Article
Integrative & Complementary Medicine
Yuan-yuan Ding, Feng Xu, Ya-feng Wang, Lin-lin Han, Shi-qian Huang, Shuai Zhao, Lu-lin Ma, Tian-hao Zhang, Wen-jing Zhao, Xiang-dong Chen
Summary: This study explores the effects of electroacupuncture (EA) on acute postoperative pain (APP) and the role of the stimulator of interferon genes/type-1 interferon (STING/IFN-1) pathway modulation. The findings suggest that EA can alleviate APP-induced hypersensitivity and mitigate neuroinflammatory response by activating the STING/IFN-1 pathway.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Anesthesiology
Hua Huang, Shermaine Huiping Tay, Winanto Ng, Shi Yan Ng, Tuck Wah Soong
Summary: The study revealed that the exon 27 of human TRPA1 can be alternatively spliced into two variants, affecting the channel function. By manipulating the splicing factor SRSF1, alternative splicing within exon 27 can be promoted, leading to decreased TRPA1 activity.
Article
Immunology
Chunliang Xu, Maria Gulinello, Paul S. Frenette
Summary: Sensory nerves play a protective role in SCD, relieving the severity of VOE, and manipulating nociception may provide a promising approach for treating SCD.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger, Marco Sisignano
Summary: This study demonstrates that the FKBP51 inhibitor SAFit2 ameliorates nerve injury-induced neuropathic pain by reducing neuroinflammation. SAFit2 reduces the infiltration of immune cells into neuronal tissue and counteracts the increased NF-kappa B pathway activation, leading to reduced cytokine and chemokine levels. Additionally, SAFit2 desensitizes the TRPV1 channel and reduces the release of pro-inflammatory neuropeptides.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Behavioral Sciences
Deborah Chiabrando, Veronica Fiorito, Sara Petrillo, Francesca Bertino, Emanuela Tolosano
Summary: This study examines the relationship between heme and the pathophysiology of pain, highlighting the important regulatory role of heme in nociception and its association with pain-related diseases. However, the molecular mechanisms linking heme to pain pathways remain unclear at present.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Immunology
Lulu Xu, Weiping Hu, Jing Zhang, Jieming Qu
Summary: This study explored the effects of V1 on acute lung inflammation and found that increased expression of V1 may have a protective role in acute inflammation, while interventions targeting V1 might cause a cytokine storm induced by infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Chase, June Bryan de la Pena, Patrick R. Smith, Jennifer Lawson, Tzu-Fang Lou, Alexander D. Stanowick, Bryan J. Black, Zachary T. Campbell
Summary: Nociceptors are sensory neurons that play a crucial role in pain sensation. A recent study explored the potential of using sensory neurons derived from human induced pluripotent stem cells (hiPSCs) as a model for nociceptor research. The study compared the gene expression profiles of hiPSC-derived sensory neurons with mouse dorsal root ganglion (DRG) tissues and found similarities in key pain-related transcripts. Additionally, the study identified a translation factor called eIF5A as a potential target for inflammation-associated pain. Inhibition of eIF5A activity showed promising results in preventing pain hypersensitivity in vivo and reducing hiPSC activity in vitro.
Article
Neurosciences
Luke Grundy, Ashlee Caldwell, Sonia Garcia-Caraballo, David Grundy, Nick J. Spencer, Xinzhong Dong, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This study demonstrates the functional expression of MrgprA3 and MrgprC11 in bladder afferents for the first time. Activation of these receptors triggers hypersensitivity to distension, which is a critically valuable factor for therapeutic target development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
Yan Liu, Yutong Liu, Nathachit Limjunyawong, Claire Narang, Hanna Jamaldeen, Shimeng Yu, Shivanie Patiram, Hong Nie, Michael J. Caterina, Xinzhong Dong, Lintao Qu
Summary: Chronic pruritus is a significant symptom of allergic contact dermatitis, but its underlying mechanisms are not well understood. TRPC3 is highly expressed in primary sensory neurons and is involved in peripheral sensitization. However, its role in acute and chronic itch is still unclear.
Article
Biochemistry & Molecular Biology
Uma Anand, Praveen Anand, Mikael Hans Sodergren
Summary: Terpenes in Cannabis sativa inhibit capsaicin-induced calcium influx by activating Na+/K+ ATPase, which contributes to their analgesic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Adrien Tassou, Maxime Thouaye, Damien Gilabert, Antoine Jouvenel, Jean-Philippe Leyris, Corinne Sonrier, Lucie Diouloufet, Ilana Mechaly, Sylvie Mallie, Juliette Bertin, Myriam Chentouf, Madeline Neiveyans, Martine Pugniere, Pierre Martineau, Bruno Robert, Xavier Capdevila, Jean Valmier, Cyril Rivat
Summary: Acute pain can lead to chronic pain, and the FLT3-tyrosine kinase receptor plays a crucial role in pain chronification after peripheral nerve injury. This study aimed to investigate whether injury-induced pain sensitization can also contribute to long-term mood disorders. The results showed that mice with double paw incisions exhibited an anxiodepressive-like phenotype and increased pain sensitivity compared to those with single incisions. These behavioral changes were associated with peripheral and spinal changes, including increased microglia activation. Blocking FLT3 and microglia activation alleviated the exaggerated pain sensitivity and anxiodepressive behaviors induced by double incisions. Humanized antibodies against FLT3 also reduced behavioral and microglia changes. Overall, this study suggests that peripheral lesions can not only cause exaggerated pain behaviors but also induce anxiodepressive disorders, and targeting peripheral FLT3 may provide a potential therapeutic approach.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Medicine, General & Internal
Luis M. Blanco-Colio, Nerea Mendez-Barbero, Ana Maria Pello Lazaro, Alvaro Acena, Nieves Tarin, Carmen Cristobal, Juan Martinez-Milla, Oscar Gonzalez-Lorenzo, Jose Luis Martin-Ventura, Ana Huelmos, Carlos Gutierrez-Landaluce, Marta Lopez-Castillo, Andrea Kallmeyer, Ester Canovas, Joaquin Alonso, Lorenzo Lopez Bescos, Jesus Egido, Oscar Lorenzo, Jose Tunon
Summary: The study found that MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation, while NT-proBNP and MCP-1 are not associated with primary outcome in patients with low inflammation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Wei-Dong Lai, Song Wang, Wen-Ting You, Si-Jia Chen, Jun-Jun Wen, Cun-Rui Yuan, Meng-Jia Zheng, Yan Jin, Jie Yu, Cheng-Ping Wen
Summary: Chronic pain is a disease characterized by long-lasting pain mediated by central and (or) peripheral sensitization. Patients with chronic pain exhibit heightened sensitivity to both harmful and non-harmful stimuli, making them less responsive to first-line analgesic treatment. Sinomenine, the main active ingredient in the plant sinomenium acutum, has been shown to have a powerful inhibitory effect on chronic pain. However, the underlying mechanism is still not fully understood. The immune system, along with inflammatory factors and neuropeptides, plays a crucial role in the pathogenesis of chronic pain. The interaction between the immune system and sensory neurons is essential for the development and maintenance of chronic pain. This review focuses on describing the potential analgesic effects of sinomenine by regulating the neuroimmune interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhangfu Fang, Fang Yi, Yang Peng, Junfeng (Jim) Zhang, Liting Zhang, Zheng Deng, Fagui Chen, Chenhui Li, Yaowei He, Chuqin Huang, Qingling Zhang, Kefang Lai, Jiaxing Xie
Summary: The study demonstrated that the TRPA1 antagonist HC-030031 reduced airway inflammation and hyperresponsiveness in a murine allergic rhinitis model by targeting TRPA1, leading to decreased type-2 inflammation in nasal mucosa and improved nose-scratching events, as well as reduced leucocyte numbers and IL-8 levels in the BAL fluid.
Article
Microbiology
Tiffany Lin, Daisy Quellier, Jeffrey Lamb, Tiphaine Voisin, Pankaj Baral, Felix Bock, Alfrun Schoenberg, Rossen Mirchev, Gerald Pier, Isaac Chiu, Mihaela Gadjeva
Summary: The study highlights the role of sensory neurons in regulating corneal neutrophil responses during P. aeruginosa keratitis, influencing disease progression. The findings suggest that therapeutic strategies targeting nociception may have beneficial effects on anti-infective therapy.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.