuang Li, Detang Zou
Summary: This study screened 21 rice varieties with strong salt tolerance and identified 40 QTL loci significantly associated with salt tolerance at the germination stage through genome-wide association analysis, providing a theoretical basis for improving rice salt tolerance in saline soils.
Article
Multidisciplinary Sciences
Samuel Mathieu, Mewen Briend, Erik Abner, Christian Couture, Zhonglin Li, Yohan Bosse, Sebastien Theriault, Tonu Esko, Benoit J. Arsenault, Patrick Mathieu
Summary: A genome-wide association analysis was conducted on a large sample size to identify genetic risk loci associated with hypothyroidism. The study found multiple risk loci involved in lymphocyte function. Candidate genes associated with hypothyroidism were identified using molecular quantitative trait loci, co-localization, and enhancer-promoter chromatin looping. Mendelian randomization analysis identified blood expressed genes and circulating proteins as potential causal molecules for hypothyroidism. Drug-gene interaction analysis revealed that certain cancer therapy drugs increase the risk of hypothyroidism. This study provides important genetic evidence for drug-induced hypothyroidism and identifies potential drug targets.
Article
Psychiatry
Anissa Abi-Dargham, Scott J. Moeller, Farzana Ali, Christine DeLorenzo, Katharina Domschke, Guillermo Horga, Amandeep Jutla, Roman Kotov, Martin P. Paulus, Jose M. Rubio, Gerard Sanacora, Jeremy Veenstra-VanderWeele, John H. Krystal
Summary: The field of psychiatry lacks robust and reliable biomarkers for diagnosing patients and providing individualized treatment recommendations. This review critically evaluates the evidence for potential biomarkers in various psychiatric disorders. The majority of candidate biomarkers have not been proven sufficiently reliable and useful for clinical adoption. Strategic investments and focused testing are necessary to overcome this gap in the biomarker validation process.
Article
Biochemistry & Molecular Biology
Samar M. Esmail, Diego Jarquin, Andreas Boerner, Ahmed Sallam
Summary: This study evaluated the NB and PM resistance of 122 diverse barley genotypes from 34 countries and found high genetic variation among the genotypes. No significant correlation was found between PM and NB resistance, but 21 genotypes immune to both diseases were identified. Furthermore, GWAS identified SNP markers associated with increased resistance to PM and NB.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.