Article
Neurosciences
Robert Kim, Terrence J. Sejnowski
Summary: By analyzing computational models and neural data, the authors demonstrate that inhibitory-to-inhibitory signaling is crucial for maintaining stable temporal dynamics and working memory in the primate prefrontal cortex.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Erin Goddard, Erika W. Contini, Muireann Irish
Summary: This study used MEG to measure the activity of the posteromedial cortex (PMC) in healthy human participants during a visuospatial working memory task. The findings suggest that the PMC plays a role in shaping object representations in other cortical regions and influences the retrieval process.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Chenjie Shen, Keith M. Skaggs, Yuanyuan Hou, Morgan Fleishman, Olivia Mosto, Alyssa Weninger, Guoping Feng
Summary: A specific region of the anterior thalamic nuclei plays a key role in spatial working memory tasks in aged mice, and targeting this region may be more beneficial for cognitive functions with fewer unintended effects compared to direct manipulation of the prefrontal cortex. Activation of neurons or circuits in this region can improve working memory, while direct activation of prefrontal cortex neurons may lead to increased anxiety levels in aged mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Wen Jia Chai, Aini Ismafairus Abd Hamid, Hazim Omar, Muhammad Riddha Abdul Rahman, Diana Noma Fitzrol, Zamzuri Idris, Abdul Rahman Izaini Ghani, Wan Nor Azlen Wan Mohamad, Faiz Mustafar, Muhammad Hafiz Hanafi, Regunath Kandasamy, Mohd Zaid Abdullah, Kannapha Amaruchkul, Pedro A. Valdes-Sosa, Maria L. Bringas-Vega, Bharat Biswal, Jitkomut Songsiri, Hamwira Yaacob, Haidi Ibrahim, Putra Sumari, Nor Azila Noh, Kamarul Imran Musa, Asma Hayati Ahmad, Azlinda Azman, Paramjit Singh Jamir Singh, Azizah Othman, Jafri Malin Abdullah
Summary: Working memory (WM) is a crucial cognitive process used for retaining and manipulating temporary information during complex cognitive tasks. Individuals with traumatic brain injury (TBI) often experience compromised WM, especially in the WM domain. This study investigated the brain responses of WM in participants with mild-moderate TBI compared to healthy controls using functional magnetic resonance imaging. The results showed that the TBI group exhibited activation dominance in the right hemisphere and slower reaction time during the task.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Craig W. Berridge, David M. Devilbiss, Andrea J. Martin, Robert C. Spencer, Rick L. Jenison
Summary: Goal-directed behavior relies on neuronal activity in the prefrontal cortex (PFC) and extended frontostriatal circuitry. Stress impairs frontostriatal-dependent cognition, but the underlying neural mechanisms are not well understood. This study investigated the effects of acute noise-stress on neural activity and connectivity within cognition-related frontostriatal circuitry in rats. The results showed that stress suppressed neuronal responses and disrupted neural coding and functional connectivity during a spatial working memory task, providing insights into the cognitive impairing effects of stress.
Article
Psychology, Biological
Ashkan Farrokhi, Shiva Tafakori, Mohammad Reza Daliri
Summary: The interaction between oscillatory rhythms at different frequencies plays a crucial role in cognitive functions. This study focuses on the medial prefrontal cortex (mPFC) and reveals the dynamic phase-amplitude coupling between theta and high frequency oscillations (HFOs) in a spatial working memory task. The coupling emerges near the turning point and diminishes afterwards.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Megan Roussy, Benjamin Corrigan, Rogelio Luna, Roberto A. Gulli, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujilio
Summary: The study found that LPFC neurons maintain robust and distinct neural codes for mnemonic and perceptual visuospatial representations during naturalistic vision, with animals using different behavioral strategies for working memory and perception tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Sihai Li, Christos Constantinidis, Xue-Lian Qi
Summary: The study investigated the roles of the dorsolateral prefrontal cortex and posterior parietal cortex in working memory, finding that neuronal activity can predict categorical judgments of information and deviations in firing rates reflect the contents of working memory.
Review
Psychiatry
Shengtao Yang, Hyojung Seo, Min Wang, Amy F. T. Arnsten
Summary: The dlPFC generates mental representations through NMDAR transmission, while disruptions can lead to cognitive deficits. AMPAR plays a crucial role in visual stimuli and sensory event responses, whereas NMDAR is important for affective and visceral responses.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Sarah Delcourte, Amel Bouloufa, Renaud Rovera, Cecile Betry, Erika Abrial, Ouria Dkhissi-Benyahya, Christophe Heinrich, Guillaume Marcy, Olivier Raineteau, Nasser Haddjeri, Guillaume Lucas, Adeline Etievant
Summary: This study reveals the significant role of prefrontal cortex astroglia in memory performance and synaptic plasticity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Xiaoyu Ma, Charles Zheng, Yenho Chen, Francisco Pereira, Zheng Li
Summary: The ability to perceive and locate spatial environments is crucial for animal survival. The medial prefrontal cortex (mPFC) has been implicated in spatially related behaviors, but its properties and how it is influenced by animal behavior are not well-defined. This study found that the population activity of mPFC neurons can predict animal locations, and this coding accuracy is higher in tasks involving working memory and reward-seeking.
Article
Neurosciences
Youngsun T. Cho, Flora Moujaes, Charles H. Schleifer, Martina Starc, Jie Lisa Ji, Nicole Santamauro, Brendan Adkinson, Antonija Kolobaric, Morgan Flynn, John H. Krystal, John D. Murray, Grega Repovs, Alan Anticevic
Summary: This study investigated how reward and loss impact spatial working memory precision and neural circuits in human subjects. The results showed that both reward and loss improved spatial working memory precision, with specific regions like precentral sulcus and intraparietal sulcus having increased BOLD signal related to better working memory precision. Conversely, areas straddling executive networks displayed decreased BOLD signal during incentivized working memory.
Article
Neurosciences
Sonja Chu, Cendri Hutcherson, Rutsuko Ito, Andy C. H. Lee
Summary: The prefrontal cortex (PFC) and medial temporal lobe (MTL) contribute differently to resolving conflict information and uncertainty during approach-avoidance decisions. The PFC may adjust response caution and evidence strength towards each choice, involving the anterior cingulate cortex and dorsolateral prefrontal cortex, while the MTL contributes to evidence generation, particularly through the hippocampus. These findings suggest unique contributions of MTL and PFC regions in arbitrating approach-avoidance conflict.
Article
Geriatrics & Gerontology
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Summary: Age-related declines in cognition, especially in working memory and executive function, are mediated by the prefrontal cortex and the dopamine system within it. Administering the DA D1 R agonist PF-6294 to aged female rhesus monkeys improved memory span on the Delayed Recognition Span Task, particularly on repeated trials.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Mark Laubach, Sebastien Bouret, Jerome Sallet
JOURNAL OF PHYSIOLOGY-PARIS
(2015)
Review
Neurosciences
Mark Laubach, Marcelo S. Caetano, Nandakumar S. Narayanan
JOURNAL OF PHYSIOLOGY-PARIS
(2015)
Article
Behavioral Sciences
Marc A. Parent, Linda M. Amarante, Kyra Swansons, Mark Laubach
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2015)
Article
Neurosciences
Linda M. Amarante, Marcelo S. Caetano, Mark Laubach
JOURNAL OF NEUROSCIENCE
(2017)
Article
Behavioral Sciences
Nicole K. Horst, Christopher J. Heath, Nichole M. Neugebauer, Eyal Y. Kimchi, Mark Laubach, Marina R. Picciotto
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Neurosciences
Nicole K. Horst, Mark Laubach
JOURNAL OF NEUROPHYSIOLOGY
(2012)
Article
Neurosciences
Marcelo S. Caetano, Nicole K. Horst, Linda Harenberg, Benjamine Liu, Amy F. T. Arnsten, Mark Laubach
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Trevor Bekolay, Mark Laubach, Chris Eliasmith
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Min Wang, Nao J. Gamo, Yang Yang, Lu E. Jin, Xiao-Jing Wang, Mark Laubach, James A. Mazer, Daeyeol Lee, Amy F. T. Arnsten
Article
Neurosciences
Nandakumar S. Narayanan, James F. Cavanagh, Michael J. Frank, Mark Laubach
NATURE NEUROSCIENCE
(2013)
Editorial Material
Neurosciences
Linda M. Amarante, Mark Laubach
Article
Neurosciences
Nicole K. Horst, Mark Laubach
FRONTIERS IN NEUROSCIENCE
(2013)
Article
Behavioral Sciences
Kyra Swanson, Hannah C. Goldbach, Mark Laubach
BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Mark Laubach, Linda M. Amarante, Kyra Swanson, Samantha R. White
Article
Behavioral Sciences
Marc A. Parent, Linda M. Amarante, Benjamine Liu, Damian Weikum, Mark Laubach
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2015)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.