期刊
NEUROSCIENCE
卷 159, 期 1, 页码 161-171出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2008.12.028
关键词
BPA; synaptic plasticity; DL; striatum; D1 receptor; D2 receptor
资金
- PCSIRT [IRT0631]
- NSFC [30,872,725]
- Nanjing Medical University Science and Technology Development Project [07NMUZ006]
- Jiangsu Province Natural Science Research Project [08KJB310007]
- Scientific Research on Priority Areas [15,086,270]
- Creative Scientific Research [16GS0308]
- MEXT, Japan
- [2009CB941701]
Prenatal and neonatal exposure to relatively low-dose bisphenol-A (BPA, 20 mu g/kg/day) causes hyper-locomotion of male rat offspring. This research investigated the developmental pattern of activity-dependent synaptic plasticity in dorsolateral (DL) striatum, a cellular basis for motor controlling, in male rat offspring with hyper-locomotion. High frequency stimulation (four-pulse bursts at 100 Hz) was undertaken to induce long-term potentiation (LTP) and long-term depression (LTD) in corticostriatal synapse during postnatal day (PD) 10-32. Herein, we show that in control rats HFS induces LTP during PD12-14 and LTD during PD24-32. Strikingly, the prenatal and neonatal exposure to low-dose BPA resulted in delay of LTP induction during PD21-32, showing a reversal of LTD induction. In addition, in PD28 BPA-rats basal population spike amplitude was increased with reduction of paired-pulse facilitation (PPF) compared to the same age control rats. Acute application of the dopamine 1 receptor (B1R) antagonist SCH23390 in slices obtained from PD28 BPA-rats inhibited not only the PS-potentiation and PPF-induction but also the induction of LTP. Furthermore, the dopamine 2 receptor (D2R) agonist quinpirole recovered the LTD induction in PD28 BPA-rats, which was D1R-dependent and metabotropic glutamate receptor-dependent. In PD28 control rats, the blockade of D2R by L-sulpiride reversed the D1R- and mGluR-dependent LTD to short-term potentiation. Therefore, the findings provide functional evidence that prenatal and neonatal exposure to low-dose BPA causes deficits in development of LTP and LTD at DL-striatum via altering the function of dopaminergic receptors. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
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